ABOUT PRAMIPEXOLE: Pramipexole is a synthetic agonist for dopamine receptors. It has a selective affinity for the dopamine receptor, D2, with little agonist activity for the D1 class. Consequently, pramipexole may be better tolerated than bromocriptine or pergolide, which is active towards both D1 and D2 receptors. Pramipexole is a dopamine agonist whose function is to restore dopamine balance in the brain.
Liquid pramipexole may be beneficial in early Parkinson's disease and as adjunctive therapy to levodopa in rats with advanced disease experiencing motor effects. Because of its diminished response to levodopa. The potential neuroprotective effects of pramipexole have been shown in animal and in vitro studies.
Absorption of pramipexole reaches peak concentrations within 2 hours of ingestion. Its bioavailability is more than 90%, which is an indication that it is efficiently absorbed as it encounters slight pre-systemic metabolism. Its half-life is between 8-12 hours. Excretion is mostly through the urine, where 90% of it is found in its unchanged form.
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|Appearance||Viscous transparent liquid|
|Stability||Room Temperature out of direct sunlight|
|Concentration||2mg per ML|
|Terms||This product is sold for research/laboratory usage only. No other uses are permited.|