How MT-II and SHU-9119-derived macrocycles were engineered for MC4R selectivity over MC1R, MC3R, and MC5R in receptor pharmacology research.

Research overview of enlicitide, an investigational oral macrocyclic peptide engineered to disrupt the PCSK9-LDLR protein interface.

Examining receptor-mediated transcytosis via LRP1 and transferrin receptor routes, and the mixed research evidence on shuttle peptide conjugation outcomes.

How isopeptide-bonded threaded lasso peptide scaffolds resist heat and proteolysis, and how genome mining pipelines are accelerating RiPP discovery research.

Research on small ORFs and lncRNA-encoded microproteins is reshaping the proteome map, with mass-spec detection challenges and cancer biology roles.