LGD-4033 10mg/ml (30ml)

Buy LGD4033 Liquid at Loti Labs

Research into selective androgen receptor modulators has advanced significantly in recent years, with LGD-4033 emerging as a compound of particular scientific interest. As laboratories worldwide investigate the mechanisms and applications of these selective androgen receptor modulators, the demand for high-purity research chemicals has grown substantially. For researchers seeking to purchase LGD-4033 for legitimate scientific investigations, understanding both the compound’s properties and sourcing requirements becomes essential.

Scientists and research institutions require reliable access to verified compounds that meet stringent analytical standards. LGD-4033, also known as Ligandrol, represents a significant advancement in SARM research, offering researchers a tool to investigate selective androgen receptor interactions in controlled laboratory environments.

Molecular Structure of LGD-4033

Chemical Formula: C14H12F6N2O

Molecular Weight: 338.258 g/mol

IUPAC Name: 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoromethylbenzonitrile

CAS #: 1165910-22-4

The molecular architecture of LGD-4033 distinguishes it from traditional compounds used in research. Originally developed by Ligand Pharmaceuticals, this nonsteroidal oral compound features a pyrrolidine ring system attached to a benzonitrile core, incorporating six fluorine atoms that contribute to its chemical stability and unique binding characteristics. Research suggests these structural elements provide the compound with strong affinity for specific receptor targets while maintaining selectivity profiles that differ significantly from anabolic steroids.

Unlike testosterone and other traditional androgens, the molecular design of LGD-4033 allows researchers to investigate tissue-selective interactions. The compound’s synthetic nature and specific stereochemistry enable controlled studies examining how structural modifications influence receptor binding and downstream cellular responses.

Mechanism of Action

LGD-4033 functions as a selective androgen receptor modulator with demonstrated high affinity for androgen receptors in research settings. Scientific investigations reveal that this compound exhibits a remarkable 10:1 anabolic-to-androgenic ratio, providing researchers with a tool to study selective activity in target tissues while minimizing broader androgenic effects typically observed with conventional compounds.

Research studies indicate that LGD-4033 operates through tissue-selective agonism at androgen receptors. In laboratory investigations, the compound demonstrates potent binding activity in muscle and bone tissue preparations, while showing reduced activity in androgen-sensitive tissues such as prostate samples. This selectivity stems from the compound’s unique molecular configuration, which influences gene transcription patterns by recruiting specific co-regulator proteins.

The research mechanism differs substantially from anabolic steroids, as LGD-4033 does not undergo significant metabolism by CYP19 aromatase or 5α-reductase enzymes in laboratory studies. This characteristic allows researchers to investigate direct receptor interactions without confounding effects from metabolic conversion products that typically complicate steroid research.

Preclinical investigations demonstrate that LGD-4033 produces robust anabolic effects at nanomolar concentrations, with in vitro efficacy measurements showing 132-133% maximum response rates and EC50 values between 3.6-4.4 nM. These pharmacodynamic properties make the compound valuable for dose-response studies and mechanistic investigations.

Research Studies

Clinical trials examining LGD-4033 have provided valuable data for the research community. Phase 1 trials enrolled 76 healthy young men in double-blind, placebo-controlled studies investigating the compound’s effects over 21-day periods. Results showed statistically significant, dose-dependent increases in lean body mass compared to placebo groups, with no serious adverse reactions reported during the study timeframe.

A subsequent Phase 2 investigation focused on 120 older adults recovering from hip fractures, examining dose ranges from 0.5 mg to 2 mg daily over several weeks. Clinical studies demonstrated significant improvements in muscle mass and strength parameters compared to placebo controls, suggesting potential applications for research into muscle wasting conditions and bone health.

Preclinical animal studies have revealed that up to 70% of body mass gains achieved during LGD-4033 administration can be retained following a four-week recovery phase. These retention rates highlight the compound’s durable impact on muscle tissue in research models and provide insights into the long term effects of selective androgen receptor modulation.

Research suggests that LGD-4033 may offer benefits for investigating muscle atrophy, osteoporosis, and related conditions affecting bone density. However, researchers emphasize that these clinical studies represent preliminary investigations, and long term benefits require further scientific evaluation before broader research applications can be established.

The research findings indicate that unlike testosterone supplementation, LGD-4033 treatment in controlled studies does not significantly affect prostate tissue parameters or produce typical androgenic responses. This selectivity profile makes the compound particularly valuable for researchers investigating muscle growth and bone health without the confounding variables associated with traditional androgenic compounds.

Storage and Safety

Proper storage protocols are essential for maintaining LGD-4033 research chemical integrity throughout its shelf life. Store LGD-4033 in a cool, dry place away from direct sunlight to preserve product stability and prevent degradation. Under appropriate environmental conditions, the compound typically maintains research-grade quality for 2-3 years from the manufacturing date.

Laboratory safety protocols require appropriate personal protective equipment during handling procedures. Research personnel should utilize gloves, safety glasses, and other protective measures when working with this potent compound. Proper ventilation and standard laboratory safety practices ensure safe handling throughout research applications.

Temperature control proves critical for long term storage, with refrigeration recommended for extended storage periods. Avoid exposure to moisture, extreme temperatures, or UV light, which may compromise the compound’s chemical stability. Research laboratories should implement proper inventory management to track storage duration and environmental conditions.

Safety considerations extend beyond storage to include proper disposal methods for unused material and contaminated laboratory equipment. Research institutions must follow established protocols for handling and disposing of research chemicals in compliance with institutional and regulatory guidelines.

Benefits of Buying from Loti Labs

Loti Labs provides premium LGD-4033 liquid with verified purity of ≥98%, setting industry standards for research chemical quality. All products include a Certificate of Analysis from U.S.-based independent laboratories, providing researchers with detailed analytical verification of product composition and purity levels. This documentation supports research reproducibility and regulatory compliance requirements.

Multiple product forms are available to meet specific research requirements, including both powder and liquid formulations that enable precise dosing in experimental protocols. The availability of different formats allows researchers to select the most appropriate form for their specific experimental designs and measurement requirements.

Research suggests that product purity significantly impacts experimental outcomes, making verified analytical data essential for meaningful scientific investigations. Loti Labs addresses this concern through rigorous quality control measures that exceed typical industry standards for research chemical suppliers.

The company’s commitment to analytical verification provides researchers with confidence in their experimental results. Third-party testing protocols ensure that each batch meets established purity specifications before distribution to research institutions and laboratories.

For fitness enthusiasts and bodybuilders seeking compounds for personal use, it’s important to note that Loti Labs products are intended strictly for research purposes. The company does not support human consumption or athletic performance enhancement applications outside of legitimate scientific investigation.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are intended as research chemicals only. This designation allows the use of these compounds strictly for in-vitro laboratory testing and experimentation. Human use or veterinary applications are strictly forbidden under this classification.

These products are not intended as supplements, and may not be misbranded, mislabeled, or misused for human consumption. The research use designation ensures compliance with regulatory guidelines while supporting legitimate scientific investigation into selective androgen receptor modulator mechanisms and applications.

Research purposes encompass a wide range of legitimate scientific investigations, including cellular studies, receptor binding assays, pharmacokinetic evaluations, and mechanistic research. However, the compounds cannot be used for physical performance enhancement, athletic performance improvement, or any applications involving human subjects outside of approved clinical research protocols.

Scientists and research institutions must maintain proper documentation demonstrating research use compliance. This includes experimental protocols, institutional review board approvals where applicable, and proper record-keeping demonstrating legitimate scientific applications.

The distinction between research chemicals and consumer products is critical for legal compliance and ethical research practices. Researchers must ensure that their intended applications align with research use only designations and institutional guidelines.

Healthcare professionals consulting on research projects should understand that these compounds lack FDA approval for human therapeutic applications. Any research involving human subjects requires appropriate regulatory oversight and ethical review processes.

Shipping Policy of Loti Labs

Loti Labs offers same-day shipping for orders placed before 1pm EST Monday through Friday, ensuring rapid delivery for time-sensitive research projects. Orders placed after 1pm EST or on weekends are processed and shipped the next business day, maintaining reliable delivery schedules for research institutions.

Free shipping is available on orders over $99, providing cost-effective procurement options for research laboratories managing budget constraints. This policy supports bulk purchasing for extended research projects while reducing overall procurement costs.

The expedited shipping schedule recognizes that research timelines often require rapid access to verified compounds. Laboratory schedules and experimental protocols benefit from predictable delivery timeframes that support project planning and execution.

Shipping policies accommodate both individual researcher needs and institutional procurement requirements. Multiple shipping options ensure that researchers can select delivery methods that align with their specific timeline and budget requirements.

Satisfaction Guarantee

Loti Labs offers a 30-day satisfaction guarantee on all products purchased from their facility. Simply return any unopened products for a full refund of the purchase price of unused materials, providing researchers with confidence in their procurement decisions.

This guarantee policy recognizes that research requirements may change during project development, and provides flexibility for laboratories managing evolving experimental protocols. The satisfaction guarantee supports research institutions in making procurement decisions without financial risk.

Quality assurance through satisfaction guarantees demonstrates the company’s confidence in their analytical verification processes and product quality standards. Researchers benefit from this policy when establishing new experimental protocols or evaluating different supplier options.

The guarantee period allows sufficient time for researchers to evaluate product quality and suitability for their specific experimental requirements. This timeframe accommodates typical research planning cycles and experimental development phases.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs undergoes rigorous third-party testing using HPLC to ensure product purity and accuracy. This verification process guarantees research-grade quality for all LGD-4033 products and provides researchers with analytical confidence in their experimental materials.

Independent laboratory verification eliminates potential conflicts of interest in quality assessment and provides objective analytical data for research documentation. Third-party testing protocols follow established analytical standards that support research reproducibility and publication requirements.

The HPLC testing methodology provides precise quantification of active compound concentrations while identifying potential impurities that could affect experimental outcomes. This analytical approach supports the high purity standards required for meaningful scientific investigation.

Batch-specific testing ensures consistent quality across different production runs and allows researchers to track analytical variations that might influence experimental results. Certificate of Analysis documentation provides detailed analytical data for research record-keeping and regulatory compliance.

Research institutions benefit from comprehensive analytical verification when establishing experimental protocols and interpreting research outcomes. The availability of detailed analytical data supports peer review processes and publication requirements in scientific journals.

Results showed that independent analytical verification significantly improves research quality and reproducibility compared to supplier self-testing approaches. This commitment to analytical transparency sets Loti Labs apart in the research chemical marketplace.

References

1. Basaria, S., et al. (2013). The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral Selective Androgen Receptor Modulator, in Healthy Young Men. The Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, 68(1), 87-95.
2. Bhattacharya, I., et al. (2016). Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a Single Dose of LGD-4033. Clinical Pharmacology in Drug Development, 5(6), 513-523.
3. Viking Therapeutics. (2015). Phase 2 Trial of VK5211 in Patients Recovering from Hip Fracture. FierceBiotech.
4. Fragkaki, A., et al. (2018). Human In Vivo Metabolism Study of LGD-4033. Drug Testing and Analysis, 10(11-12), 1635-1645.
5. Australian Government Department of Health. (2020). Therapeutic Goods Administration: Regulation of Selective Androgen Receptor Modulators (SARMs).
6. GlobeNewswire. (2025). Ligandrol LGD-4033 SARMs: Benefits, Results & Alternatives. Retrieved from https://www.globenewswire.com

For researchers seeking to buy LGD-4033 for legitimate scientific investigations, Loti Labs provides verified, research-grade compounds with comprehensive analytical documentation. The combination of rigorous quality control, third-party testing, and research use only compliance ensures that scientists have access to the high-purity materials required for meaningful scientific advancement in selective androgen receptor modulator research.

For more information on LGD-4033 Ligandrol please visit Wikipedia.

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Weight	0.1875 lbs
Appearance	Viscous cloudy liquid
Stability	Room Temperature out of direct sunlight
Molar Mass	338.253
CAS Number	1165910-22-4
Container	30ml Bottle
Molecular Formula	C14H12F6N2O
Concentration	10mg per ML
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.156 lbs