Browse the latest articles in this research category.
Covers the chemistry of hydrocarbon stapling and macrocyclic constraints, how these modifications improve alpha-helical stability, protease resistance, and membrane permeability in peptide drug design.
Read articleExplains how CPPs like TAT, penetratin, and polyarginine cross cell membranes, their applications in delivering cargo molecules to intracellular targets, and recent advances in…
Read articleTable of Contents Toggle Receptor Pharmacology: The CLR/RAMP1 Complex CGRP and Migraine: From Observation to Mechanism Research Frontiers Calcitonin gene-related peptide (CGRP) is a…
Read articleTable of Contents Toggle Pemvidutide: A Dual Agonist with a Liver-Targeting Profile The Glucagon Paradox: Why Activate a “Counterregulatory” Hormone Receptor? Mechanism of Action…
Read articleTable of Contents Toggle Why Orforglipron Is Different Mechanism of Action: Small Molecule, Same Target Pharmacokinetics: Why Oral Delivery Matters for Research Implications for…
Read articleTable of Contents Toggle What Is Follistatin 344? Isoform Differences: FS-288, FS-300, and FS-344 Current Research Landscape and Open Questions What Is Follistatin 344?…
Read articleChemical modifications such as PEGylation, lipidation, and albumin-binding can dramatically extend peptide half-life from minutes to days. This article covers the science behind these…
Read articleGonadorelin is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone. It serves as a fundamental research tool for assessing pituitary responsiveness and HPG axis…
Read articleVIP is a 28-amino-acid neuropeptide with widespread distribution across the central and peripheral nervous systems.
Read articleFOXO4-DRI is a cell-penetrating peptide that selectively disrupts the FOXO4-p53 interaction in senescent cells. Published research in murine models showed restoration of multiple aging…
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