ABOUT T4 (LEVOTHYROXINE): Levothyroxine (T4) is a synthetic version of one of the body’s natural thyroid hormones: thyroxine (T4).
T4 binds to the thyroid receptor protein in the nucleus. It is converted to its active metabolite, L-triiodothyronine (T3) and causes metabolic effects by controlling DNA transcription and protein synthesis. Levothyroxine is a chiral compound in the L-form.
According to research in animal test subjects, T4 is absorbed from the gastrointestinal tract. It’s absorption is increased by fasting and decreased in certain malabsorption syndromes, by certain foods, and with age. The bioavailability is decreased by dietary fiber.
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