Tamoxifen Citrate 20mg/ml (30ml)

Buy Tamoxifen Citrate Liquid from Loti Labs

Tamoxifen citrate is a key compound in breast cancer research, primarily due to its potential to interact with estrogen receptors based on the tissue type. This makes it crucial for studying hormone receptor-positive cancers. This article will provide an overview of tamoxifen citrate, its mechanisms, research applications, and safety guidelines.

Key Takeaways

• Tamoxifen Citrate is a selective estrogen receptor modulator (SERM) primarily used in research to study hormone receptor-positive breast cancers by examining estrogen’s effects on cancer cell growth.
• The compound exhibits dual functionality; acting as an estrogen antagonist in breast tissue while potentially exhibiting estrogenic effects in other tissues, such as bone.
• Tamoxifen is for research use in laboratory settings only, with strict form and storage guidelines to maintain its stability and efficacy for accurate study results.

Overview of Tamoxifen Citrate

Tamoxifen Citrate, with the CAS Number 54965-24-1, is a stilbenoid compound featuring a tertiary amine in its chemical structure. This non-steroidal compound is classified as a selective estrogen receptor modulator (SERM), meaning it can both activate and block estrogen receptors depending on the tissue type. This dual functionality is what makes Tamoxifen particularly intriguing in breast cancer research.

Initially approved by the FDA on December 30, 1977, for research purposes, Tamoxifen was primarily intended for studying breast cancer. Since then, it has become a cornerstone in managing estrogen receptor-positive breast cancers in research settings, demonstrating its efficacy over the decades. As a non-steroidal antiestrogen, Tamoxifen has been the subject of extensive research focusing on its ability to inhibit the binding of estradiol to estrogen receptors.

Research suggests that Tamoxifen can influence breast cancer, especially hormone receptor-positive types, by studying cancer cell growth. Tamoxifen can potentially prevent breast cancer cell proliferation by competing with estrogen at receptor sites in breast tissue. This antiestrogen effect is crucial in managing and studying breast cancer, making Tamoxifen a vital tool in the fight against this disease.

Tamoxifen’s action also extends to other hormone-positive cancers, demonstrating its versatility as a research compound. Understanding these varied applications allows researchers to explore new ways to combat estrogen receptor-positive cancers and develop more effective treatments.

Mechanism of Action

Tamoxifen interacts with estrogen receptors in breast tissue at a molecular level, providing insights into the growth of estrogen receptor-positive tissues. This action classifies Tamoxifen as a selective estrogen receptor modulator (SERM). In breast tissue, Tamoxifen is studied for its potential to inhibit estrogen’s effects, which may slow cancer cell proliferation.

Tamoxifen’s effects vary across different tissues. While it acts as an estrogen antagonist in breast tissue, it can exhibit estrogenic agonist properties in other tissues, like bone. This dual behavior allows for targeted action depending on the tissue type, making Tamoxifen a versatile tool in cancer research.

Tamoxifen reduces cell cycling in breast cancer cells, classifying it as a cytostatic agent. By slowing the cell cycle, Tamoxifen is researched for its potential to inhibit cancer cell growth and spread, offering a valuable mechanism for studying hormone-sensitive or hormone receptor-positive breast cancers.

Research Applications in Animal Studies

Tamoxifen Citrate Liquid from Loti Labs is for research and laboratory use only, not intended for human use. This distinction underscores the compound’s role in advancing scientific knowledge rather than direct medical treatment. In animal studies, Tamoxifen Citrate has been widely utilized to explore its effects on breast cancer cells and hormone-positive breast cancer.

Research suggests that Tamoxifen shows significant potential as an antiestrogen agent in breast cancer research. Animal studies have demonstrated its ability to inhibit the growth of breast cancer cells by blocking estrogen receptors, providing valuable insights into its mechanism of action and potential applications.

Utilizing Tamoxifen Citrate in controlled laboratory settings provides researchers with opportunities to gain insights into its potential effects, paving the way for new discoveries and advancements in cancer research. This focus on animal studies ensures that the findings are robust and can inform future research directions.

Storage

Proper storage of Tamoxifen is essential for maintaining its stability and efficacy. Tamoxifen should be stored at room temperature, between 20°C and 25°C, and kept away from direct sunlight. An opened liquid Tamoxifen container is viable for three months; any remaining Tamoxifen after this period should be discarded. These guidelines help ensure the compound remains effective throughout its use.

Liquid Form Concentration

The liquid formulation of Tamoxifen features a concentration of 20 mg per milliliter. This highly concentrated form allows for precise measurement in research applications, ensuring that researchers can achieve accurate and consistent results in their studies.

Stability and Storage Conditions

Tamoxifen is stable at room temperature and should be kept out of direct sunlight to maintain its efficacy. Exposure to light can degrade the compound, reducing its effectiveness in research applications. Therefore, it is crucial to store Tamoxifen in its original container, protecting it from light and ensuring its stability.

Adhering to these storage guidelines ensures Tamoxifen remains potent and reliable throughout studies. Proper handling and storage are crucial for achieving accurate and reproducible results in laboratory settings.

Potential Effects Observed in Research

Research suggests that Tamoxifen acts as an antiestrogen in breast tissue, potentially competing with estrogen at receptor sites to exert antitumor effects. This competitive binding is a key mechanism by which Tamoxifen may inhibit breast cancer cell growth, making it a valuable research tool. Studies indicate that Tamoxifen can potentially reduce the expression of some genes associated with the proliferation of cancer cells while increasing others linked to resistance.

High-throughput screening has identified additional agents that, when combined with Tamoxifen, may improve its effectiveness against estrogen receptor-positive breast cancer in animal models. This combination approach offers new avenues for exploring resistance mechanisms and enhancing Tamoxifen’s potential applications.

In bone tissue, research suggests Tamoxifen’s estrogenic effects may help prevent osteoporosis. By stimulating estrogen receptors in bone, Tamoxifen may reduce the risk of osteoporosis in certain research contexts. These diverse effects highlight Tamoxifen’s versatility and potential benefits beyond breast cancer research.

Summary

In summary, Tamoxifen Citrate Liquid from Loti Labs is a powerful tool for breast cancer research, offering insights into the mechanisms of hormone receptor-positive cancers. Its ability to block estrogen receptors in breast tissue and its varied effects in different tissues make it a versatile compound for scientific studies.

By understanding the proper form, storage conditions, and safety guidelines, researchers can maximize the potential of Tamoxifen in their studies. The comprehensive information provided in this guide equips researchers with the knowledge needed to handle and utilize Tamoxifen effectively, paving the way for new discoveries and advancements in cancer research.

Frequently Asked Questions

What is the concentration of Tamoxifen in its liquid form?

The concentration of Tamoxifen in its liquid form is 20 mg per milliliter.

How should Tamoxifen be stored?

Tamoxifen should be stored at room temperature, away from direct sunlight, and kept in its original container to ensure its stability.

What are the potential side effects of Tamoxifen observed in research?

Research suggests that Tamoxifen may cause side effects such as hot flashes, skin rashes, dry skin, itching, and, in rare cases, severe skin reactions like blisters and peeling. It is important to monitor these effects and consult a healthcare professional if they occur.

Is Tamoxifen Citrate Liquid from Loti Labs intended for human use?

Tamoxifen Citrate Liquid from Loti Labs is not intended for human use; it is designated solely for research and laboratory purposes.

What are the primary research applications of Tamoxifen in animal studies?

Tamoxifen is primarily used in animal studies to investigate its effects on breast cancer and hormone-positive breast cancer, highlighting its role as an antiestrogen agent. Its applications contribute significantly to our understanding of cancer research strategies and potential prevention techniques.

References and Citations

1. Jordan, V.C. (2006). Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer. British Journal of Pharmacology, 147(S1), S269-S276. doi:10.1038/sj.bjp.0706419
2. Osborne, C.K., & Schiff, R. (2011). Mechanisms of Endocrine Resistance in Breast Cancer. Annual Review of Medicine, 62, 233-247. doi:10.1146/annurev-med-070909-182917
3. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). (2005). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. The Lancet, 365(9472), 1687-1717. doi:10.1016/S0140-6736(05)66544-0
4. Fisher, B., Costantino, J.P., Wickerham, D.L., et al. (1998). Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Journal of the National Cancer Institute, 90(18), 1371-1388. doi:10.1093/jnci/90.18.1371
5. Howell, A., Cuzick, J., Baum, M., et al. (2005). Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years’ adjuvant treatment for breast cancer. The Lancet, 365(9453), 60-62. doi:10.1016/S0140-6736(04)17666-6
6. Shagufta, A., & Ahmad, I. (2018). Tamoxifen a pioneering drug: An update on the therapeutic potential of tamoxifen derivatives. European Journal of Medicinal Chemistry, 143, 515-531. doi:10.1016/j.ejmech.2017.11.056
7. Clarke, R., Liu, M.C., Bouker, K.B., et al. (2003). Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. Oncogene, 22(47), 7316-7339. doi:10.1038/sj.onc.1206937

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For more information on Tamoxifen Citrate visit Wikipedia.

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Weight	0.1875 lbs
Appearance	Viscous cloudy liquid
Stability	Room Temperature out of direct sunlight
Molar Mass	563.7
CAS Number	54965-24-1
Container	30ml Bottle
Molecular Formula	C32H37NO8
Concentration	20mg per ML
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.156 lbs