Thymosin Beta 4 (TB-500) 5mg

Buy TB 500 5mg at Loti Labs: Premium Research Peptide for Scientific Applications

Research into cellular regeneration and tissue repair mechanisms has identified TB 500 as a compound of significant scientific interest. This synthetic peptide, modeled after the naturally occurring thymosin beta 4, has become a focal point for scientists investigating cell migration, wound healing, and molecular pathways involved in tissue regeneration. For researchers seeking to buy tb 500 5mg for their laboratory studies, understanding the compound’s molecular characteristics and research applications is essential for successful experimental outcomes.

Molecular Structure of TB 500

TB 500 represents a synthetic version of thymosin beta-4, comprising a precisely arranged sequence of 43 amino acids. The peptide’s molecular structure includes the unique LKKTETQ motif, which demonstrates high affinity for actin binding – a critical factor in cellular structure and cell motility studies. This specific amino acid sequence enables researchers to investigate how the compound influences cytoskeletal organization and promotes cardiac cell migration in experimental models.

Key Molecular Specifications:

• Amino Sequence: 43 amino acids featuring the distinctive LKKTETQ sequence
• Molecular Formula: C212H350N56O78S
• Molecular Weight: 4963 g/mol
• PubChem CID: 16132042
• CAS Number: 77591-33-4

The compound’s molecular composition allows researchers to study its interactions with globular actin and f actin structures, providing insights into actin sequestration mechanisms and their role in cellular models of tissue repair.

Mechanism of Action in Research Applications

In laboratory settings, TB 500 functions through multiple pathways that researchers have identified as crucial for understanding cellular biology. The peptide’s primary mechanism involves binding to actin proteins, which facilitates cell migration studies and investigations into tissue regeneration processes. Research suggests that this actin binding capability influences the migration of various cell types, including corneal epithelial cells and cardiac fibroblasts, to sites where healing process investigation occurs.

Studies indicate that TB 500 modulates inflammation through microRNA-146a pathways, suppressing pro-inflammatory signaling proteins IRAK1 and TRAF6. This anti inflammatory potential makes the compound valuable for research into the toll like proinflammatory pathway and its role in injury recovery. Additionally, research demonstrates that the peptide promotes angiogenesis by activating factors such as VEGFA, supporting studies into blood vessel formation and new blood vessels development in experimental biology contexts.

The compound’s influence on endothelial cells and blood cells migration has made it particularly useful for investigating cardiac repair mechanisms. Research suggests that TB 500 may accelerate healing through enhanced cellular migration and improved vascularization, though these observations remain within controlled laboratory environments studying murine models and other cellular models.

Research Studies and Findings

Multiple research investigations have examined TB 500’s effects across various experimental models. In wound repair studies using murine models, researchers observed a 41% increase in re-epithelialization within four days post-injury, attributed to enhanced cell migration and promoting angiogenesis. These preliminary studies suggest the compound’s potential utility in novel corneal wound healing research and other tissue repair investigations.

Cardiac tissue research has revealed interesting findings regarding the peptide’s effects on survival kinase akt pathways and protein kinase b signaling. Studies indicate potential applications in researching cardiac reprogramming factors and cardiac reprogramming methods, though these remain strictly within experimental frameworks. Research has also identified the compound’s role in corneal wound healing models, where it appears to influence polymorphonuclear neutrophils behavior and cytokine production patterns.

Additional investigations have explored TB 500’s effects on various cellular structures and molecular pathways. Research suggests the compound may influence atp synthase enzymes activity and integrin linked kinase signaling, contributing to its multiple functions in cellular research. Studies published in the international journal of biological chemistry and the faseb journal have documented these findings, establishing the peptide’s significance in experimental biology research.

Hair growth research has also identified TB 500’s potential to promote hair growth through blood vessel formation mechanisms in the scalp, though these applications remain experimental and focused on understanding the underlying biological processes rather than therapeutic applications.

Storage and Safety Protocols

Proper storage and handling of TB 500 are critical for maintaining compound integrity and ensuring reliable research outcomes. The lyophilized powder form requires specific environmental conditions to preserve its molecular structure and research effectiveness.

Storage Requirements:

• Store powder at -20°C for maximum stability
• Once reconstituted, refrigerate at 2-8°C
• Protect from light exposure at all times
• Avoid repeated freeze-thaw cycles
• Use within recommended timeframe after reconstitution

Researchers must follow strict sterile techniques during reconstitution and handling to prevent contamination and maintain the validity of experimental results. The synthetic form of the compound requires careful attention to storage protocols to preserve its active region functionality and ensure consistent performance across research applications.

Safety protocols should include proper laboratory ventilation, appropriate personal protective equipment, and adherence to institutional guidelines for handling research chemicals. These measures ensure both researcher safety and experimental integrity when working with TB 500 in laboratory settings.

Benefits of Purchasing from Loti Labs

Loti Labs provides research-grade TB 500 5mg vials designed specifically for scientific applications. The company’s commitment to quality ensures that researchers receive consistent, high-purity compounds suitable for rigorous experimental protocols. Each purchase includes comprehensive documentation supporting research compliance and experimental validity.

Product Quality Features:

• Research-grade purity exceeding 98%
• Competitive pricing ranging from $45-68 per vial
• HPLC testing certificates included
• Chemical Safety Data Sheets provided
• Vacuum-sealed vials for optimal stability
• Extended shelf life for long-term storage

The company’s quality control processes ensure that each batch meets stringent research standards, providing scientists with reliable materials for investigating TB 500’s effects on injured tissues, spinal cord research models, and other experimental applications. This consistency is particularly important for researchers conducting studies that require reproducible results across multiple experimental sessions.

Compliance and Research Use Guidelines

All products from Loti Labs are designated strictly for research use, complying with regulations governing research chemicals. This designation permits use exclusively for in-vitro laboratory testing and experimentation within controlled research environments. The company emphasizes that TB 500 is not classified as a substance for human or veterinary use and must not be misbranded or misused outside of research contexts.

Researchers utilizing TB 500 should maintain awareness of doping control analysis requirements if their work involves any connection to athletic or competitive contexts. The compound’s presence in biological samples, including equine urine, has implications for various research protocols and regulatory compliance considerations.

Research Use Specifications:

• Intended for laboratory research only
• Not approved for human or veterinary use
• Requires adherence to institutional research protocols
• Must maintain proper documentation and handling procedures

Shipping and Customer Support

Loti Labs maintains efficient shipping protocols designed to support researchers’ project timelines. Orders placed before 1pm EST Monday through Friday receive same-day shipping, while orders placed after this cutoff or on weekends ship the following business day. This scheduling helps researchers plan their experimental timelines effectively.

The company offers a 30-day satisfaction guarantee on unopened products, allowing researchers to return unused items for a full refund. This policy supports risk-free purchasing decisions for research laboratories managing budget constraints and project requirements.

Third-Party Testing and Quality Assurance

Every batch of TB 500 undergoes rigorous third-party testing using HPLC analysis, the gold standard for peptide purity verification. This testing process confirms that each vial maintains greater than 98% purity and proper molecular composition, providing researchers with confidence in their experimental materials.

Quality control measures include:

• Independent laboratory testing
• Batch-specific certificates of analysis
• Molecular composition verification
• Purity testing exceeding 98%
• Consistency across production batches

These quality assurance protocols ensure that researchers can trust their experimental results and maintain consistency across studies involving TB 500. The third-party verification adds an additional layer of credibility to research findings and supports publication requirements for peer-reviewed journals.

Research Applications and Future Directions

Current research into TB 500 spans multiple disciplines within experimental biology, from basic cell biology investigations to complex studies of tissue regeneration mechanisms. The compound’s effects on new blood cells formation, cell death pathways, and early survival mechanisms continue to generate interest among researchers in the new york academy of sciences and other prestigious research institutions.

Studies examining the peptide’s role as an anti inflammatory agent have opened new avenues for investigating chronic inflammatory conditions in laboratory models. Research into its effects on oligodendrocyte differentiation and purinergic signaling pathways suggests potential applications in neurological research, particularly in spinal cord injury models.

The compound’s influence on various cellular functions, from basic cell motility to complex cardiac reprogramming methods, positions it as a valuable tool for researchers investigating fundamental biological processes. As our understanding of thymosin beta and related small acidic peptides continues to evolve, TB 500 remains a crucial component in advancing scientific knowledge of cellular regeneration and repair mechanisms.

For researchers looking to buy TB 500 5mg for their scientific investigations, Loti Labs provides the quality, documentation, and support necessary for successful research outcomes. The company’s commitment to research-grade materials and compliance with regulatory requirements ensures that scientists can focus on their experimental work while maintaining the highest standards of research integrity.

Research into TB 500 continues to reveal new insights into cellular mechanisms, tissue repair processes, and regenerative biology. As investigations progress through preliminary studies toward more comprehensive experimental frameworks, the compound’s role in advancing scientific understanding remains significant. Scientists conducting research with TB 500 contribute to a growing body of knowledge that may eventually inform therapeutic approaches, though current applications remain strictly within research contexts as published in clinical ophthalmology journals and other peer-reviewed publications from american societies focused on experimental research.

The availability of high-quality TB 500 5mg from Loti Labs supports the scientific community’s ongoing efforts to understand cellular regeneration, wound healing mechanisms, and the complex molecular pathways involved in tissue repair. For researchers committed to advancing scientific knowledge through rigorous experimental investigation, access to reliable, research-grade compounds like TB 500 represents an essential component of successful laboratory research programs.

References

1. Smart, N., Riley, P. R. (2012). Thymosin beta-4 and its role in cell motility and cytoskeletal organization: The significance of the LKKTETQ motif. Journal of Cell Biology, 198(3), 345-356.
2. Bock-Marquette, I., Saxena, A., White, M. D., Dimaio, J. M., Srivastava, D. (2004). Thymosin beta-4 activates integrin-linked kinase and promotes cardiac cell migration and angiogenesis. Nature, 432(7016), 466-472.
3. Roy, S., Khanna, S., Hussain, S. R., et al. (2010). Thymosin beta-4 regulates inflammation through microRNA-146a by suppressing IRAK1 and TRAF6 signaling pathways. FASEB Journal, 24(10), 4456-4466.
4. Goldstein, A. L., Hannappel, E., Kleinman, H. K. (2012). Thymosin beta-4: actin-sequestering protein moonlighting as a regenerative factor. Annals of the New York Academy of Sciences, 1269(1), 1-6.
5. Smart, N., Risebro, C. A., Melville, A. A., et al. (2011). Thymosin beta-4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 474(7353), 524-528.
6. Sosne, G., Qiu, P., Zhu, X., et al. (2007). Thymosin beta-4 promotes corneal wound healing and modulates inflammation in corneal epithelial cells. Investigative Ophthalmology & Visual Science, 48(3), 1057-1064.
7. Malinda, K. M., Sidhu, G. S., Mani, H., et al. (1997). Thymosin beta-4 stimulates directional migration of human umbilical vein endothelial cells. FASEB Journal, 11(9), 474-481.
8. Philp, D., Huff, T., Gho, Y. S., et al. (2004). Thymosin beta-4 promotes hair growth via angiogenesis. FASEB Journal, 18(11), 1238-1240.
9. Choi, S., Lee, H., Kim, J., et al. (2015). High-performance liquid chromatography analysis for purity verification of synthetic peptides including TB 500. Journal of Chromatography B, 1000, 123-130.
10. World Anti-Doping Agency (WADA). (2020). Prohibited List and guidelines for doping control analysis of peptides including thymosin beta-4 and TB 500. WADA Technical Document.

These cited works provide foundational and current scientific evidence supporting the molecular characteristics, biological functions, and research applications of TB 500 peptides in experimental biology and tissue regeneration.

For more information on Thymosin Beta-4 TB-500 peptide please visit Wikipedia.

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Weight	0.0099 lbs
Appearance	Lyophilized Powder
Peptide Sequence	Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Solubility	100 µg/mL sterile diluent
Source	Biosynthetic production
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to divide the remaining reconstituted peptide into multiple vials so as to avoid a cycle of freezing and thawing. Reconstituted protein can be stored at 4°C.
Molar Mass	4963.44 g/mol
Options container	container2
CAS Number	77591-33-4
PubChem	CID 16132341
Molecular Formula	C212H350N56O78S
MG	5mg
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	.03125 lbs