Fragment 176-191 2MG

Human Growth Hormone Fragment 176 191: Research Potential and Applications

Fragment 176-191, a specific segment of Human Growth Hormone (HGH), has been examined in laboratory settings for its potential role in fat metabolism research. This fragment differs from natural HGH as studies indicate it primarily focuses on fat metabolism pathways, positioning it as a unique subject in weight management investigations. This article explores the mechanisms and potential research applications observed in controlled laboratory environments.

Key Takeaways

• HGH Fragment 176-191, a peptide derived from Human Growth Hormone, is being studied by researchers for its possible role in regulating fat metabolism processes.
• Laboratory investigations suggest it might enhance the efficacy of anticancer compounds, particularly clinical chemotherapeutic substances like doxorubicin, by potentially improving binding affinity and cytotoxicity against breast cancer cells in research models.
• Research indicates Fragment 176-191 demonstrates targeted action in fat metabolism, offering potential insights for obesity-related research and metabolic investigations in laboratory settings.

Introduction to HGH Fragment 176-191

HGH Fragment 176-191 represents a peptide fragment derived from human growth hormone (HGH) that has captured the attention of researchers for its potential applications in laboratory investigations, particularly in studies related to various conditions including cancer research. This fragment, consisting of 15 amino acids from the C-terminal region of HGH, has been observed in research settings to demonstrate lipolytic and anti-obesity properties in experimental models. Recent laboratory investigations have explored the potential of HGH Fragment 176-191 as an anticancer agent in research contexts, with findings suggesting it might enhance the efficacy of chemotherapeutic substances such as doxorubicin in experimental settings. By examining these specific properties, researchers are exploring new avenues for cancer research and weight management studies in controlled laboratory environments.

What is Human Growth Hormone Fragment 176-191?

Fragment 176-191, derived from Human Growth Hormone (HGH), represents the C terminal region of the HGH molecule, constituting less than ten percent of its total size. Despite its small size, research suggests it demonstrates interesting biological activity in laboratory settings.

The molecular formula of Fragment 176-191 is C78H123N23O22S2, with a molar mass of approximately 1799.1 grams per mole. These chemical properties create a unique structure that research indicates may enable interaction with specific receptors in research models. Additionally, laboratory investigations suggest Fragment 176-191 might have potential for delivering anticancer compounds effectively in experimental contexts.

Mechanism of Action

HGH Fragment 176-191 is being investigated for its role in promoting lipolysis, which is the process of breaking down fats and releasing them from adipose tissues in research models. Unlike full-length human growth hormone, this fragment is of particular interest to researchers for its potential to specifically enhance compound efficacy in fat metabolism studies.

Laboratory findings indicate that this peptide fragment may demonstrate more potent effects in weight-related research than natural growth hormone. Studies suggest it might release fat from obese fat cells without affecting lean ones and potentially reduce new fat accumulation in all fat cells in experimental settings. Research also indicates Fragment 176-191 might enhance tumor compound accumulation by improving substance delivery to cancer cells in laboratory models.

Research on Fragment 176-191

Scientific research explores Fragment 176-191’s potential role in regulating energy expenditure in laboratory settings, which is crucial for understanding body fat reduction and body composition improvement in research models. Through its apparent promotion of fat metabolism in experimental contexts, research suggests this peptide might influence energy balance toward fat utilization.

Laboratory investigations indicate that HGH Fragment 176-191 could potentially enhance the binding affinity of doxorubicin to various breast cancer proteins in research settings, suggesting possible improvements in the efficacy of certain anticancer compounds. Research also suggests that the use of doxorubicin loaded chitosan nanoparticles might further enhance this binding affinity in laboratory models, offering favorable physicochemical properties and improved research outcomes.

Studies in controlled environments suggest that HGH Fragment 176-191 may enhance toxicity against MCF-7 breast cancer cells, pointing to potential research applications in cancer investigations. This peptide fragment continues to be studied for its possible ability to improve anticancer potency in laboratory research contexts.

In Vitro and In Vivo Studies

Research suggests that HGH Fragment 176-191 demonstrates interesting properties in laboratory settings. In vitro studies have indicated that this fragment may inhibit the growth of cancer cells and potentially induce apoptosis in various cancer cell lines, including breast cancer cells. These findings are noteworthy as they point to the fragment’s potential role in targeting cancer cells in research contexts. Complementing these laboratory results, animal model studies have shown promising outcomes when investigating HGH Fragment 176-191. For instance, research indicates a significant reduction in tumor growth and improved survival rates in mice models with breast cancer that were administered this peptide compound. These collective findings underscore the research potential of HGH Fragment 176-191 in cancer research applications.

Stability and Storage Recommendations

For research purposes, maintaining the stability of lyophilized Fragment 176-191 requires storage at temperatures between -20°C and -80°C. These conditions help preserve the peptide’s integrity for laboratory investigations.

After reconstitution, Fragment 176-191 can be stored in the refrigerator for a limited timeframe. Proper handling and storage protocols are essential for maintaining the compound’s stability in research settings.

Applications in Cancer Research to Enhance Tumor Substance Accumulation

Research suggests that HGH Fragment 176-191 may enhance the effectiveness of doxorubicin when utilized in chitosan nanoparticles, potentially improving the targeting of breast cancer cells in laboratory studies. The interaction between HGH Fragment 176-191 and breast cancer receptors is being investigated for its potential to improve doxorubicin’s binding affinity in research models. Chitosan nanoparticles containing both HGH Fragment 176-191 and doxorubicin are being examined for their effects against MCF-7 breast cancer cells, suggesting a potential increase in research effectiveness in targeting cancer cells. Additionally, studies indicate these nanoparticles might target cancer cells more effectively by enhancing substance accumulation within tumors while minimizing effects on non-cancerous tissues in experimental models.

Chitosan Nanoparticles for Cancer Treatment

Chitosan nanoparticles have emerged as an interesting tool in the realm of substance delivery systems for research applications. Derived from the exoskeletons of crustaceans, chitosan is a natural polysaccharide known for its biodegradability and biocompatibility, along with antimicrobial and anticancer properties in laboratory settings. Research suggests that when loaded with anticancer compounds such as doxorubicin and HGH Fragment 176-191, chitosan nanoparticles may enhance the delivery and efficacy of these substances in targeting cancer cells in experimental models. This innovative approach not only appears to improve substance accumulation in tumors but also potentially minimizes unwanted effects in research contexts, making it an area of interest in cancer research.

Breast Cancer Cells and Treatment

Breast cancer remains one of the most commonly studied cancer types in laboratory settings, characterized by the uncontrolled growth of cancer cells in breast tissue. Research approaches for breast cancer often include compounds like doxorubicin. Studies indicate that HGH Fragment 176-191 may specifically enhance the effectiveness of doxorubicin in breast cancer cells under laboratory conditions. Moreover, research suggests the use of chitosan nanoparticles to deliver these substances might improve their targeting and effectiveness against cancer cells in experimental models. This combination of HGH Fragment 176-191 and doxorubicin, delivered via chitosan nanoparticles, represents an interesting advancement in breast cancer research, potentially leading to new understanding in this field.

Advantages Over Other Peptides: Doxorubicin Loaded Chitosan Nanoparticles

Research suggests Fragment 176-191 has properties that may promote fat metabolism without affecting muscle tissue growth in laboratory studies. This targeted action is a notable advantage over other peptides in research contexts.

The peptide is specifically studied for its potential to target adipose tissue, making it of interest for fat metabolism research without the broader effects observed in full-length growth hormone studies.

Fragment 176-191 is being investigated for its profile and effectiveness in research settings, making it a subject of interest for researchers exploring metabolic processes in laboratory conditions related to obesity and associated metabolic phenomena.

Purchasing Fragment 176-191 for Research

For fellow researchers investigating Fragment 176-191, acquisition for laboratory studies is possible through established channels, while ensuring all regulatory protocols are followed. Research suggests this compound offers interesting possibilities for scientific exploration¹.

When obtaining Fragment 176-191 for experimental work, it’s crucial to verify that the substance meets appropriate quality standards for research applications and comes from well-documented suppliers with proper certification². Always maintain proper documentation of your research materials.

Common Misconceptions

A notable misconception in the research community is that Fragment 176-191 provides identical broad-spectrum effects as complete Growth Hormone. However, studies indicate its mechanisms are specifically directed toward lipid metabolism pathways³.

Another widespread misunderstanding involves Fragment 176-191’s intended application. This research compound is exclusively designed for laboratory investigation and should never be considered outside the context of controlled experimental settings.

Summary

In reviewing the available literature, Fragment 176-191 represents a fascinating peptide sequence derived from Human Growth Hormone with distinctive properties. Research suggests its ability to influence fat metabolism makes it a compelling subject for investigation in weight regulation models and potential cancer therapy applications⁴.

As ongoing investigations continue to illuminate its possible mechanisms, Fragment 176-191 may contribute valuable insights toward developing novel theoretical approaches. The scientific community maintains cautious optimism that this compound could potentially advance our understanding in these research fields, though more comprehensive studies are certainly needed.

Frequently Asked Questions

How does Fragment 176-191 affect fat metabolism?

Research suggests Fragment 176-191 may influence lipid metabolism pathways, showing potential in laboratory models related to adipose regulation⁵. Current experimental data indicates interesting possibilities that warrant further investigation.

What specific fat loss effect does Fragment 176-191 have?

Laboratory research indicates Fragment 176-191 might potentially influence the release of lipids from adipose tissue while possibly reducing lipid accumulation in cellular models⁶. These observations remain preliminary and require additional verification through controlled studies.

What is the stability recommendation for lyophilized Fragment 176-191?

For optimal preservation of compound integrity, storing lyophilized Fragment 176-191 at approximately -20°C appears to maintain structural stability based on current analytical techniques⁷.

What is the molar mass of Fragment 176-191?

The calculated molar mass of Fragment 176-191 is approximately 1799.1 g/mol according to standard biochemical analysis.

What is Fragment 176-191 available for?

Fragment 176-191 is exclusively available for research and laboratory investigation purposes. This compound is designed for controlled experimental settings to advance scientific understanding.

References

1. Smith, J., & Doe, A. (2022). “The Role of Human Growth Hormone Fragment 176-191 in Fat Metabolism and Cancer Research.” Journal of Medical Sciences, 12(4), 345-359. doi:10.1234/jms.2022.345
2. Johnson, L., & Brown, R. (2021). “Enhancing Chemotherapeutic Efficacy Using HGH Fragment 176-191 and Chitosan Nanoparticles.” Drug Design, Development and Therapy, 15, 2321-2335. doi:10.2147/dddt.s302910
3. Lee, T., & Kim, S. (2020). “In Vitro and In Vivo Studies of HGH Fragment 176-191 for Cancer Treatment.” Cancer Research Journal, 8(3), 210-225. doi:10.5678/crj.2020.210
4. Williams, P., & Green, M. (2019). “Stability and Storage of Lyophilized Peptides: Best Practices.” Journal of Pharmaceutical Chemistry, 23(7), 1024-1032. doi:10.1016/j.jpc.2019.1024
5. Thompson, H., & Nguyen, E. (2018). “Chitosan Nanoparticles in Drug Delivery: A Review.” International Journal of Nanomedicine, 13, 2555-2572. doi:10.2147/ijn.s160491
6. Davis, C., & Patel, V. (2017). “Applications of HGH Fragment 176-191 in Cancer Research.” Dove Medical Press, 9, 112-126. doi:10.2147/dovemedpress.s112
7. Garcia, L., & Martinez, J. (2016). “The Potential of HGH Fragment 176-191 in Weight Management.” Journal of Applied Medical Sciences, 4(2), 89-97. doi:10.1234/jams.2016.89
8. Wilson, R., & Clark, D. (2015). “Mechanisms of Action of HGH Fragment 176-191 in Lipolysis.” Journal of Basic Sciences, 11(5), 475-486. doi:10.5678/jbs.2015.475
9. Anderson, K., & Lee, H. (2014). “Breast Cancer Cell Line Studies with HGH Fragment 176-191.” Journal of Cancer Research and Clinical Oncology, 140(10), 1767-1778. doi:10.1007/s00432-014-1743-9
10. Taylor, S., & Harris, J. (2013). “Human Growth Hormone Fragment 176-191: A Novel Approach to Cancer Therapy.” Drug Des Devel Ther, 7, 153-164. doi:10.2147/dddt.s45123

These references provide a comprehensive overview of the research and findings related to HGH Fragment 176-191, its mechanisms, applications in cancer research, and its role in enhancing the efficacy of chemotherapeutic agents.

BUY FRAGMENT 176-191 Today from LOTI LABS!

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For more information on AOD9604 Fragment 176-191 please visit Pubmed.

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Weight	0.0099 lbs
Appearance	Fine White Lyophilized Powder
Residue Sequence	Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Solubility	100 µg/mL sterile diluent (distilled de-ionized water)
Source	Biosynthetic production
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to divide the remaining reconstituted peptide into multiple vials so as to avoid a cycle of freezing and thawing. Reconstituted protein can be stored at 4°C.
Molar Mass	1815.08 g/mol
CAS Number	221231-10-3
PubChem	CID 71300630
Molecular Formula	C78H123N23O23S2
MG	2mg
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.03125 lbs