Examining phage-derived bicyclic peptides, RGD motif variants like norArg-Gly-Asp, and αvβ3 vs αIIbβ3 selectivity in conjugate research design.
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How MT-II and SHU-9119-derived macrocycles were engineered for MC4R selectivity over MC1R, MC3R, and MC5R in receptor pharmacology research.
Research overview of enlicitide, an investigational oral macrocyclic peptide engineered to disrupt the PCSK9-LDLR protein interface.
Examining receptor-mediated transcytosis via LRP1 and transferrin receptor routes, and the mixed research evidence on shuttle peptide conjugation outcomes.
How isopeptide-bonded threaded lasso peptide scaffolds resist heat and proteolysis, and how genome mining pipelines are accelerating RiPP discovery research.
Research on small ORFs and lncRNA-encoded microproteins is reshaping the proteome map, with mass-spec detection challenges and cancer biology roles.
Sea anemone-derived ShK and engineered analogs like ShK-186 and HsTX1[R14A] are studied for selective Kv1.3 blockade in effector memory T cell research.
GV1001, an hTERT-derived 16-mer, is studied for bradykinin receptor B1 signaling, microglial phagocytosis, and mTORC2-dependent neuroprotective mechanisms.
Research into KPV, the tripeptide fragment of alpha-MSH, explores anti-inflammatory signaling in gut and skin models without melanocortin receptor pigmentation effects.
VK2735 research covers dual GIP/GLP-1 receptor binding data, lipidated side-chain design, and injectable versus oral formulation science.