ABOUT CLOMIPHENE: Clomiphene is a non-steroidal, ovulatory stimulant. It binds to estrogen receptors, but unlike what happens to estradiol, an endogenous estrogen, its binding is for a longer duration. This results in a net reduction are the estrogenic effect.
Studies in animal test subjects show that due to its structural similarity to estrogen, clomiphene citrate can bind to estrogen receptors throughout the reproductive system. Unlike estrogen, liquid clomiphene binds to the nuclear receptor for a longer time, spanning weeks instead of hours, resulting in the depletion of estrogen receptor concentrations by preventing its physiologic replacement.
Its actions occur at the level of the hypothalamus, and depletion of the estrogen receptors there impedes the proper interpretation of blood estrogen concentration. This triggers a compensatory system of altered pulsatile Gonadotropin-releasing hormone (GnRH), which leads to higher levels of gonadotropin release from the anterior pituitary.
An increase in pituitary gonadotropin release drives ovarian follicular activities leading to a rise in Luteinizing and Follicle Stimulating hormones and a fall after a 5-day administration in animal test subjects.
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|Appearance||Viscous cloudy liquid|
|Molecular Formula||C26H28CINO C6H8O7|
|Terms||This product is sold for research/laboratory usage only. No other uses are permited.|