Review Of Tadalafil Citrate | Buy Tadalafil Liquid 30mg Per MLAdmin
Tadalafil is a selective phosphodiesterase-5 (PDE5) inhibitor with the potential ability to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension in animals.
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SCIENTIFIC RESEARCH ON TADALAFIL
A 2006 study of rats treated with 2 mg/kg tadalafil daily for three months after radical pelvic surgery induced erectile dysfunction indicated that treated rats had superior erectile hemodynamics.
Molecular studies indicated that declines in erectile function after cavernous nerve injury were associated with the decreased smooth muscle-to-collagen ratio in the corporeal tissues and evidence of hypoxia.
Tadalafil treatment improved the decline in smooth muscle to collagen ratio and restored oxygenation, associated with the superior vasodilatory activity of tissues obtained from treated rats for in vitro studies.
MECHANISM OF ACTION
Tadalafil is a β-carboline-based type 5 phosphodiesterase inhibitor. Its molecular structure mimics cGMP allowing for competitive binding to the catalytic site of PDE5.
Tadalafil has a faster onset of action than the other five phosphodiesterase inhibitors. Clinically, this translates to a longer therapeutic effect of up to 36 hours.
Excretion is primarily in feces, with about one-third of the metabolized drug excreted in the urine.
Tadalafil’s benefit results from its multifactorial mechanism of action on various organs in animal test subjects. Its effects include the following:
- It improves erectile dysfunction in research subjects.
- It improves depression and cognitive functions in experimental animals.
- It prevents the formation of urethral strictures.
- It reduces inflammation in endothelial cells of pulmonary arteries in rats.
- It relaxes vascular smooth muscle and increases blood perfusion and oxygenation of the prostatic tissue of animal test subjects.
SIDE EFFECTS OF TADALAFIL
Tadalafil side effects include:
- Facial flushing
- Nasal congestion
- Back pain
- Abdominal pain
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- Forgue ST, Patterson BE, Bedding AW, Payne CD, Phillips DL, Wrishko RE, Mitchell MI: Tadalafil pharmacokinetics in healthy subjects. Br J Clin Pharmacol. 2006 Mar;61(3):280-8. doi: 10.1111/j.1365-2125.2005.02553.x. [Article]
- Arif SA, Poon H: Tadalafil: a long-acting phosphodiesterase-5 inhibitor for the treatment of pulmonary arterial hypertension. Clin Ther. 2011 Aug;33(8):993-1004. doi: 10.1016/j.clinthera.2011.06.008. Epub 2011 Jul 16. [Article]
- Monica FZ, De Nucci G: Tadalafil for the treatment of benign prostatic hyperplasia. Expert Opin Pharmacother. 2019 Jun;20(8):929-937. doi: 10.1080/14656566.2019.1589452. Epub 2019 Mar 22. [Article]
- Takahiro R, Nakamura S, Kohno H, Yoshimura N, Nakamura T, Ozawa S, Hirono K, Ichida F, Taguchi M: Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65. doi: 10.1248/bpb.b14-00566. [Article]