Melanotan 1 VS Melanotan 2 | Buy MT2

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Melanotan 1 VS Melanotan 2 | Buy MT2

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Researching about Melanotan, one would probably stumble upon Melanotan 1 or Melanotan 2. Though these two peptides only differ by a single number, they definitely differ from each other in many aspects.

What is Melanotan?

For starters, Melanotan is a synthetic peptide made to mimic the action of melanocortins. These melanocortins include melanocyte-stimulating hormone (MSH), alpha-melanocyte stimulating hormone (α-MSH), and adrenal-cortical-stimulating hormone (ACTH).

MSH includes a number of peptide hormones that stimulates the production of melanin which is responsible for the pigmentation of the skin and hair or many animals. This includes Melanotan 1 (MT1) and 2 (MT2).

What is Melanotan 1?

Melanotan 1 also known as Afamelanotide is an analog of the alpha-melanocyte stimulating hormone (α-MSH). First synthesized in the University of Arizona in the 1980s, MT1 is currently being studied to help with some skin disorders.

What is Melanotan 2 ?

Melanotan 2 or MT2 is similarly a synthetic analog of α-MSH. Just like Melanotan 1 it also has a direct effect on melanogenesis or the production of melanin in the skin. However, an unintended accident led to the discovery of its other effects.

Aside from stimulating melanogenesis, MT2 has demonstrated potential effect on female sexual dysfunction and erectile dysfunction in several animal experiments conducted throughout the years.

Melantan 1 vs Melanotan 2

In terms of chemical structure and mechanism of action these two peptides don’t differ much from each other. However, in terms of their effect, there are things that they both exhibit and some exclusive to each.

Melanotan 1. When it comes to effects, Melanotan 1 primarily increases melanogenesis by binding to the melanocortin 1 receptor (MC1). MT1 is currently approved by FDA and other regulating bodies for treatment of different skin related illnesses.

It was approved by the Italian Medicines Agency [(AIFA) Agenzia Italiana del Farmaco] for the treatment of Erythropoietic Protoporphyria (EPP) in 2010. It was also approved by the European Medicines Agency (EMA) for treating phototoxicity in people with EPP in 2015.

As of 2019, the US FDA approved MT1 for reducing pain caused by sun exposure in people with EPP.

Melanotan2. Similar to MT1, MT2 also increases melanogenesis by stimulating the melanocortin 1 receptor. However, unlike MT1, MT2 has the ability to stimulate other melanocortin receptors, specifically MC1, MC3, MC4, MC5.

This stimulation of other MC receptors results to other effects including penile erection, sexual arousal, and appetite suppression.

Studies on animal and rat models have demonstrated that MT2 is also superpotent in stimulating the MC4 receptor. It shows that MT2 is 10-100x more potent than endogenous melanocyte hormones. This results to appetite suppression and weight loss in rats.

Effects Melanotan 1 Melanotan 2
MelanogenesisYES YES
Penile ArectionNO YES
Sexual ArousalNO YES
Appetite SuppressionNO YES
Weight LossNO YES
Other side effects (nausea, vomiting, flushing, yawning, etc.)NO YES

Price and Availability

If looking to buy melanotan or searching for melanotan for sale, it is important to note that even though these two peptides are almost identical, their price and availability differs. MT 1 is generally more expensive than MT 2. MT1 is also not easily found, unlike MT 2 which is widely available and cheaper.

Choosing which Melanotan to buy will greatly depend on what type of study or research you are conducting. Buying Melanotan from Loti Labs will ensure the integrity of your research since all their peptides are tested via mass spectrometry and HPLC.  

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