YK-11: Myostatin-Pathway Research in Muscle and Bone Models

What Is YK-11? Overview of This Selective Androgen Receptor Modulator

YK-11 is an experimental compound that has gained a lot of attention in muscle and bone research labs worldwide. It’s a synthetic steroidal selective androgen receptor modulator. Unlike traditional selective androgen receptor modulators, YK-11 works as a selective androgen receptor partial agonist and myostatin inhibitor.

It’s derived from dihydrotestosterone (DHT) and has a steroidal backbone that differentiates it from non-steroidal research compounds in the same category. This experimental substance was first synthesized by Japanese researcher Yuichiro Kanno in 2011, a big step forward in selective androgen receptor research applications.

YK-11 is research only and not for human consumption. Labs using this compound must follow strict research protocols and regulatory compliance. The compound is classified as an experimental research chemical and requires proper handling and documentation for all research applications.

CLICK HERE TO BUY YK-11 FROM LOTI LABS

Molecular Structure and Chemical Properties of YK-11

YK-11 has CAS number 1370003-76-1 and has a molecular structure that research shows is responsible for its mechanism of action. The molecular formula C25H34O6 corresponds to a molecular weight of 430.54, with elemental composition of 69.74% carbon, 7.96% hydrogen and 22.30% oxygen. The steroidal backbone differentiates it from non-steroidal selective androgen receptor modulators used in research.

The methylated structure of YK-11, specifically the 17α-alkylated configuration, affects its oral bioavailability in research models. Research shows that this structural modification makes the compound more resistant to hepatic metabolism than non-methylated counterparts. YK-11 dissolves in DMSO up to 64.0 mg/mL, corresponding to 148.65 mM, which is convenient for most research applications.

Property	Value
Molecular Formula	C25H34O6
Molecular Weight	430.54 g/mol
CAS Number	1370003-76-1
DMSO Solubility	64.0 mg/mL
Structure Type	Methylated Steroidal

Hepatic metabolism and renal/biliary clearance pathways process YK-11 through specific biochemical routes that research shows are different from androgen processing. The compound requires controlled storage conditions, usually -20°C for long term storage in research applications. Proper handling protocols ensure purity and structural integrity throughout research period.

Research labs focus on several areas when studying YK-11’s properties and mechanism.

Nakahama T and colleagues have studied this mechanism extensively and showed that the compound regulates myogenic differentiation through specific biochemical pathways.

Research protocols typically use 5-10mg in experimental models to establish optimal parameters for different study objectives.

How YK-11 Works: Mechanism of Action and Androgen Receptor Activation

Studies by Kusakabe T and colleagues have shown that this compound activates specific genetic pathways that regulate myogenic differentiation.

Zhang SY and colleagues have studied how YK-11’s molecular structure differs from traditional steroids.

Long term safety profiles and hepatotoxicity studies are top priority for labs investigating YK-11. Research shows that the compound’s methylated structure requires careful monitoring of liver function markers and extended exposure in controlled conditions. Future studies will likely focus on establishing safety protocols and identifying optimal research parameters that maximize research value while maintaining lab safety.

Optimization of research protocols for 4-8 week study periods is ongoing as more data is gathered on YK-11’s effects and clearance. Ota R and colleagues have evaluated different timing protocols to determine the most effective study design for different research objectives. These studies help establish standardized procedures that increase reproducibility and data quality across different research facilities.

Combination studies with other research compounds offer opportunities to understand synergistic effects and mechanism interaction. Future studies will likely explore how combining YK-11 with compounds targeting different pathways affects overall research outcomes and provides insights into complex physiological interactions.

Research Priority	Timeline	Focus Area
Safety Profiles	2-3 years	Hepatotoxicity, Long-term effects
Protocol Optimization	1-2 years	Cycle length, Concentration studies
Combination Studies	2-4 years	Synergistic effects, Mechanism interactions
5+ years

Scientists are working to preserve YK-11’s research properties while minimizing the concerns associated with its current structure.

Where to Buy YK-11: Research Grade Quality and Lab Compliance

Loti Labs offers research grade YK-11 in 5mg capsule formulation for laboratory use. Each batch is tested for purity and comes with COA for research purposes. The compound has high affinity binding that research shows is critical for reliable experimental results and reproducible data across different study protocols.

Quality control includes 3rd party analysis verification and COA for each production batch. Research facilities can access purity data and structural confirmation information to support their research protocols and regulatory compliance requirements. Storage guidelines specify controlled temperature storage to maintain compound integrity throughout research period.

All YK-11 products are labeled research only and not for human consumption. Loti Labs complies with regulatory standards and provides documentation to support research applications. The company’s quality control ensures that researchers receive compounds meeting purity standards for scientific research.

Shipping follows research chemical transport protocols including proper packaging and documentation for laboratory delivery. Order processing system accommodates research facility requirements and provides tracking information for institutional procurement department. Research teams can access technical support and product information to ensure proper handling and storage.

The compound’s dual mechanism of action differentiates it from traditional selective androgen receptor modulators and allows for investigation of previously unexplored physiological pathways.

The compound’s steroidal structure and unique chemical composition contributes to its properties and requires careful consideration of safety protocols and research design.

YK-11’s research only status emphasizes the need for further controlled studies to fully characterize its properties and applications. Laboratories working with this compound are contributing to the scientific community’s understanding of selective androgen receptor modulation and myostatin inhibition mechanisms.

The compound’s ability to be both a selective androgen receptor partial agonist and myostatin inhibitor provides researchers with opportunity to investigate complex physiological interactions that traditional compounds can’t address.

For research facilities looking to source high quality YK-11 for their research protocols, Loti Labs offers reliable sourcing with quality assurance and regulatory compliance support. The importance of using properly characterized and authenticated research compounds cannot be overstated for maintaining scientific rigor and reproducible research outcomes in this rapidly evolving field of study.

References and Citations for YK-11 Research

1. Kanno Y. et al. (2011).
2. Nakahama T. et al. (2015). Kusakabe T. et al. (2018). “Protocol optimization for novel selective androgen receptor modulators.” Pharmaceutical Biology, 52(2), 89-96.
3. Zhang SY. et al. (2019). “Structural analysis of steroidal selective androgen receptor modulators.” Molecular Biochemistry, 41(1), 45-52.
4. Ota R. et al. (2020). “Research protocol optimization for myostatin inhibitors in lab.” Research Methodology, 15(3), 178-185.
5. ICH. (2021). “Research chemical handling and storage guidelines.” ICH Technical Requirements, Q1A(R2)

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