Evidence-led explainers and analytical insights for serious research teams.
De novo macrocycles activate the insulin receptor with no sequence link to insulin, revealing dimerization and biased signaling mechanics.
Read the articleDe novo macrocycles activate the insulin receptor with no sequence link to insulin, revealing dimerization and biased signaling mechanics.
Read articleA multi-objective computational design case study on peptides disrupting the TIM-3/galectin-9 checkpoint axis in T-cell culture models.
Read articleHow macrocyclic peptides distinguish RAS-ON from RAS-OFF states and discriminate NRAS from its close isoform relatives.
Read articleHow bioPROTACs and ubiquibodies differ from small-molecule PROTACs, and why binder discovery limits genetically encoded protein degraders.
Read articleWhy natural antimicrobial peptides stall on proteolysis, hemolysis, and salt sensitivity, and how peptidomimetic backbones engineer around it.
Read articleHow multi-guided diffusion models generate non-hemolytic antimicrobial peptide candidates, and why in silico hit rates still need wet-lab validation.
Read articleFocused educational resources should make the next step obvious. Move from a research question into the corresponding Loti collection without losing context.
Start with focused, readable science written for research context.
Understand the methods, terminology, and variables that shape research.
Move directly into the relevant Loti research collection without dead ends.
