RESEARCH USE ONLY · FORMULATION Safety Data Sheet
16-section GHS safety data sheet for RESEARCH USE ONLY · FORMULATION covering hazard identification, safe handling, storage, exposure controls, transport and disposal. Research use only. Specifications and current certificates of analysis are in the MK-677 compound library page.
01Identification
| Product identifier | MK-677 25mg/ml (30ml) |
|---|---|
| Other means of identification | Loti Labs catalog listing “MK-677 25mg/ml (30ml)” (lotilabs.com product ID 4534); SDS document ID LL-SDS-4534-001. |
| Formulation type | Liquid research formulation |
| Active ingredient | Ibutamoren mesylate |
| Active ingredient CAS number | 159752-10-0 |
| Active ingredient molecular formula | C28H40N4O8S2 |
| Active ingredient PubChem CID | 6450830 |
| Active ingredient IUPAC name | 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid |
| Recommended use | Research laboratory chemical for in-vitro scientific research and development. |
| Restrictions on use | Not for human or veterinary use. Not for food, drug, cosmetic, household, agricultural, clinical, therapeutic, or diagnostic applications. |
Supplier details
| Company | Loti Labs |
|---|---|
| Address | 1204 S Broad St, Brooksville, FL 34601, United States |
| Telephone | 877-LOTI-LAB (877-568-4522) |
| Website | https://lotilabs.com/ |
| Emergency contact | CHEMTREC |
| Emergency phone | 800-424-9300 CHEMTREC (USA) +1-703-527-3887 CHEMTREC (International) 24 hours/day; 7 days/week |
02Hazard(s) identification
Mixture hazard determination, measured data applied. Physical hazard: the carrier (75% polyethylene glycol 400 / 25% vegetable glycerine) has a measured closed-cup flash point of 183 °C (361.4 °F) by ASTM D93 Method A. This is above the 93 °C upper limit of the GHS flammable-liquid classes, so the mixture is NOT classified as a flammable or combustible liquid under GHS. The laboratory's Class IIIB combustible liquid (NFPA workplace fire-code terminology) designation is a workplace fire-code label, not a GHS class and not a transport class.
| OSHA/GHS classification | Physical hazards: not classified as a flammable liquid (measured closed-cup flash point 183 °C, above the 93 °C GHS limit). Health hazards: no health-hazard class assigned on the reviewed active-ingredient evidence and concentration. |
|---|---|
| Signal word | None assigned (no hazard class triggered). |
| Hazard pictograms | None assigned. |
| Hazard statements | None assigned. See hazards not otherwise classified below. |
| Hazards not otherwise classified | Treat as a research formulation of incompletely characterized active material. Avoid contact, ingestion, and release to the environment. Ibutamoren is an orally active growth hormone secretagogue; systemic exposure may increase appetite, fluid retention and blood glucose. |
| Unknown acute toxicity | Approximately 1.91% of the mixture consists of an ingredient of unknown acute toxicity (the active ingredient; no acute toxicity estimate for it was used in classification). The mixture was not classified on the basis of testing of the mixture as a whole. |
Prudent laboratory handling
P264 Wash hands and exposed skin thoroughly after handling.
P280 Wear protective gloves, protective clothing, and eye protection.
P501 Dispose of contents/container in accordance with applicable regulations.
Prudent practice statements; no GHS label elements are required because no hazard class is assigned.
Health hazard of the active ingredient: the active is present at 25 mg/mL, equivalent to approximately 1.914% w/w using the measured mixture density of 1.306 g/mL. No health-hazard class is triggered by the active on available data. The active is a growth-hormone secretagogue with significant endocrine pharmacology and is addressed under hazards not otherwise classified. Health-hazard classification of the mixture was determined against the GHS generic concentration cut-off values in 29 CFR 1910.1200 Appendix A (0.1% for carcinogenicity, germ cell mutagenicity and reproductive toxicity; 1% for acute toxicity, irritation and specific target organ toxicity).
03Composition / information on ingredients
| Component | CAS | Formula | MW | Concentration |
|---|---|---|---|---|
| Ibutamoren mesylate | 159752-10-0 | C28H40N4O8S2 | 624.8 g/mol | 25 mg/mL (≈ 1.914% w/w) |
| Vegetable glycerine (glycerol) | 56-81-5 | C3H8O3 | 92.09 g/mol | 25% v/v of carrier base |
| Polyethylene glycol 400 (PEG 400) | 25322-68-3 | (C2H4O)n | 380-420 g/mol (avg) | 75% v/v of carrier base |
Liquid research formulation containing Ibutamoren mesylate at 25 mg/mL in a carrier base of 75% polyethylene glycol 400 / 25% vegetable glycerine. The stated carrier percentages are nominal % v/v of the carrier base supplied by Loti Labs, prior to addition of the active ingredient; active concentration is stated separately. The active corresponds to approximately 1.914% w/w of the mixture using the measured density of 1.306 g/mL.
Prime Process Safety Center tested the client-supplied sample identified as Mix 2 as received (report PPSCQ2686-TR-092026). Loti’s controlled formulation record assigns Mix 2 (75% PEG-400 / 25% vegetable glycerine, nominal % v/v) to this product. The measured density is recorded as laboratory data; it differs from an idealized component-density estimate and is not used as proof of composition.
04First-aid measures
| Inhalation | Move person to fresh air. Keep at rest. Obtain medical advice if symptoms develop or persist. |
|---|---|
| Skin contact | Remove contaminated clothing. Wash thoroughly with soap and water. Seek medical advice if irritation develops. |
| Eye contact | Rinse cautiously with water for at least 15 minutes. Remove contact lenses if easy to do. Continue rinsing. Obtain medical attention if irritation persists. |
| Ingestion | Rinse mouth. Do not induce vomiting unless directed by medical personnel. Contact a poison center or physician if swallowed or symptoms occur. |
| Most important symptoms/effects | No formulation-specific clinical data available. Exposure may cause irritation. Systemic absorption of the active ingredient (a growth hormone secretagogue) may increase appetite, fluid retention and blood glucose (Sections 2 and 11). |
| Immediate medical attention | Treat symptomatically. No specific antidote known. |
05Fire-fighting measures
| Suitable extinguishing media | Water spray, dry chemical, carbon dioxide, or foam appropriate to the surrounding fire. |
|---|---|
| Unsuitable extinguishing media | Do not direct a solid water stream into hot or burning liquid; it may cause spattering. |
| Specific hazards | The liquid formulation has a measured closed-cup flash point of 183 °C and contains no volatile flammable components. Thermal decomposition of organic components may generate carbon oxides, nitrogen oxides, and other irritating or toxic fumes; sulfur oxides may also form under fire or thermal decomposition conditions. |
| Protective equipment | Firefighters should wear full protective equipment and positive-pressure self-contained breathing apparatus. |
The carrier (75% polyethylene glycol 400 / 25% vegetable glycerine) has a measured closed-cup flash point of 183 °C and contains no volatile flammable components; no flammable-vapor precautions beyond good laboratory practice are required. Use water spray to cool containers exposed to fire.
06Accidental release measures
Personal precautions
Restrict access. Avoid contact and aerosol generation. Ensure adequate ventilation. Remove ignition sources where applicable. Wear PPE described in Section 8.
Environmental precautions
Prevent release to drains, sewers, surface water, and soil.
Containment and cleanup
Absorb with inert compatible material, collect into a sealed labeled container, and clean the affected area.
07Handling and storage
Precautions for safe handling
Handle as a potentially bioactive research formulation of unknown or incompletely characterized toxicity. Avoid contact with eyes, skin, and clothing. Avoid generating dust, mist, or aerosols. Keep away from heat and ignition sources. Do not eat, drink, smoke, or apply cosmetics in work areas. Wash thoroughly after handling.
Storage conditions
Keep tightly closed in the original labeled container. Protect from heat, ignition sources, light, moisture, and physical damage. Follow product-label and lot-specific storage conditions.
Incompatibilities
Strong oxidizing agents, strong acids, strong bases, excessive heat, direct sunlight, and ignition sources.
Other information
Liquid research formulation containing Ibutamoren mesylate at 25 mg/mL in a carrier base of 75% polyethylene glycol 400 / 25% vegetable glycerine. The active corresponds to approximately 1.914% w/w of the mixture using the measured density of 1.306 g/mL.
08Exposure controls / personal protection
Occupational exposure limits
No OSHA PEL, NIOSH REL, or ACGIH TLV identified for Ibutamoren mesylate. Glycerin (mist): OSHA PEL 15 mg/m³ total particulate and 5 mg/m³ respirable fraction (8-h TWA, 29 CFR 1910.1000 Table Z-1). Maintain exposure as low as reasonably achievable.
Engineering controls
Use local exhaust ventilation or effective containment for open transfer, dilution, or any task with potential for airborne dust, mist, or vapor. Provide accessible eyewash and safety shower. Use appropriate local exhaust ventilation.
Personal protective equipment
| Eye / face protection | Safety glasses with side shields as a minimum; chemical splash goggles for splash, aerosol, or open-transfer tasks. |
|---|---|
| Hand protection | Disposable nitrile gloves suitable for the mixture. Inspect before use and replace if contaminated, damaged, or degraded. |
| Skin protection | Laboratory coat, long trousers, and closed-toe footwear. Add a chemical-resistant apron for splash-prone handling. |
| Respiratory protection | Normally unnecessary inside effective containment. Where controls cannot prevent exposure, use a NIOSH-approved respirator under a compliant respiratory-protection program (29 CFR 1910.134). |
| Hygiene | Wash hands after handling and before breaks. Remove contaminated clothing. Decontaminate work surfaces and equipment. |
PPE must be selected by the employer based on task-specific risk assessment, quantity, physical form, and exposure potential.
09Physical and chemical properties
| Physical state | Liquid formulation |
|---|---|
| Appearance | Clear, colorless to slightly colored liquid. |
| Color | Not separately determined; see Appearance. |
| Odor / odor threshold | No reliable formulation-specific data available |
| Melting point / freezing point | Not determined for formulation |
| Boiling point / range | Not determined for formulation |
| Flammability | Not classified as a flammable or combustible liquid under GHS (measured flash point 183 °C, above the 93 °C limit); Class IIIB combustible liquid (NFPA workplace fire-code terminology) |
| Lower / upper flammability or explosion limits | Not determined for the mixture (closed-cup flash point 183 °C). |
| Flash point | 183 °C (361.4 °F), closed cup, ASTM D93 Method A, measured on the Mix 2 carrier (Prime Process Safety Center report PPSCQ2686-TR-092026, dated 2026-09-15) |
| Auto-ignition / decomposition temperature | Not determined for formulation |
| pH | 6.16 at 30 °C (measured, Mix 2 carrier) |
| Kinematic viscosity | 2.005 mm²/s at 25 °C (measured); dynamic viscosity 2.619 mPa·s |
| Particle characteristics | Not applicable (liquid). |
| Solubility | No product-specific measured solubility data available |
| Partition coefficient | No formulation-specific data available |
| Vapor pressure / relative vapor density | Vapor pressure: not determined for the mixture. Relative vapor density: not determined for the mixture. |
| Evaporation rate | Not determined for the mixture. |
| Relative density | 1.306 (measured density 1.306 g/mL, Mix 2 carrier) |
| Active ingredient molecular weight | 624.8 g/mol |
| Active ingredient molecular formula | C28H40N4O8S2 |
Measured physicochemical data (Section 9): closed-cup flash point 183 °C (361.4 °F) by ASTM D93 Method A; pH 6.16 at 30 °C; density 1.306 g/mL; kinematic viscosity 2.005 mm²/s and dynamic viscosity 2.619 mPa·s at 25 °C. Determined on the Mix 2 carrier under ISO/IEC 17025 accreditation (Prime Process Safety Center report PPSCQ2686-TR-092026, dated 2026-09-15) and applied to this product by GHS bridging, the active being a non-volatile solid at approximately 1.914% w/w. Sustained combustibility was reported as not applicable because the flash point exceeds 60.5 °C (UN Manual of Tests and Criteria). Melting point, boiling point, vapor pressure, and partition coefficient remain undetermined for the formulation.
10Stability and reactivity
| Reactivity | No dangerous reaction known under recommended handling and storage conditions. |
|---|---|
| Chemical stability | Expected to be stable when stored as directed; active compounds may degrade with heat, light, moisture, oxidation, or pH extremes. |
| Possibility of hazardous reactions | Hazardous polymerization is not expected. |
| Conditions to avoid | Heat, ignition sources, moisture, direct sunlight, ultraviolet exposure, and prolonged exposure to air. |
| Incompatible materials | Strong oxidizers, strong acids, and strong bases. |
| Hazardous decomposition products | Carbon monoxide, carbon dioxide, nitrogen oxides, and other irritating or toxic fumes under fire or thermal decomposition conditions; sulfur oxides may also form under fire or thermal decomposition conditions. |
11Toxicological information
Toxicological assessment: The classification in Section 2 reflects the available component and formulation information. No additional GHS health-hazard classification is assigned beyond the hazards stated in Section 2.
| Likely routes of exposure | Inhalation, eye contact, skin contact, and ingestion. |
|---|---|
| Acute toxicity | No reliable quantitative formulation-specific oral, dermal, or inhalation toxicity data identified. |
| Skin corrosion / irritation | No reliable standardized formulation-specific test data identified. Irritation cannot be excluded. |
| Serious eye damage / irritation | No reliable standardized formulation-specific test data identified. Irritation cannot be excluded. |
| Respiratory / skin sensitization | No reliable formulation-specific data identified. Sensitization cannot be excluded. |
| Carcinogenicity | The active ingredient is not identified in the IARC Monographs or NTP Report on Carcinogens and is not regulated as a carcinogen by OSHA (29 CFR 1910 Subpart Z); IARC and NTP sources are cited in Section 16. |
11. Toxicological information · continued
| Germ cell mutagenicity | No reliable formulation-specific data identified. |
|---|---|
| Reproductive toxicity | No reliable formulation-specific data identified. |
| STOT, single / repeated exposure | No reliable formulation-specific data identified. |
| Aspiration hazard | No formulation-specific determination available. |
| Symptoms / delayed effects | No formulation-specific symptoms established. Ibutamoren is an orally active growth hormone secretagogue; accidental systemic exposure may increase appetite, fluid retention and blood glucose (active-ingredient pharmacology, not mixture-specific data). Other effects may be immediate or delayed; data are insufficient. |
| Numerical measures of toxicity | No reliable formulation-specific numerical toxicity values available. |
| Interactive effects | No information on interactive effects was identified. |
| Alternative information / method | No read-across or structure-activity (SAR) information from other chemicals was used. The mixture was assessed from ingredient data using the cut-off and additivity methods of 29 CFR 1910.1200 Appendix A; where data are unavailable this is stated for each endpoint. |
| Derived no-effect level (DNEL) | No formulation-specific DNEL has been derived. |
| Predicted no-effect concentration (PNEC) | No formulation-specific PNEC has been derived. |
Formal toxicology data for ibutamoren are limited and no classification-triggering endpoints are established.
12Ecological information
| Ecotoxicity | No reliable formulation-specific fish, aquatic invertebrate, or algae data identified. Avoid environmental release. |
|---|---|
| Persistence / degradability | No reliable formulation-specific biodegradation data identified. |
| Bioaccumulative potential | No reliable formulation-specific BCF or log Kow data identified. |
| Mobility in soil / other adverse effects | No reliable formulation-specific data available. |
13Disposal considerations
Waste treatment
Dispose of material, contaminated PPE, absorbents, and containers through a licensed waste contractor in accordance with federal, state, and local requirements. Do not discharge to drains, sewers, or waterways. The waste generator is responsible for determining whether the waste meets hazardous-waste criteria at the time of disposal.
14Transport information
| Framework | UN number | Proper shipping name | Class | Packing group |
|---|---|---|---|---|
| U.S. DOT | None assigned | Not regulated as dangerous goods | Not applicable | |
| IATA | None assigned | Not regulated as dangerous goods | Not applicable | |
| IMDG | None assigned | Not regulated as dangerous goods | Not applicable |
Not regulated as dangerous goods for transport (measured closed-cup flash point 183 °C); no quantity provisions apply.
| Environmental hazards | Not listed as a marine pollutant (49 CFR 172.101 Appendix B; IMDG Code). No aquatic-toxicity data meeting the UN environmentally hazardous substance criteria were identified for the product. |
|---|---|
| Transport in bulk | Not applicable. The product is supplied in non-bulk packagings and is not transported in bulk under IMO instruments (MARPOL Annex II / IBC Code). |
| Special precautions | No special transport precautions beyond keeping containers closed, upright and protected from heat and physical damage. |
Transport assessment (Section 14): the measured closed-cup flash point of 183 °C is far above the 60 °C Class 3 threshold, and above the 93 °C combustible-liquid limit. The mixture is not a Class 3 flammable liquid and is not otherwise known to meet the criteria of any UN transport hazard class on available data. No UN number, proper shipping name, class, or packing group applies; the product is consigned as not regulated as dangerous goods for road, air, and sea transport. The laboratory's Class IIIB designation is a workplace fire-code label and is not a transport classification.
15Regulatory information
Jurisdiction: this SDS is prepared for supply and use in the United States under the OSHA Hazard Communication Standard (29 CFR 1910.1200). Active ingredient CAS number(s) assessed: 159752-10-0. U.S. TSCA: no exact CAS match on that public inventory (159752-10-0); confidential identities are not visible in the public file. Carrier components polyethylene glycol (25322-68-3) and glycerol (56-81-5) are listed as active on the TSCA Inventory. California Proposition 65: no exact active-ingredient CAS match on the official list dated July 31, 2026. CERCLA/SARA: no listed component was identified under 40 CFR 302.4 or 40 CFR 372.65 in the reviewed public records; threshold and release-reporting duties remain quantity- and use-dependent. Sources checked: EPA TSCA non-confidential Inventory (July 2026), OEHHA Proposition 65 list (July 31, 2026), 40 CFR 302.4 and 40 CFR 372.65. Public-inventory status is not product approval or authorization.
16Other information
| Document ID | LL-SDS-4534-001 |
|---|---|
| REVISION DATE | 2026-10-22 |
| VERSION | 1.8 |
| Prepared for | Loti Labs |
| Basis | OSHA Hazard Communication Standard, 29 CFR 1910.1200, including Appendix D; OSHA HCS 2024 alignment (primarily GHS Revision 7). Jurisdiction: United States; Section 14 covers U.S.-origin shipments under 49 CFR, the IATA Dangerous Goods Regulations and the IMDG Code. |
| Revision history | Revision 1.8 (2026-10-22): final line-by-line consistency review of all sections; Section 5 unsuitable extinguishing media stated (Appendix D 5(a)); Section 4 symptoms aligned with Sections 2 and 11; Section 11 symptoms aligned with Section 2; wording, spelling (U.S.), units and batch-method text standardized. Revision 1.7 (2026-10-18): checked against the batch Certificate(s) of Analysis listed below; batch-documentation statements (assay, counter-ion, water and solvent content) corrected to match what the batch COAs actually report; Section 1 other means of identification completed; Section 2 unknown-acute-toxicity statement added (Appendix D 2(e)); Section 9 completed for all Appendix D properties (color, flammability limits, vapor density, evaporation rate, particle characteristics); Section 11 interactive-effects and data-basis statements added (Appendix D 11(e), 11(g)); Section 14 environmental-hazard, bulk-transport and special-precaution entries completed; Section 15 limited to U.S. federal and state requirements (non-U.S. inventory statements removed); Section 8 glycerin mist exposure limit added for the carrier; Section 3 carrier composition stated on its confirmed basis (nominal % v/v of the carrier base). Revision 1.6 (2026-10-03): completed manual formulation, classification and label review; aligned signal words, pictograms and precautionary statements; reconciled active-ingredient evidence across Sections 2 and 11; confirmed the Mix 2 not-regulated transport determination. |
| Batch documentation reviewed | SR Bio Labs COA, lot LOT-MK67-00006, dated 2026-03-21: identity by LC-MS (mass 524.7 Da); purity 99.91% (HPLC). The COA identifies ibutamoren (free-base formula C27H36N4O5S) but prints a calculated mass of 524.7 Da, which matches neither the free base (528.7) nor the mesylate (624.8). The same lot code (LOT-MK67-00006) also appears on a March 2026 capsule COA. The mesylate identity in this SDS follows the Loti Labs product specification and the December 2025 capsule COA (LOT-MK67-00005), which reports ibutamoren mesylate (C28H40N4O8S2, 624.7 Da). The COA tests the active-ingredient material; the finished-solution concentration is not assayed on the COA. This SDS is product-level; lot-specific identity, purity and content are governed by the batch Certificate of Analysis. |
Principal sources consulted
PubChem. Ibutamoren mesylate, Compound Summary, CID 6450830. National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/6450830. Accessed 2026-07-15.
PubChem. Polyethylene glycol 400 (CAS 25322-68-3) and Glycerol (CID 753). National Center for Biotechnology Information. Accessed 2026-07-15.
OSHA. Hazard Communication Standard, 29 CFR 1910.1200, including Appendix D, Safety Data Sheets. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1200. Accessed 2026-07-15.
OSHA. Hazard Communication Standard Final Rule (2024). https://www.osha.gov/hazcom/rulemaking. Accessed 2026-07-15.
United Nations. Globally Harmonized System of Classification and Labelling of Chemicals, Revision 7 (2017). https://unece.org/transport/dangerous-goods/ghs-rev7-2017. Accessed 2026-07-15.
NTP / IARC. Report on Carcinogens and IARC Monographs classifications. https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/roc; https://monographs.iarc.who.int/agents-classified-by-the-iarc/. Accessed 2026-07-15.
EPA. TSCA Chemical Substance Inventory, non-confidential portion (July 2026 release). https://www.epa.gov/tsca-inventory. Accessed 2026-10-18.
OEHHA. Proposition 65 List of chemicals known to the State of California to cause cancer or reproductive toxicity (list dated July 31, 2026). https://oehha.ca.gov/proposition-65/proposition-65-list. Accessed 2026-10-18.
Key abbreviations
CAS, Chemical Abstracts Service · GHS, Globally Harmonized System · IATA, International Air Transport Association · IMDG, International Maritime Dangerous Goods · NIOSH, National Institute for Occupational Safety and Health · OSHA, Occupational Safety and Health Administration · PPE, Personal protective equipment · STOT, Specific target organ toxicity.
Document review and approval
The reviewer confirmed that the supplied form, composition, hazard classification, transport classification and regulatory content of this safety data sheet were reviewed and approved for release.
| Checked by | Dr Afroza Begum |
|---|---|
| Credentials | PhD in Biosciences |
| Date | |
| Signature | Afroza Begum |
Scope of review: Reviewed for content, classification, labelling and transport under 29 CFR 1910.1200 (Appendices A to D) and 49 CFR. Compound identity was checked against public references (PubChem, CAS) and the supplier’s product specification. Batch composition, purity and certificates of analysis were not verified as part of this review. Transport classification reviewed for consistency with 49 CFR; classification for shipment remains the shipper’s responsibility. Applies to version 1.8 dated 2026-10-22 only.
RESEARCH USE ONLY. Loti Labs products are supplied for laboratory, analytical and research use. They are not drugs, foods or cosmetics and are not for human or veterinary use.