Covers larazotide’s unique mechanism of modulating zonulin-mediated tight junctions, research in celiac disease models, intestinal permeability (‘leaky gut’) studies, and Phase 3 clinical trial data.
Category Archives: Peptides
Explores amylin co-secretion with insulin, pramlintide as a synthetic analog, mechanisms in gastric emptying, glucagon suppression, and satiety, plus the emerging cagrilintide-amylin connection in metabolic research.
Covers alpha-defensins and beta-defensins as key innate immune effectors, their membrane-disrupting antimicrobial mechanisms, roles in wound repair, and emerging research on defensin-microbiome interactions.
Examines cerebrolysin’s unique composition of low-molecular-weight neuropeptides and amino acids, its neurotrophic factor-like activity, research in stroke recovery, TBI, and Alzheimer’s disease models.
Covers how peptide-drug conjugates use homing peptides (RGD, NGR, somatostatin analogs) to deliver cytotoxic payloads to specific tissues, comparing PDCs with ADCs and their advantages in size and penetration.
Explains how ECM degradation generates bioactive peptide fragments (matrikines), covering tripeptide GHK as the prototype, elastin-derived peptides, and their roles in fibroblast signaling and angiogenesis.
Covers glucagon-like peptide-2’s trophic effects on intestinal mucosa, the GLP-2 receptor, teduglutide as an approved analog, and research into short bowel syndrome and gut barrier integrity.
Explores thymulin’s unique zinc-dependent structure, its secretion by thymic epithelial cells, research into T-cell maturation, immune modulation, and the thymulin-zinc-neuroendocrine axis.
Covers the chemistry of hydrocarbon stapling and macrocyclic constraints, how these modifications improve alpha-helical stability, protease resistance, and membrane permeability in peptide drug design.
Explains how CPPs like TAT, penetratin, and polyarginine cross cell membranes, their applications in delivering cargo molecules to intracellular targets, and recent advances in CPP-drug conjugates.