Dihexa 10mg Safety Data Sheet
16-section GHS safety data sheet for Dihexa 10mg covering hazard identification, safe handling, storage, exposure controls, transport and disposal. Research use only. Specifications and current certificates of analysis are in the Dihexa compound library page.
01Identification
| Product identifier | Dihexa 10mg |
|---|---|
| Other means of identification | Loti Labs catalog listing “Dihexa 10mg” (lotilabs.com product ID 71281); SDS document ID LL-SDS-71281-001. |
| Product type | Solid research material |
| Declared active component(s) | Dihexa (10 mg) |
| Primary active CAS number | 1401708-83-5 |
| Primary active molecular formula | C27H44N4O5 |
| Primary active molecular weight | 504.7 g/mol |
| Primary active PubChem CID | 129010512 |
| Recommended use | Research laboratory chemical for in-vitro scientific research and development. |
| Restrictions on use | Not for human or veterinary use. Not for food, drug, cosmetic, household, agricultural, clinical, therapeutic, or diagnostic applications. |
Supplier details
| Company | Loti Labs |
|---|---|
| Address | 1204 S Broad St, Brooksville, FL 34601, United States |
| Telephone | 877-LOTI-LAB (877-568-4522) |
| Website | https://lotilabs.com/ |
| Emergency contact | CHEMTREC |
| Emergency phone | 800-424-9300 CHEMTREC (USA) +1-703-527-3887 CHEMTREC (International) 24 hours/day; 7 days/week |
Dihexa (N-hexanoyl-L-tyrosyl-L-isoleucyl-6-aminohexanamide; PNB-0408) is a synthetic oligopeptide derivative related to angiotensin IV: CAS 1401708-83-5, C27H44N4O5, 504.7 g/mol, PubChem CID 129010512. IUPAC name: (2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanamide.
02Hazard(s) identification
| OSHA/GHS classification | Not classified as hazardous under 29 CFR 1910.1200 on the reviewed evidence for the active material in the supplied solid. No GHS health-hazard class is assigned; biological activity, fine-powder exposure and data limitations are addressed under hazards not otherwise classified. |
|---|---|
| Signal word | None assigned (no hazard class triggered). |
| Hazard pictograms | None assigned. |
| Hazard statements | None assigned. See hazards not otherwise classified below. |
| Hazards not otherwise classified | Fine powder may cause mechanical irritation. Treat as a potentially bioactive material of unknown toxicity. |
| Unknown acute toxicity | Not applicable to a single-substance product; available acute toxicity information is summarized in Section 11. |
Prudent laboratory handling
P264 Wash hands and exposed skin thoroughly after handling.
P280 Wear protective gloves, protective clothing, and eye protection.
P501 Dispose of contents/container in accordance with applicable regulations.
These are supplemental safe-handling statements for the completed classification stated above; they do not assign an additional GHS hazard class.
Dihexa is reported in nonclinical literature as a potent modulator of hepatocyte growth factor/c-Met signaling; treat unintended exposure as potentially bioactive even though GHS classification data are unavailable.
03Composition / information on ingredients
| Component | CAS | Formula | MW | Declared amount |
|---|---|---|---|---|
| Dihexa | 1401708-83-5 | C27H44N4O5 | 504.7 g/mol | 10 mg |
Dihexa is a neutral compound (N-terminally acylated, C-terminal amide); no counter-ion is declared. The declared vial amount is listed above; no other intentionally added ingredients are declared.
Composition note: the intentionally added components are limited to those listed in the composition table; identity, purity and content are stated on the COA for each lot.
04First-aid measures
| Inhalation | Move person to fresh air. Keep at rest. Obtain medical advice if symptoms develop or persist. |
|---|---|
| Skin contact | Remove contaminated clothing. Wash thoroughly with soap and water. Seek medical advice if irritation develops. |
| Eye contact | Rinse cautiously with water for at least 15 minutes. Remove contact lenses if easy to do. Continue rinsing. Obtain medical attention if irritation persists. |
| Ingestion | Rinse mouth. Do not induce vomiting unless directed by medical personnel. Contact a poison center or physician if swallowed or symptoms occur. |
| Most important symptoms/effects | No product-specific clinical data available. Exposure may cause mechanical irritation. |
| Immediate medical attention | Treat symptomatically. No specific antidote known. |
05Fire-fighting measures
| Suitable extinguishing media | Water spray, dry chemical, carbon dioxide, or foam appropriate to the surrounding fire. |
|---|---|
| Unsuitable extinguishing media | No substance-specific restriction identified. Avoid methods that disperse dust. |
| Specific hazards | Organic nitrogen-containing peptide solid. Thermal decomposition may generate carbon oxides and nitrogen oxides. |
| Protective equipment | Firefighters should wear full protective equipment and positive-pressure self-contained breathing apparatus. |
06Accidental release measures
Personal precautions
Restrict access. Avoid dust formation and all contact. Ensure adequate ventilation. Wear PPE described in Section 8.
Environmental precautions
Prevent release to drains, sewers, surface water, and soil.
Containment and cleanup
Gently collect without raising dust using suitable tools or a HEPA-filtered vacuum. Place in a sealed, labeled container. Clean affected surfaces and dispose of waste in accordance with Section 13.
07Handling and storage
Precautions for safe handling
Handle as a potentially bioactive research substance of unknown toxicity. Conduct weighing, transfer, and reconstitution in a certified chemical fume hood, ventilated balance enclosure, or other effective containment. Avoid generating or breathing dust or aerosols. Avoid eye, skin, and clothing contact. Do not eat, drink, smoke, or apply cosmetics in work areas. Wash thoroughly after handling.
Storage conditions
Store tightly closed, dry, and protected from light and moisture. Follow the lot-specific storage condition shown on the product label. Long-term storage of dry peptides is commonly at −20 °C or colder; do not assign a shelf life beyond supplier documentation.
Incompatibilities
Strong oxidizing agents, strong acids, strong bases, excessive heat, moisture, direct sunlight, and ultraviolet light.
08Exposure controls / personal protection
Occupational exposure limits
No OSHA PEL, NIOSH REL, or ACGIH TLV identified for the peptide component(s). Maintain exposure as low as reasonably achievable.
Engineering controls
Use local exhaust ventilation or a certified containment device for open handling of powder. Larger-scale work should use closed transfer or glovebox/isolator controls. Provide an accessible eyewash and safety shower.
Personal protective equipment
| Eye / face protection | Safety glasses with side shields as a minimum; chemical splash goggles for dust, aerosol, or splash-generating tasks. |
|---|---|
| Hand protection | Disposable nitrile gloves. Inspect before use; change immediately if contaminated, damaged, or degraded. Consider double gloves for neat powder. |
| Skin protection | Laboratory coat, long trousers, and closed-toe footwear. Add a chemical-resistant apron or disposable coverall for higher-exposure work. |
| Respiratory protection | Normally unnecessary inside effective containment. If controls cannot prevent particulate exposure, use a NIOSH-approved particulate respirator under a compliant program (29 CFR 1910.134). |
| Hygiene | Wash hands after handling and before breaks. Remove contaminated clothing. Decontaminate work surfaces and equipment. |
PPE must be selected by the employer based on task-specific hazard assessment, quantity, physical form, and exposure potential.
09Physical and chemical properties
| Physical state | Solid |
|---|---|
| Appearance | Solid research material. |
| Color | White (batch COA sample description: “White lyophilized powder”). |
| Odor / odor threshold | No reliable product-specific data available |
| Melting point / freezing point | No reliable data available |
| Boiling point / range | Not applicable / decomposes; no reliable data available |
| Flammability | No reliable data available |
| Lower / upper flammability or explosion limits | Not applicable (solid); no minimum explosible concentration (MEC) data are available for dispersed dust. |
| Flash point | Not applicable (solid) |
| Auto-ignition / decomposition temperature | No reliable data available |
| pH | Not applicable (dry solid) |
| Kinematic viscosity | Not applicable to solid |
| Solubility | Formulation, pH, and lot dependent |
| Partition coefficient | No experimental data available |
| Vapor pressure / relative vapor density | Vapor pressure: negligible (non-volatile solid). Relative vapor density: not applicable (solid). |
| Evaporation rate | Not applicable (non-volatile solid). |
| Specific gravity / relative density | Not determined |
| Particle characteristics | No lot-specific particle-size data available |
| Primary molecular formula | C27H44N4O5 |
| Primary molecular weight | 504.7 g/mol |
| Stability in solution | Subject to hydrolytic and oxidative degradation typical of peptides. Protect from light and microbial contamination; use a laboratory-established stability period for the prepared solution. |
Physicochemical summary: non-volatile solid with negligible vapor pressure; a sharp melting point is typically not observed because the material chars or decomposes on heating. Flash point and pH are not applicable to the dry solid. Solution pH depends on concentration and buffer.
10Stability and reactivity
| Reactivity | No dangerous reaction known under recommended handling and storage conditions. |
|---|---|
| Chemical stability | Expected to be stable as dry material when stored as directed; peptide may undergo hydrolytic or oxidative degradation. |
| Possibility of hazardous reactions | Hazardous polymerization is not expected. |
| Conditions to avoid | Heat, moisture, direct sunlight, UV exposure, dust generation, and prolonged exposure to air. |
| Incompatible materials | Strong oxidizers, strong acids, and strong bases. |
| Hazardous decomposition products | Carbon monoxide, carbon dioxide, nitrogen oxides, and other irritating or toxic fumes under fire or thermal decomposition conditions. |
11Toxicological information
Toxicological assessment: Available substance-specific information does not meet the criteria for an additional GHS health-hazard classification beyond the hazards stated in Section 2. Limited toxicological data do not establish absence of hazard.
| Likely routes of exposure | Inhalation, eye contact, skin contact, and ingestion. |
|---|---|
| Acute toxicity | No reliable quantitative oral, dermal, or inhalation LD₅₀/LC₅₀ data identified. |
| Skin corrosion / irritation | No reliable standardized test data identified. Mechanical or nonspecific irritation cannot be excluded. |
| Serious eye damage / irritation | No reliable standardized test data identified. Fine powder may mechanically irritate eyes. |
| Respiratory / skin sensitization | No reliable product-specific data identified. Sensitization cannot be excluded. |
| Carcinogenicity | Not listed as a carcinogen by IARC, NTP, or OSHA. |
11. Toxicological information · continued
| Germ cell mutagenicity | No reliable product-specific data identified. |
|---|---|
| Reproductive toxicity | No reliable product-specific data identified. |
| STOT, single exposure | No reliable product-specific data identified. |
| STOT, repeated exposure | No reliable product-specific data identified. |
| Aspiration hazard | Not applicable to supplied solid under normal conditions. |
| Symptoms / delayed effects | No product-specific symptoms established. Dust may cause mechanical irritation; data are insufficient. |
| Numerical measures of toxicity | No reliable numerical toxicity values available. |
| Interactive effects | No information on interactive effects was identified. |
| Alternative information / method | No read-across or structure-activity (SAR) information from other chemicals was used; where substance-specific data are unavailable this is stated for each endpoint. |
| Derived no-effect level (DNEL) | No product-specific DNEL has been derived. |
| Predicted no-effect concentration (PNEC) | No product-specific PNEC has been derived. |
12Ecological information
| Ecotoxicity | No reliable product-specific fish, aquatic invertebrate, or algae toxicity data identified. Avoid environmental release. |
|---|---|
| Persistence / degradability | No reliable product-specific biodegradation data identified. |
| Bioaccumulative potential | No measured BCF or log Kow identified. |
| Mobility in soil / other adverse effects | No reliable data available. |
Sections 12 to 15 are included for completeness; OSHA does not enforce their substantive content under Appendix D of 29 CFR 1910.1200.
13Disposal considerations
Waste treatment
Dispose of material, contaminated PPE, and containers through a licensed waste contractor in accordance with federal, state, and local requirements. Do not discharge to drains, sewers, or waterways. Do not reuse empty containers. The waste generator is responsible for determining whether the waste meets hazardous-waste criteria at the time of disposal.
14Transport information
| Framework | UN number | Proper shipping name | Class | Packing group |
|---|---|---|---|---|
| U.S. DOT | Not applicable | Not regulated as dangerous goods | Not applicable | |
| IATA | Not applicable | Not regulated as dangerous goods | Not applicable | |
| IMDG | Not applicable | Not regulated as dangerous goods | Not applicable |
The stated transport classification applies to the supplied form and composition; quantity-, packaging-, carrier-, and mode-specific consignment requirements apply at shipment.
| Environmental hazards | Not listed as a marine pollutant (49 CFR 172.101 Appendix B; IMDG Code). No aquatic-toxicity data meeting the UN environmentally hazardous substance criteria were identified for the product. |
|---|---|
| Transport in bulk | Not applicable. The product is supplied in non-bulk packagings and is not transported in bulk under IMO instruments (MARPOL Annex II / IBC Code). |
| Special precautions | No special transport precautions beyond keeping containers closed and protected from heat, moisture, light and physical damage. |
Transport determination: this solid product does not meet the criteria of a U.S. DOT, IATA or IMDG dangerous-goods class and is not regulated as dangerous goods in the supplied form.
15Regulatory information
Jurisdiction: this SDS is prepared for supply and use in the United States under the OSHA Hazard Communication Standard (29 CFR 1910.1200). Active ingredient CAS number assessed: 1401708-83-5. U.S. TSCA: no exact CAS match on the July 2026 EPA non-confidential TSCA Inventory. California Proposition 65: no exact CAS match on the official list dated July 31, 2026. CERCLA/SARA: no listed component was identified under 40 CFR 302.4 or 40 CFR 372.65 in the reviewed public records; threshold and release-reporting duties remain quantity- and use-dependent. Sources checked: EPA TSCA non-confidential Inventory (July 2026), OEHHA Proposition 65 list (July 31, 2026), 40 CFR 302.4 and 40 CFR 372.65. Public-inventory status is not product approval or authorization.
16Other information
| Document ID | LL-SDS-71281-001 |
|---|---|
| REVISION DATE | 2026-10-22 |
| VERSION | 1.8 |
| Prepared for | Loti Labs |
| Basis | OSHA Hazard Communication Standard, 29 CFR 1910.1200, including Appendix D; OSHA HCS 2024 alignment (primarily GHS Revision 7). Jurisdiction: United States; Section 14 covers U.S.-origin shipments under 49 CFR, the IATA Dangerous Goods Regulations and the IMDG Code. |
| Revision history | Revision 1.8 (2026-10-22): final line-by-line consistency review of all sections; Section 5 unsuitable extinguishing media stated (Appendix D 5(a)); wording, spelling (U.S.), units and batch-method text standardized. Revision 1.7 (2026-10-18): first issue for this catalog listing, prepared with the same template, classification method and Appendix D content as the other sheets in this package and checked against the batch Certificate of Analysis listed below. |
| Batch documentation reviewed | Bioviridian COA (verification code COA5955), lot LL-DIH-626, dated 2026-07-09: identity by LC-MS (mass 504.66 Da); purity 99.7% (RP-HPLC, 214 nm); measured content 10.26 mg. The COA's QR code resolves to an unrelated record (COA4543); the printed verification code COA5955 and its matching laboratory record were used. The printed identity and mass are consistent with this SDS. This SDS is product-level; lot-specific identity, purity and content are governed by the batch Certificate of Analysis. |
Principal sources consulted
PubChem. Dihexa, Compound Summary, CID 129010512. National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/129010512. Accessed 2026-10-18.
OSHA. Hazard Communication Standard, 29 CFR 1910.1200, including Appendix D. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1200. Accessed 2026-07-15.
OSHA. Hazard Communication Standard Final Rule (2024). https://www.osha.gov/hazcom/rulemaking. Accessed 2026-07-15.
United Nations. Globally Harmonized System, Revision 7 (2017). https://unece.org/transport/dangerous-goods/ghs-rev7-2017. Accessed 2026-07-15.
NTP / IARC. Report on Carcinogens and IARC classifications. https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/roc; https://monographs.iarc.who.int/agents-classified-by-the-iarc/. Accessed 2026-07-15.
EPA. TSCA Chemical Substance Inventory, non-confidential portion (July 2026 release). https://www.epa.gov/tsca-inventory. Accessed 2026-10-18.
OEHHA. Proposition 65 List of chemicals known to the State of California to cause cancer or reproductive toxicity (list dated July 31, 2026). https://oehha.ca.gov/proposition-65/proposition-65-list. Accessed 2026-10-18.
Key abbreviations
CAS, Chemical Abstracts Service · GHS, Globally Harmonized System · IATA, International Air Transport Association · IMDG, International Maritime Dangerous Goods · NIOSH, National Institute for Occupational Safety and Health · OSHA, Occupational Safety and Health Administration · PPE, Personal protective equipment · STOT, Specific target organ toxicity.
Document review and approval
The reviewer confirmed that the supplied form, composition, hazard classification, transport classification and regulatory content of this safety data sheet were reviewed and approved for release.
| Checked by | Dr Afroza Begum |
|---|---|
| Credentials | PhD in Biosciences |
| Date | |
| Signature | Afroza Begum |
Scope of review: Reviewed for content, classification, labelling and transport under 29 CFR 1910.1200 (Appendices A to D) and 49 CFR. Compound identity was checked against public references (PubChem, CAS) and the supplier’s product specification. Batch composition, purity and certificates of analysis were not verified as part of this review. Transport classification reviewed for consistency with 49 CFR; classification for shipment remains the shipper’s responsibility. Applies to version 1.8 dated 2026-10-22 only.
RESEARCH USE ONLY. Loti Labs products are supplied for laboratory, analytical and research use. They are not drugs, foods or cosmetics and are not for human or veterinary use.