Evidence-led explainers and analytical insights for serious research teams.
BI 3034701 adds NPY2R to GLP-1R/GIPR co-agonism; explore the gut-brain rationale and open questions behind this tri-agonist design.
Read the articleBI 3034701 adds NPY2R to GLP-1R/GIPR co-agonism; explore the gut-brain rationale and open questions behind this tri-agonist design.
Read articleGEP44 fuses GLP-1R and Y1/Y2 receptor pharmacophores into one peptide; explore chimeric design logic and rodent and shrew model findings.
Read articleBRP, a 12-amino-acid hypothalamic peptide found via peptidomic mining, alters feeding in rodent and porcine models independent of GLP-1R.
Read articleHow computational design balances GLP-1R, GIPR, and GCGR potency ratios in next-gen triple agonist candidates like ASC37.
Read articleExploring cone snail venom peptide libraries, disulfide frameworks, and alpha, omega, and mu conotoxin classes as channel-selective research probes.
Read articleResearch overview of metal-coordinating self-assembling peptides, mtDNA-driven cGAS-STING activation, and multivalent polymer-peptide mimics.
Read articleFocused educational resources should make the next step obvious. Move from a research question into the corresponding Loti collection without losing context.
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