09March 9, 2020
Tesamorelin – A Novel Growth Hormone Releasing Hormone | Buy Tesamorelin
Tesamorelin is a peptide that deserves mention because of its implication in the management of HIV. Specifically, tesamorelin is used in HIV patients with lipodystrophy, a condition characterized by abnormal fat distribution. Studies show that it could reduce cardiovascular diseases in HIV infected test subjects.
In November 2010, tesamorelin was approved by the US Food and Drug Administration for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy, effectively helping to reduce excess fat associated with the condition. Tesamorelin is effective in helping reduce belly fat in HIV patients, improving body composition and addressing visceral adiposity. This condition happens as a result of the HIV infection itself and antiretroviral therapy. It is sold under the trade name Egrifta.
Tesamorelin is sold at Loti Labs for research purposes only and isn’t formulated for human consumption. We go to great lengths to provide exceptionally high-quality products to our customers as a USA based peptide and research company.
In this article, we will discuss the tesamorelin peptide, what it is, its effects and where to buy this peptide. Peptides like tesamorelin are short chains of amino acids that serve as building blocks for proteins in the body.
WHAT IS TESAMORELIN?
Tesamorelin is a synthetic analogue of growth hormone releasing hormone (GHRH) designed to stimulate the pituitary gland to increase growth hormone production. This boost in growth hormone leads to higher levels of insulin like growth factor (IGF-1), which plays a crucial role in reducing visceral adipose tissue and excess abdominal fat. By targeting these specific fat stores, tesamorelin helps address abdominal fat that is often resistant to diet and exercise.
While tesamorelin is effective in promoting fat loss, it is important to be aware of potential injection site reactions. These reactions, such as redness, swelling, or mild pain at the injection site, are among the most common side effects. To minimize discomfort and reduce the risk of irritation, it is recommended to rotate injection sites and follow proper injection techniques. If you experience persistent or severe reactions, consult your healthcare provider for guidance.
Tesamorelin is a synthetic analogue of growth hormone releasing hormone (GHRH) designed to stimulate the pituitary gland to increase growth hormone production. This boost in growth hormone leads to higher levels of insulin like growth factor (IGF-1), which plays a crucial role in reducing visceral adipose tissue and excess abdominal fat. By targeting these specific fat stores, tesamorelin helps address abdominal fat that is often resistant to diet and exercise.
While tesamorelin is effective in promoting fat loss, it is important to be aware of potential injection site reactions. These reactions, such as redness, swelling, or mild pain at the injection site, are among the most common side effects. To minimize discomfort and reduce the risk of irritation, it is recommended to rotate injection sites and follow proper injection techniques. If you experience persistent or severe reactions, consult your healthcare provider for guidance.
Mechanism of action
Tesamorelin is also known as (TH9507). It is a synthetic agonist of growth hormone-releasing factor that stimulates the production and release of endogenous growth hormone, thereby enhancing growth hormone production. It consists of all 44 amino acids of human GHRH with the addition of a trans-3-hexenoic acid group. It is also potent and more stable than GHRH and is resistant to cleavage by the dipeptidyl aminopeptidase enzyme.
Peptides like Tesamorelin interact with the human body by binding to receptors in the pituitary gland, influencing hormone levels and metabolic functions throughout the body.
When tested in animals, it significantly reduced visceral adipose tissue (VAT). Tesamorelin was found to reduce triglycerides and total cholesterol levels in test subjects with lipodystrophy associated with antiretroviral therapy of HIV infection. Tesamorelin is also being evaluated as therapy of insulin resistance, obesity, and nonalcoholic fatty liver. Unlike recombinant human growth hormone, Tesamorelin has shown a favorable safety profile with fewer liver-related adverse events in studies.
In summary, peptide therapy works by using synthetically designed peptides to activate or stimulate specific biological processes in the body.
STRUCTURE OF TESAMORELIN AND ITS IMPACT ON BODY COMPOSITION
Tesamorelin is a synthetic peptide with the sequence: Unk-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Kys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2.
Molecular Formula: C221H366N72O67S
Molecular weight: 5136 g/molS
CAS number: 804475-66-9
Tesamorelin specifically targets body fat, particularly visceral and abdominal fat, making it effective for reducing stubborn belly fat and improving overall body composition. Clinical studies have also demonstrated significant increases in lean muscle mass and muscle density following Tesamorelin treatment, further supporting its impact on body composition and metabolic health.
MECHANISM OF ACTION ON VISCERAL ADIPOSE TISSUE
Tesamorelin activates GHRH receptors in the pituitary gland, which leads to the synthesis and release of growth hormone-releasing hormone that acts on multiple cells of the body, including hepatocytes, where it stimulates the production of insulin-like growth factor-1 (IGF-1). IGF-1 mediates many of the effects of growth hormone, which in the liver include growth, inhibition of programmed cell death, glucose intolerance, and lipolysis.
Studies show that tesamorelin’s main mechanism of action is through lipolysis. Lipolysis is the breakdown of lipids and triglycerides, which are both fats that are found in the body. Tesamorelin stimulates fat burning by increasing growth hormone levels, which enhances the body’s ability to break down and utilize stored fat, especially visceral fat. This process helps the body in burning fat more effectively, particularly in the visceral region. Generally, lipids and triglycerides are stored in the body to be used later for energy. However, a high level of either can increase the risk of heart disease.
The effectiveness of Tesamorelin in improving metabolic health and promoting fat loss depends on multiple factors, including lifestyle and individual health status.
BENEFITS OF TESAMORELIN
Tesamorelin offers a multitude of benefits for those aiming to enhance their body composition and overall health. One of the most significant advantages is its ability to reduce excess visceral adipose tissue. This type of fat, which accumulates around the organs in the abdominal cavity, is linked to various metabolic concerns, including cardiovascular disease and insulin resistance. By targeting and decreasing visceral fat, tesamorelin helps mitigate these risks. Tesamorelin also contributes to weight loss by reducing both visceral and abdominal fat, supporting improved body composition and weight management.
In addition to reducing visceral fat, tesamorelin is known to improve overall body composition. It achieves this by not only decreasing fat mass but also increasing lean body mass. This dual action makes it a valuable tool for those looking to achieve a healthier, more balanced physique.
Another critical benefit of tesamorelin is its support for cardiovascular health. By reducing visceral fat and enhancing insulin sensitivity, it helps lower the risk of heart disease. Tesamorelin supports cardiovascular health by improving lipid profiles and reducing inflammation, further decreasing risk factors for heart disease. This makes it particularly beneficial for individuals with metabolic concerns.
Moreover, tesamorelin promotes muscle growth and increases muscle mass. This can lead to improved strength, fitness, and overall health. Its ability to enhance metabolic health by reducing insulin resistance and improving glucose metabolism further underscores its potential as a comprehensive health booster.
WHO IS A GOOD CANDIDATE FOR TESAMORELIN?
Tesamorelin is particularly beneficial for individuals struggling with excess visceral adipose tissue. This type of fat is not just a cosmetic concern; it poses significant health risks, especially when it accumulates around the organs in the abdominal cavity. Good candidates for tesamorelin treatment include:
- Individuals with Human Immunodeficiency Virus (HIV): Those experiencing lipodystrophy, a condition characterized by abnormal fat distribution due to HIV infection and antiretroviral therapy, can benefit significantly from tesamorelin. Immune system health should be monitored during tesamorelin therapy in this population.
- Individuals with Excess Abdominal Fat: Those with a high waist circumference and excess abdominal fat are ideal candidates. Tesamorelin can help reduce this stubborn fat, improving both appearance and health.
- Individuals with Metabolic Concerns: Those dealing with insulin resistance, cardiovascular disease, or other metabolic issues can find tesamorelin beneficial. Its ability to improve insulin sensitivity and support cardiovascular health makes it a valuable treatment option.
- Individuals Looking to Improve Body Composition: Anyone aiming to enhance their body composition by reducing fat mass and increasing lean body mass can benefit from tesamorelin.
Peripheral edema is a potential side effect of tesamorelin therapy and should be considered when determining if someone is a good candidate for treatment.
ADMINISTRATION AND DOSAGE
Tesamorelin is typically administered via subcutaneous injection, making it a convenient option for many users. The recommended dosage is generally 2 mg per day, delivered through a subcutaneous injection. It’s crucial to adhere to this dosage and follow the administration instructions carefully to achieve the best results and minimize potential side effects. Tesamorelin should be stored away from direct light to maintain its stability and prevent degradation.
When performing a subcutaneous injection, avoid injecting into areas with scar tissue to ensure proper absorption of the medication.
For optimal outcomes, it’s essential to consult with a healthcare provider who can tailor the dosage to individual needs and monitor progress. This ensures that the treatment is both safe and effective, helping users achieve their health and fitness goals.
Missed Dose Instructions
If you miss a dose of tesamorelin, take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not take two doses at once to make up for a missed dose. For personalized advice on managing missed doses, always consult your healthcare provider, as they can tailor recommendations to your specific treatment plan and health needs.
Peptide Therapy and Tesamorelin
Peptide therapy has emerged as a promising approach for addressing a range of health concerns, particularly those related to body composition and metabolic health. Tesamorelin, as part of this innovative field, works by stimulating natural growth hormone production, which in turn helps reduce excess visceral adipose tissue and belly fat. This process not only supports fat loss but also contributes to a healthier body composition, making it easier for individuals to lose weight and improve their overall health.
For those considering peptide therapy, it is essential to work with qualified medical professionals who can provide expert guidance and monitor progress. Medical supervision ensures that peptide therapy, including tesamorelin, is both safe and effective, maximizing benefits while minimizing potential risks. By integrating tesamorelin into a comprehensive health plan, individuals can take meaningful steps toward achieving their wellness goals.
Cardiovascular Health Benefits
One of the standout advantages of tesamorelin is its positive impact on cardiovascular health. By targeting and reducing visceral adipose tissue and excess abdominal fat, tesamorelin helps lower the amount of visceral fat—a key risk factor for cardiovascular disease. This reduction in visceral fat can lead to improved lipid metabolism, which is essential for maintaining healthy cholesterol levels and reducing the risk of heart disease.
Additionally, tesamorelin has been shown to enhance insulin sensitivity, further supporting cardiovascular health. Clinical trials have demonstrated that individuals using tesamorelin experience improvements in these critical areas, making it a valuable option for those looking to manage cardiovascular risk factors associated with abdominal fat and metabolic dysfunction.
Improving Quality of Life
Tesamorelin therapy offers more than just physical changes—it can significantly enhance quality of life, especially for individuals with HIV associated lipodystrophy or those dealing with excess abdominal fat. By reducing visceral adipose tissue and improving body composition, tesamorelin supports better metabolic function, higher energy levels, and a greater sense of overall well being.
These improvements can translate into increased confidence, a more active lifestyle, and better self-esteem. For many, the benefits of tesamorelin therapy extend beyond the physical, fostering a renewed sense of vitality and motivation. To achieve the best results, it is important to combine tesamorelin therapy with a healthy lifestyle and regular medical supervision, ensuring that all aspects of health and well being are supported throughout the treatment journey.
Missed Dose Instructions
If you miss a dose of tesamorelin, take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not take two doses at once to make up for a missed dose. For personalized advice on managing missed doses, always consult your healthcare provider, as they can tailor recommendations to your specific treatment plan and health needs.
Peptide Therapy and Tesamorelin
Peptide therapy has emerged as a promising approach for addressing a range of health concerns, particularly those related to body composition and metabolic health. Tesamorelin, as part of this innovative field, works by stimulating natural growth hormone production, which in turn helps reduce excess visceral adipose tissue and belly fat. This process not only supports fat loss but also contributes to a healthier body composition, making it easier for individuals to lose weight and improve their overall health.
For those considering peptide therapy, it is essential to work with qualified medical professionals who can provide expert guidance and monitor progress. Medical supervision ensures that peptide therapy, including tesamorelin, is both safe and effective, maximizing benefits while minimizing potential risks. By integrating tesamorelin into a comprehensive health plan, individuals can take meaningful steps toward achieving their wellness goals.
Cardiovascular Health Benefits
One of the standout advantages of tesamorelin is its positive impact on cardiovascular health. By targeting and reducing visceral adipose tissue and excess abdominal fat, tesamorelin helps lower the amount of visceral fat—a key risk factor for cardiovascular disease. This reduction in visceral fat can lead to improved lipid metabolism, which is essential for maintaining healthy cholesterol levels and reducing the risk of heart disease.
Additionally, tesamorelin has been shown to enhance insulin sensitivity, further supporting cardiovascular health. Clinical trials have demonstrated that individuals using tesamorelin experience improvements in these critical areas, making it a valuable option for those looking to manage cardiovascular risk factors associated with abdominal fat and metabolic dysfunction.
Improving Quality of Life
Tesamorelin therapy offers more than just physical changes—it can significantly enhance quality of life, especially for individuals with HIV associated lipodystrophy or those dealing with excess abdominal fat. By reducing visceral adipose tissue and improving body composition, tesamorelin supports better metabolic function, higher energy levels, and a greater sense of overall well being.
These improvements can translate into increased confidence, a more active lifestyle, and better self-esteem. For many, the benefits of tesamorelin therapy extend beyond the physical, fostering a renewed sense of vitality and motivation. To achieve the best results, it is important to combine tesamorelin therapy with a healthy lifestyle and regular medical supervision, ensuring that all aspects of health and well being are supported throughout the treatment journey.
POTENTIAL SIDE EFFECTS AND INTERACTIONS
Like any medication, tesamorelin may cause potential side effects and interactions. Common side effects include injection site reactions such as redness, swelling, and pain. These are typically mild and resolve on their own as the body adjusts to the medication. However, it’s important to be aware of other potential effects on glucose metabolism, such as increased blood sugar levels, which may require monitoring and management.
Other possible side effects include headache, fatigue, and dizziness. While these are generally mild and may diminish as the body adjusts, it’s essential to monitor them and consult with a healthcare provider if they persist or worsen. If you experience severe side effects or suspect an overdose, seek immediate medical attention. Prompt medical attention is crucial for any persistent or serious symptoms.
Tesamorelin may also interact with other medications, particularly insulin and oral hypoglycemic agents. Therefore, it’s crucial to inform your healthcare provider of all medications you are taking to avoid adverse interactions. Additionally, tesamorelin may not be suitable for individuals with certain medical conditions, such as cancer or benign or malignant tumors. Regular follow-up appointments with a healthcare provider can help ensure the treatment’s safety and efficacy, allowing for adjustments as needed.
LOOKING FOR WHERE TO BUY PEPTIDES
Tesamorelin can be purchased from Loti Labs. It is important to buy peptides which are USA-made to ensure the integrity of your research. Tesamorelin sold from Loti Labs is tested through HPLC and Mass spectrometry to ensure quality. Tesamorelin is commonly sold in 2mg vials. It is available in lyophilized powder form.
References
- National Center for Biotechnology Information. PubChem Database. Tesamorelin, CID=16137828, https://pubchem.ncbi.nlm.nih.gov/compound/Tesamorelin (accessed on Mar. 4, 2020)
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Tesamorelin. [Updated 2018 Oct 20]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548730/
- Knoop, Andre et al. “Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.” Analytical and bioanalytical chemistry vol. 408,12 (2016): 3145-53. doi:10.1007/s00216-016-9377-3
- Patel A, Gandhi H, Upaganlawar A. Tesamorelin: A hope for ART-induced lipodystrophy. J Pharm Bioallied Sci. 2011;3(2):319–320. doi:10.4103/0975-7406.80763
- Fourman LT, Czerwonka N, Feldpausch MN, et al. Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV. AIDS. 2017;31(16):2253–2259. doi:10.1097/QAD.0000000000001614