ABOUT TAMOXIFEN: Tamoxifen is a nonsteroidal selective estrogen receptor modulator (SERM). It competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. This results in a reduction in DNA synthesis and cellular response to estrogen.
Liquid tamoxifen exhibits both estrogenic agonist and antagonist effects in different parts of the body of animal test subjects. In the breast tissue, it is an antagonist, causing antiestrogenic and antitumor effects. Through downstream intracellular processes, it slows cell cycling, which classifies it as cytostatic. In the bone, it stimulates estrogen receptors instead of blocking them, exerting an estrogenic agonist effect, and may prevent osteoporosis.
In experimental animals, concentrations of tamoxifen and its metabolites are 8- to 70-fold higher in tissues (brain, adipose, liver, heart, lung, kidney, uterus, testis) than in serum. The highest levels are found in lung and liver tissue, with substantial amounts found in kidney and adipose tissue.
Tamoxifen can be metabolized in vitro by both microsomal cytochrome P450 and flavin mono-oxygenase pathways to intermediates that bind irreversibly to microsomal proteins.
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For more information on Tamoxifen Citrate visit Wikipedia.
|Appearance||Viscous cloudy liquid|
|Stability||Room Temperature out of direct sunlight|
|Concentration||20mg per ML|
|Terms||This product is sold for research/laboratory usage only. No other uses are permited.|