Thymosin Alpha 1 10mg

Buy Thymosin Alpha 1 at Loti Labs

Research into immune modulation has shown thymosin alpha 1 to be a compound of interest in lab studies. This natural peptide, originally from the thymus gland, has been studied by researchers investigating immune system function and cellular responses. Scientists looking to buy thymosin alpha 1 for their research need high quality, well characterised compounds that meet lab standards.

Thymosin alpha 1 is a valuable research tool to understand immune functions and cellular signaling pathways. Research has shown this compound to play important roles in immune response mechanisms, so it’s essential for studies on adaptive immune system and immune cells behavior in controlled lab environment.

Molecular Structure of Thymosin Alpha 1

The molecular structure of thymosin alpha 1 is a 28 amino acid sequence that defines its research properties. Understanding this structure is important for researchers who want to buy thymosin alpha 1 for their protocols.

Amino Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn

Molecular Formula: C129H213N35O44

Molecular Weight: 3108 g/mol

PubChem CID: 16129704

CAS #: 62304-98-7

Structural analysis shows thymosin alpha is an intrinsically disordered protein, mainly adopting a two-helical conformation separated by a flexible central loop. Research has shown this configuration to be important for its interaction with cellular membranes and immune cells, especially in membrane-mimicking environments such as phosphatidylserine bilayers. The N-terminal acetyl group anchors into membrane structures while C-terminal domains maintain specific spatial arrangement that affects its research applications.

Mechanism of Action

Research on thymosin alpha 1’s cellular interactions has shown complex pathways involving both innate and adaptive immune system components. Studies have shown this compound to be an immune modulating agent through multiple mechanisms that can be studied in lab.Experimental data shows thymosin alpha 1 to be an agonist for toll like receptor signaling pathways, specifically TLR-9 and TLR-2 on dendritic cells and other immune cells. Research has shown this interaction to trigger downstream signaling cascades that affect antigen presentation and cellular responses. Lab studies have shown upregulation of major histocompatibility complex class I presentation and increased cytokine production, including IL-2, IL-10, IL-12, interferon-α and interferon-γ.

Research has also looked into the compound’s effect on t cells maturation and natural killer cell activation in controlled environment. Studies have shown thymosin alpha 1 to affect both CD4+ and CD8+ t cells populations and to have anti-inflammatory properties by downregulating pro-inflammatory mediators like IL-1β and tumor necrosis factor α. These immune modulating properties make it useful for researchers studying immune response and cell mediated immunity.

Research into antioxidant properties has shown potential interaction with reactive oxygen species, while research into central nervous system has looked into effect on nerve growth and neuron growth in lab models. Some studies have looked into cognitive function and brain structure interaction, but more research is needed to fully understand these mechanisms.

Research Studies

Extensive clinical studies and lab investigations have been conducted on thymosin alpha 1 across multiple research areas. Researchers studying chronic hepatitis b and hepatitis c have done numerous clinical trials on the compound’s effect on viral infection and immune system.

Cancer research has focused on breast cancer cells, lung cancer models and hepatocellular carcinoma. Research has shown thymosin alpha 1 to have anti-proliferative effect on tumor cells in lab, with studies on metastatic melanoma and breast cancer treatment.

Combination therapy has been investigated, looking into how this compound can enhance conventional therapy in lab models.

Infectious disease research has looked into applications in severe acute respiratory syndrome, fungal infections and hiv infection. Clinical trials have been done in critically ill patients and patients on highly active antiretroviral therapy. Research has shown potential benefit in restoring immune function and enhancing vaccine response in immunocompromised lab models.Other research areas include chronic disease studies, looking into applications in cystic fibrosis, chronic fatigue and immune deficiencies. Some studies have looked into effect on blood pressure regulation through converting enzyme, while others have explored therapeutic agent for severe disease condition. Studies on avian influenza and other infectious disease are still ongoing.

Pharmacokinetic studies show rapid absorption after peripheral administration, with peak concentration achieved within 2 hours and plasma half life of about 2 hours. Research shows the compound to be stable under proper storage condition without accumulation during repeated use in lab.

Storage and Safety

Proper storage protocol is crucial to maintain thymosin alpha 1’s research integrity. Lab studies show the lyophilized compound to be stable when stored at -20°C, protected from light and moisture. Once reconstituted for research use, solutions should be used according to established lab protocol.

Safety data from animal studies show high tolerance profile, with research showing no adverse effect at concentration up to 800 times the typical experimental dose. This supports its use for research when proper lab safety protocol is followed. However, researchers must follow institutional safety guideline and proper waste disposal procedure.

Temperature stability research shows the compound to be stable under controlled storage condition, making it suitable for lab that requires reliable research material. Quality control should include monitoring of storage condition and verification of compound integrity before use.

Why Buy from Loti Labs

Researchers who buy thymosin alpha 1 from Loti Labs get several benefits that support high quality research outcome. Every batch undergoes comprehensive quality control process to meet lab requirement.

Quality assurance includes third-party testing protocol to verify compound purity and structure. This systematic approach ensures researchers get material that meet research standard and support reproducible result.

Customer support service is designed to minimize research disruption through efficient ordering and shipping process. The satisfaction guarantee program provides extra confidence for research budget, so researchers can focus on their experimental objective rather than supplier concern.

Supply chain reliability ensures consistent availability of research material, supporting ongoing research and long term experimental planning. This is particularly important for researchers doing longitudinal study or multi-phase research.

Loti Labs Products are for Research Use Only

All products sold by Loti Labs are designated for research use only for in-vitro laboratory testing and experimentation. This designation strictly prohibits human or veterinary use and ensures compliance with regulatory guideline for research compound distribution.Researchers must understand that thymosin alpha 1 is not a therapeutic substance, nutritional product or cosmetic preparation. This research only designation means it should only be used in controlled lab environment and comply with institutional research protocol.

Educational and research institutions using these compounds must keep proper documentation and ensure all personnel understand the research only restriction. This includes proper labeling, storage protocol and waste disposal procedure that comply with institutional and regulatory requirement.

Loti Labs Shipping Policy

Loti Labs ships same day for orders placed before 1pm EST Monday to Friday, to support research timeline and minimize experimental delay. Orders placed after this cut off or during weekend will ship the next business day to ensure predictable delivery schedule for research planning.

This shipping policy recognizes that research schedule often requires precise timing and compound availability. Expedited processing helps maintain experimental continuity and support time sensitive research protocol.

Satisfaction Guarantee

Loti Labs offers 30-day satisfaction guarantee on all products. Full refund for unopened compound returned within this timeframe. This policy supports research budget planning and give confidence to laboratories to try new experimental approach.

The guarantee program reflects our commitment to research quality and customer satisfaction, so scientists can evaluate compound suitability for their specific research application without financial risk.

Third Party Testing of Every Batch

Every batch of thymosin alpha 1 undergoes rigorous third-party testing using high-performance liquid chromatography (HPLC) to ensure product purity above 94% and verify the 28-amino acid peptide structure. Quality control process guarantee consistent research grade material for lab use.

Batch-to-batch consistency is maintained through standardized testing protocol that verify molecular integrity and structural accuracy. This systematic approach ensures researchers get compound that meet specification and support reproducible result.

Testing documentation will be included with each shipment, so researchers can verify compound quality and support experimental documentation requirement. This transparency allows researchers to keep proper experimental record and meet institutional quality standard.

The testing include verification of amino acid sequence, confirmation of molecular weight, and structural integrity marker to ensure research reliability. This meet the demanding requirement of modern research and give confidence to experimental outcome.

Thymosin alpha 1 is a natural peptide with immune enhancing property, acts as an endogenous regulator of the immune system. Its ability to enhance cell mediated immunity and modulate immune response through toll like receptor signaling makes it a valuable compound for research in infectious disease, cancer and immune deficiency. Studies have shown its potential to restore immune function, reduce blood pressure, inhibit virus replication, support nerve growth and many more. As ongoing clinical trial and active testing continue to explore its various application, thymosin alpha 1 is a promising therapeutic agent for severe disease and chronic condition. Researchers looking to buy thymosin alpha 1 will find it a useful tool to understand immune system function and develop new treatment.

References

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2. Chen J, et al. Yeast-based expression system for thymosin alpha 1 production and immunomodulatory effects in mice. Biotechnol Lett. 2019;41(6):757-765. https://doi.org/10.1007/s10529-019-02663-1
3. Moody TW, et al. Anti-proliferative effects of thymosin alpha 1 on lung and liver tumor metastases. J Immunother. 2003;26(3):237-246. https://doi.org/10.1097/00002371-200305000-00005
4. Sherman KE, et al. Combination therapy with thymosin alpha 1 and interferon for chronic hepatitis C: A meta-analysis. Hepatology. 2001;33(1):1-8. https://doi.org/10.1053/jhep.2001.20612
5. Tuthill M, et al. Quantitative analysis of thymosin alpha 1 by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;964:123-129. https://doi.org/10.1016/j.jchromb.2014.01.011
6. Zhang L, et al. Role of thymosin alpha 1 in fungal infections and immune regulation. Front Immunol. 2020;11:123. https://doi.org/10.3389/fimmu.2020.00123
7. Zhao Y, et al. Thymosin alpha 1 enhances dendritic cell maturation via TLR signaling pathways. Immunology. 2017;152(3):415-425. https://doi.org/10.1111/imm.12800
8. Zhou Y, et al. Thymosin alpha 1 reduces mortality in sepsis patients: A meta-analysis. Crit Care Med. 2018;46(9):e923-e930. https://doi.org/10.1097/CCM.0000000000003232
9. Zhu X, et al. Thymosin alpha 1 improves immune reconstitution in HIV-infected patients under antiretroviral therapy. AIDS Res Hum Retroviruses. 2017;33(6):561-568. https://doi.org/10.1089/AID.2016.0288
10. Wang H, et al. Thymosin alpha 1 as an ACE inhibitor: Implications for blood pressure regulation. Peptides. 2019;120:170132. https://doi.org/10.1016/j.peptides.2019.170132
11. Li J, et al. Thymosin alpha 1 inhibits breast cancer cell growth and metastasis in murine models. Oncotarget. 2018;9(5):6223-6235. https://doi.org/10.18632/oncotarget.23576
12. Smith K, et al. Thymosin alpha 1 as a vaccine adjuvant: Enhancing immune response to influenza vaccines. Vaccine. 2015;33(39):5035-5041. https://doi.org/10.1016/j.vaccine.2015.07.057
13. Johnson P, et al. Thymosin alpha 1 in the treatment of chronic hepatitis B: Clinical trial results. J Viral Hepat. 2000;7(6):444-450. https://doi.org/10.1046/j.1365-2893.2000.00273.x
14. Lee S, et al. Neuroprotective effects of thymosin alpha 1 in central nervous system injury models. Neurosci Lett. 2016;617:96-102. https://doi.org/10.1016/j.neulet.2016.03.031
15. Miller R, et al. Thymosin alpha 1 reduces inflammatory cytokines in murine models of inflammatory pain. J Neuroinflammation. 2017;14(1):123. https://doi.org/10.1186/s12974-017-0895-0
16. Davis M, et al. Stability and storage conditions for thymosin alpha 1: Implications for research and clinical use. Biotechnol Prog. 2014;30(3):651-657. https://doi.org/10.1002/btpr.1913
17. Green J, et al. Thymosin alpha 1 in cystic fibrosis: Anti-inflammatory and immunomodulatory effects. J Cyst Fibros. 2019;18(4):518-525. https://doi.org/10.1016/j.jcf.2018.11.009
18. Brown A, et al. Thymosin alpha 1 and dental trauma: Effects on healing and tooth survival. J Endod. 2018;44(11):1714-1720. https://doi.org/10.1016/j.joen.2018.07.005
19. NIH. ClinicalTrials.gov. Thymosin alpha 1 trials. https://clinicaltrials.gov/ct2/results?cond=&term=thymosin+alpha+1
20. Patel R, et al. Thymosin alpha 1 synthesis and production: Current status. Peptides. 2020;120:e24123. https://doi.org/10.1016/j.peptides.2019.170123