Tamoxifen Citrate 20mg/ml (30ml)

Buy Tamoxifen Citrate Liquid from Loti Labs

Tamoxifen citrate represents a significant compound, primarily because of its fascinating ability to interact with estrogen receptors differently depending on tissue type. This characteristic makes it invaluable for laboratory studies focusing on hormone receptor-positive cancers. In this article, we’ll explore tamoxifen citrate’s research applications, mechanisms, and proper laboratory handling guidelines.

Key Takeaways

• Tamoxifen Citrate functions as a selective estrogen receptor modulator (SERM) utilized exclusively in research settings to investigate hormone receptor-positive breast cancers by examining how estrogen influences cancer cell growth.
• Research suggests this fascinating compound demonstrates dual functionality; acting as an estrogen antagonist in breast tissue while potentially showing estrogenic effects in other tissues, such as bone.
• Tamoxifen is strictly for research use in controlled laboratory environments, with specific form and storage protocols essential for maintaining its stability and effectiveness for accurate experimental outcomes.

Overview of Tamoxifen Citrate

Tamoxifen Citrate, identified by CAS Number 54965-24-1, is characterized as a stilbenoid compound featuring a tertiary amine in its chemical structure. This non-steroidal substance falls under the classification of selective estrogen receptor modulators (SERMs), meaning laboratory studies show it can both activate and inhibit estrogen receptors depending on the tissue being examined. This fascinating dual nature is what makes Tamoxifen particularly valuable in breast cancer research contexts.

The FDA initially approved Tamoxifen for research purposes on December 30, 1977, primarily for investigating breast cancer. Since that time, it has become fundamental in laboratory studies of estrogen receptor-positive breast cancers, with research suggesting considerable efficacy over decades of experimental application. As a non-steroidal antiestrogen compound, Tamoxifen has been extensively studied for its ability to inhibit estradiol binding to estrogen receptors in controlled research settings.

Research suggests that Tamoxifen can influence breast cancer models, particularly hormone receptor-positive types, through its effects on cancer cell proliferation in laboratory conditions. Studies indicate Tamoxifen may prevent breast cancer cell growth by competing with estrogen at receptor sites in breast tissue samples. This antiestrogen effect is crucial for research involving breast cancer, positioning Tamoxifen as an essential tool in scientific investigations of this condition.

Laboratory findings suggest Tamoxifen’s action extends to other hormone-positive cancer models, demonstrating its versatility as a research compound. Understanding these various applications allows investigators to explore novel approaches to studying estrogen receptor-positive cancers and develop more effective experimental protocols.

Mechanism of Action

Tamoxifen interacts with estrogen receptors in breast tissue at the molecular level, providing valuable research insights into the growth patterns of estrogen receptor-positive tissues. This interaction classifies Tamoxifen as a selective estrogen receptor modulator (SERM) in laboratory contexts. In breast tissue samples, research suggests Tamoxifen may inhibit estrogen’s effects, potentially slowing cancer cell proliferation in experimental models.

Research indicates Tamoxifen’s effects vary across different tissue types. While it functions as an estrogen antagonist in breast tissue, laboratory studies suggest it can exhibit estrogenic agonist properties in other tissues, such as bone. This dual behavior enables targeted research depending on the tissue being studied, making Tamoxifen a versatile compound in cancer research protocols.

In laboratory settings, Tamoxifen reduces cell cycling in breast cancer cells, classifying it as a cytostatic agent. By slowing the cell cycle in experimental models, research suggests Tamoxifen may inhibit cancer cell growth and spread, offering valuable mechanisms for investigating hormone-sensitive or hormone receptor-positive breast cancers under controlled conditions.

Research Applications in Animal Studies

Tamoxifen Citrate Liquid from Loti Labs is exclusively intended for research and laboratory use, not for human applications. This important distinction emphasizes the compound’s role in advancing scientific knowledge rather than direct therapeutic intervention. In animal studies, Tamoxifen Citrate has been extensively utilized to explore its effects on breast cancer cells and hormone-positive breast cancer models.

Research suggests that Tamoxifen demonstrates significant potential as an antiestrogen agent in breast cancer investigations. Animal studies have shown its ability to inhibit the growth of breast cancer cells by blocking estrogen receptors, providing valuable insights into its mechanism of action and potential research applications.

Utilizing Tamoxifen Citrate in controlled laboratory environments gives researchers opportunities to gain crucial insights into its potential effects, creating pathways for new discoveries and advancements in cancer research. This focus on animal studies ensures that the findings maintain scientific integrity and can inform future research directions.

Storage

Proper storage of Tamoxifen is fundamental for maintaining its stability and effectiveness in research settings. Research indicates that Tamoxifen should be kept at room temperature, specifically between 20°C and 25°C, and away from direct sunlight exposure. When working with an opened liquid Tamoxifen container, laboratory findings suggest it remains viable for three months; any remaining substance after this timeframe should be properly disposed of. Following these protocols helps ensure the compound maintains its research-relevant properties throughout experimental applications.

Liquid Form Concentration

The liquid formulation of Tamoxifen presents a concentration of 20 mg per milliliter. This highly concentrated form allows researchers to achieve precise measurements in laboratory applications, supporting accurate and consistent experimental results. This concentration has been established as optimal for various research protocols involving this compound.

Stability and Storage Conditions

Studies indicate that Tamoxifen maintains stability at room temperature but should be shielded from direct sunlight to preserve its research properties. Exposure to light can potentially alter the compound’s molecular structure, reducing its effectiveness in experimental applications. Therefore, it’s crucial for researchers to store Tamoxifen in its original container, protecting it from light and ensuring consistent results across studies.

Adhering to these storage guidelines ensures that Tamoxifen remains a reliable tool throughout research projects. Proper handling and storage practices are essential components of sound experimental design, contributing significantly to reproducible and trustworthy laboratory outcomes.

Summary

In summary, Tamoxifen Citrate Liquid from Loti Labs represents a valuable tool for breast cancer research, offering important insights into the mechanisms of hormone receptor-positive cancers in laboratory settings. Research suggests its ability to block estrogen receptors in breast tissue and its varied effects in different tissues make it a versatile compound for scientific studies and experimental models.

By understanding the proper form, storage conditions, and safety guidelines, investigators can maximize the potential of Tamoxifen in their research protocols. The comprehensive information provided in this guide equips scientific teams with the knowledge needed to handle and utilize Tamoxifen effectively in laboratory environments, potentially contributing to new discoveries and advancements in cancer research models.

Frequently Asked Questions

What is the concentration of Tamoxifen in its liquid form?

The concentration of Tamoxifen in its liquid form is 20 mg per milliliter, which is optimized for research applications.

How should Tamoxifen be stored?

Tamoxifen should be stored at room temperature, away from direct sunlight, and kept in its original container to ensure its stability for experimental use.

Is Tamoxifen Citrate Liquid from Loti Labs intended for human use?

Tamoxifen Citrate Liquid from Loti Labs is exclusively designed for research and laboratory purposes. It is not intended for human use under any circumstances.

What are the primary research applications of Tamoxifen in animal studies?

Tamoxifen is primarily utilized in animal studies to investigate its effects on breast cancer and hormone-positive breast cancer models, highlighting its role as an antiestrogen agent. Research suggests these applications contribute significantly to our understanding of cancer research strategies and potential prevention approaches in experimental settings.

References and Citations

1. Jordan, V.C. (2006). Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer. British Journal of Pharmacology, 147(S1), S269-S276. doi:10.1038/sj.bjp.0706419
2. Osborne, C.K., & Schiff, R. (2011). Mechanisms of Endocrine Resistance in Breast Cancer. Annual Review of Medicine, 62, 233-247. doi:10.1146/annurev-med-070909-182917
3. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). (2005). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. The Lancet, 365(9472), 1687-1717. doi:10.1016/S0140-6736(05)66544-0
4. Fisher, B., Costantino, J.P., Wickerham, D.L., et al. (1998). Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Journal of the National Cancer Institute, 90(18), 1371-1388. doi:10.1093/jnci/90.18.1371
5. Howell, A., Cuzick, J., Baum, M., et al. (2005). Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years’ adjuvant treatment for breast cancer. The Lancet, 365(9453), 60-62. doi:10.1016/S0140-6736(04)17666-6
6. Shagufta, A., & Ahmad, I. (2018). Tamoxifen a pioneering drug: An update on the therapeutic potential of tamoxifen derivatives. European Journal of Medicinal Chemistry, 143, 515-531. doi:10.1016/j.ejmech.2017.11.056
7. Clarke, R., Liu, M.C., Bouker, K.B., et al. (2003). Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. Oncogene, 22(47), 7316-7339. doi:10.1038/sj.onc.1206937

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Weight	0.1875 lbs
Appearance	Viscous cloudy liquid
Stability	Room Temperature out of direct sunlight
Molar Mass	563.7
CAS Number	54965-24-1
Container	30ml Bottle
Molecular Formula	C32H37NO8
Concentration	20mg per ML
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.156 lbs