Ketotifen Fumarate 1mg/ml (30ml)

Buy Ketotifen Fumarate: Premium Grade Compound for Laboratory Studies

Research into allergic mechanisms and histamine pathways requires access to high-quality compounds with verified purity and consistent performance. When laboratories seek to buy ketotifen fumarate for their investigations, the choice of supplier significantly impacts experimental outcomes and data reliability. This comprehensive guide examines the molecular properties, research applications, and quality considerations essential for selecting ketotifen fumarate as a research compound.

Ketotifen fumarate represents a valuable tool in immunology and allergy research, functioning through dual mechanisms that make it particularly useful for studying mast cell biology and histamine receptor interactions. Understanding its chemical properties, storage requirements, and research applications enables scientists to make informed decisions when incorporating this compound into their experimental protocols.

Molecular Structure of Ketotifen Fumarate

The precise chemical characterization of ketotifen fumarate provides essential information for researchers planning experimental protocols. The compound’s systematic name, 4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate, reflects its complex benzocycloheptathiophene core structure with the fumarate salt enhancement.

Property	Specification
Chemical Name	4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate
Molecular Formula	C23H23NO5S
Molecular Weight	425.5 g/mol
PubChem CID	5282408
CAS Number	34580-14-8

The fumarate salt form offers distinct advantages for laboratory applications, including enhanced solubility characteristics and improved stability compared to the base compound. Research suggests that this formulation provides more consistent dissolution properties in common laboratory solvents, particularly DMSO and ethanol, which are frequently used in cellular studies.

The compound’s structural features contribute to its dual pharmacological profile, combining antihistamine properties with mast cell stabilizing effects. This unique combination makes ketotifen fumarate particularly valuable for researchers investigating the complex interactions between histamine pathways and inflammatory mediator release.

Mechanism of Action

Ketotifen fumarate functions through two distinct yet complementary pathways that make it an invaluable research compound for allergy and immunology studies. Understanding these mechanisms helps researchers design appropriate experimental protocols and interpret results within the context of histamine receptor biology and mast cell function.

H1 Receptor Antagonism

The primary action involves non-competitive antagonism of histamine H1 receptors, where ketotifen binds to allosteric sites distinct from the endogenous histamine binding location. Research demonstrates that this non-competitive binding pattern results in sustained receptor blockade that cannot be easily reversed by increasing histamine concentrations, making it particularly useful for studying long-term histamine pathway modulation.

Studies examining receptor binding kinetics show that ketotifen exhibits prolonged residence time at H1 receptors, which correlates with extended duration of action in experimental models. This characteristic proves beneficial for chronic urticaria research models and extended observation periods in laboratory settings.

Mast Cell Stabilization

The secondary mechanism involves direct stabilization of mast cell membranes, preventing degranulation and the subsequent release of inflammatory mediators including histamine, leukotrienes, and platelet-activating factor. Research indicates that this stabilizing action requires repeated exposure to achieve maximum effect, typically observed after multiple dosing cycles in experimental protocols.

In vitro studies demonstrate concentration-dependent inhibition of mast cell activation, with documented IC50 values varying based on cell type and experimental conditions. The compound’s ability to prevent both immediate and late-phase inflammatory responses makes it valuable for studying the complete allergic cascade in research models.

Additional research suggests that ketotifen’s mast cell stabilizing properties extend beyond simple membrane effects, potentially involving modulation of calcium signaling pathways and cytoskeletal organization within these immune cells.

Research Studies

Laboratory investigations utilizing ketotifen fumarate have provided valuable insights into allergic mechanisms and histamine receptor biology. When researchers buy ketotifen fumarate for their studies, they gain access to a compound with extensive documentation in peer-reviewed literature and established protocols for various experimental applications.

In Vitro Applications

Cell culture studies demonstrate ketotifen’s efficacy in human mast cell and basophil models, where research shows concentration-dependent effects on mediator release and cellular activation. Solubility studies reveal optimal preparation methods using DMSO as a vehicle for stock solutions, ensuring consistent experimental results across different laboratory settings.

Mouse model investigations have elucidated anti-allergic mechanisms with particular focus on airway hyperresponsivity and systemic anaphylactic responses. These studies provide valuable dose-response data and timeline information for researchers planning similar experimental protocols.

Comparative Research

Published investigations comparing ketotifen to other antihistamines and mast cell stabilizers highlight its unique dual-action profile. Research suggests that this combination of effects provides advantages in models studying chronic inflammatory processes where both immediate hypersensitivity and prolonged inflammatory cascades require investigation.

The compound serves as an effective reference standard in studies evaluating novel anti-allergic compounds, providing established benchmarks for potency and mechanism comparisons. This application proves particularly valuable for pharmaceutical research and compound screening protocols.

Analytical Methods

HPLC analysis methods for ketotifen fumarate have been extensively validated, providing researchers with reliable protocols for concentration verification and stability studies. These analytical approaches ensure accurate dosing in experimental protocols and enable researchers to monitor compound integrity throughout extended studies.

Storage and Safety

Proper storage and handling protocols ensure ketotifen fumarate maintains its research-grade quality throughout experimental timelines. Understanding these requirements prevents degradation that could compromise experimental results and ensures safe laboratory practices.

Storage Conditions

Store ketotifen fumarate in tightly closed containers under cool, dry conditions away from direct sunlight and moisture. Room temperature storage proves suitable for powder and capsule formulations, while specialized forms may require refrigeration between 2-8°C to maintain optimal stability.

Laboratory storage areas should maintain consistent temperature and humidity levels, avoiding locations near heat sources or areas subject to temperature fluctuations. The compound’s photosensitivity necessitates storage in amber glass containers or opaque packaging to prevent light-induced degradation.

Safety Protocols

Laboratory safety protocols should include appropriate personal protective equipment (PPE) during handling, including lab coats, gloves, and protective eyewear. Adequate ventilation systems, preferably fume hoods, should be utilized during weighing and solution preparation to prevent inhalation exposure.

Emergency procedures should be established for accidental exposure, including eye wash stations and safety showers in laboratory areas where the compound is handled. All personnel should receive training on proper handling techniques and emergency response procedures before working with the compound.

Waste Disposal

Disposal procedures must follow institutional guidelines for hazardous organic chemicals, ensuring compliance with local environmental regulations. Unused compound should never be disposed of through standard laboratory drains or general waste systems.

Benefits of Buying from Loti Labs

When laboratories need to buy ketotifen fumarate for research applications, Loti Labs offers several advantages that support successful experimental outcomes and regulatory compliance. The company’s focus on research-grade quality and customer support addresses the specific needs of scientific investigations.

Quality Assurance

Purchasing ketotifen fumarate from Loti Labs ensures verified 99.92% HPLC purity with comprehensive Certificate of Analysis documentation for each batch. This exceptional purity level exceeds standard research requirements and minimizes the risk of experimental interference from impurities.

The company’s quality control standards include rigorous testing protocols that verify both chemical identity and purity specifications. Each lot undergoes complete analytical characterization, providing researchers with detailed information about their compound’s properties and ensuring batch-to-batch consistency.

Technical Support

Laboratory researchers benefit from technical support services that assist with experimental design considerations and troubleshooting. This support proves particularly valuable for laboratories new to working with ketotifen fumarate or those developing novel experimental protocols.

Competitive pricing structures make high-quality ketotifen fumarate accessible to academic and commercial research facilities, supporting budget-conscious research programs without compromising compound quality. Bulk purchasing options provide additional cost savings for laboratories conducting extensive studies.

Documentation and Compliance

Comprehensive documentation accompanies each order, including detailed specifications, handling guidelines, and regulatory compliance information. This documentation supports institutional procurement requirements and assists with regulatory submissions when research results progress toward publication or further development.

Products from Loti Labs Are for Research Use Only

All ketotifen fumarate products sold by Loti Labs carry the designation as research chemicals intended strictly for in-vitro laboratory testing and experimentation. This classification ensures compliance with regulatory frameworks governing the sale and distribution of chemical compounds not approved for human or veterinary use.

The research use only designation allows utilization of this compound exclusively within controlled laboratory environments for scientific investigation purposes. Human or veterinary use remains strictly forbidden under this classification, and the product cannot be misbranded, mislabeled, or misused as a therapeutic substance.

This compound is not classified as a substance for therapeutic applications, food additive, or cosmetic ingredient and may not be misrepresented as such. Researchers must ensure their experimental protocols comply with institutional guidelines and applicable regulations governing research chemical use.

Regulatory Compliance

Institutions purchasing ketotifen fumarate must maintain appropriate documentation demonstrating research use only applications. This includes experimental protocols, institutional approval documentation, and proper storage and handling records as required by institutional oversight committees.

The research use only designation provides legal protection for both suppliers and researchers when compounds are used appropriately within established regulatory frameworks. Deviation from these guidelines exposes all parties to potential regulatory and legal liabilities.

Shipping Policy of Loti Labs

Loti Labs offers same day shipping for orders placed before 1pm EST Monday through Friday, ensuring minimal delay between order placement and receipt. This expedited processing supports time-sensitive research protocols and reduces laboratory downtime waiting for critical compounds.

Orders placed after 1pm EST or on weekends will be shipped the next business day, maintaining consistent and predictable delivery schedules. The company’s shipping infrastructure ensures proper handling and temperature control during transit, preserving compound integrity from warehouse to laboratory.

Tracking information is provided for all shipments, allowing laboratories to monitor delivery progress and plan experimental schedules accordingly. Special handling requirements for temperature-sensitive formulations are accommodated through appropriate shipping methods and packaging.

Satisfaction Guarantee

Loti Labs offers a 30 day satisfaction guarantee on all products purchased from the company. Simply return any unopened products within this timeframe for a full refund of the purchase price of unused products, providing customer assurance regarding both product quality and order fulfillment.

This guarantee reflects the company’s confidence in their quality control processes and customer service standards. The policy provides researchers with protection against receiving products that do not meet specifications or experimental requirements.

The return process requires products to remain in unopened condition, ensuring that returned materials maintain their original integrity and can be properly disposed of according to regulatory requirements. This policy supports institutional purchasing confidence while maintaining appropriate safety standards.

Third Party Testing of Every Batch

Every batch of ketotifen fumarate sold by Loti Labs undergoes rigorous third party testing using HPLC to ensure product purity and accuracy. Independent laboratory analysis provides objective verification of compound specifications, supporting research reproducibility and data integrity.

The third party testing approach eliminates potential conflicts of interest in quality assessment and provides researchers with confidence in analytical results. Each Certificate of Analysis includes detailed test results from accredited analytical laboratories, ensuring transparency in quality verification processes.

Ketotifen fumarate consistently achieves 99.92% purity verification through independent laboratory analysis, exceeding typical research grade standards. This exceptional purity level supports sensitive analytical methods and minimizes experimental variables that could affect research outcomes.

Analytical Methods

HPLC analysis protocols follow established pharmaceutical and research industry standards, providing quantitative assessment of both purity and identity. These methods detect potential impurities at levels well below those that might affect experimental results.

Mass spectrometry confirmation supplements HPLC analysis, providing additional verification of molecular identity and ensuring that researchers receive the correct compound for their investigations. This comprehensive analytical approach supports the most demanding research applications.

Research Applications and Considerations

When laboratories buy ketotifen fumarate, they typically incorporate it into investigations studying allergic mechanisms, histamine receptor biology, or inflammatory pathway modulation. Understanding optimal experimental conditions and preparation methods ensures successful research outcomes.

Experimental Preparation

Researchers commonly prepare stock solutions using DMSO as a vehicle, taking advantage of ketotifen fumarate’s favorable solubility characteristics in this solvent. Proper preparation techniques include complete dissolution verification and appropriate storage of prepared solutions to maintain compound stability.

Concentration selection should consider the compound’s documented IC50 values in relevant experimental systems, typically ranging from nanomolar to low micromolar levels depending on the specific research model. Dose-response studies help establish optimal working concentrations for individual experimental protocols.

Model Systems

In vitro models utilizing human mast cells or basophils provide relevant systems for studying ketotifen’s dual mechanisms of action. These cellular models allow researchers to examine both immediate effects on histamine release and longer-term impacts on inflammatory mediator production.

Animal models, particularly mouse systems, offer opportunities to study systemic effects and dose-response relationships in complex biological environments. Research suggests that multiple dosing regimens may be necessary to achieve maximal effects, reflecting the compound’s clinical pharmacology profile.

Analytical Considerations

Researchers should establish analytical methods for measuring ketotifen concentrations in experimental samples, ensuring accurate dose verification and enabling pharmacokinetic studies. HPLC methods provide reliable quantification approaches for most research applications.

Sample stability considerations include protection from light and appropriate storage temperatures for both compound stocks and experimental samples. These precautions prevent degradation that could affect experimental results and data interpretation.

Quality Standards and Regulatory Considerations

The research chemical market requires strict adherence to quality standards and regulatory guidelines to ensure both product integrity and legal compliance. When laboratories buy ketotifen fumarate, understanding these requirements supports appropriate procurement and use decisions.

Documentation Requirements

Institutional procurement processes often require comprehensive product documentation, including detailed specifications, analytical test results, and safety information. Loti Labs provides complete documentation packages that meet typical institutional requirements and support regulatory compliance.

Certificate of Analysis documents include batch-specific test results, expiration dating, and storage recommendations. This information supports proper inventory management and ensures researchers use compounds within their validated stability periods.

Compliance Monitoring

Regular review of research protocols ensures continued compliance with research use only designations and institutional guidelines. This monitoring includes verification that experimental applications remain within approved research parameters and that proper documentation is maintained.

Training programs for laboratory personnel should address proper handling techniques, safety protocols, and regulatory requirements specific to research chemicals. Updated training ensures that all staff members understand their responsibilities regarding compliant compound use.

Future Directions and Research Opportunities

The continued evolution of allergy and immunology research creates ongoing opportunities for ketotifen fumarate applications in novel experimental paradigms. Understanding emerging research trends helps laboratories plan future studies and experimental investments.

Emerging Applications

Recent research explores ketotifen’s potential applications in studying inflammatory pathways beyond traditional allergic mechanisms. These investigations may reveal additional biological targets and expand the compound’s utility in diverse research contexts.

Advanced analytical techniques continue to reveal new aspects of ketotifen’s mechanism of action, potentially identifying additional therapeutic targets and research applications. These discoveries may lead to new experimental protocols and research directions.

Technological Advances

Improvements in analytical chemistry and cell culture techniques enhance researchers’ ability to study ketotifen’s effects with greater precision and sensitivity. These technological advances support more sophisticated experimental designs and detailed mechanistic investigations.

High-throughput screening approaches may incorporate ketotifen as a reference compound for evaluating novel anti-allergic agents. These applications require reliable sources of high-purity compound to ensure accurate comparative results.

Conclusion

Ketotifen fumarate represents a valuable research compound for investigations into allergic mechanisms, histamine receptor biology, and mast cell function. When laboratories buy ketotifen fumarate from Loti Labs, they receive a product that meets the highest standards for research applications, with verified purity, comprehensive documentation, and reliable customer support.

The compound’s dual mechanism of action, combining H1 receptor antagonism with mast cell stabilization, provides researchers with a versatile tool for studying complex allergic and inflammatory processes. Proper handling, storage, and experimental design ensure optimal results while maintaining compliance with research use only guidelines.

For laboratories seeking high-quality ketotifen fumarate for their research programs, Loti Labs offers the combination of product excellence, analytical verification, and customer service necessary for successful scientific investigations. The company’s commitment to quality and compliance supports researchers in advancing our understanding of allergic mechanisms and developing new therapeutic approaches.

To order ketotifen fumarate or obtain additional information about specifications and availability, contact Loti Labs through their website or customer service team. Their technical support staff can assist with experimental design considerations and provide guidance on optimal compound handling for specific research applications.

---

References

1. Falk ES. Ketotifen in the treatment of atopic dermatitis. Results of a double blind study. Riv Eur Sci Med Farmacol. 1993 Mar-Apr;15(2):63-6.
2. Sokol, K. C., Amar, N. K., Starkey, J., & Grant, J. A. Ketotifen in the management of chronic urticaria: resurrection of an old drug. Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology. 2013;111(6):433–436. doi:10.1016/j.anai.2013.10.003
3. Pinol, J., & Carapeto, F. J. Ketotifen in the treatment of chronic urticaria and angioneurotic edema. Allergologia et Immunopathologia. 1984;12(1):19-27.
4. CareFirst Specialty Pharmacy. Ketotifen Compounded. Available at: https://www.cfspharmacy.pharmacy/ketotifen-compounded
5. Harbor Compounding Pharmacy. Ketotifen Capsules. Available at: https://www.harborcompounding.com/ketotifen-capsules
6. Thermo Fisher Scientific. Ketotifen fumarate, 99%. Available at: https://www.thermofisher.com/order/catalog/product/J63708.MD

For more information on Ketotifen please visit Wikipedia.

---

Weight	0.1875 lbs
Appearance	Viscous cloudy liquid
Stability	Room Temperature out of direct sunlight
Molar Mass	425.5
CAS Number	34580-14-8
Container	30ml Bottle
Molecular Formula	C19H19NOS C4H4O4
Concentration	1mg per ML
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.156 lbs