Ketotifen Fumarate 1mg/ml (30ml)

Buy Ketotifen Fumarate: Premium Grade Compound for Laboratory Studies

When researching allergic mechanisms and histamine pathways, high-quality compounds with verified purity and consistent performance are required. When labs buy ketotifen fumarate for their research, the supplier choice can impact experimental outcomes and data reliability. This guide covers the molecular properties, research applications and quality considerations for selecting ketotifen fumarate as a research compound.

Ketotifen fumarate is a valuable tool in immunology and allergy research, working through dual mechanisms that makes it useful for studying mast cell biology and histamine receptor interactions. Understanding its chemical properties, storage requirements and research applications allows scientists to make informed decisions when adding this compound to their protocols.

Molecular Structure of Ketotifen Fumarate

The chemical characterization of ketotifen fumarate provides essential information for researchers planning their experiments. The compound’s systematic name, 4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate, reflects its complex benzocycloheptathiophene core structure with the fumarate salt enhancement.

Property	Specification
Chemical Name	4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate
Molecular Formula	C23H23NO5S
Molecular Weight	425.5 g/mol
PubChem CID	5282408
CAS Number	34580-14-8

The fumarate salt form has advantages for laboratory use, including better solubility and stability compared to the base compound. Research shows this formulation has more consistent dissolution properties in common laboratory solvents, such as DMSO and ethanol, which are used in cell studies.

The compound’s structure contributes to its dual pharmacological profile, antihistamine and mast cell stabilizing effects. This combination makes ketotifen fumarate very useful for researchers studying histamine pathways and inflammatory mediator release.

Mechanism of Action

Ketotifen fumarate works through two distinct yet complementary mechanisms that makes it a valuable research compound for allergy and immunology studies. Understanding these mechanisms helps researchers design their experiments and interpret results in the context of histamine receptor biology and mast cell function.

H1 Receptor Antagonism

The primary action is non-competitive antagonism of histamine H1 receptors, where ketotifen binds to allosteric sites distinct from the endogenous histamine binding site. Research shows this non-competitive binding pattern results in sustained receptor blockade that cannot be easily reversed by increasing histamine concentrations, making it very useful for studying long-term histamine pathway modulation.

Studies on receptor binding kinetics show ketotifen has prolonged residence time at H1 receptors, which correlates with longer duration of action in experimental models. This is useful for chronic urticaria research models and longer observation periods in lab settings.

Mast Cell Stabilization

The secondary mechanism is direct stabilization of mast cell membranes, preventing degranulation and the subsequent release of inflammatory mediators including histamine, leukotrienes and platelet-activating factor. Research shows this stabilizing effect requires repeated exposure to achieve maximum effect, typically seen after multiple dosing cycles in experimental protocols.

In vitro studies show concentration-dependent inhibition of mast cell activation, with documented IC50 values varying depending on cell type and experimental conditions. The compound prevents both immediate and late phase inflammatory responses making it useful for studying the whole allergic cascade in research models.

Additional research suggests ketotifen’s mast cell stabilizing effect goes beyond simple membrane effects, possibly involving modulation of calcium signaling pathways and cytoskeletal organization in these immune cells.

Research Studies

Laboratory studies using ketotifen fumarate have provided valuable information on allergic mechanisms and histamine receptor biology. When researchers buy ketotifen fumarate for their research, they get a compound with extensive literature documentation and established protocols for various experimental uses.

In Vitro Applications

Cell culture studies show ketotifen’s effect in human mast cell and basophil models, where research shows concentration dependent effects on mediator release and cellular activation. Solubility studies reveal optimal preparation methods using DMSO as a vehicle for stock solutions, ensuring consistent results across different lab settings.Mouse studies have shown anti-allergic mechanisms with focus on airway hyperresponsivity and systemic anaphylactic responses. These studies provide dose response and time course data for researchers planning similar experiments.

Comparative Research

Published studies comparing ketotifen to other antihistamines and mast cell stabilizers highlight its dual action profile. Research shows this combination of effects is useful for models studying chronic inflammatory processes where both immediate hypersensitivity and prolonged inflammatory cascades need to be investigated.

The compound is a reference standard for studies of new anti-allergic compounds, providing established benchmarks for potency and mechanism of action. This is particularly useful for pharmaceutical research and compound screening.

Analytical Methods

HPLC methods for ketotifen fumarate have been validated, providing researchers with methods for concentration verification and stability studies. These methods ensure accurate dosing in experiments and allow researchers to monitor compound integrity during long term studies.

Storage and Safety

Proper storage and handling protocols ensure ketotifen fumarate remains research grade throughout experimental timelines. Understanding these requirements prevents degradation that can affect experimental results and ensures safe laboratory practices.

Storage Conditions

Store ketotifen fumarate in tightly closed containers under cool, dry conditions away from direct sunlight and moisture. Room temperature storage is suitable for powder and capsule formulations, while specialized forms may need to be refrigerated between 2-8°C to maintain stability.

Laboratory storage areas should have consistent temperature and humidity, avoiding areas near heat sources or temperature fluctuations. The compound is photosensitive and should be stored in amber glass containers or opaque packaging to prevent light induced degradation.

Safety Protocols

Laboratory safety protocols should include PPE during handling, lab coats, gloves and protective eyewear. Ventilation systems, preferably fume hoods, should be used during weighing and solution preparation to prevent inhalation exposure.

Emergency procedures should be established for accidental exposure, including eye wash stations and safety showers in laboratory areas where the compound is handled. All personnel should be trained on handling techniques and emergency response procedures before working with the compound.

Waste Disposal

Waste disposal should follow institutional guidelines for hazardous organic chemicals and comply with local environmental regulations. Unused compound should never be disposed of through laboratory drains or general waste systems.

Buy from Loti Labs

When you need to buy ketotifen fumarate for your research, Loti Labs offers several advantages to support your experimental outcomes and regulatory compliance. The company focuses on research grade quality and customer support to meet your research needs.

Quality

Buying ketotifen fumarate from Loti Labs means verified 99.92% HPLC purity with Certificate of Analysis for each batch. This is above research grade and minimizes the risk of experimental interference from impurities.

Our quality control includes rigorous testing to verify chemical identity and purity specifications. Each lot is fully characterized, so you get detailed information about your compound and batch to batch consistency.

Technical Support

Lab researchers get technical support to help with experimental design and troubleshooting. This is especially useful for labs new to ketotifen fumarate or developing new protocols.

Competitive pricing makes high quality ketotifen fumarate available to academic and commercial research institutions, so you can have budget friendly research without compromising on compound quality. Bulk purchasing options are also available for large studies.

Documentation and Compliance

Each order comes with detailed documentation including specifications, handling guidelines and regulatory compliance information. This supports your institutional procurement requirements and helps with regulatory submissions when your research is ready for publication or further development.

Products from Loti Labs are for Research Use Only

All ketotifen fumarate products sold by Loti Labs are research chemicals intended for in vitro laboratory testing and experimentation only. This classification ensures compliance with regulations governing the sale and distribution of compounds not approved for human or veterinary use.

The research use only designation allows use of this compound only within controlled laboratory environment for scientific research purposes. Human or veterinary use is strictly forbidden under this classification and the product cannot be misbranded, mislabeled or misused as a therapeutic substance.

This compound is not a substance for therapeutic applications, food additive or cosmetic ingredient and cannot be misrepresented as such. You must ensure your experimental protocols comply with your institutional guidelines and applicable regulations for research chemicals.

Regulatory Compliance

Institutions purchasing ketotifen fumarate must maintain documentation to prove research use only applications. This includes experimental protocols, institutional approval documentation and proper storage and handling records as required by your institutional oversight committee.The research use only designation protects both suppliers and researchers when compounds are used within established regulatory frameworks. Deviation from these guidelines exposes all parties to regulatory and legal liabilities.

Shipping Policy of Loti Labs

Loti Labs ships same day for orders placed before 1pm EST Monday through Friday to minimize delay between order and receipt. This expedited processing supports time sensitive research protocols and reduces lab downtime waiting for critical compounds.

Orders placed after 1pm EST or on weekends will be shipped the next business day to maintain consistent and predictable delivery schedule. Our shipping infrastructure ensures proper handling and temperature control during transit to preserve compound integrity from warehouse to lab.

Tracking information is provided for all shipments so you can track delivery and plan your experiments accordingly. Special handling requirements for temperature sensitive formulations are accommodated through appropriate shipping methods and packaging.

Satisfaction Guarantee

Loti Labs offers 30 day satisfaction guarantee on all products purchased from us. Simply return any unopened products within this timeframe for full refund of the purchase price of unused products, so you can be confident in product quality and order fulfillment.

This guarantee reflects our confidence in our quality control and customer service. The policy protects you from receiving products that don’t meet specifications or experimental requirements.

The return process requires products to be unopened so returned materials can be properly disposed of according to regulations. This policy gives you institutional purchasing confidence while maintaining safety standards.

Third Party Testing of Every Batch

Every batch of ketotifen fumarate sold by Loti Labs is third party tested using HPLC to ensure product purity and accuracy. Independent laboratory analysis provides objective verification of compound specifications to support research reproducibility and data integrity.

Third party testing eliminates any conflict of interest in quality assessment and gives you confidence in analytical results. Each Certificate of Analysis includes detailed test results from accredited analytical laboratories so you can see transparency in quality verification process.

Ketotifen fumarate consistently achieves 99.92% purity verification through independent laboratory analysis, above research grade standards. This high purity level supports sensitive analytical methods and minimizes experimental variables that can affect research outcomes.

Analytical Methods

HPLC analysis protocols follow pharmaceutical and research industry standards to quantitate purity and identity. These methods detect impurities at levels well below what would affect experimental results.Mass spectrometry confirmation of HPLC analysis provides additional verification of molecular identity so you receive the correct compound for your research. This comprehensive analytical approach supports the most demanding research applications.

Research Applications and Considerations

When you buy ketotifen fumarate, you typically use it in studies of allergic mechanisms, histamine receptor biology or inflammatory pathway modulation. Understanding optimal experimental conditions and preparation methods is key to successful research.

Experimental Preparation

Researchers prepare stock solutions using DMSO as a vehicle, taking advantage of ketotifen fumarate’s solubility in this solvent. Proper preparation techniques include complete dissolution verification and storage of prepared solutions to maintain compound stability.

Concentration selection should consider the compound’s IC50 values in relevant experimental systems, typically nanomolar to low micromolar range depending on the research model. Dose-response studies help you determine optimal working concentrations for your experimental protocol.

Model Systems

In vitro models using human mast cells or basophils are relevant systems to study ketotifen’s dual mechanisms of action. These cellular models allow you to study immediate effects on histamine release and longer term effects on inflammatory mediator production.

Animal models, especially mouse systems, provide opportunity to study systemic effects and dose-response relationships in complex biological environment. Research suggests multiple dosing regimens may be required to achieve maximal effects, reflecting the compound’s clinical pharmacology.

Analytical Considerations

You should establish analytical methods to measure ketotifen concentrations in your experimental samples to verify dose and enable pharmacokinetic studies. HPLC methods work for most research applications.

Sample stability considerations include protection from light and storage temperature for both compound stocks and experimental samples. These precautions prevent degradation that can affect experimental results and data interpretation.

Quality Standards and Regulatory Considerations

The research chemical market requires strict adherence to quality standards and regulatory guidelines to ensure product integrity and legal compliance. When you buy ketotifen fumarate, understanding these requirements supports your procurement and use decisions.

Documentation Requirements

Institutional procurement processes often require product documentation including specifications, analytical test results and safety information. Loti Labs provides complete documentation packages that meet institutional requirements and regulatory compliance.

Certificate of Analysis includes batch specific test results, expiration dating and storage recommendations. This information helps you manage your inventory and use compounds within their validated stability period.

Compliance Monitoring

Regular review of research protocols ensures compliance with research use only designation and institutional guidelines. This includes verification that experimental applications stay within approved research parameters and proper documentation is maintained.

Training programs for laboratory personnel should cover proper handling techniques, safety protocols and research chemical specific regulatory requirements. Updated training ensures all staff understand their responsibilities for compliant compound use.

Future Directions and Research Opportunities

Allergy and immunology research continues to evolve and creates ongoing opportunities for ketotifen fumarate in new experimental paradigms. Understanding emerging research trends helps labs plan future studies and experimental investments.

Emerging Applications

Recent research explores ketotifen’s applications beyond traditional allergic mechanisms. These studies may reveal new biological targets and expand the compound’s use in different research areas.

Advanced analytical techniques will continue to uncover new aspects of ketotifen’s mechanism of action and may identify additional therapeutic targets and research applications. This may lead to new experimental protocols and research directions.

Technological Advances

Improvements in analytical chemistry and cell culture techniques allow researchers to study ketotifen with greater precision and sensitivity. These advances support more complex experimental designs and mechanistic studies.

High-throughput screening may use ketotifen as a reference compound to evaluate new anti-allergic agents. These applications require a reliable source of high purity compound to ensure accurate comparative results.

Conclusion

Ketotifen fumarate is a valuable research compound for allergic mechanisms, histamine receptor biology and mast cell function. When you buy ketotifen fumarate from Loti Labs, you get a product that meets the highest standards for research, verified purity, complete documentation and reliable customer support.

The compound’s dual mechanism of action, H1 receptor antagonism and mast cell stabilization, provides researchers with a tool to study complex allergic and inflammatory processes. Proper handling, storage and experimental design ensures optimal results and compliance with research use only guidelines.

For labs looking for high quality ketotifen fumarate for their research programs, Loti Labs offers the combination of product excellence, analytical verification and customer service to support your research. The company’s commitment to quality and compliance helps you understand allergic mechanisms and develop new therapies.To purchase ketotifen fumarate or for more information on specifications and availability contact Loti Labs through their website or customer service.

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References

1. Falk ES. Ketotifen in the treatment of atopic dermatitis. Results of a double blind study. Riv Eur Sci Med Farmacol. 1993 Mar-Apr;15(2):63-6.
2. Sokol, K. C., Amar, N. K., Starkey, J., & Grant, J. A. Ketotifen in the management of chronic urticaria: resurrection of an old drug. Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology. 2013;111(6):433–436. doi:10.1016/j.anai.2013.10.003
3. Pinol, J., & Carapeto, F. J. Ketotifen in the treatment of chronic urticaria and angioneurotic edema. Allergologia et Immunopathologia. 1984;12(1):19-27.
4. CareFirst Specialty Pharmacy. Ketotifen Compounded. https://www.cfspharmacy.pharmacy/ketotifen-compounded
5. Harbor Compounding Pharmacy. Ketotifen Capsules. https://www.harborcompounding.com/ketotifen-capsules
6. Thermo Fisher Scientific. Ketotifen fumarate, 99%. https://www.thermofisher.com/order/catalog/product/J63708.MD

For more information on Ketotifen please visit Wikipedia.

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Weight	0.1875 lbs
Appearance	Viscous cloudy liquid
Stability	Room Temperature out of direct sunlight
Molar Mass	425.5
CAS Number	34580-14-8
Container	30ml Bottle
Molecular Formula	C19H19NOS C4H4O4
Concentration	1mg per ML
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.156 lbs