IGF-1 LR3 1mg

Buy IGF-1 LR3 at Loti Labs: Premium Research Peptides for Scientific Investigation

Research into insulin like growth factors has revealed the significant potential of IGF-1 LR3 as a powerful tool for investigating cellular mechanisms and growth pathways. This synthetic analog of human insulin like growth factor represents a breakthrough in peptide research, offering scientists enhanced stability and potency compared to naturally occurring compounds. For researchers seeking to buy igf 1 lr3 of exceptional quality, understanding both the molecular characteristics and practical applications becomes essential for successful experimental outcomes.

The modified version of IGF-1 has garnered attention across multiple research domains, from muscle growth studies to investigations of cell proliferation and protein synthesis mechanisms. Unlike its natural counterpart, IGF-1 LR3 demonstrates remarkable resistance to degradation while maintaining consistent bioactivity throughout extended experimental periods. This enhanced stability profile makes it an invaluable research tool for scientists studying growth factor pathways and their effects on various tissues and cells.

Molecular Structure of IGF-1 LR3

The molecular architecture of IGF-1 LR3 reflects sophisticated bioengineering designed to overcome the limitations of natural insulin like growth factor compounds. This synthetic analog features a distinctive 13-amino acid N-terminal extension combined with an arginine substitution at position 3, replacing the original glutamic acid residue. These structural modifications fundamentally alter the peptide’s interaction with igf binding proteins, resulting in increased potency and extended biological activity.

Key Molecular Specifications:

Property	Value
Amino Sequence	Long Arginine 3 modification of human IGF-1 with 13-amino acid N-terminal extension
Molecular Formula	C423H684N122O128S7
Molecular Weight	9117.60 g/mol
PubChem CID	56841671
CAS Number	946870-92-4

The long arginine modification at the n terminus creates a peptide that demonstrates significantly different pharmacokinetic properties compared to native IGF-1. Research has shown that this structural alteration reduces binding affinity to IGF-binding proteins while maintaining high-affinity interactions with IGF-1 receptors. The resulting compound exhibits a longer half life of approximately 20-30 hours, representing a dramatic improvement over the brief 10-minute duration of natural IGF-1 activity in vitro.

 

Studies examining the molecular behavior of this peptide have demonstrated that the arginine substitution and extended amino acid chain work synergistically to create a more potent and stable research compound. The molecular weight of 9117.60 g/mol reflects the additional amino acids incorporated into the structure, while the complex molecular formula indicates the sophisticated arrangement of carbon, hydrogen, nitrogen, oxygen, and sulfur atoms that comprise this advanced peptide.

Mechanism of Action

IGF-1 LR3 operates through high-affinity binding to IGF-1 receptors, initiating complex cellular signaling cascades that regulate fundamental biological processes including cell growth, protein synthesis, and fat metabolism. Upon receptor binding, the compound activates multiple intracellular pathways, primarily the Ras-MAPK and PI3K/Akt/mTOR signaling networks. These pathways coordinate diverse cellular responses ranging from cell proliferation to metabolic adaptations that researchers study extensively in laboratory settings.

The enhanced potency of IGF-1 LR3 stems from its reduced interaction with IGF-binding proteins, which normally sequester and inactivate growth factors in biological systems. Research suggests that this low affinity for binding proteins allows more free peptide to remain available for receptor activation, producing more pronounced and sustained cellular responses compared to natural insulin like growth factors. This characteristic makes IGF-1 LR3 particularly valuable for researchers investigating growth factor signaling mechanisms and their downstream effects.

Primary Signaling Pathways:

• Ras-MAPK Pathway: Regulates cell proliferation and differentiation responses
• PI3K/Akt/mTOR Network: Controls protein synthesis, cell survival, and metabolic functions
• Metabolic Signaling: Influences glucose uptake and fatty acid oxidation in target tissues

The longer half life of IGF-1 LR3 provides researchers with consistent experimental conditions over extended periods, eliminating the need for frequent compound administration that could introduce variables into study protocols. This stability allows for more precise measurements of cellular responses and enables researchers to study both acute and chronic effects of growth factor stimulation in various experimental models.

Research has demonstrated that IGF-1 LR3 can stimulate both hypertrophy and hyperplasia in skeletal muscle cells, offering scientists a unique tool for investigating muscle repair mechanisms and growth factor efficacy. The compound’s ability to influence nutrient partitioning and cellular metabolism makes it valuable for studies examining metabolic disorders and aging-related changes in tissue function.

Research Studies and Applications

Current scientific investigations utilizing IGF-1 LR3 span multiple research domains, with particular focus on understanding growth factor mechanisms in disease models and cellular aging processes. Research suggests that this synthetic analog provides valuable insights into conditions affecting muscle integrity, metabolic function, and cellular regeneration. Scientists have employed IGF-1 LR3 in studies examining cancer cachexia, age-related muscle loss, and various metabolic disorders, contributing to our understanding of growth factor biology and potential therapeutic targets.

Investigations into muscle growth mechanisms have utilized IGF-1 LR3 to explore how insulin like growth factors influence both existing muscle fiber enlargement and the formation of new muscle cells. Research conducted in fetal sheep models has provided data on growth factor effects during development, while in vitro studies using human and animal cell cultures have elucidated specific molecular pathways activated by IGF-1 stimulation. These studies have shown that IGF-1 LR3 consistently promotes protein synthesis and cellular proliferation across diverse experimental conditions.

Key Research Areas:

1. Muscle Physiology Studies: Investigating mechanisms of muscle repair and growth factor responses
2. Metabolic Research: Examining effects on glucose metabolism and fat utilization
3. Aging Research: Studying cellular responses to growth factor stimulation in aging models
4. Disease Models: Exploring potential mechanisms in muscle wasting conditions

Recent studies have examined the role of IGF-1 LR3 in wound healing acceleration and bone density improvement, with researchers measuring cellular responses in controlled laboratory environments. Data from these investigations suggest that the compound influences multiple cellular processes simultaneously, making it a valuable tool for understanding complex biological interactions. The consistent potency and extended duration of action allow researchers to study both immediate cellular responses and longer-term adaptations to growth factor stimulation.

Scientists studying growth hormone deficiency models have utilized IGF-1 LR3 to investigate downstream effects of growth factor signaling disruption. These studies have contributed important data regarding the relationship between insulin like growth factors and overall growth regulation, particularly in understanding how synthetic analogs might differ from endogenous compounds in their cellular effects and tissue distribution patterns.

Research examining the efficacy of different peptides in promoting cellular survival under stress conditions has shown that IGF-1 LR3 demonstrates potent protective effects, though more research is needed to fully understand the mechanisms involved. The ability to measure consistent responses across multiple experimental paradigms has made this compound particularly valuable for comparative studies and dose-response investigations.

Storage and Safety Protocols

Proper handling and storage of IGF-1 LR3 requires adherence to established protocols that maintain peptide integrity and ensure consistent research results. The compound is typically supplied as a lyophilized white powder that demonstrates optimal stability when stored at -20°C prior to reconstitution. Research laboratories should maintain these storage conditions consistently, as temperature fluctuations can compromise peptide structure and reduce experimental effectiveness.

Storage Requirements:

Storage Phase	Temperature	Duration	Conditions
Lyophilized	-20°C	Long-term	Sealed, dry environment
Reconstituted	2-8°C	7 days maximum	Sterile conditions
Working Solutions	4°C	Use within 24 hours	Light protection

Once reconstituted with bacteriostatic water, IGF-1 LR3 solutions should be maintained under refrigeration and utilized within seven days to preserve bioactivity. Researchers must avoid freeze-thaw cycles, as these temperature transitions can denature the protein structure and significantly impact experimental outcomes. Laboratory protocols should emphasize sterile handling techniques throughout all phases of peptide preparation and usage.

The white appearance of properly stored IGF-1 LR3 serves as a visual indicator of compound integrity, while any discoloration or precipitation may signal degradation. Safety protocols require that all handling occur within appropriate laboratory environments equipped with proper ventilation and safety equipment. Researchers should maintain detailed records of storage conditions and preparation procedures to ensure experimental reproducibility and data integrity.

Contact with oxygen should be minimized during storage and handling, as oxidation can affect peptide stability and potency. Laboratory personnel should use appropriate personal protective equipment and follow institutional guidelines for handling research peptides. The stability of IGF-1 LR3 under proper storage conditions allows researchers to plan extended experimental protocols while maintaining confidence in compound effectiveness throughout the study period.

Benefits of Choosing Loti Labs

Researchers seeking to buy igf 1 lr3 will find that Loti Labs offers exceptional quality standards and comprehensive testing protocols that ensure reliable experimental outcomes. Our IGF-1 LR3 products consistently demonstrate greater than 98% purity as verified through SDS-PAGE analysis, with rigorous quality control measures confirming the absence of contaminating proteins or carrier substances that could confound research results. This level of purity is essential for scientists conducting precise cellular and molecular investigations.

The manufacturing process utilizes USA-made peptides from accredited American laboratories, ensuring consistent quality standards and regulatory compliance. Each batch undergoes extensive molecular weight confirmation through advanced analytical techniques, including high-performance liquid chromatography (HPLC) and functional assays such as luciferase reporter assays. These testing protocols verify both structural integrity and biological activity, providing researchers with confidence in their experimental materials.

Quality Assurance Features:

• Purity Verification: >98% purity confirmed through SDS-PAGE analysis
• Bioactivity Testing: Luciferase reporter assays confirm functional activity
• Carrier-Free Formulation: No contaminating proteins or carrier substances
• Molecular Weight Confirmation: HPLC verification of proper structure
• Batch-to-Batch Consistency: Rigorous testing ensures reproducible results

Our commitment to research excellence extends beyond product quality to include comprehensive customer support and reliable shipping protocols. Orders placed before 1 PM EST on business days receive same-day shipping, while weekend orders ship the following business day. This rapid fulfillment allows researchers to maintain experimental schedules without delays due to supply chain issues.

The satisfaction guarantee offered by Loti Labs provides additional assurance for research institutions and individual scientists. Any unopened products may be returned within 30 days for a full refund, demonstrating our confidence in product quality and customer satisfaction. This policy allows researchers to evaluate our peptides with minimal risk while establishing reliable supply relationships for ongoing research programs.

Third-party testing of every batch ensures that researchers receive peptides meeting the highest industry standards. These independent analyses provide objective verification of purity, potency, and structural integrity, supporting the reproducibility and reliability essential for scientific research. The transparent approach to quality documentation allows researchers to maintain detailed records required for publication and regulatory compliance.

Research Use Only Designation

All IGF-1 LR3 products from Loti Labs are designated strictly for research purposes and laboratory experimentation. This classification allows utilization of these compounds exclusively for in vitro testing and controlled scientific studies. The designation explicitly prohibits human or veterinary use, and these peptides are not classified as substances intended for therapeutic, cosmetic, or nutritional applications.

Researchers purchasing IGF-1 LR3 must ensure compliance with institutional review board protocols and applicable regulations governing peptide research. The research use only designation requires that all experimental work occur within appropriate laboratory settings under proper supervision and safety protocols. Scientists should maintain detailed documentation of experimental procedures and comply with all applicable guidelines for peptide handling and disposal.

Important Compliance Requirements:

• Laboratory use only under controlled conditions
• No human or animal therapeutic applications
• Compliance with institutional research protocols
• Proper documentation of experimental procedures
• Adherence to safety and disposal guidelines

The regulatory framework surrounding research peptides requires clear labeling and appropriate handling to prevent misuse or misunderstanding of intended applications. Loti Labs ensures that all products include proper research use only labeling and documentation to support compliant laboratory practices. Researchers should review all applicable regulations and institutional policies before initiating experimental protocols using IGF-1 LR3.

Understanding the legal and regulatory context of peptide research helps ensure that scientific investigations proceed within appropriate boundaries while maximizing the potential for meaningful research outcomes. The research use only designation protects both researchers and institutions while enabling valuable scientific investigations into growth factor biology and cellular mechanisms.

Shipping and Customer Support

Loti Labs maintains efficient shipping protocols designed to support research timelines and ensure peptide integrity during transport. Orders placed before 1 PM EST Monday through Friday receive same-day processing and shipping, while orders submitted after this cutoff or during weekends ship on the next business day. This reliable schedule allows researchers to plan experimental protocols with confidence in material availability.

Shipping Schedule:

Order Timing	Shipping Day
Before 1 PM EST (Mon-Fri)	Same day
After 1 PM EST (Mon-Fri)	Next business day
Weekends	Following Monday

Tracking information is provided for all shipments, allowing researchers to monitor delivery progress and plan laboratory schedules accordingly. The reliable shipping performance has made Loti Labs a trusted supplier for research institutions requiring consistent peptide availability.

Customer support services include technical assistance for storage and handling questions, as well as guidance on product selection for specific research applications. The technical support team understands the requirements of peptide research and can provide recommendations based on experimental goals and laboratory capabilities. This expertise helps researchers optimize their experimental protocols and achieve reliable results.

For researchers needing to establish ongoing supply relationships, Loti Labs offers flexible ordering options and can accommodate bulk purchases for extended research programs. The customer service team works with research institutions to establish accounts and streamline ordering processes, reducing administrative burden and ensuring consistent peptide availability for long-term studies.

Third-Party Testing and Quality Verification

Every batch of IGF-1 LR3 produced by Loti Labs undergoes comprehensive third-party testing using state-of-the-art analytical methods to ensure product quality and consistency. High-performance liquid chromatography (HPLC) analysis verifies molecular structure and purity levels, while SDS-PAGE electrophoresis confirms proper protein molecular weight and the absence of degradation products. These independent testing protocols provide objective verification of product specifications and support research reproducibility.

The testing regimen includes functional bioactivity assays using luciferase reporter systems to confirm that IGF-1 LR3 retains proper biological activity after synthesis and purification. These assays measure the compound’s ability to activate cellular signaling pathways, ensuring that researchers receive peptides capable of producing expected experimental responses. The combination of structural and functional testing provides comprehensive quality verification.

Testing Protocol Overview:

1. HPLC Analysis: Molecular structure and purity verification
2. SDS-PAGE Electrophoresis: Molecular weight confirmation
3. Bioactivity Assays: Functional activity testing using reporter systems
4. Contamination Screening: Detection of impurities or degradation products
5. Stability Testing: Verification of storage stability and shelf life

Certificates of analysis accompany each product batch, providing detailed documentation of testing results and specifications. These certificates include specific purity percentages, molecular weight confirmation, and bioactivity data, allowing researchers to maintain detailed records for experimental documentation and publication requirements. The transparent reporting approach supports scientific rigor and regulatory compliance.

The independent nature of third-party testing eliminates potential conflicts of interest and provides objective evaluation of product quality. Testing laboratories employ standardized methods and equipment calibrated to industry standards, ensuring accurate and reliable results. This approach demonstrates our commitment to scientific integrity and supports the research community’s need for dependable experimental materials.

Regular auditing of testing protocols and facilities ensures continued adherence to quality standards and industry best practices. The testing program undergoes periodic review and updates to incorporate new analytical methods and maintain compliance with evolving industry standards. This commitment to continuous improvement supports long-term reliability and customer confidence.

 

Conclusion

IGF-1 LR3 represents a significant advancement in peptide research tools, offering scientists enhanced stability, potency, and experimental flexibility compared to natural insulin like growth factor compounds. The synthetic analog’s unique molecular modifications, including the long arginine substitution and extended amino acid sequence, provide researchers with a powerful instrument for investigating cellular mechanisms, growth factor signaling, and metabolic processes across diverse experimental paradigms.

For scientists seeking to buy igf 1 lr3 of exceptional quality, Loti Labs offers comprehensive solutions combining rigorous quality control, reliable shipping, and extensive customer support. Our commitment to third-party testing, batch-to-batch consistency, and research use only compliance ensures that researchers receive peptides meeting the highest standards for scientific investigation. The combination of molecular precision and practical reliability makes our IGF-1 LR3 products ideal for both routine laboratory work and cutting-edge research applications.

The growing body of research utilizing IGF-1 LR3 continues to reveal new insights into growth factor biology, cellular aging, and tissue regeneration mechanisms. As more research expands our understanding of these complex biological processes, the availability of high-quality research peptides becomes increasingly important for scientific progress. The enhanced stability and extended half life of IGF-1 LR3 make it particularly valuable for long-term studies and complex experimental protocols requiring consistent compound activity.

Whether investigating muscle growth mechanisms, cellular survival pathways, or metabolic adaptations, researchers can rely on Loti Labs to provide IGF-1 LR3 peptides that meet stringent quality standards and support reliable experimental outcomes. Our dedication to scientific excellence and customer satisfaction ensures that researchers have access to the tools needed for meaningful scientific discovery and advancement in growth factor research.

Contact our technical support team for additional information about IGF-1 LR3 specifications, experimental applications, or assistance with product selection for your specific research requirements.

References

1. Hill, R. A., Hunter, R. A., Lindsay, D. B., & Owens, P. C. (1999). Action of long(R3)-insulin-like growth factor-1 on protein metabolism in beef heifers. Domestic Animal Endocrinology, 16(4), 219–229. https://doi.org/10.1016/s0739-7240(99)00015-6
2. Conlon, M. A., & Kita, K. (2001). Porcine growth hormone and LongR(3)IGF-I can improve recovery from surgery-induced weight loss in guinea pigs. General and Comparative Endocrinology, 123(3), 332–336. https://doi.org/10.1006/gcen.2001.7674
3. Stremming, J., Heard, S., White, A., Chang, E. I., Shaw, S. C., Wesolowski, S. R., Jonker, S. S., Rozance, P. J., & Brown, L. D. (2021). IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus. American Journal of Physiology-Endocrinology and Metabolism, 320(3), E527–E538. https://doi.org/10.1152/ajpendo.00453.2020
4. Jonker, S. S., Giraud, G. D., Chang, E. I., Elman, M. R., & Louey, S. (2020). Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep. FASEB Journal, 34(8), 10041–10055. https://doi.org/10.1096/fj.202000215R
5. Bailes, J., & Soloviev, M. (2021). Insulin-like growth factor-1 (IGF-1) and its monitoring in medical diagnostic and in sports. Biomolecules, 11(2), 217.
6. Ketha, H., & Singh, R. J. (2015). Clinical assays for quantitation of insulin-like-growth-factor-1 (IGF1). Methods, 81, 93-98.
7. Yakar, S., Werner, H., & Rosen, C. J. (2018). 40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton. Journal of Molecular Endocrinology, 61(1), T115–T137.
8. Thornton, K. J., Kamanga-Sollo, E., White, M. E., & Dayton, W. R. (2016). Active G protein–coupled receptors (GPCR), matrix metalloproteinases 2/9 (MMP2/9), heparin-binding epidermal growth factor (HB-EGF), epidermal growth factor receptor (EGFR), ERBB2, and insulin-like growth factor 1 receptor (IGF-1R) are necessary for trenbolone acetate–induced alterations in protein turnover rate of fused bovine satellite cell cultures. Journal of Animal Science, 94(6), 2332–2343.
9. Dyer, A. H., Vahdatpour, C., Sanfeliu, A., & Tropea, D. (2016). The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity. Neuroscience, 325, 89-99.
10. Miescher, I., Rieber, J., Calcagni, M., & Buschmann, J. (2023). In Vitro and In Vivo Effects of IGF-1 Delivery Strategies on Tendon Healing: A Review. International Journal of Molecular Sciences, 24(3), 2370.

For more information on IGF-1 LR3 please visit Wikipedia.

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Weight	0.0099 lbs
Appearance	Fine White Lyophilized Powder
Sequence	MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
Solubility	100 µg/mL sterile diluent (distilled de-ionized water)
Source	E-coli Expression
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to divide the remaining reconstituted peptide into multiple vials so as to avoid a cycle of freezing and thawing. Reconstituted protein can be stored at 4°C.
Molar Mass	9111.0 g/mol
CAS Number	946870-92-4
Molecular Formula	C990H1528N282O300S7
MG	1mg
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.03125 lbs