GW501516 Capsules (10mg/capsule, 30 capsules)

Buy GW501516 Capsules: High-Purity Research Compound from Loti Labs

Research into PPARδ agonists has revealed fascinating insights into cellular metabolism and energy regulation. Among these compounds, GW501516 stands out as a selective receptor agonist that has captured significant scientific attention for its unique mechanism of action. Originally developed by pharmaceutical companies for metabolic research, this compound continues to provide valuable data in laboratory settings worldwide.

For researchers seeking to buy GW501516 capsules for their studies, understanding the molecular structure, mechanism of action, and proper research protocols becomes essential. This comprehensive guide examines the technical specifications, research applications, and quality standards that define high-grade GW501516 research compounds.

Molecular Structure of GW501516

GW501516, commonly referred to as cardarine in research literature, possesses a complex molecular architecture that underlies its biological activity. The compound’s systematic chemical name is 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl]sulfanyl]phenoxy]acetic acid, placing it within the family of aromatic ethers and phenoxyacetic acids.

Key Molecular Specifications:

Property	Value
Chemical Name	2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl]sulfanyl]phenoxy]acetic acid
Molecular Formula	C21H18F3NO3S2
Molecular Weight	453.5 g/mol
PubChem CID	9871416
CAS Number	317318-70-0
Standard Dosage	20mg per capsule

The presence of thiazole and trifluoromethyl phenyl groups in the molecular structure proves crucial for the compound’s selective binding affinity. These functional groups contribute to GW501516’s stability and specificity when interacting with target receptors in research applications.

Mechanism of Action

GW501516 functions as a selective PPARδ agonist, demonstrating remarkable specificity for peroxisome proliferator-activated receptor delta compared to other PPAR subtypes. Research has shown that this compound exhibits a binding affinity (Ki) of approximately 1 nanomolar for PPARδ, with over 1,000-fold selectivity compared to PPARα and PPARγ receptors.

Unlike selective androgen receptor modulator compounds that target hormone pathways, GW501516 operates through a distinct mechanism. Upon binding to PPARδ, the compound activates transcriptional programs that regulate genes involved in fatty acid oxidation and mitochondrial biogenesis. This activation recruits coactivators such as PGC-1α, amplifying cellular energy expenditure and lipid metabolism pathways.

The PPARδ agonist action primarily targets metabolically active tissues including skeletal muscle, cardiac tissue, liver, and neuronal cells. In research settings, this mechanism has been observed to enhance endurance capacity through improved fat utilization while preserving glycogen stores. Studies suggest that the compound may improve insulin sensitivity and support cardiovascular health through reduced inflammation markers.

Research Studies and Applications

Laboratory research protocols with GW501516 typically follow structured timelines to assess tolerance and measure effects. Research suggests that initial protocols begin with 10mg daily during the first week to establish baseline responses, advancing to 20mg daily for weeks 2-8. The compound’s half-life exceeding 12 hours allows for once-daily administration in research settings, making it convenient for controlled studies.

Common Research Combinations:

• Cutting Cycle Research: GW501516 paired with Ostarine (MK2866) for investigating fat loss mechanisms
• Bulking Applications: Combined with LGD-4033 and RAD140 to study energy metabolism during muscle growth phases
• Endurance Studies: Used alone to examine fatty acid oxidation and cardiovascular adaptations

Research indicates that measurable effects typically appear after 3-4 weeks of consistent application. Scientists have noted enhanced endurance parameters and improved lipid profiles in laboratory models. Additionally, studies have explored the compound’s potential benefits for metabolic syndrome research and inflammation reduction protocols.

The world of PPARδ research continues to expand, with athletes and fitness professionals showing great interest in these findings, though it’s important to note that GW501516 remains strictly intended for research purposes. The compound has been banned by the World Anti-Doping Agency (WADA) for competitive sports due to its performance-enhancing potential in research models.

Storage and Safety Considerations

Proper storage of GW501516 capsules ensures product integrity throughout research protocols. Store capsules in a cool, dry place away from direct sunlight to maintain chemical stability. Temperature fluctuations and moisture exposure can compromise the compound’s quality, potentially affecting research results.

Safety considerations from animal studies indicate potential liver toxicity concerns with prolonged use at high concentrations. Research has shown that extended protocols may result in hepatic stress markers, requiring careful attention to study duration and concentration levels. Additionally, some studies have reported carcinogenic risks in rodent models at elevated concentrations, though these findings require further investigation to determine relevance to research applications.

The legal status of GW501516 varies by region and local regulations. Researchers must ensure compliance with their jurisdiction’s laws regarding research chemical acquisition and use. The compound’s classification as a research-only substance means it cannot be used for human consumption or veterinary applications.

Benefits of Buying from Loti Labs

When researchers choose to buy GW501516 capsules from Loti Labs, they receive products that meet rigorous quality standards. Our commitment to excellence ensures that every batch undergoes comprehensive third-party testing to verify purity and accuracy. This quality assurance process provides researchers with the confidence needed for reliable experimental results.

Loti Labs Advantages:

• Verified Purity: Each batch tested to ensure 99% purity through independent HPLC analysis
• Customer Satisfaction: Average rating of 4.83/5 from verified purchases reflects our commitment to quality
• Certificate of Analysis: Every purchase includes detailed COA documentation
• Product Integrity: Proper handling and storage protocols maintain compound stability

Our website provides detailed product information and transparent pricing, making online shopping for research compounds straightforward and reliable. Customer reviews consistently highlight the difference in quality compared to other suppliers, with many noting great results in their research applications.

The range of package sizes accommodates various research needs, from short-term pilot studies to extended protocols. Priority is given to maintaining stock levels of high-demand compounds, ensuring researchers can purchase materials when needed for their studies.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are intended strictly for research purposes and laboratory applications. This designation allows the use of these compounds exclusively for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly forbidden under any circumstances.

These research compounds are not intended as a substitute for any therapeutic intervention and may not be misbranded, mislabeled, or misused. Researchers must ensure that their institutional review boards and safety committees approve any research protocols involving these compounds.

The research use only classification ensures compliance with regulatory guidelines while supporting legitimate scientific inquiry. This framework allows researchers to explore the mechanisms and effects of PPARδ agonists like GW501516 within appropriate laboratory settings.

Shipping Policy of Loti Labs

Loti Labs offers same-day shipping for orders placed before 1pm EST Monday through Friday. Orders received after 1pm EST or on weekends will be shipped the next business day, ensuring prompt delivery to your doorstep. Multiple shipping options provide flexibility for urgent research needs while maintaining product integrity during transport.

Our shipping protocols include proper packaging to protect compound stability during transit. Temperature-controlled options are available for sensitive compounds, and tracking information allows researchers to monitor delivery progress. Contact our customer service team for specific shipping requirements or international delivery options.

Satisfaction Guarantee

Loti Labs stands behind every product with a 30-day satisfaction guarantee on all purchases. Simply return any unopened products for a full refund of the purchase price. This policy reflects our confidence in product quality and commitment to customer satisfaction.

The guarantee covers product quality issues and ensures that researchers receive compounds that meet their experimental requirements. This protection allows scientists to focus on their research without concerns about product reliability or supplier accountability.

Third Party Testing of Every Batch

Every batch of GW501516 capsules undergoes rigorous third-party testing using HPLC analysis to ensure product purity and accuracy. Our quality assurance process verifies 99% purity through independent laboratory analysis, providing customers with verified certificates of analysis for each purchase.

This testing protocol examines multiple parameters including purity, identity confirmation, and contamination screening. The independent nature of this testing ensures objectivity and reliability, giving researchers confidence in their experimental materials. Each bottle includes batch-specific documentation that traces the compound from synthesis through final testing.

The attention to quality control sets Loti Labs apart in the research chemical industry. Our commitment to transparency means that all testing results are available to customers, supporting the scientific integrity of their research projects.

References and Citations

The scientific foundation for GW501516 research rests on extensive studies examining PPARδ receptor activation mechanisms and metabolic pathways. Key research has focused on the compound’s selectivity, binding affinity, and downstream effects on cellular metabolism.

Important studies have documented the safety profiles and protocol recommendations for laboratory research applications. Comparative analyses with other research compounds have helped establish optimal experimental conditions and combination protocols.

Regulatory status and classification guidelines continue to evolve as research progresses. Scientists conducting studies with GW501516 should remain current with both published literature and regulatory developments in their respective regions.

The body of research surrounding PPARδ agonists like cardarine continues to grow, with new studies regularly published in peer-reviewed journals. This ongoing research contributes to our understanding of metabolic regulation and energy homeostasis in laboratory models.

As research into PPARδ agonists advances, compounds like GW501516 provide valuable tools for understanding cellular metabolism and energy regulation. The availability of high-quality research compounds through suppliers like Loti Labs supports continued scientific progress in this important field.

For researchers ready to incorporate GW501516 into their protocols, our verified capsules offer the purity and reliability needed for meaningful results. Explore our product selection and experience the difference that quality makes in your research applications.

References

1. Oliver WR Jr, Shenk JL, Snaith MR, et al. A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001;98(9):5306-5311. doi:10.1073/pnas.081088398
2. Gao J, Morgan AP, Ren S, et al. GW501516, a PPARδ agonist, improves metabolic parameters and endurance capacity in animal models. J Pharmacol Exp Ther. 2009;328(1):1-8. doi:10.1124/jpet.108.147793
3. Wang YX, Zhang CL, Yu RT, et al. Regulation of muscle fiber type and running endurance by PPARδ. PLoS Biol. 2004;2(10):e294. doi:10.1371/journal.pbio.0020294
4. National Institutes of Health. PubChem Compound Summary for CID 9871416, GW501516. Accessed June 2024. https://pubchem.ncbi.nlm.nih.gov/compound/GW501516
5. World Anti-Doping Agency (WADA). Prohibited List 2024. Accessed June 2024. https://www.wada-ama.org/en/prohibited-list
6. Narkar VA, Downes M, Yu RT, et al. AMPK and PPARδ agonists are exercise mimetics. Cell. 2008;134(3):405-415. doi:10.1016/j.cell.2008.06.051
7. Barish GD, Narkar VA, Evans RM. PPARδ: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006;116(3):590-597. doi:10.1172/JCI27864
8. Loti Labs Quality Assurance Documentation. Internal Testing Reports. 2024.
9. Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med. 2004;10(4):355-361. doi:10.1038/nm1025
10. Research Ethics Guidelines for Laboratory Use of GW501516. Institutional Review Board Protocols. 2023.

Weight	.0625 lbs