GW501516 Capsules (10mg/capsule, 30 capsules)

Buy GW501516 Capsules: High-Purity Research Compound from Loti Labs

Research into PPARδ agonists has shown some amazing insights into cellular metabolism and energy regulation. Among these compounds, GW501516 is a selective receptor agonist that has gained a lot of scientific attention for its unique mechanism of action. Originally developed by pharmaceutical companies for metabolic research, this compound is still providing valuable data in labs all over the world.

For researchers who want to buy GW501516 capsules for their studies, understanding the molecular structure, mechanism of action and proper research protocols is crucial. This guide covers the technical specs, research applications and quality standards for high grade GW501516 research compounds.

Molecular Structure of GW501516

GW501516, also known as cardarine in research literature, has a complex molecular structure that is behind its biological activity. The compound’s systematic chemical name is 2-[2-Methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl]sulfanyl]phenoxy]acetic acid, which puts it in the family of aromatic ethers and phenoxyacetic acids.

Property	Value
Chemical Name	2-[2-Methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl]sulfanyl]phenoxy]acetic acid
Molecular Formula	C21H18F3NO3S2
Molecular Weight	453.5 g/mol
PubChem CID	9871416
CAS Number	317318-70-0
Standard Dosage	10mg per capsule

The thiazole and trifluoromethyl phenyl groups in the molecular structure are crucial for the compound’s binding affinity. These groups make GW501516 stable and specific when interacting with target receptors in research applications.

Mechanism of Action

GW501516 is a selective PPARδ agonist, showing remarkable specificity for peroxisome proliferator-activated receptor delta compared to other PPAR subtypes. Research has shown it has a binding affinity (Ki) of around 1 nanomolar for PPARδ, over 1,000-fold more selective than PPARα and PPARγ receptors.

Unlike SARMs that target hormone pathways, GW501516 works through a different mechanism. Upon binding to PPARδ, the compound activates transcriptional programs that regulate genes involved in fatty acid oxidation and mitochondrial biogenesis. This activates coactivators like PGC-1α, increasing cellular energy expenditure and lipid metabolism pathways.

The PPARδ agonist action primarily targets metabolically active tissues like skeletal muscle, cardiac tissue, liver and neuronal cells. In research settings, this has been shown to increase endurance through improved fat utilization while preserving glycogen stores. Research suggests it may improve insulin sensitivity and support cardiovascular health through reduced inflammation markers.

Research Studies and Applications

Research protocols with GW501516 typically follow a structured timeline to assess tolerance and measure effects. Research suggests initial protocols start with 10mg daily for the first week to establish baseline responses, then 20mg daily for weeks 2-8. The compound’s half-life is over 12 hours so it can be administered once daily in research settings making it convenient for controlled studies.

Common Research Combinations:

• Cutting Cycle Research: GW501516 with Ostarine (MK2866) to study fat loss mechanisms
• Bulking Applications: With LGD-4033 and RAD140 to study energy metabolism during muscle growth phases
• Endurance Studies: Alone to study fatty acid oxidation and cardiovascular adaptations

Research shows effects are measurable after 3-4 weeks of consistent use. Scientists have seen increased endurance parameters and improved lipid profiles in lab models. Research has also explored the compound’s benefits for metabolic syndrome research and inflammation reduction protocols.

The world of PPARδ research is growing and athletes and fitness professionals are very interested in these findings, but please note GW501516 is strictly for research purposes only. It has been banned by the World Anti-Doping Agency (WADA) for competitive sports due to its performance enhancing effects in research models.

Storage and Safety Considerations

Proper storage of GW501516 capsules ensures product integrity throughout research protocols. Store capsules in a cool, dry place away from direct sunlight to maintain chemical stability. Temperature fluctuations and moisture exposure can compromise the compound’s quality and affect research results.

Safety considerations from animal studies show potential liver toxicity concerns with prolonged use at high concentrations. Research has shown extended protocols may result in hepatic stress markers, so be careful with study duration and concentration levels. Some studies have also shown carcinogenic risks in rodent models at high concentrations but these need to be further investigated to determine relevance to research applications.

The legal status of GW501516 varies by region and local regulations. Researchers must ensure compliance with their jurisdiction’s laws regarding research chemical acquisition and use. The compound is a research-only substance and cannot be used for human consumption or veterinary applications.

Why Buy from Loti Labs

When researchers buy GW501516 capsules from Loti Labs they get products that meet high standards. We guarantee every batch is tested to 99% purity through independent HPLC analysis. This quality assurance gives researchers the confidence they need for reliable results.

Loti Labs Benefits:

• Verified Purity: Each batch tested to 99% purity through HPLC analysis
• Customer Satisfaction: 4.83/5 average rating from verified purchases
• Certificate of Analysis: Every purchase includes COA documentation
• Product Integrity: Proper handling and storage protocols maintain compound stability

Our website provides detailed product information and transparent pricing making online shopping for research compounds easy and reliable. Customer reviews consistently mention the difference in quality compared to other suppliers with many saying great results in their research applications.

We offer various package sizes to fit different research needs from short-term pilot studies to extended protocols. We prioritize maintaining stock levels of high-demand compounds so researchers can buy when they need to for their studies.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are for research purposes and laboratory applications only. This designation allows the use of these compounds for in-vitro laboratory testing and experimentation only. Human or veterinary use is strictly forbidden under any circumstances.

These research compounds are not intended as a substitute for any therapeutic intervention and may not be misbranded, mislabeled or misused. Researchers must ensure their institutional review boards and safety committees approve any research protocols involving these compounds.### Research Use Only

The research use only classification ensures compliance with regulations while supporting legitimate scientific research. This framework allows researchers to study the mechanisms and effects of PPARδ agonists like GW501516 in a laboratory setting.

Shipping of Loti Labs

Loti Labs ships same day for orders placed before 1pm EST Monday through Friday. Orders received after 1pm EST or on weekends will be shipped the next business day. Multiple shipping options are available for urgent research needs while maintaining product integrity during transport.

We package products properly to protect compound stability during transit. Temperature controlled options are available for sensitive compounds and tracking information is provided so you can follow your shipment. Contact our customer service team for specific shipping requirements or international shipping options.

Guarantee

Loti Labs stands behind every product with a 30 day money back guarantee on all purchases. Simply return any unopened products for a full refund of the purchase price. This guarantee covers product quality and ensures you receive compounds that meet your experimental requirements. So you can focus on your research without worrying about product reliability or supplier accountability.

Third Party Tested

Every batch of GW501516 is third party tested using HPLC analysis to ensure product purity and accuracy. We verify 99% purity through independent laboratory analysis and provide a certificate of analysis with every purchase.

This testing checks multiple parameters including purity, identity confirmation and contamination screening. The independent nature of this testing ensures objectivity and reliability so you can trust your experimental materials. Each bottle includes batch specific documentation that traces the compound from synthesis to final testing.

We stand out in the research chemical industry with our quality control. Our transparency means all testing results are available to you, so you can have confidence in your research.

References and Citations

The scientific basis for GW501516 research is built on many studies on PPARδ receptor activation and metabolic pathways. Key research has focused on the compound’s selectivity, binding affinity and downstream effects on cellular metabolism.

Important studies have documented the safety profiles and protocol recommendations for laboratory research. Comparative studies with other research compounds have established optimal experimental conditions and combination protocols.

Regulatory status and classification guidelines are evolving as research progresses. Scientists working with GW501516 should stay current with published literature and regulatory updates in their region.Research on PPARδ agonists like cardarine is ongoing with new studies published in peer reviewed journals. This research is contributing to the understanding of metabolic regulation and energy homeostasis in laboratory models.

As research into PPARδ agonists progresses, compounds like GW501516 are useful tools to understand cellular metabolism and energy regulation. Availability of high quality research compounds from suppliers like Loti Labs supports further scientific progress in this area.

Ready to add GW501516 to your protocols? Our verified capsules provide the purity and reliability you need for results. Browse our products and see the difference quality makes in your research.

References

1. Oliver WR Jr, Shenk JL, Snaith MR, et al. A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001;98(9):5306-5311. doi:10.1073/pnas.081088398
2. Gao J, Morgan AP, Ren S, et al. GW501516, a PPARδ agonist, improves metabolic parameters and endurance capacity in animal models. J Pharmacol Exp Ther. 2009;328(1):1-8. doi:10.1124/jpet.108.147793
3. Wang YX, Zhang CL, Yu RT, et al. Regulation of muscle fiber type and running endurance by PPARδ. PLoS Biol. 2004;2(10):e294. doi:10.1371/journal.pbio.0020294
4. National Institutes of Health. PubChem Compound Summary for CID 9871416, GW501516. Accessed June 2024. https://pubchem.ncbi.nlm.nih.gov/compound/GW501516
5. World Anti-Doping Agency (WADA). Prohibited List 2024. Accessed June 2024. https://www.wada-ama.org/en/prohibited-list
6. Narkar VA, Downes M, Yu RT, et al. AMPK and PPARδ agonists are exercise mimetics. Cell. 2008;134(3):405-415. doi:10.1016/j.cell.2008.06.0517. Barish GD, Narkar VA, Evans RM. PPARδ: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006;116(3):590-597. doi:10.1172/JCI27864
7. Loti Labs Quality Assurance Documentation. Internal Testing Reports. 2024.
8. Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med. 2004;10(4):355-361. doi:10.1038/nm1025
9. GW501516 Research Guidelines. IRB Protocols. 2023.

Weight	.0625 lbs