Exemestane 25mg/ml (30ml)

Buy Exemestane Liquid for Research: High-Purity Aromatase Inhibitor from Loti Labs

Research into aromatase inhibition mechanisms requires compounds of exceptional purity and consistency. When investigators seek to buy exemestane for laboratory studies, the quality and documentation of the research compound becomes paramount to achieving reproducible experimental results. Exemestane serves as a critical tool in breast cancer research, hormonal pathway studies, and aromatase enzyme investigations across diverse research applications.

This comprehensive guide examines the molecular characteristics, research applications, and quality considerations essential for laboratories seeking to purchase research-grade exemestane. From its precise chemical structure to storage protocols and supplier evaluation criteria, understanding these factors ensures optimal experimental outcomes in aromatase inhibition studies.

Molecular Structure of Exemestane

Exemestane presents a sophisticated steroidal architecture that underlies its research utility in aromatase studies. The compound’s systematic nomenclature, 6-Methylideneandrosta-1,4-diene-3,17-dione, reflects its structural relationship to naturally occurring androgens while incorporating modifications that confer its unique inhibitory properties.

Chemical Properties and Identification

Property	Value
Chemical Name	6-Methylideneandrosta-1,4-diene-3,17-dione
Molecular Formula	C20H24O2
Molecular Weight	296.4 g/mol
PubChem CID	60198
CAS Number	107868-30-4

The exemestane chemical structure cas number 107868-30-4 provides unambiguous identification for research procurement and experimental documentation. Research suggests that this steroidal framework enables exemestane to function as a substrate analog, facilitating its interaction with the aromatase enzyme through molecular mimicry of natural androgen substrates.

In laboratory settings, exemestane typically appears as a crystalline powder with high chemical stability under proper storage conditions. The compound’s molecular architecture incorporates strategic modifications to the basic steroid backbone, including a methylene group at position 6 that contributes to its irreversible binding characteristics.

Mechanism of Action in Research Applications

Exemestane functions as a selective, irreversible aromatase inhibitor through a sophisticated molecular mechanism that makes it invaluable for research into estrogen biosynthesis pathways. The compound demonstrates exceptional binding affinity with a Ki of 4.3 nM, indicating nanomolar-range potency that enables precise experimental control in laboratory studies.

Enzyme Inhibition Characteristics

Research demonstrates that exemestane competitively binds to the aromatase enzyme (CYP19A1), preventing the conversion of androgens to estrogens in experimental systems. This interaction proves particularly significant in postmenopausal research models where aromatase represents the primary source of estrogen biosynthesis, contrasting with premenopausal systems where ovarian production predominates.

The compound exhibits distinct IC50 values across research models: 30 nM for human placental aromatase and 40 nM for rat ovarian aromatase. These values demonstrate exemestane’s effectiveness across species commonly used in laboratory research, from human tissue preparations to rodent experimental models. The slight variation between human placental microsome aromatase and rat systems provides researchers with comparative data for cross-species study design.

Research indicates that exemestane time dependently inactivates the aromatase enzyme through irreversible binding, distinguishing it from reversible inhibitors. This mechanism creates a “suicide inhibition” effect where the enzyme becomes permanently inactivated, leading to sustained effects that persist beyond the compound’s pharmacokinetic presence in experimental systems.

Cellular Research Applications

In cellular studies, exemestane at 1 μM concentration increases alkaline phosphatase activity in hFOB cells, providing researchers with a measurable endpoint for investigating bone metabolism pathways. This observation has expanded research applications beyond traditional aromatase studies to include investigations of bone health mechanisms and metabolic interactions.

The compound’s selectivity profile enables researchers to study estrogen-dependent processes with minimal interference from off-target effects. Research suggests that exemestane displaces natural substrates from the aromatase active site while forming covalent bonds that prevent enzyme regeneration, creating a model system for studying permanent enzyme inhibition.

Research Studies and Laboratory Applications

Research-grade exemestane with 99.96% purity serves as a cornerstone compound in aromatase inhibition studies and breast cancer research protocols. Laboratory investigations utilizing this compound have contributed significantly to understanding estrogen-dependent processes, tumor biology, and hormonal regulation mechanisms across diverse experimental systems.

Cancer Research Applications

Extensive research demonstrates exemestane’s utility in breast cancer models, particularly studies investigating hormone-dependent tumor growth and regression mechanisms. In DMBA-induced mammary tumor models, exemestane administration results in measurable tumor regressions, providing researchers with a robust system for studying estrogen-dependent cancer progression.

Studies focusing on advanced breast cancer utilize exemestane to model therapeutic interventions and resistance mechanisms. Research protocols examining the transition from early breast cancer to advanced stages often incorporate exemestane to investigate how aromatase inhibition affects cancer progression in laboratory settings. These cancer trials provide valuable data on cell proliferation patterns, apoptosis pathways, and molecular mechanisms underlying tumor response.

Research suggests that exemestane’s effects extend beyond simple aromatase inhibition to include direct cellular interactions that influence tumor microenvironments. Investigators studying the compound’s impact on cancer cell lines observe significant reductions in proliferation markers and alterations in gene expression profiles associated with estrogen-responsive pathways.

Laboratory Protocol Considerations

Standard research protocols utilize exemestane at concentrations designed to achieve optimal aromatase inhibition while maintaining experimental validity. The compound’s bioavailability characteristics suggest enhanced absorption when administered after a meal in animal studies, leading many researchers to incorporate feeding protocols into their experimental designs.

Research indicates that exemestane’s effects on various biological systems extend beyond its primary mechanism. Studies examining bone metabolism observe changes in serum osteocalcin levels and serum pyridinoline markers, providing insights into estrogen’s role in skeletal physiology. Some research protocols monitor these parameters as secondary endpoints in longer-term studies.

Investigators working with rodent models often incorporate ovariectomy induced increase measurements to establish baseline estrogen suppression before exemestane administration. This approach enables researchers to distinguish between direct compound effects and secondary consequences of estrogen depletion in experimental systems.

Storage and Safety Considerations for Research

Proper storage and handling protocols ensure exemestane maintains its research utility throughout extended laboratory studies. The compound requires controlled environmental conditions to preserve its chemical integrity and biological activity, making storage protocols a critical consideration for research facilities.

Optimal Storage Conditions

Research-grade exemestane should be stored at room temperature between 20°C and 25°C (68°F–77°F) with protection from moisture and direct light exposure. Short-term temperature excursions up to 30°C (86°F) during shipping typically do not compromise compound integrity, though prolonged exposure may affect experimental outcomes.

Laboratory protocols emphasize maintaining exemestane in dry conditions, as moisture exposure can lead to chemical degradation that impacts research results. Many research facilities store the compound in desiccated environments with appropriate documentation of storage conditions for experimental record-keeping.

The compound’s stability profile supports extended storage periods when proper conditions are maintained, allowing research facilities to purchase larger quantities for long-term studies. This stability characteristic proves particularly valuable for multi-year research protocols investigating chronic estrogen suppression effects.

Research Protocol Monitoring

Laboratory studies typically incorporate monitoring protocols to track potential experimental variables that could influence research outcomes. Common observations in research subjects include manifestations such as hot flashes, headaches, fatigue, and joint-related symptoms that may indicate biological response to estrogen suppression.

Research protocols often include monitoring liver enzyme changes (ALT, AST), bone density measurements, and white blood cell count fluctuations as part of comprehensive experimental monitoring. These parameters provide valuable data on the compound’s systemic effects while ensuring research subject welfare in longer-term studies.

Investigators should note potential interactions with grapefruit and grapefruit juice, which may alter exemestane metabolism through cytochrome P450 enzyme inhibition. Many research protocols specifically exclude these substances to prevent experimental confounds that could compromise data interpretation.

Serious experimental complications requiring protocol modification include signs of allergic reaction, cardiovascular symptoms such as chest pain or arrhythmias, and indicators of liver complications including elevated transaminases. Research facilities typically establish clear protocols for managing these situations while preserving data integrity.

Environmental and Interaction Considerations

Research suggests that certain environmental factors can influence exemestane’s experimental effects. Temperature fluctuations, humidity changes, and exposure to light may impact compound stability and experimental reproducibility. Laboratory protocols typically account for these variables through controlled storage and handling procedures.

Studies examining exemestane’s interactions with other research compounds provide valuable insights for investigators designing combination studies. Understanding these interactions helps researchers avoid potential confounds while maximizing experimental validity in complex study designs.

Benefits of Buying Liquid Exemestane from Loti Labs

Loti Labs provides research-grade exemestane with independently verified 99.96% purity, representing one of the highest purity standards available for laboratory reagents. This exceptional purity level ensures consistent experimental results and minimizes variables that could compromise research outcomes in aromatase inhibition studies.

Quality Assurance and Documentation

Each batch of exemestane from Loti Labs undergoes comprehensive third-party testing using high-performance liquid chromatography (HPLC), the gold standard analytical method for confirming compound purity and detecting potential contaminants or degradation products. This rigorous testing protocol provides researchers with confidence in their experimental reagents.

Every shipment includes detailed Certificates of Analysis (COA) documenting chemical identity, purity specifications, and compliance with laboratory research standards. These documents prove essential for research documentation, regulatory compliance, and experimental validation requirements that many institutions mandate for research chemicals.

The manufacturing processes at Loti Labs adhere to strict quality control protocols designed to ensure batch-to-batch consistency. This consistency proves crucial for long-term research studies where compound variability could introduce experimental artifacts or compromise data interpretation across multiple experimental phases.

Shipping and Logistics Advantages

Loti Labs offers same-day shipping for orders placed before 1pm EST Monday through Friday, ensuring minimal lead times for urgent research needs. This rapid shipping capability supports tight research timelines and prevents experimental delays that could compromise study protocols.

Orders placed after the 1pm EST cutoff or during weekends ship the next business day, providing predictable logistics for research planning. This reliable shipping schedule enables research facilities to coordinate compound arrival with experimental protocols, minimizing storage time and optimizing experimental workflows.

The company’s streamlined shipping processes include appropriate packaging and handling procedures designed to maintain compound integrity during transport. These protocols ensure that research-grade exemestane arrives in optimal condition for immediate laboratory use.

Customer Support and Satisfaction

Loti Labs maintains a 30-day satisfaction guarantee on all products, allowing researchers to return unopened products for a full refund of the purchase price. This guarantee reduces financial risk for laboratories purchasing exemestane in bulk quantities or for preliminary studies where compound requirements may change.

The company’s technical support team provides assistance with product specifications, storage recommendations, and documentation requirements that research facilities may need for institutional compliance. This support proves particularly valuable for laboratories new to working with exemestane or those requiring specific documentation formats.

Research Use Only: Important Laboratory Guidelines

All exemestane products sold by Loti Labs are designated strictly for research chemical applications. This designation allows the use of this compound exclusively for in-vitro laboratory testing and experimentation within controlled research environments. Human or veterinary use is strictly forbidden under these guidelines.

The research use only designation ensures compliance with regulatory frameworks governing laboratory chemicals while supporting legitimate scientific investigation. Exemestane is not intended as medicine, food, cosmetic, or any other consumer product, and may not be misbranded, mislabeled, or misused for such purposes.

Laboratory Safety and Compliance

Research facilities utilizing exemestane must maintain appropriate safety protocols and documentation consistent with laboratory chemical handling requirements. These protocols typically include proper personal protective equipment, ventilation systems, waste disposal procedures, and emergency response plans specific to the research environment.

Investigators should ensure their research protocols comply with institutional review board requirements and applicable regulations governing laboratory research. Many institutions require specific documentation and approval processes for studies involving compounds like exemestane, particularly in longer-term research applications.

The compound’s classification as a research chemical requires laboratories to maintain detailed records of acquisition, use, and disposal consistent with institutional and regulatory requirements. These documentation requirements support research integrity while ensuring appropriate oversight of laboratory chemical use.

Ordering and Support Information

Researchers seeking to buy exemestane for laboratory studies can access detailed product information, pricing, and technical specifications through Loti Labs’ research chemical catalog. The company maintains comprehensive product documentation to support research planning and institutional procurement processes.

Technical support services include assistance with product selection, storage recommendations, and documentation requirements that research facilities may need for compliance purposes. This support ensures researchers can make informed decisions about exemestane procurement while meeting their specific research requirements.

For laboratories requiring bulk quantities or custom packaging, Loti Labs offers consultation services to accommodate specialized research needs. These services prove particularly valuable for large-scale studies or multi-institutional research collaborations requiring coordinated chemical procurement.

The ordering process includes verification of research credentials and intended use documentation to ensure compliance with research use only guidelines. This verification process protects both researchers and suppliers while maintaining the integrity of the research chemical supply chain.

Research facilities considering exemestane for their laboratory studies will find that Loti Labs provides the quality standards, documentation, and support services essential for conducting rigorous scientific investigations. The combination of exceptional purity, comprehensive testing, and reliable logistics makes Loti Labs an optimal choice for researchers requiring high-quality exemestane for their aromatase inhibition studies.

References

1. Di Salle, E., et al. “Novel aromatase and 5 alpha-reductase inhibitors.” Journal of Steroid Biochemistry and Molecular Biology, vol. 49, no. 4-6, 1994, pp. 289-294.
2. Miki, Y., et al. “Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane.” Bone, vol. 10, no. 17, 2004, pp. 5717-5723.
3. Goss, P.E., et al. “Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized rats.” Clinical Cancer Research, vol. 10, no. 17, 2004, pp. 5717-5723.
4. Zaccheo, T., Giudici, D., and Di Salle, E. “Inhibitory effect of combined treatment with the aromatase inhibitor exemestane and tamoxifen on DMBA-induced mammary tumors in rats.” Journal of Steroid Biochemistry and Molecular Biology, vol. 44, no. 4-6, 1993, pp. 677-680.
5. Cancer Research UK. “Exemestane (Aromasin) Patient Information.” https://www.cancerresearchuk.org/about-cancer/treatment/drugs/exemestane-aromasin
6. MedChemExpress. “Exemestane (FCE 24304) | Aromatase Inhibitor.” https://www.medchemexpress.com/Exemestane.html
7. Walgreens. “Aromasin 25mg Tablets | Drug Details.” https://www.walgreens.com/rx-druginfo/drug-name?drugId=157807
8. Selleck Chemicals. “Exemestane | Aromatase inhibitor.” https://www.selleckchem.com/products/Exemestane.html

For more information regarding exemestane visit Wikigenes.

Weight	0.1875 lbs
Appearance	Viscous cloudy liquid
Stability	Room Temperature out of direct sunlight
Molar Mass	296.40
CAS Number	107868-30-4
Container	30ml Bottle
Molecular Formula	C20H24O2
Concentration	25mg per ML
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.156 lbs