DSIP (Delta Sleep Inducing Peptide) 2mg

Buy DSIP Delta Sleep Inducing Peptide at Loti Labs

Delta sleep inducing peptide is one of the most interesting peptides in modern sleep research. First isolated from cerebral venous blood during slow wave sleep studies in 1977, this natural occurring substance has become a key compound for researchers studying sleep regulation mechanisms and neurobiological pathways. For researchers looking for high quality research compounds, understanding DSIP’s molecular properties and getting verified, pure samples is crucial for reproducible results.

Molecular Structure of DSIP

Delta sleep inducing peptide has a specific molecular structure that defines its biological activity. Research has established the following technical specs:

Property	Value
Amino Sequence	Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular Formula	C43H58N10O14
Molecular Weight	850 g/mol
PubChem CID	46506906
CAS Number	62568-57-4

This nonapeptide structure, WAGGDASGE, is unique among natural occurring substance compounds. The specific amino acid sequence allows DSIP to cross biological barriers and interact with central nervous system receptors in research models.

Mechanism of Action

DSIP acts as a neuropeptide in research models, showing multiple ways of biological interaction. Research suggests this sleep inducing peptide works through modulation of key brain areas, including the hypothalamus and brainstem structures that regulate circadian rhythm in animal models.

Studies show DSIP influences neurotransmitter systems, particularly GABA pathways associated with inhibitory signaling. Unlike classical compounds that induce pharmacological sedation, research suggests DSIP induces natural sleep onset mechanisms without sedative effects in research subjects.

The compound has good blood brain barrier penetration in research models, making it different from many other neuropeptides. This property makes it useful in central nervous system studies and neurobiological research applications. Also research suggests DSIP may interact with opioid receptor systems, contributing to its effects in pain perception studies.

Research Studies

Extensive research has been done on DSIP in various research paradigms and shows multiple applications in research settings.

Sleep Research Applications

Clinical pilot study data shows DSIP improves sleep structure and efficiency in chronic insomniac patients. Research suggests it reduces sleep latency and increases sleep duration and normalizes disturbed sleep cycles. Studies on severe chronic insomnia have shown DSIP improves sleep structure without the side effects of classical sleep compounds.

Delta wave sleep enhancement is of particular interest, research shows DSIP promotes deeper, more restorative sleep phases in research subjects. This has implications for human sleep behavior and sleep onset mechanism research.

Pain Management Research

Research has been done on DSIP in chronic pain studies and shows reduced pain perception in various research models. Clinical studies show promising results for chronic conditions like migraines and chronic tinnitus. 97% of patients with alcohol withdrawal showed symptom improvement, 87% of patients with opiate withdrawal syndromes showed significant symptom reduction.

This suggests DSIP modulates pain threshold mechanisms and withdrawal symptoms through central nervous system pathways. Research is ongoing to investigate its stress protective potency and its role in managing severe pain episodes in research settings.

Neuroprotection Studies

Research shows DSIP preserves normal mitochondrial function under hypoxic conditions, making it useful for cerebral ischemia research models. Studies demonstrate the compound’s ability to maintain blood flow and reduce oxidative stress in rat brain mitochondria during hypoxia stress.

Also research has shown DSIP’s potential in impaired motor control studies and its effects on various psychiatric illnesses research models. The compound’s neuroprotective properties extends to preserving normal mitochondrial function during oxygen deprivation scenarios.

Cancer Prevention Research

Long term studies in female mice have shown remarkable findings on spontaneous tumor incidence. Research shows monthly DSIP administration resulted to 2.6 fold reduction in tumor development and 22.6% decrease in chromosomal defects in bone marrow. These cancer prevention studies suggest potential chemopreventive properties worth exploring.

Additional Research Applications

DSIP research has been expanded to multiple therapeutic areas:

• Muscle Physiology: Studies show DSIP inhibits somatostatin in skeletal muscle, potentially promoting hypertrophy and hyperplasia in research models
• Mood Research: The compound modulates monoamine oxidase type A (MAO-A) and serotonin concentrations, opening research avenues for major depressive disorder and major depression studies
• Hormonal Studies: Research shows DSIP influences growth hormone pathways and normalizes blood pressure in research subjects* Circadian Research: Studies show DSIP regulates circadian rhythm through pineal gland N-acetyltransferase activity

Double blind study protocols have been used to validate these findings, but researchers note some variability across different lab settings.

Storage and Handling

Proper handling ensures DSIP remains intact throughout research use. Lyophilized powder should be stored at 4°C or below, away from light and moisture. While it’s stable at room temperature for several weeks, long term storage requires -20°C.

Storage Guidelines:

• Lyophilized: 4°C short term, -20°C long term
• Reconstituted solutions: 3+ weeks at +4°C, 3-4 months at -20°C
• Avoid freeze-thaw cycles
• Equilibrate to room temperature before opening sealed vials

Research protocols must state that DSIP is a research chemical for laboratory use only. It must be handled by qualified personnel following SDS and institutional guidelines.

Why Buy DSIP from Loti Labs

Loti Labs offers clinical grade DSIP in 2mg lyophilized powder vials, manufactured under strict quality control. Each batch is fully validated for consistent results across various research applications. Loti Labs commitment to quality makes it the perfect source for sleep researchers, receptor-ligand binding assays and advanced neurobiological studies.

Research institutions benefit from Loti Labs’ emphasis on product authenticity and purity verification. Our DSIP meets the highest standards for reproducible results, for research on sleep apnea mechanisms to stress induced metabolic disorders.

Benefits:

• High purity compound for multiple research applications
• Consistent batch to batch quality for reliable results
• Documentation to support regulatory compliance
• Professional customer support

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are research chemicals only. This means use is limited to in-vitro laboratory testing and experimentation in qualified research institutions. Human or veterinary use is prohibited under regulations.

DSIP cannot be misbranded, mislabeled or misused outside of legitimate research. Researchers must comply with IRB and relevant regulatory bodies when using DSIP in their protocols.

Shipping Policy of Loti Labs

Loti Labs ships same day on orders placed before 1pm EST Monday-Friday. Orders placed after 1pm EST or on weekends ship the following business day so you get your compounds as soon as possible for time sensitive experiments.

Guarantee

30 day satisfaction guarantee on all products. Unopened products can be returned for full refund of purchase price.

Third Party Testing of Every Batch

Every DSIP batch is tested by a third party using HPLC to ensure purity and accuracy. Mass spectrometry and amino acid analysis verify the Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu sequence and 99%+ purity.

This includes:

• HPLC purity test
• Mass spectrometry sequence verification
• Amino acid composition analysis
• Contamination screening
• Identity confirmation

So you can be sure you are getting authentic DSIP for your experiments, from basic sleep research to complex neurobiological studies.

References and Citations

1. Monnier M, et al. (1977). Isolation, structure and activity of the delta-sleep-inducing peptide. Proc Natl Acad Sci USA, 74(3): 1282-1286.
2. Schoenenberger GA, et al. (1984). Characterization of a delta-sleep-inducing peptide-like substance from human plasma. Biochem Biophys Res Commun, 122(2): 703-709.
3. Graf MV, Kastin AJ. (1986). Delta-sleep-inducing peptide (DSIP): an update. Peptides, 7(6): 1165-1187.
4. Yehuda S, Carasso RL. (1988). DSIP–a tool for investigating the sleep onset mechanism: a review. Int J Neurosci, 38(3-4): 345-353.
5. Pollard BJ, Pomfrett CJ. (2001). Delta sleep-inducing peptide. Eur J Anaesthesiol, 18(7): 419-422.

Weight	.03125 lbs