CJC-1295 w/DAC Review | Buy CJC-1295 Peptide

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CJC-1295 w/DAC Review | Buy CJC-1295 Peptide

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What is CJC-1295 with DAC?

CJC 1295 with DAC

CJC-1295 is a synthetically modified and tetrasubstituted form of Growth Hormone-Releasing Hormone (GHRH1-29). The substitution of four amino acids from the core moiety makes CJC-1295 peptide more resistant to cleaving by proteolytic enzymes.

It contains a chain of 30 amino acids, a molecular weight of 3368.7, and molecular formula of C152H252N44O42 . CJC-1295 works by binding to serum albumin a, the addition of Drug Affinity Complex or DAC prolongs the half-life of CJC-1295 as well as the duration of action in animal test subjects.

Mechanism of Action of CJC-1295 with DAC

Studies of CJC-1295 peptide using animal test subjects shows how this peptide works by interacting with the Growth Hormone (GH), Insulin-like Growth Factor 1 (IGF-1), and Dipeptidyl Amino Peptidase-IV (DPP-IV) enzyme.

DPP-IV is an antigenic enzyme involved for things such as signal transduction, apoptosis or programmed cell death, and immune system regulation. It has also a direct effect on the half-life of Growth Hormone (GH) cutting it to just under seven minutes.

CJC-1295 has shown to reduce the production of the DPP-IV enzyme. This results in a feedback loop where the half-life GH and IGF-1 is prolonged and last more than seven days after administration on animal test subjects.

CJC-1295 Effects

The mechanism of action of CJC-1295 peptide shows how it can dramatically increase Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1)’s half-life which in turn elevates the processes which involves GH and IGF-1. Below are some of these effects:

Increased Protein Synthesis. The prolonged half-life of GH and IGF-1 caused by CJC-1295 has been found to increase the rate of protein synthesis in animal subjects. This results to a significant growth in their muscle size and muscle mass over time.

 Increased Bone Density. The increase in protein synthesis has been found to have a role in boosting bone density. Animal subjects has shown to have higher mineral matter per square centimeter in their bones after they are given CJC-1295.

Decreased Body Fat. The effect of CJC-1295 on DPP-IV and GHRH has also been found to play an important role in lipolysis or the reduction of body fat. It has been found to increase lipolysis in test subjects thus reducing their total body fat.

Improves Quality of Sleep. Although there is no way to quantitatively measure the quality of sleep animal subjects gets, this effect is based on the reasoning that the elevated rate of protein synthesis is compensated by elevated amount of deep sleep as well.

CJC-1295 without DAC vs CJC-1295 with DAC

When buying peptides, it is important to know the effects of these peptides and how the addition of certain compounds can alter its properties. The market offers a variety of options for those who are looking to buy peptides.

Although unmodified CJC-1295 has shown to exhibit the effects discussed above, the addition of DAC is said to improve its overall effect. Animal tests also shows that CJC-1295 with DAC has higher protein synthesis effects, faster recovery time, higher increase in bone density, and higher muscle growth effects compared to that with the unmodified CJC-1295. (Reference 1)

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  1. Benquet C, Castaigne J-P, Pham K, Robitaille M, Frohman LA, CJC-1295 (DAC-GRF), a long acting GRF analog, enhances pulsatile GH secretion, increases IGF-I levels, and restores linear growth. Program of the 86th Annual Meeting of The Endocrine Society, New Orleans, LA, 2004, p 491 (Abstract P3-109)

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