Buy CJC-1295 with DAC at Loti Labs

CJC-1295 with DAC represents a significant advancement in growth hormone releasing hormone research, offering laboratory researchers an extended half life synthetic analogue for experimental studies. This peptide has gained considerable attention in research settings due to its unique drug affinity complex modification, which fundamentally alters its pharmacokinetic properties compared to standard growth hormone releasing peptides.

Research suggests that CJC-1295 with DAC provides investigators with a valuable tool for studying growth hormone pathways, particularly in experimental settings where prolonged stimulation of growth hormone release is desired. Unlike its counterpart without the DAC modification, this peptide demonstrates sustained activity that extends far beyond traditional growth hormone releasing hormones.

For laboratory research applications requiring reliable, high-purity peptides, understanding the molecular characteristics and proper sourcing becomes crucial. This comprehensive examination explores the technical specifications, research applications, and procurement considerations for CJC-1295 with DAC from Loti Labs.

Molecular Structure of CJC-1295 with DAC

CJC-1295 with DAC functions as a synthetic analogue of the naturally occurring growth hormone releasing hormone, incorporating the first 29 amino acids of native GHRH with specific modifications designed to enhance stability and extend biological activity. The peptide’s structure includes critical amino acid substitutions and a specialized lysine linker that facilitates attachment to the drug affinity complex.

Technical Specifications:

Property	Value
Amino Sequence	Synthetic analog of GHRH containing first 29 amino acids linked with Drug Affinity Complex via lysine linker
Molecular Formula	C152H252N44O46
Molecular Weight	3647.15 g/mol
PubChem CID	56841945 (for DAC negative species)
CAS Number	863288-34-0
The dac modification represents the key distinguishing feature of this peptide. The drug affinity complex consists of a maleimide derivative, specifically N-epsilon-3-maleimidopropionamide, which attaches via the lysine linker. This chemical modification enables the peptide to bind with endogenous albumin in experimental systems, dramatically extending its circulation time compared to peptides lacking this modification.

Research indicates that the DAC enhances the peptide’s resistance to enzymatic degradation while maintaining functional affinity to growth hormone releasing hormone receptors. The molecular design incorporates D-alanine and glutamine substitutions that further optimize stability and receptor binding characteristics essential for laboratory research applications.

Mechanism of Action

CJC-1295 with DAC operates through interaction with growth hormone releasing hormone receptors located in the anterior pituitary gland. In experimental models, the peptide demonstrates its function as a growth hormone secretagogue by mimicking endogenous growth hormone releasing factor activity.

The mechanism involves several key processes observed in laboratory research:

Receptor Binding and Activation:

• Binds specifically to GHRH receptors on somatotroph cells
• Activates cyclic adenosine monophosphate signaling pathways
• Stimulates growth hormone secretion from anterior pituitary tissue

Extended Half Life Properties: Research suggests the dac modification provides the peptide with a half life of approximately 6-8 days, representing a substantial improvement over short half life alternatives. This extended duration results from the peptide’s ability to bind endogenous albumin, which protects it from rapid clearance and enzymatic breakdown.

Sustained Hormonal Effects: Studies in experimental settings demonstrate that single injection protocols can elevate growth hormone levels by 2- to 10-fold for extended periods. Additionally, research suggests insulin like growth factor levels remain elevated for 9-11 days or longer with repeated administration in laboratory models.

The prolonged stimulation profile distinguishes CJC-1295 with DAC from other peptides requiring once daily administration. This characteristic makes it particularly valuable for research protocols investigating sustained growth hormone release patterns and long acting growth hormone releasing hormone effects.

Research Studies

Scientific investigation of CJC-1295 with DAC has produced substantial data regarding its pharmacokinetic properties and biological activity in experimental settings. Research comparing this peptide to other growth hormone releasing peptides consistently demonstrates superior duration of action and sustained hormonal elevation.

Pharmacokinetic Research: Multiple studies have examined the enhanced bioavailability resulting from the DAC modification. Research suggests that CJC 1295 dac maintains elevated growth hormone and insulin like growth factor levels significantly longer than peptides without albumin-binding modifications. Comparative studies between CJC-1295 with and without DAC highlight the critical role of the drug affinity complex in extending therapeutic window and reducing administration frequency requirements.

Hormonal Response Studies: Laboratory research using healthy adults and experimental models demonstrates consistent patterns of growth hormone production following administration of CJC 1295 with dac. Studies indicate that:

• Growth hormone levels increase 2-10 fold above baseline
• IGF I levels remain elevated for extended periods
• Pulsatile secretion patterns are modified toward more sustained release
• Normal growth hormone rhythms are influenced by continuous stimulation

Long-term Effect Research: Multiple dosing studies reveal that sustained IGF I levels can be maintained for up to 28 days in experimental protocols. This finding suggests that long acting analog properties enable researchers to study prolonged anabolic signaling without frequent re-administration.

Research published in peer-reviewed journals, including work referenced in Nature Reviews Drug Discovery, emphasizes the therapeutic advantages of albumin-binding peptides for achieving sustained hormonal effects in research applications. These studies provide the scientific foundation for understanding how CJC-1295 with DAC functions differently from traditional growth hormone releasing hormones.

Storage and Safety

Proper handling and storage protocols are essential for maintaining peptide integrity and ensuring laboratory research safety. CJC-1295 with DAC requires specific environmental conditions to preserve its molecular structure and biological activity.

Storage Requirements:

• Lyophilized powder: Store at 2-8°C in refrigerated conditions
• Reconstituted solution: Maintain refrigeration and use within recommended timeframes
• Protect from light and excessive temperature fluctuations
• Avoid freeze-thaw cycles that may compromise peptide integrity

Laboratory Safety Protocols: Research use requires adherence to standard laboratory safety procedures:

1. Sterile Technique: Use appropriate aseptic methods during reconstitution with bacteriostatic water
2. Personal Protection: Employ standard laboratory protective equipment
3. Waste Disposal: Follow institutional guidelines for research chemical disposal
4. Documentation: Maintain detailed records of storage conditions and handling procedures

Reconstitution Guidelines: When preparing CJC-1295 with DAC for experimental use, sterile bacteriostatic water provides the appropriate diluent. Gentle mixing prevents peptide degradation while ensuring complete dissolution. Research protocols should specify exact reconstitution procedures based on experimental requirements.

Research Compliance: All handling procedures must comply with institutional research guidelines and applicable regulations governing research chemicals. Laboratory personnel should receive appropriate training on peptide handling and safety protocols before working with CJC-1295 with DAC in experimental settings.

Benefits of Buying from Loti Labs

Loti Labs provides pharmaceutical-grade CJC-1295 with DAC specifically manufactured for laboratory research applications. Their commitment to quality control and researcher support distinguishes them as a reliable source for scientific investigations requiring consistent, high-purity peptides.

Quality Assurance Standards:

• Minimum 98% purity verified through rigorous third-party testing
• Independent laboratory validation ensures product accuracy and consistency
• Pharmaceutical-grade manufacturing meets research quality requirements
• Available in convenient 2mg vial sizes for varied experimental needs

Logistical Advantages: Loti Labs streamlines the procurement process for research institutions:

• Same-day shipping for orders placed before 1pm EST on weekdays
• Free shipping available on orders over $99
• Prompt order processing minimizes delays in experimental timelines
• Reliable delivery ensures timely receipt of critical research materials

Customer Support: The 30-day satisfaction guarantee demonstrates confidence in product quality while providing researchers with purchase protection. This policy allows return of unopened products for full refund, encouraging trustworthy transactions essential in the competitive peptide supply market.

Research-Focused Service: Understanding the unique requirements of laboratory research, Loti Labs tailors their service to support scientific investigations. Their experience with research chemical supply ensures appropriate packaging, documentation, and handling that meets the standards expected by research professionals.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are intended as research chemicals only. This designation allows the use of these compounds strictly for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly forbidden. This product is not a substance for human consumption, food, or cosmetic applications and may not be misbranded, mislabeled, or misused as such.

The research use only classification ensures compliance with regulatory standards while preventing inappropriate applications. Laboratory researchers must acknowledge this limitation and operate within ethical and legal frameworks when utilizing CJC-1295 with DAC in experimental settings.

Research applications may include:

• Growth hormone pathway studies
• Receptor binding investigations
• Pharmacokinetic research protocols
• Comparative peptide efficacy studies
• Molecular mechanism investigations

Regulatory Compliance: Loti Labs maintains strict adherence to research chemical regulations through:

• Clear product labeling indicating research use only status
• Documentation emphasizing experimental applications
• Marketing materials focused on laboratory research
• Customer education regarding appropriate usage

Shipping Policy of Loti Labs

Loti Labs processes and ships orders with efficiency designed to support research timelines. Orders placed before 1pm EST Monday through Friday receive same-day shipping, while orders placed after this cutoff or on weekends ship the next business day.

The free shipping threshold of $149 supports cost-effective procurement for larger research projects, recognizing that laboratory research often requires multiple compounds or larger quantities for comprehensive studies. This shipping policy helps researchers manage budgets while ensuring reliable delivery of essential research materials.

Satisfaction Guarantee

The 30-day satisfaction guarantee reflects Loti Labs’ confidence in their product quality and commitment to customer satisfaction. Researchers can return unopened products within this timeframe for full refund of the purchase price, providing confidence in ordering decisions.

This guarantee policy particularly benefits research institutions that may need to adjust orders based on changing experimental requirements or project modifications. The return policy demonstrates customer-centric service valued in competitive peptide supply markets.

Third Party Testing of Every Batch

Every batch of CJC-1295 with DAC undergoes rigorous third-party testing to ensure minimum 98% purity and confirm product accuracy. This pharmaceutical-grade quality control exceeds standards typically found with suppliers that may not provide similarly validated products.

The independent laboratory validation process includes:

• Purity Analysis: Verification of minimum 98% purity levels
• Identity Confirmation: Molecular structure verification
• Contaminant Detection: Screening for impurities that could affect research results
• Potency Assessment: Confirmation of biological activity

This comprehensive testing approach ensures reproducibility and accuracy essential in research contexts where consistent results are paramount. The quality assurance provided by third-party testing elevates research confidence and supports publication-quality experimental work.

Comparative Analysis: CJC-1295 with DAC vs. Standard Formulations

Understanding the distinctions between CJC-1295 with DAC and other growth hormone releasing peptides helps researchers select appropriate compounds for specific experimental protocols. The DAC modification fundamentally alters the peptide’s behavior in research applications.

Half Life Differences: Research demonstrates that CJC-1295 without DAC exhibits a significantly shorter half life, resulting in growth hormone release patterns characterized by sharp peaks and valleys. This necessitates more frequent administration in experimental protocols, often requiring once daily administration to maintain consistent hormonal levels.

In contrast, CJC 1295 with dac provides sustained elevation of growth hormone and IGF I levels, creating more stable experimental conditions. This extended activity profile proves particularly valuable for research investigating:

• Long-term anabolic signaling pathways
• Sustained growth hormone effects on tissue metabolism
• Chronic exposure models in experimental settings
• Reduced administration frequency protocols

Synergistic Research Applications: While CJC-1295 without DAC is sometimes combined with other peptides in research protocols, the sustained action of CJC-1295 with DAC may reduce the need for complex peptide combinations. Research suggests that the extended half life properties provide consistent hormonal stimulation without requiring additional growth hormone secretagogues.

Current Research Trends and Future Applications

CJC-1295 with DAC continues to serve as a leading compound in peptide-based growth hormone research due to its unique pharmacokinetic profile and consistent experimental results. Current research trends focus on several key areas:

Mechanistic Studies: Researchers are investigating the precise mechanisms by which the drug affinity complex extends circulation time and maintains biological activity. These studies explore albumin binding kinetics, receptor affinity maintenance, and the relationship between structural modifications and functional outcomes.

Comparative Pharmacology: Ongoing research examines CJC-1295 with DAC alongside other growth hormone releasing peptides to establish optimal protocols for specific research applications. These comparative studies help define the experimental contexts where extended half life provides advantages over shorter-acting alternatives.

Advanced Applications: Future research directions may include:

• Novel modifications to further enhance stability or selectivity
• Combination protocols with other research peptides
• Investigation of tissue-specific effects in experimental models
• Development of specialized delivery systems for research applications

Research Methodology Development: The peptide’s consistent performance makes it valuable for developing standardized research protocols. Its predictable pharmacokinetic profile enables researchers to design experiments with confidence in timing and dosing considerations.

Technical Considerations for Laboratory Use

Successful research applications of CJC-1295 with DAC require attention to technical details that affect experimental outcomes. Understanding these considerations helps researchers optimize their protocols and achieve reproducible results.

Reconstitution Protocols: Proper reconstitution with bacteriostatic water ensures optimal peptide stability and activity. Research protocols should specify exact volumes and mixing procedures to maintain consistency across experimental replications. The gentle dissolution process prevents peptide degradation that could compromise research results.

Experimental Design Factors: The extended half life of CJC-1295 with DAC influences experimental design considerations:

• Timing of sample collection relative to administration
• Washout periods between experimental phases
• Frequency of administration in chronic studies
• Control group design for comparative studies

Quality Control in Research: Researchers should implement quality control measures including:

• Verification of peptide identity and purity upon receipt
• Proper storage condition monitoring
• Documentation of reconstitution and handling procedures
• Regular assessment of peptide stability during storage

Conclusion

CJC-1295 with DAC represents a significant advancement in growth hormone releasing hormone research peptides, offering laboratory researchers unique advantages through its drug affinity complex modification. The extended half life, sustained hormonal effects, and reliable pharmacokinetic profile make it an invaluable tool for investigating growth hormone pathways in experimental settings.

Loti Labs provides researchers with pharmaceutical-grade CJC-1295 with DAC backed by rigorous third-party testing and quality assurance protocols. Their commitment to research compliance, efficient shipping, and customer satisfaction supports the scientific community’s need for reliable, high-quality research materials.

For laboratory research applications requiring consistent, long-acting growth hormone releasing hormone activity, CJC-1295 with DAC offers distinct advantages over traditional peptides. The combination of technical excellence and reliable sourcing from Loti Labs ensures researchers have access to the quality materials essential for advancing scientific understanding of growth hormone physiology.

Researchers interested in procuring CJC-1295 with DAC for their laboratory research protocols can contact Loti Labs for detailed specifications, ordering information, and technical support. Their expertise in research peptide supply and commitment to scientific advancement makes them an ideal partner for institutions conducting growth hormone research.

References

1. Jette, L. et al. (2009). Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Hormone & IGF Research, 19(6), 471-477.
2. van Hout, M. C., & Hearne, E. (2016). Netnography of female use of the synthetic growth hormone CJC-1295: pulses and potions. Substance Use & Misuse, 51(1), 73-84.
3. Alba, M. et al. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology-Endocrinology and Metabolism, 291(6), E1290-E1294.
4. Knoop, A. et al. (2016). Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS. Analytical and Bioanalytical Chemistry, 408, 3145-3153.
5. McDonald J., Lambert D.G. (2022). Drug-receptor interactions in anaesthesia. BJA Education, 22(1), 20-25.
6. Biotech Peptides. (n.d.). CJC-1295 DAC Peptide. Retrieved from https://biotechpeptides.com/product/cjc-1295-dac-5mg
7. Paradigm Peptides. (n.d.). Buy CJC 1295 | Order CJC 1295 with DAC. Retrieved from https://paradigmpeptides.com/product/cjc-1295-with-dac
8. Sports Technology Labs. (n.d.). High Quality CJC-1295 for sale online. Retrieved from https://sportstechnologylabs.com/product/cjc-1295-dac
9. Particle Peptides. (n.d.). CJC-1295 + DAC 5mg. Retrieved from https://particlepeptides.com/en/buy-peptides/62-cjc-1295-dac-5mg.html

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Weight	.03125 lbs