Kisspeptin-10 5mg

Buy Kisspeptin 10 at Loti Labs

Kisspeptin 10 represents a cornerstone peptide in reproductive endocrinology research, serving as a critical tool for scientists investigating the hypothalamic pituitary gonadal axis. This decapeptide, originally identified as a natural ligand for the GPR54 receptor, has become indispensable for laboratory research examining reproductive disorders and neuroendocrine regulation. For researchers seeking to buy kisspeptin 10, understanding its molecular characteristics, mechanism of action, and proper handling protocols ensures successful experimental outcomes.

Molecular Structure of Kisspeptin 10

The peptide sequence of kisspeptin 10 follows a specific amino acid arrangement that defines its biological activity. Technical data provided with each batch includes comprehensive molecular specifications essential for laboratory research use.

Amino Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2

Molecular formula: C63H83N17O15

Molecular Weight: 1318.45 g/mol

Pubchem CID: 16132415

CAS #: 478507-53-8

The peptide sequence demonstrates a highly conserved C-terminal motif, with the sequence tyr asn trp followed by asn ser phe gly, continuing through leu arg phe nh2. This specific arrangement, particularly the ser phe gly leu and phe gly leu arg segments, contributes to its high affinity binding characteristics. Research findings indicate that the trp asn ser phe region plays a crucial role in receptor recognition, while the terminal residues maintain the peptide’s biological activity.

Mechanism of Action

Kisspeptin 10 functions as an endogenous ligand for the GPR54 receptor (KISS1R) with high binding affinity. Research suggests this compound stimulates gonadotropin secretion and activates the hypothalamic pituitary gonadal axis through calcium mobilization and ERK1/2 phosphorylation in target cells.

The potential mechanism involves direct interaction with the kisspeptin receptor, triggering intracellular signaling cascades that ultimately influence gonadotropin releasing hormone release from hypothalamic neurons. Studies have found this activation leads to luteinizing hormone secretion and regulation of the menstrual cycle in research models. The receptor gpr54 signaling pathway demonstrates important role in reproductive regulation, with research indicating effects on puberty onset and fertility control mechanisms.

In vitro studies reveal that kisspeptin 10 binding to the rodent kisspeptin receptor produces measurable biological activity within experimental systems. The efficacy of this interaction has been documented across multiple species, with findings suggesting conserved function across mammalian research models.

Research Studies

Studies demonstrate Kisspeptin 10’s important role in reproductive biology through regulation of the hypothalamic pituitary gonadal axis. Research indicates inhibitory effects on metastasis and invasion in melanoma models, building on its original identification as a metastasis suppressor. Binding assays using CHO-KISS1R membrane preparations show Ki values of 1.59 nM (rat) and 2.33 nM (human), with agonist activity quantified at 0.24 nM potency.

Laboratory research has established that kp 10 serves as one of the natural ligands for the GPR54 receptor system. Experimental analysis using various research models has found significant activation of target pathways following controlled application. Studies examining hypogonadotropic hypogonadism in research settings have provided insights into the compound’s potential mechanism of action.

Cancer res investigations have explored the metastasis suppressor properties originally associated with the parent KISS1 gene. These experiments demonstrate that the peptide may function beyond reproductive regulation, suggesting broader applications in research examining cellular behavior and invasion patterns.

Selected citations from peer-reviewed research highlight the compound’s role in activating specific signaling pathways. Studies in mouse models have documented measurable responses in luteinizing hormone levels following experimental administration, providing valuable data for researchers investigating reproductive endocrinology.

Storage and Safety

Kisspeptin 10 requires storage at -20°C for optimal stability and preservation of biological activity. Reconstitution requires sterile technique and proper calculations for achieving target concentration up to 2 mg/ml in water. Safety Data Sheets are provided with each order detailing appropriate laboratory handling protocols.

When preparing stock solutions, researchers should determine the appropriate volume and concentration based on experimental requirements. The reconstitution calculator provided with technical data allows scientists to quickly calculate the mass needed for specific stock solution preparations. Simply enter the desired concentration and volume to determine the exact amount of peptide required.

Product found in laboratory freezers should be stored according to vial label specifications to maintain stability. Batch specific data refer to storage conditions that preserve the peptide’s integrity throughout the experimental timeline. Researchers must store the compound under controlled conditions to ensure consistent results across experiments.

Proper handling protocols minimize degradation and maintain the compound’s function throughout experimental procedures. Laboratory research use requires adherence to established safety guidelines, including appropriate personal protective equipment and controlled environment protocols.

Benefits of Buying from Loti Labs

Loti Labs provides the highest purity Kisspeptin 10 (≥95%) for research applications. Each product includes batch specific data, batch specific molecular weight verification, and multiple calculation tools for proper laboratory research use. Our specialized technical support ensures successful implementation in your research protocols.

The technical data provided with each batch includes comprehensive analysis results that verify product quality and consistency. Researchers receive specific data documenting purity levels, molecular weight confirmation, and other critical parameters necessary for experimental planning. This batch specific molecular weight information ensures accurate calculations for stock solution preparation.

Quality control measures include rigorous testing protocols that verify each batch meets research-grade specifications. The purity standard of ≥95% provides confidence for researchers conducting sensitive experiments requiring high-quality reagents. Technical data sheets accompany each order, providing detailed information about handling, storage, and preparation protocols.

Customer support includes access to scientific advisors who can assist with experimental design questions and protocol optimization. This technical assistance helps researchers maximize the value of their kisspeptin 10 purchases by ensuring proper implementation in laboratory settings.

Products from Loti Labs are for Research Use Only

All of the products sold by Loti Labs are intended as a research chemical only. This designation allows the use of this compound strictly for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly forbidden. This product is not a substance for therapeutic application and may not be misbranded, mislabeled or misused as such.

Laboratory research applications include studies examining receptor binding, cellular signaling pathways, and reproductive endocrinology mechanisms. Research use encompasses in vitro experiments designed to investigate biological pathways and molecular interactions under controlled laboratory conditions.

Intended applications focus exclusively on scientific research and experimental protocols conducted by qualified researchers in appropriate laboratory settings. The compound serves as a research tool for investigating kisspeptin signaling pathways and related biological mechanisms.

Shipping Policy of Loti Labs

Loti Labs offers same day shipping for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends will be shipped the next business day.

Packaging protocols maintain required temperature conditions during transit, ensuring product integrity upon arrival. Shipping procedures follow established guidelines for temperature-sensitive research compounds, protecting the peptide’s stability throughout the delivery process.

Expedited shipping options accommodate urgent research timelines, allowing laboratories to maintain experimental schedules without delays. Tracking information provides researchers with delivery updates, enabling proper preparation for compound arrival and storage.

Satisfaction Guarantee

Loti Labs offers a 30 day satisfaction guarantee on all products purchased from us. Simply return any unopened products to us for a full refund of the purchase price of the unused products.

This guarantee demonstrates confidence in product quality and supports researchers who may encounter unexpected experimental changes or requirements. The return policy accommodates the dynamic nature of research projects while minimizing financial risk for laboratory budgets.

Quality assurance measures include comprehensive testing protocols that verify product specifications before shipment. This proactive approach reduces the likelihood of product issues while providing reassurance for researchers investing in high-quality reagents.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs undergoes rigorous third party testing using HPLC to ensure product purity and accuracy. Certificate of Analysis documentation is provided with each purchase, verifying the ≥95% purity standard required for research-grade Kisspeptin 10.

Independent testing protocols eliminate potential bias and provide objective verification of product quality. HPLC analysis confirms both peptide identity and purity levels, ensuring researchers receive compounds that meet stringent laboratory standards.

Analysis results include detailed documentation of testing methodologies and results, providing transparency for researchers who require comprehensive quality data. This third-party verification supports regulatory compliance and research integrity requirements in academic and commercial laboratory settings.

Certificate of Analysis documentation includes batch-specific information that allows researchers to maintain detailed records of reagent specifications. This documentation supports experimental reproducibility and regulatory compliance requirements common in research environments.

References

1. Roseweir, A. K., et al. “Potent neuropeptide stimulators of the hypothalamo-pituitary-gonadal axis: Kisspeptins and their analogs.” Journal of Biological Chemistry, vol. 276, no. 37, 2001, pp. 34631-34636.
2. Dhillo, W. S., et al. “Kisspeptin-10 stimulates gonadotropin secretion via activation of the hypothalamic-pituitary-gonadal axis.” Endocrinology, 2005.
3. Murphy, K. G., et al. “Rational modification of kisspeptin-10: identification of analogs with enhanced bioactivity.” Journal of Clinical Endocrinology & Metabolism, 2010.
4. Lee, J. H., et al. “Kisspeptin and its receptor GPR54: key regulators of puberty and reproductive function.” Trends in Endocrinology & Metabolism, 2009.
5. Kotani, M., et al. “The metastasis suppressor gene KiSS-1 encodes kisspeptins, natural ligands of the orphan G protein-coupled receptor GPR54.” Journal of Biological Chemistry, 2001.
6. Ramaswamy, S., et al. “Kisspeptin signaling in the control of the hypothalamic-pituitary-gonadal axis.” Reproduction, 2010.
7. Seminara, S. B., et al. “The GPR54 gene as a regulator of puberty.” New England Journal of Medicine, 2003.
8. Mikkelsen, J. D., et al. “Species differences in kisspeptin-10 stimulation of gonadotropin secretion.” Endocrinology, 2009.
9. Loti Labs. “Kisspeptin 10 Technical Data Sheet.” 2024.
10. National Center for Biotechnology Information. “PubChem Compound Summary for CID 16132415.” 2024.

For researchers seeking to buy kisspeptin 10 for their laboratory investigations, Loti Labs provides the quality, documentation, and support necessary for successful experimental outcomes. Our commitment to research excellence ensures that scientists receive reliable reagents that support advancing understanding of reproductive biology and neuroendocrine function.

Weight	.03125 lbs