GW-501516 10mg/ml (30ml)

Buy GW501516 Research Chemical: High-Purity PPARδ Agonist for Laboratory Studies

Research into energy metabolism and lipid catabolism has consistently highlighted the importance of selective peroxisome proliferator activated receptors modulators in cellular studies. Scientists investigating metabolic pathways require access to high-quality research chemicals that meet stringent purity standards and regulatory compliance requirements. When researchers buy gw501516 for laboratory investigations, the compound’s unique properties as a PPARδ agonist make it valuable for studies examining fatty acid oxidation, energy uncoupling, and metabolic regulation in controlled research environments.

GW501516, commonly known as cardarine in research circles, represents a significant tool for researchers studying energy metabolism and related cellular processes. This compound’s development history and subsequent research applications demonstrate its continued relevance in scientific investigations, though studies suggest careful attention to safety protocols and regulatory guidelines remains essential for all research purposes.

Molecular Structure of GW501516

Chemical Formula: C21H18F3NO3S2

Molecular Weight: 453.498 g/mol

CAS #: 317318-70-0

EC50: 1.1nM

Half-life: 16-24 hours

The molecular structure of GW501516 features a trifluoromethyl-substituted phenyl ring configuration with two sulfur atoms, thiazole, and ether functionalities. Researchers working with this compound will find it appears as a white to beige powder that demonstrates light sensitivity characteristics. The melting point ranges between 134-136°C, with analysis indicating a predicted boiling point of approximately 584.5°C.

Laboratory investigations have established that GW501516 maintains solubility in DMSO at concentrations up to 20 mg/mL, making it suitable for various research applications. The compound demonstrates chemical stability when protected from light and stored at appropriate temperatures, typically -20°C for long-term storage protocols.

 

Mechanism of Action

GW501516 functions as a selective peroxisome proliferator-activated receptor delta (PPARδ) agonist with over 1,000-fold selectivity versus PPARα and PPARγ. Originally developed by GlaxoSmithKline in the 1990s, this compound recruits coactivator PGC-1α to upregulate genes involved in energy expenditure proteins and activates AMP-activated protein kinase pathways in research models.

Research demonstrates that GW501516 binds the PPARδ receptor with a Ki of 1 nM and an EC50 of 1 nM, revealing both high affinity and potency characteristics. Upon binding to PPARδ, the compound recruits coactivators such as PGC-1α, which upregulates transcription of genes involved in energy expenditure, metabolism, and fatty acid oxidation processes.

Animal research has shown that GW501516 treatment increases the activity of energy metabolism pathways and boosts fatty acid oxidation particularly in skeletal muscle cells. Studies suggest the compound provides insights into diet-induced obesity mechanisms and insulin resistance pathways in laboratory models. Research with animal studies has indicated increases in high-density lipoprotein levels and reductions in very-low-density lipoprotein concentrations, suggesting effects on lipid profiles in controlled investigations.

However, researchers must note that activation of PPARδ by GW501516 may also contribute to increased cell proliferation signals. A 2018 study reported that GW501516 enhanced growth of colitis-associated cancer in animal models via increased inflammation and upregulation of energy substrate transporters, highlighting the importance of understanding potential complications in research settings.

Research Studies

GW501516 has been utilized in various research applications including lipid metabolism and fatty acid oxidation studies in skeletal muscle cells. Scientific investigations have focused on energy metabolism research, mitochondrial biogenesis, cardiovascular health, and metabolic syndrome protocols. Studies typically employ concentrations of 10mg daily for metabolic research, while human clinical trials used doses ranging from 2.5mg to 18mg daily before discontinuation.

Primary Research Domains

Research Area	Applications	Key Findings
Lipid Metabolism	Fatty acid oxidation studies	Increased muscle cell fat utilization
Energy Metabolism	Mitochondrial biogenesis research	Enhanced energy expenditure pathways
Cardiovascular Research	Lipid profile investigations	Improved HDL/VLDL ratios in animal studies
Metabolic Syndrome	Insulin resistance studies	Protective effects against diet-induced obesity

Research suggests that GW501516’s effects on metabolism are profound, with investigations showing shifts in substrate utilization from glucose to fatty acids. The compound serves as a valuable tool for dissecting energy metabolism pathways and understanding metabolic syndrome mechanisms in laboratory settings.

Scientists have employed GW501516 to explore regulatory networks of metabolic syndrome, mitochondrial function, and exercise mimetics. Studies suggest the compound’s ability to stimulate mitochondrial biogenesis and upregulate proteins critical to energy expenditure makes it particularly valuable for research into obesity and type II diabetes mechanisms.

Further research continues to examine the compound’s effects on cardiovascular health markers, with animal research indicating potential improvements in lipid profiles that may be relevant to atherosclerosis research. However, researchers must balance these findings against safety profile considerations revealed in long-term animal studies.

Storage and Safety

Store GW501516 at room temperature in cool, dry conditions away from moisture. Protect from direct sunlight and temperature fluctuations to maintain stability. Use glass containers to prevent plasticizer leaching and contamination. GW501516 is not approved by FDA for human consumption, and animal studies at 3mg/kg/day showed rapid cancer development in multiple organs, emphasizing the importance of proper laboratory handling protocols.

Storage Requirements

Proper storage of GW501516 is essential for maintaining compound integrity and ensuring research reliability. The substance should be stored in a cool dry place at room temperature, protected from moisture and direct sunlight to avoid degradation. Temperature fluctuations and exposure to light increase the risk of decomposition, potentially affecting research results.

Researchers should store GW501516 in glass containers rather than plastic to prevent plasticizer leaching, which could contaminate the compound and potentially confound experimental results. Long-term storage at -20°C is recommended for maintaining compound stability over extended periods.

Safety Considerations

From a safety perspective, GW501516 is not approved by the FDA for human use under any circumstances. Animal studies have raised significant safety concerns, with rodent research at 3mg/kg/day demonstrating rapid and aggressive development of cancer in multiple organs including liver, bladder, stomach, skin, thyroid, tongue, testes, ovaries, and uterus.

These findings emphasize the critical importance of strict laboratory protocols when handling and experimenting with GW501516. All use must be restricted to in-vitro research environments, with stringent controls on exposure, labeling, and waste disposal. The compound’s potential side effects profile, including liver toxicity concerns identified in animal research, necessitates appropriate safety measures and expert handling procedures.

Researchers should implement comprehensive safety protocols including proper ventilation, personal protective equipment, and contamination prevention measures. The world anti doping agency has banned GW501516 since 2009 due to its misuse as a performance enhancement substance, though this does not affect its legitimate research applications when properly managed.

Benefits of Buying from Loti Labs

Loti Labs offers GW501516 with minimum 98% purity, verified through comprehensive laboratory testing. Our products are packaged in pharmaceutical-grade containers with proper labeling and come with detailed documentation for research verification. We maintain transparent business practices with dedicated customer support and quality assurance protocols that exceed industry standards.

Quality Assurance Standards

When researchers buy cardarine online from Loti Labs, they receive a great product that undergoes rigorous quality control measures. Each batch is third-party tested, most often via high-performance liquid chromatography (HPLC), to verify both purity and content. This analysis ensures that researchers receive consistent, high-quality materials for their investigations.

The company provides packaging in pharmaceutical-grade, properly labeled containers to ensure safety, traceability, and compliance with laboratory standards. Loti Labs promotes transparency in business practices by supplying detailed documentation and supporting research verification processes that researchers require for their work.

Customer support and quality assurance protocols advertised by the company aim to exceed typical industry standards, providing researchers with confidence in their purchase decisions. The company’s commitment to quality extends beyond initial delivery to ongoing support for research applications and technical inquiries.

Documentation and Verification

Every purchase includes comprehensive documentation that supports research verification and regulatory compliance. The detailed labeling and documentation provided helps researchers maintain proper chain of custody and ensures appropriate handling throughout their investigations.

Loti Labs emphasizes transparency in their business practices, providing detailed information about product specifications, testing protocols, and quality measures. This approach supports researchers who require thorough documentation for their institutional review processes and research protocols.

 

Products from Loti Labs are for Research Use Only

All of the products sold by Loti Labs are intended as a research chemical only. This designation allows the use of this compound strictly for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly forbidden. This product is not a food or cosmetic and may not be misbranded, mislabeled or misused as such. GW501516 has been banned by WADA since 2009 for competitive sports but remains legal for laboratory research applications.

Regulatory Compliance

The research use designation represents a crucial legal and regulatory distinction that researchers must understand. This classification means the compound is licensed solely for laboratory experimentation, quality control, and in-vitro research applications. Any usage outside of controlled laboratory procedures is prohibited and subject to enforcement actions.

Since 2009, GW501516 has been on the World Anti-Doping Agency’s prohibited list due to its misuse as an enhanced endurance agent among athletes. Despite this prohibition in competitive sports, the compound remains available for legitimate research purposes when used in compliance with regulatory guidelines.

Researchers should note that GW501516 is not considered a selective androgen receptor modulator, though it shares some research applications with such compounds. The substance works through different mechanisms, specifically targeting peroxisome proliferator activated receptors rather than androgen receptor pathways.

Appropriate Research Applications

Laboratory investigations using GW501516 should focus on understanding metabolic pathways, energy regulation, and cellular mechanisms rather than performance enhancement or weight loss applications. Researchers studying genes involved in metabolism, fat oxidation, and energy uncoupling will find this compound valuable for their investigations.

The compound’s effects on testosterone levels, heart disease markers, and insulin resistance make it relevant for researchers investigating cardiovascular health and metabolic syndrome mechanisms. However, all applications must remain within approved research use guidelines and institutional review board protocols.

Studies suggest that proper research use of GW501516 can provide valuable insights into energy metabolism, lipid catabolism, and cellular regulation mechanisms. Researchers must ensure their investigations comply with institutional guidelines and focus on advancing scientific understanding rather than developing dietary supplements or performance enhancement applications.

Shipping Policy of Loti Labs

Loti labs offers same day shipping for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends will be shipped the next business day.

The company’s shipping policies provide for efficient delivery of research materials, ensuring researchers receive their orders promptly. This logistics approach aims to maximize customer satisfaction and support research timelines while maintaining proper handling and packaging standards.

Delivery protocols include appropriate packaging to protect compound integrity during transport and ensure compliance with shipping regulations for research chemicals. The company’s commitment to prompt delivery supports researchers who require timely access to materials for their investigations.

Satisfaction Guarantee

Loti Labs offers a 30 day satisfaction guarantee on all products purchased from us. Simply return any unopened products to us for a full refund of the purchase price of the unused products.

This guarantee provides researchers with confidence in their purchase decisions and reflects the company’s commitment to product quality and customer service. The satisfaction guarantee is intended to provide reassurance regarding product quality, handling, and the company’s commitment to supporting research applications.

Researchers can purchase with confidence knowing that unopened products can be returned within the specified timeframe. This policy supports budget-conscious research environments and provides flexibility for researchers managing multiple project requirements.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs undergoes rigorous third party testing using HPLC to ensure product purity and accuracy. Our GW501516 is verified by accredited US laboratories with published results and comes with a certificate of analysis (COA) for each batch, guaranteeing minimum 98% purity standards.

Analytical Testing Protocols

The third-party testing protocols employed by Loti Labs ensure that researchers receive consistent, high-quality materials for their investigations. High-performance liquid chromatography analysis provides detailed information about compound purity, content, and potential contaminants that could affect research results.

Each certificate of analysis includes comprehensive data about the specific batch, including purity percentages, testing methodologies, and laboratory accreditation information. This documentation supports researchers who require detailed analytical information for their institutional review processes and publication requirements.

The verification by accredited US laboratories provides additional assurance of testing quality and reliability. Researchers can review published results and COA documentation to verify that materials meet their specific research requirements and institutional standards.

Quality Standards and Verification

The minimum 98% purity standard maintained by Loti Labs exceeds many industry benchmarks and supports high-quality research applications. This purity level ensures that researchers can conduct investigations with confidence in their material quality and consistency.

Batch-specific documentation allows researchers to maintain proper records for their investigations and supports reproducibility requirements. The detailed analytical information provided with each batch helps researchers understand any variations between shipments and adjust protocols accordingly.

The comprehensive testing and documentation approach supports researchers working in regulated environments or preparing materials for publication. Quality verification extends beyond initial testing to ongoing support for research applications and technical inquiries about specific batches.

Conclusion

Researchers investigating energy metabolism, fatty acid oxidation, and peroxisome proliferator pathways will find GW501516 to be a valuable tool for their laboratory investigations. When scientists buy gw501516 from Loti Labs, they receive a thoroughly tested research chemical that meets stringent purity standards and comes with comprehensive documentation supporting their research objectives.

The compound’s unique properties as a selective PPARδ agonist, combined with its established research applications in metabolic studies, make it an important addition to research laboratories studying cellular energy regulation. However, researchers must maintain strict adherence to research use only guidelines and implement appropriate safety protocols based on findings from animal studies.

Loti Labs’ commitment to quality, third-party testing, and regulatory compliance provides researchers with the confidence and reliability they need for their scientific investigations. The company’s comprehensive approach to quality assurance, customer service, and documentation supports the advancement of legitimate research while maintaining appropriate regulatory compliance.

For researchers seeking reliable access to high-purity GW501516 for their metabolic investigations, Loti Labs offers the quality, testing protocols, and customer support necessary for successful research outcomes. Contact our team to discuss specific research requirements, review certificate of analysis documentation, or explore how our quality assurance protocols can support your laboratory’s research objectives.

References

1. Tanaka T, et al. Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A. 2003;100(26):15924–15929.
2. Chen W, et al. A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. Sci Rep. 2015;5:9884.
3. Fan W, et al. PPARδ promotes running endurance by preserving glucose. Cell Metab. 2017;25(5):1186–1193.e4.
4. Oliver WR Jr, et al. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001;98(9):5306–5311.
5. Dressel U, et al. The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol. 2003;17(12):2477–2493.
6. Magliano DC, et al. Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. Endocrine. 2015;50(2):355–367.
7. Van Wagoner RM, et al. Chemical composition and labeling of substances marketed as selective androgen receptor modulators and sold via the internet. JAMA. 2017;318(20):2004–2010.
8. Burri L, et al. The role of PPARα activation in liver and muscle. PPAR Res. 2010;2010:542359.
9. Leone TC, et al. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A. 1999;96(13):7473–7478.
10. Kersten S, et al. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999;103(11):1489–1498.
11. Coll T, et al. Activation of peroxisome proliferator-activated receptor-δ by GW501516 prevents fatty acid-induced nuclear factor-κB activation and insulin resistance in skeletal muscle cells. Endocrinology. 2010;151(4):1560–1569.
12. Sahebkar A, et al. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease. Expert Opin Pharmacother. 2014;15(4):493–503.
13. Sprecher DL. Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta. Am J Cardiol. 2007;100(11A):n20–n24.

For more information on GW-501516 Cardarine please visit Wikipedia.

Weight	0.1875 lbs
Appearance	Viscous cloudy liquid
Stability	Room Temperature out of direct sunlight
Molar Mass	453.498
CAS Number	317318-70-0
Container	30ml Bottle
Molecular Formula	C21H18F3NO3S2
Concentration	10mg per ML
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.156 lbs