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Buy GLP-3 (R) 20mg for Advanced Metabolic Research at Loti Labs

Research into novel triple glucagon receptor agonists has revealed promising compounds for metabolic studies, with hormone receptor agonist GLP-3 (R) emerging as a particularly significant investigational substance. This compound represents a breakthrough in metabolic research applications, offering researchers the opportunity to study a unique triple hormone receptor agonist that simultaneously targets multiple pathways involved in glucose metabolism and energy expenditure.

Current clinical trials investigating this compound have generated substantial interest within the research community, particularly regarding its potential applications in studying metabolic health, obesity, and related conditions. Research suggests that GLP-3 (R)’s distinctive mechanism of action may provide valuable insights into hormone receptor activity and metabolic pathway interactions.

For researchers seeking to buy GLP-3 (R) 20mg for their laboratory investigations, understanding the compound’s molecular properties, mechanism of action, and proper handling requirements is essential for successful experimental outcomes.

Molecular Structure of GLP-3 (R)

GLP-3 (R) functions as a triple hormone receptor agonist targeting glucagon like peptide 1 (GLP-1), glucose dependent insulinotropic polypeptide (GIP), and glucagon receptors. This novel triple gip/GLP-1/glucagon receptor approach distinguishes it from single-target compounds currently under investigation.

Key Molecular Properties:

Property	Specification
Amino Sequence	Triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors
Molecular Formula	C228H350N50O70
Molecular Weight	4731.33 g/mol
CAS Number	2381089-83-2
PubChem CID	SID 474492335
Classification	Novel triple glucagon receptor agonist
The compound’s substantial molecular weight and complex amino acid sequence reflect its sophisticated design as a single peptide capable of activating multiple receptor pathways simultaneously. This molecular architecture enables researchers to study the integrated effects of multi-pathway activation in laboratory settings.

Research indicates that the extended half life of this compound makes it suitable for studies requiring sustained receptor activity over prolonged periods. The molecular structure’s stability under proper storage conditions allows for consistent experimental results across multiple research applications.

Mechanism of Action

GLP-3 (R) works through a unique triple agonist mechanism that simultaneously activates three distinct hormone receptor pathways. Research suggests this approach may provide more comprehensive metabolic effects compared to compounds targeting individual receptors.

GLP-1 Receptor Activity

The compound demonstrates significant activity at GLP-1 receptors, which play crucial roles in glucose levels regulation and energy expenditure. Studies have shown that GLP-1 receptor agonist activity influences multiple metabolic pathways, including glucose production and insulin sensitivity.

GIP Receptor Targeting

As a glucose dependent insulinotropic receptor agonist, GLP-3 (R) interacts with gastric inhibitory polypeptide pathways. Research indicates this mechanism contributes to glycemic control and may influence adipose tissue metabolism in experimental models.

Glucagon Receptor Engagement

The glucagon receptor agonist properties of this compound affect hepatic glucose production and energy metabolism. Preclinical studies suggest this activity may influence liver fat metabolism and overall metabolic health parameters.

Research findings indicate that this triple agonist approach creates synergistic effects that exceed the sum of individual pathway activations. Studies examining receptor activity demonstrate that simultaneous targeting of these pathways produces significant improvements in multiple metabolic parameters.

Research Studies and Clinical Evidence

Current clinical studies investigating GLP-3 (R) have provided valuable data regarding its research applications and potential mechanisms. The compound has progressed through multiple phases of investigation, generating substantial research interest.

Phase 2 Clinical Trial Results

Phase 2 clinical trials demonstrated dose-dependent responses across multiple metabolic parameters. Research suggests that participants receiving higher doses (8-12mg) showed significant improvements, with 79-93% achieving meaningful metabolic changes. These findings have informed current research protocols and dosing strategies.

Key research observations include:

• Significant weight reduction compared to placebo group
• Improvements in body mass index (BMI) measurements
• Reductions in waist circumference
• Changes in cardiovascular risk factors
• Modifications in blood pressure parameters

Ongoing Phase 3 TRIUMPH Trials

Current Phase 3 TRIUMPH trials are investigating optimal research protocols, including potential formulations for enhanced research applications. These clinical studies are examining various dosing strategies and their effects on multiple endpoints.

Research protocols in these trials include:

• Extended 48 weeks observation periods
• Multiple dose level investigations
• Comprehensive safety profile assessments
• Secondary endpoint evaluations
• Comparisons with existing compounds

Research Applications Beyond Weight Studies

Clinical proof from various studies suggests potential applications in multiple research areas. Investigations have examined effects on:

• Liver Disease Research: Studies examining how the compound may reduce liver fat and address fatty liver disease
• Metabolic Health Parameters: Research on insulin resistance and glucose metabolism
• Cardiovascular Research: Investigations into low density lipoprotein cholesterol and related factors
• Body Composition Studies: Research on adipose tissue distribution and body weight changes

Research indicates that at least one dose level has shown promise across multiple metabolic parameters, though further studies are needed to establish optimal research protocols.

Storage and Safety Protocols

Proper handling and storage of GLP-3 (R) are critical for maintaining compound integrity and ensuring reliable research results. The substance requires specific environmental conditions to preserve its molecular structure and biological activity.

Storage Requirements

Parameter	Specification
Temperature	2°C to 8°C (36°F to 46°F)
Light Protection	Store in original packaging, protect from light
Humidity	Controlled environment, avoid moisture exposure
Temperature Limits	Never freeze; avoid exposure above 30°C
Researchers must maintain consistent refrigerated storage conditions throughout the compound’s lifecycle. Temperature fluctuations can compromise molecular integrity and affect experimental outcomes.

Handling Protocols

Research protocols should include proper handling procedures to ensure compound stability:

• Use appropriate personal protective equipment
• Minimize exposure to ambient temperatures
• Follow institutional safety guidelines
• Maintain cold chain during transport
• Document storage conditions for quality assurance

Research Observations

Studies have documented various research observations during compound administration. Common findings in research protocols include mild-to-moderate gastrointestinal responses, which researchers should consider when designing experimental protocols.

The safety profile observed in clinical studies provides valuable information for researchers planning laboratory investigations. Understanding these patterns helps inform proper research design and monitoring protocols.

Benefits of Buying from Loti Labs

Loti Labs provides high-quality research compounds specifically designed for laboratory investigations. Their commitment to quality assurance and research compliance makes them an ideal source for researchers seeking to buy GLP-3 (R) 20mg for their studies.

Research Use Only Designation

All products sold by Loti Labs are intended as research chemicals only. This designation allows the use of these compounds strictly for in-vitro laboratory testing and experimentation. Human consumption or veterinary use is strictly forbidden. These products are not substances for human use, food, or cosmetics and may not be misbranded, mislabeled, or misused as such.

This research-only designation ensures compliance with regulatory requirements and maintains the integrity of scientific investigation. Researchers must adhere to institutional guidelines and regulatory frameworks when procuring and using these compounds.

Quality Assurance and Testing

Every batch of compounds sold by Loti Labs undergoes rigorous third-party testing using High-Performance Liquid Chromatography (HPLC) to ensure product purity and accuracy. This comprehensive testing protocol provides researchers with confidence in their experimental materials.

Testing Protocols Include:

• Purity verification through HPLC analysis
• Identity confirmation via spectroscopic methods
• Contamination screening
• Stability testing under storage conditions
• Certificate of analysis with each batch

Shipping Policy

Loti Labs offers same-day shipping for orders placed before 1 PM EST, Monday through Friday. Orders placed after 1 PM EST or on weekends are shipped the next business day. This efficient shipping policy ensures researchers receive their materials promptly for time-sensitive experiments.

The company maintains proper cold chain protocols during shipping to preserve compound integrity. Specialized packaging ensures temperature stability throughout the delivery process.

Satisfaction Guarantee

Loti Labs provides a 30-day satisfaction guarantee on all products purchased. Researchers can return any unopened products for a full refund of the purchase price of unused materials. This guarantee demonstrates the company’s confidence in product quality and commitment to researcher satisfaction.

Research Applications and Future Directions

Current research suggests multiple potential applications for GLP-3 (R) in laboratory investigations. The compound’s unique triple agonist mechanism provides researchers with opportunities to study complex metabolic interactions.

Metabolic Research Applications

Research indicates potential applications in studying:

• Energy Metabolism: Investigations into energy expenditure and metabolic rate
• Glucose Homeostasis: Studies on glycemic control and insulin sensitivity
• Lipid Metabolism: Research on liver fat regulation and adipose tissue function
• Hormone Interactions: Investigations into multi-pathway receptor activity

Comparative Research Opportunities

Researchers can utilize GLP-3 (R) compared to other compounds to understand mechanism differences. Studies comparing single receptor agonists with this triple agonist approach provide valuable insights into metabolic pathway interactions.

The relatively small sample size of current studies creates opportunities for researchers to contribute additional data to the scientific understanding of this compound class.

Research Considerations

When designing studies with GLP-3 (R), researchers should consider:

• Appropriate experimental models for compound administration
• Proper controls and comparison groups
• Adequate observation periods for meaningful results
• Compliance with institutional review requirements
• Documentation of research protocols and outcomes

Research suggests that the compound’s extended half life allows for flexible dosing schedules in experimental protocols, though researchers must carefully design studies to account for this pharmacokinetic property.

Conclusion

GLP-3 (R) represents a significant advancement in metabolic research applications, offering researchers the opportunity to study a novel triple hormone receptor agonist with unique mechanisms of action. The compound’s distinctive approach to targeting GLP-1, GIP, and glucagon receptors simultaneously provides valuable research opportunities for understanding complex metabolic interactions.

For researchers seeking to buy GLP-3 (R) 20mg for their laboratory investigations, Loti Labs offers high-quality compounds with comprehensive quality assurance protocols. Their commitment to research compliance, third-party testing, and customer satisfaction makes them an ideal partner for scientific investigations.

The growing body of research surrounding this compound suggests significant potential for advancing our understanding of metabolic pathways and hormone receptor interactions. As clinical studies continue to generate data, researchers have unprecedented opportunities to contribute to this expanding field of investigation.

To procure GLP-3 (R) 20mg for your research applications, contact Loti Labs today and experience their commitment to scientific excellence and research integrity. Their comprehensive support for the research community ensures you receive the highest quality compounds for your investigational needs.

References

1. Jastreboff, A. M. et al. Triple-hormone-receptor agonist retatrutide for obesity—a phase 2 trial. N. Engl. J. Med. 389, 514–526 (2023).
2. Naeem, M., Imran, L., & Banatwala, U. E. S. S. Unleashing the power of retatrutide: a possible triumph over obesity and overweight: a correspondence. Health Sci Rep. 7, e1864 (2024).
3. Sanyal, A. J. et al. Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial. Nat Med 30, 2037–2048 (2024).
4. The Care Pharmacy. Retatrutide: Uses, Side Effects, Availability and More. Available at: https://thecarepharmacy.com/retatrutide-uses-side-effects-availability-and-more (Accessed 2024).
5. Food and Drug Administration (FDA). Retatrutide FDA Approval Status. Drugs.com. Available at: https://www.drugs.com/history/retatrutide.html (Accessed 2024).
6. Coskun, T. et al. LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept. Cell Metab. 34, 1234–1247 (2022).
7. Rinella, M. E. et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. Ann. Hepatol. (2023).

Please consult these references for detailed information on retatrutide’s development, clinical trials, and research applications.

 

Weight	.03125 lbs