CJC-1295 W/ DAC 2mg

Buy CJC-1295 with DAC at Loti Labs

CJC-1295 with DAC is a major breakthrough in growth hormone releasing hormone research, offering laboratory researchers a long half life synthetic analogue for research use. This peptide has gained a lot of attention in research circles due to its drug affinity complex modification which fundamentally changes its pharmacokinetic properties compared to standard growth hormone releasing peptides.

Research shows that CJC-1295 with DAC gives investigators a tool to study growth hormone pathways, especially in situations where prolonged stimulation of growth hormone release is needed. Unlike its counterpart without the DAC modification, this peptide has sustained activity that goes beyond traditional growth hormone releasing hormones.

For laboratory research applications requiring reliable, high purity peptides, understanding the molecular characteristics and sourcing becomes crucial. This article will cover the technical specifications, research applications and procurement considerations for CJC-1295 with DAC from Loti Labs.

Molecular Structure of CJC-1295 with DAC

CJC-1295 with DAC is a synthetic analogue of the natural growth hormone releasing hormone, consisting of the first 29 amino acids of native GHRH with specific modifications to enhance stability and biological activity. The peptide structure includes critical amino acid substitutions and a special lysine linker to attach the drug affinity complex.

Technical Specifications:

Property	Value
Amino Sequence	Synthetic analog of GHRH containing first 29 amino acids linked with Drug Affinity Complex via lysine linker
Molecular Formula	C152H252N44O46
Molecular Weight	3647.15 g/mol
PubChem CID	56841945 (for DAC negative species)
CAS Number	863288-34-0

The dac modification is the key feature of this peptide. The drug affinity complex is a maleimide derivative, specifically N-epsilon-3-maleimidopropionamide, which attaches via the lysine linker. This chemical modification allows the peptide to bind to endogenous albumin in experimental systems, extending its circulation time compared to peptides without this modification.

Research shows that the DAC makes the peptide resistant to enzymatic degradation while maintaining functional affinity to growth hormone releasing hormone receptors. The molecular design includes D-alanine and glutamine substitutions that further optimize stability and receptor binding properties for research use.

Mechanism of Action

CJC-1295 with DAC works by binding to growth hormone releasing hormone receptors in the anterior pituitary gland. In experimental models, the peptide acts as a growth hormone secretagogue by mimicking endogenous growth hormone releasing factor activity.

The mechanism involves several key processes observed in research:

Receptor Binding and Activation:

• Binds specifically to GHRH receptors on somatotroph cells
• Activates cyclic adenosine monophosphate signaling pathways
• Stimulates growth hormone secretion from anterior pituitary tissue

Extended Half Life: Research shows the dac modification gives the peptide a half life of approximately 6-8 days, a big improvement over short half life alternatives. This extended duration is due to the peptide binding to endogenous albumin which protects it from rapid clearance and enzymatic breakdown.

Sustained Hormonal Effects: Studies in experimental models show single injection protocols can elevate growth hormone levels 2-10 fold for extended periods. Research also shows insulin like growth factor levels are elevated 9-11 days or more with repeated administration.

The prolonged stimulation profile of CJC-1295 with DAC is different from other peptides that require once daily administration. This makes it very useful for research protocols investigating sustained growth hormone release patterns and long acting growth hormone releasing hormone effects.

Research Studies

Scientific research on CJC-1295 with DAC has generated a lot of data on its pharmacokinetic properties and biological activity in experimental models. Research comparing this peptide to other growth hormone releasing peptides consistently shows longer duration of action and sustained hormonal elevation.

Pharmacokinetic Research: Multiple studies have looked at the enhanced bioavailability of the DAC modification. Research shows CJC 1295 dac maintains growth hormone and insulin like growth factor levels significantly longer than peptides without albumin-binding modifications. Comparative studies between CJC-1295 with and without DAC highlight the importance of the drug affinity complex in extending the therapeutic window and reducing administration frequency.

Hormonal Response Studies: Research in healthy adults and experimental models using CJC 1295 with dac shows consistent growth hormone production patterns. Studies show:

• Growth hormone levels increase 2-10 fold above baseline
• IGF I levels are elevated for extended periods
• Pulsatile secretion patterns are modified to more sustained release
• Normal growth hormone rhythms are influenced by continuous stimulationLong-term Effect Research: Multiple dosing studies show IGF I levels can be maintained for up to 28 days in experimental models. This suggests long acting analog properties allow researchers to study anabolic signaling for extended periods without re-administration.

Research published in peer-reviewed journals, including work cited in Nature Reviews Drug Discovery, highlights the benefits of albumin-binding peptides for sustained hormonal effects in research. These studies provide the scientific basis for how CJC-1295 with DAC works differently from traditional growth hormone releasing hormones.

Storage and Safety

Proper handling and storage protocols are crucial for peptide integrity and laboratory safety. CJC-1295 with DAC requires specific conditions to preserve its molecular structure and biological activity.

Storage Requirements:

• Lyophilized powder: Store at 2-8°C in refrigerated conditions
• Reconstituted solution: Store in refrigeration and use within recommended timeframes
• Protect from light and temperature fluctuations
• Avoid freeze-thaw cycles that may compromise peptide integrity

Laboratory Safety Protocols: Research use requires following standard laboratory safety procedures:

1. Sterile Technique: Use aseptic methods during reconstitution with bacteriostatic water
2. Personal Protection: Use standard laboratory protective equipment
3. Waste Disposal: Follow institutional guidelines for research chemical disposal
4. Documentation: Maintain records of storage conditions and handling procedures

Reconstitution Guidelines: When reconstituting CJC-1295 with DAC for research use, sterile bacteriostatic water is the appropriate diluent. Gentle mixing prevents peptide degradation and ensures complete dissolution. Research protocols should specify exact reconstitution procedures based on experimental requirements.

Research Compliance: All handling procedures must comply with institutional research guidelines and regulations governing research chemicals. Laboratory personnel should receive training on peptide handling and safety protocols before working with CJC-1295 with DAC in experimental models.

Why Buy from Loti Labs

Loti Labs offers pharmaceutical-grade CJC-1295 with DAC specifically designed for research use. Their quality control and researcher support make them a trusted supplier for scientific investigations requiring consistent, high purity peptides.

Quality Assurance:

• Minimum 98% purity verified through third-party testing
• Independent lab validation ensures product accuracy and consistency
• Pharmaceutical-grade manufacturing meets research standards
• Available in 2mg vial sizes for various experimental needs
• Same-day shipping for orders placed before 1pm EST on weekdays
• Free shipping on orders over $99
• Quick order processing to minimize experimental delays
• Reliable delivery for timely receipt of research materials

Customer Support: The 30-day money back guarantee demonstrates confidence in product quality and provides researchers with purchase protection. This policy allows return of unopened products for full refund, promoting honest transactions in the competitive peptide market.

Research-Focused Service: Loti Labs understands the unique needs of laboratory research and tailors their service to support scientific investigations. Their experience with research chemicals ensures proper packaging, documentation and handling that meets the standards expected by research professionals.

Loti Labs Products are for Research Use Only

All products sold by Loti Labs are for research use only. This designation allows the use of these compounds strictly for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly forbidden. This product is not a substance for human consumption, food or cosmetic use and may not be misbranded, mislabeled or misused as such.

The research use only classification ensures compliance with regulations and prevents misuse. Laboratory researchers must acknowledge this limitation and operate within ethical and legal frameworks when using CJC-1295 with DAC in experimental models.

Research applications may include:

• Growth hormone pathway studies
• Receptor binding experiments
• Pharmacokinetic research
• Comparative peptide efficacy studies
• Molecular mechanism studies

Regulatory Compliance: Loti Labs adheres to research chemical regulations through:

• Clear product labeling indicating research use only status
• Documentation highlighting experimental applications
• Marketing materials focused on laboratory research
• Customer education on proper use

Shipping of Loti Labs

Loti Labs processes and ships orders with efficiency to support research timelines. Orders placed before 1pm EST Monday through Friday ship same day, orders placed after this cut off or on weekends ship next business day.

The free shipping threshold of $99 supports cost-effective purchasing for larger research projects, recognizing that laboratory research often requires multiple compounds or larger quantities for comprehensive studies. This shipping policy helps researchers manage budgets and get research materials delivered on time.

Guarantee

The 30-day money back guarantee shows Loti Labs’ confidence in their product and commitment to customer satisfaction. Researchers can return unopened products within this timeframe for full refund of the purchase price, so you can order with confidence.

This guarantee policy is especially beneficial for research institutions that need to adjust orders based on changing experimental requirements or project modifications. The return policy is customer focused and valued in competitive peptide market.

Third Party Tested Every Batch

Every batch of CJC-1295 with DAC is third party tested to ensure minimum 98% purity and product accuracy. This pharmaceutical grade quality control is above what you’ll find with suppliers that may not test their products.

The third party laboratory validation process includes:

• Purity Analysis: Minimum 98% purity verification
• Identity Confirmation: Molecular structure verification
• Contaminant Detection: Impurity screening that can affect research results
• Potency Assessment: Biological activity confirmation

This comprehensive testing ensures reproducibility and accuracy in research where consistency is key. The quality assurance provided by third party testing increases research confidence and supports publication quality research.

CJC-1295 with DAC vs Standard Formulations

Understanding the differences between CJC-1295 with DAC and other growth hormone releasing peptides helps researchers choose the right compound for their experimental protocols. The DAC modification changes the peptide’s behavior in research applications.

Half Life Differences: Research shows that CJC-1295 without DAC has a much shorter half life, resulting in growth hormone release patterns with sharp peaks and valleys. This requires more frequent administration in experimental protocols, often daily administration to maintain hormonal levels.

CJC 1295 with dac on the other hand provides sustained growth hormone and IGF I levels, more stable experimental conditions. This extended activity profile is useful for research on:

• Long term anabolic signaling pathways
• Sustained growth hormone effects on tissue metabolism
• Chronic exposure models in experimental settings
• Reduced frequency of administration

Synergistic Research: While CJC-1295 without DAC is sometimes used with other peptides in research protocols, the sustained action of CJC-1295 with DAC may reduce the need for peptide combinations. Research suggests that the extended half life provides consistent hormonal stimulation without the need for additional growth hormone secretagogues.

Current Research and Future Applications

CJC-1295 with DAC remains a top compound in peptide based growth hormone research due to its unique pharmacokinetic profile and consistent results. Current research is focused on:

Mechanistic Studies: Researchers are investigating how the drug affinity complex extends circulation time and maintains biological activity. These studies are looking at albumin binding kinetics, receptor affinity maintenance and the relationship between structural modifications and functional outcomes.

Comparative Pharmacology: Ongoing research is comparing CJC-1295 with DAC with other growth hormone releasing peptides to establish optimal protocols for specific research applications. These comparative studies will define the experimental contexts where extended half life is advantageous over shorter acting alternatives.

Future Directions: Future research may include:

• Novel modifications to further enhance stability or selectivity
• Combination protocols with other research peptides
• Tissue specific effects in experimental models
• Development of specialized delivery systems for research

Methodology Development: The peptide’s consistency makes it useful for developing standardized research protocols. Its predictable pharmacokinetic profile allows researchers to design experiments with confidence in timing and dosing.

Technical Considerations for Lab Use

Successful use of CJC-1295 with DAC requires attention to technical details that affect experimental outcomes. Understanding these details will help researchers optimize their protocols and get reproducible results.

Reconstitution Protocols: Proper reconstitution with bacteriostatic water ensures optimal peptide stability and activity. Research protocols should specify exact volumes and mixing procedures to maintain consistency across experimental replications. Gentle dissolution prevents peptide degradation that can affect research results.

Experimental Design Factors: The extended half life of CJC-1295 with DAC impacts experimental design:

• Timing of sample collection relative to administration
• Washout periods between experimental phases
• Frequency of administration in chronic studies
• Control group design for comparative studies

Quality Control in Research: Researchers should implement quality control measures:

• Verify peptide identity and purity upon receipt
• Monitor storage conditions
• Document reconstitution and handling procedures
• Regularly check peptide stability during storage

Conclusion

CJC-1295 with DAC is a major advancement in growth hormone releasing hormone research peptides, offering laboratory researchers unique benefits through its drug affinity complex modification. The extended half life, sustained hormonal effects and reliable pharmacokinetic profile makes it a valuable tool for growth hormone research in experimental settings.Loti Labs offers researchers pharmaceutical grade CJC-1295 with DAC tested by third party and quality assured. Their focus on research compliance, fast shipping and customer satisfaction meets the scientific community’s need for high quality research materials.

For laboratory research that requires long acting growth hormone releasing hormone activity, CJC-1295 with DAC has distinct advantages over traditional peptides. Technical excellence and reliable sourcing from Loti Labs means researchers have access to the quality materials they need to advance growth hormone knowledge.

Researchers interested in ordering CJC-1295 with DAC for their research protocols can contact Loti Labs for specifications, ordering and technical support. Their expertise in research peptides and commitment to science makes them the perfect partner for institutions researching growth hormone.

References

1. Jette, L. et al. (2009). Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Hormone & IGF Research, 19(6), 471-477.
2. van Hout, M. C., & Hearne, E. (2016). Netnography of female use of the synthetic growth hormone CJC-1295: pulses and potions. Substance Use & Misuse, 51(1), 73-84.
3. Alba, M. et al. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology-Endocrinology and Metabolism, 291(6), E1290-E1294.
4. Knoop, A. et al. (2016). Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS. Analytical and Bioanalytical Chemistry, 408, 3145-3153.
5. McDonald J., Lambert D.G. (2022). Drug-receptor interactions in anaesthesia. BJA Education, 22(1), 20-25.

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Weight	.03125 lbs