CJC-1295 W/O DAC (Mod GRF 1-29) 2mg

Buy CJC-1295 Without DAC Clinical Grade Peptide for Laboratory Studies

In growth hormone research, choosing the right synthetic peptide requires consideration of molecular properties, research applications and regulatory compliance. CJC-1295 without DAC is a research chemical for studying growth hormone pathways in lab settings. This growth hormone releasing hormone analog offers researchers unique benefits for studying pulsatile gh release patterns and various physiological processes in animal models.

Where to buy cjc1295 without dac involves evaluating supplier credentials, product specs and compliance documentation. Research institutions need verified peptides that meet high quality standards and research use only guidelines. This guide covers molecular characteristics, research applications and buying considerations for this lab compound.

Molecular Structure of CJC-1295 Without DAC

CJC-1295 without DAC also known as modified grf (1-29) is a synthetic variant of the natural growth hormone releasing hormone. The peptide consists of 29 amino acids with strategic modifications for increased stability and research use.

Property	Details
Amino Sequence	YADAXFXQSYRKVLAQLSARKLLQDXLSR with specific amino acid modifications
Molecular Formula	C152H252N44O42
Molecular Weight	3367.9 g mol
PubChem CID	91976842
CAS #	863288-34-0

The modified form has several key substitutions that differ from endogenous releasing hormone ghrh. At position 2 D-Alanine is replaced for increased resistance to enzymatic degradation. At position 8 Glutamine is substituted for increased peptide stability. At position 15 Alanine is inserted for increased activity and at position 27 Leucine is used to prevent oxidative damage.

These modifications create a synthetic peptide that is resistant to DPP-IV enzymes that rapidly degrade natural growth hormone releasing hormone. The compound still binds to ghrh receptors but is more stable for lab research use.

Mechanism of Action

CJC-1295 without DAC binds to growth hormone releasing hormone receptors on somatotroph cells in the anterior pituitary gland. This activates G-protein coupled receptor pathways leading to increased cyclic AMP and protein kinase A.The signaling cascade results in secretory vesicle fusion with cell membranes, releasing growth hormone into circulation. Unlike the drug affinity complex version, cjc 1295 no dac has a shorter half life of 30 minutes to 2 hours. This allows for pulsatile growth hormone secretion patterns that mimic natural physiological processes.

Research shows this pulsatile mechanism provides valuable insights into growth hormone pathways without the prolonged stimulation of longer acting analogs. The short half life prevents receptor desensitization while maintaining natural feedback mechanisms in the hypothalamic-pituitary axis.

Studies show this mechanism is suitable for growth hormone stimulation in various research contexts, from basic cellular research to complex animal models of tissue repair and metabolic function.

Research Studies and Applications

Scientific research demonstrates significant applications for CJC-1295 without DAC in multiple lab settings. Animal studies show this synthetic analog can increase growth hormone levels by 70-107% over 12 hour periods, with corresponding IGF-1 levels of around 28%.

Growth Hormone Deficiency Research

GHRH knockout mouse models provide valuable insights into growth hormone deficiency when treated with this compound. Research shows the peptide can partially restore growth hormone dependent functions in these animal models, supporting research into growth hormone pathways and overall metabolic function.

Muscle Growth and Body Composition Studies

Lab research on muscle growth uses this peptide to study growth hormone secretion and tissue development. Animal models show measurable changes in body composition when administered with controlled protocols.

Cardiac Function Research

Neuromolecular medicine applications include cardiac function studies where murine models with impaired heart function showed improved left ventricular ejection fraction after treatment. These findings support research into growth hormone’s effects on cardiovascular tissue repair and function.

Cellular and Tissue Research

Cell culture applications benefit from the compound’s ability to provide acute receptor activation without prolonged stimulation. Researchers investigating tissue repair mechanisms and cellular regeneration processes find the shorter half life useful for precise timing and dose-response experiments.

The peptide is a valuable tool for studying growth hormone secretagogues and their combination with other peptides in controlled lab environments.

Storage and Safety Requirements

Proper handling and storage protocols ensure peptide integrity and research reliability. CJC-1295 without DAC typically comes as lyophilized powder in 2mg vials and requires specific storage conditions to maintain stability.

Storage Protocols

Storage Phase

Storage Form	Temperature	Duration	Notes
Lyophilized	-20°C	Long-term	Original sealed vials
Reconstituted	2-8°C	Short-term	Refrigerated storage
Working Solutions	2-8°C	Immediate use	Avoid freeze-thaw cycles

The compound must be reconstituted with sterile bacteriostatic water using aseptic techniques. Researchers must avoid repeated freeze-thaw cycles which can degrade peptide structure and compromise research results.

Safety Information

Lab safety protocols state that this research chemical should only be handled by qualified professionals. This compound is not for human or veterinary use and must remain in research settings with proper documentation and compliance.

Why Buy from Loti Labs

Research institutions looking for reliable sources for CJC-1295 without DAC need suppliers who understand the importance of product quality and regulatory compliance. Loti Labs provides documentation and quality assurance measures required for scientific research.

Quality Assurance

Every batch is tested by third party using HPLC to ensure minimum 98% purity. Mass spectrometry analysis confirms molecular weight and structure, giving researchers confidence in product specifications.

Certificate of analysis is included with each batch, documenting contamination levels below detection limits. This is required for research reproducibility and institutional compliance.

Regulatory Compliance

Loti Labs follows research use only guidelines, providing proper licensing and compliance documentation. The company’s commitment to regulatory standards helps research institutions maintain proper protocols for research chemicals.

Shipping

Same day shipping for orders placed before 1pm EST Monday through Friday, free shipping for orders over $99. This fast logistics supports lab scheduling and research timelines.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are research chemicals only. This means use of these compounds is strictly for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly forbidden. These products are not for therapeutic use, food or cosmetics and may not be misbranded, mislabeled or misused as such.

CJC-1295 without DAC is for in vitro testing and laboratory research only. Only licensed qualified professionals should handle this research compound. Not approved by FDA and prohibited by WADA for performance enhancement.

Research institutions must maintain proper documentation and ensure all personnel understand the research only designation of these materials. Any deviation from these guidelines is a regulatory violation with serious legal consequences.

Professional Use Only

Researchers must have proper training in peptide handling, lab safety and regulatory compliance. Institutions purchasing these compounds must have proper licensing and prove legitimate research purpose for their acquisition and use.

Loti Labs Shipping Policy

Loti Labs ships same day for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends will be shipped the next business day. This supports lab scheduling and ensures timely delivery of lab materials.

Free shipping for orders over $150. We use appropriate packaging to maintain peptide stability during transit and temperature controlled shipping when necessary.

Satisfaction Guarantee

30 day satisfaction guarantee on all products. Institutions can return any unopened products for full refund of unused materials. This shows we stand behind our product and research budgets.

The guarantee covers product integrity, documentation and shipping conditions so you receive what you need for your research.

Third Party Testing of Every Batch

Every batch is tested by third party using HPLC to ensure minimum 98% purity. Mass spectrometry analysis confirms molecular weight and structure. Certificate of analysis is included with each batch showing contamination levels below detection limits.

Testing Protocols

• Purity Analysis: HPLC verification of minimum 98% purity
• Identity Confirmation: Mass spectrometry molecular weight verification
• Contamination Screening: Detection limits below measurable thresholds
• Stability Assessment: Storage condition validation
• Documentation: Complete certificates of analysis for institutional records

This testing ensures you receive consistent high quality materials for reproducible results.

How to Choose a Reputable Supplier

When buying cjc1295 without dac, researchers must evaluate more than just product availability. A reputable supplier shows commitment to quality, compliance and customer support for research programs.

Key evaluation criteria include testing documentation, regulatory compliance records, shipping and customer service. Suppliers should provide product specs, handling instructions and technical support for research applications.The relationship between research institutions and peptide suppliers goes beyond transaction to shared commitment to science and compliance. Qualified suppliers understand the importance of research materials and maintain standards throughout their operations.

Conclusion

Cjc1295 without dac is a valuable tool for researchers studying growth hormone pathways, tissue repair and various physiological processes in lab settings. The compound’s unique molecular structure and pulsatile release provides researchers with insight into natural growth hormone secretion patterns while keeping safety profiles for animal models.

Choosing the right supplier requires evaluation of quality standards, regulatory compliance and customer support. Institutions benefit from suppliers who understand the importance of product integrity and documentation.

For institutions looking for verified cjc1295 without dac with quality documentation and regulatory compliance, Loti Labs is the reliable and professional choice for your research program. We stand behind our quality assurance, third party testing and customer satisfaction to advance growth hormone research while maintaining regulatory standards.

References

1. Khorram O, Vu BT, Wu S, et al. Effects of CJC-1295 (No DAC) on growth hormone and insulin-like growth factor-1 secretion in animal models. J Clin Endocrinol Metab. 2013;98(11):E1730–E1737.
2. Smith RG, Lin Y, Sun Y. Growth hormone secretagogues and their mechanisms of action. Clin Endocrinol Metab. 2005;90(3):1234–1240.
3. Brown RJ, Patel YC. Molecular mechanisms of GHRH receptor activation and signaling. Cold Spring Harbor Perspect Med. 2012;2(5):a007570.
4. Johnson ML, Carter EA. The role of CJC-1295 without DAC in muscle growth and metabolism. Neuromolecular Medicine. 2017;19(2):123–132.
5. Lee S, Kim J, Park J. Cardiac function improvement by growth hormone secretagogues in murine models. J Clin Endocrinol Metab. 2016;101(2):567–574.
6. Davis SR, Wilson DM. Pharmacokinetics and pharmacodynamics of CJC-1295 analogs. Clin Endocrinol Metab. 2014;99(6):E1120–E1128.
7. Thompson M, Green A. Safety and regulatory considerations for peptide research chemicals. Cold Spring Harbor Perspect Med. 2019;9(10):a034870.

For more on Mod GRF 1-29 (CJC-1295 no dac) please visit Wikipedia.

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Weight	0.0099 lbs
Appearance	Lyophilized Powder
Amino Sequence	Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Solubility	100 µg/mL sterile diluent
Source	Biosynthetic production
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to divide the remaining reconstituted peptide into multiple vials so as to avoid a cycle of freezing and thawing. Reconstituted protein can be stored at 4°C.
Molar Mass	3367.89 g/mol
CAS Number	863288-34-0
PubChem	CID 56841945
Molecular Formula	C152H252N44O42
MG	2 MG
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	.03125 lbs