Evidence-led explainers and analytical insights for serious research teams.
Comparing lipidation, albumin binding, Fc fusion, XTEN polymers, and glycan shielding as mechanisms for extending peptide half-life in research.
Read the articleComparing lipidation, albumin binding, Fc fusion, XTEN polymers, and glycan shielding as mechanisms for extending peptide half-life in research.
Read articleHow GLP-1/GIP/glucagon peptide backbones are conjugated to PPAR ligands for cell-targeted nuclear receptor pharmacology in research models.
Read articleBI 3034701 adds NPY2R to GLP-1R/GIPR co-agonism; explore the gut-brain rationale and open questions behind this tri-agonist design.
Read articleGEP44 fuses GLP-1R and Y1/Y2 receptor pharmacophores into one peptide; explore chimeric design logic and rodent and shrew model findings.
Read articleBRP, a 12-amino-acid hypothalamic peptide found via peptidomic mining, alters feeding in rodent and porcine models independent of GLP-1R.
Read articleHow computational design balances GLP-1R, GIPR, and GCGR potency ratios in next-gen triple agonist candidates like ASC37.
Read articleFocused educational resources should make the next step obvious. Move from a research question into the corresponding Loti collection without losing context.
Start with focused, readable science written for research context.
Understand the methods, terminology, and variables that shape research.
Move directly into the relevant Loti research collection without dead ends.
