Exemestane Review | Buy Aromasin Liquidadmin
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Research has indicated that estrogen hormones are implicated in the occurrence and development of breast cancer in women. With this in mind, Endocrine manipulation has been used therapeutically for many years. In particular, research was initially undertaken to observe the regression of local cancers following ovary removal in patients who were pre menopausal.
Ovaries are the main source of estrogen in these patients. However, post menopause, the main source of circulating estrogen is the result of the aromatization of androstenedione and testosterone. This reaction is facilitated by Aromatase which is a member of the cytochrome P-450 (CYP) family. Aromatase is normally found in the liver and adrenal glands, as well as in fat tissue.
Research into treatment of hormone-sensitive breast cancer
Against this background, various endocrine strategies have been tested in the search for effective cancer treatments. This has resulted in the development of specific antagonists of aromatase. These are third-generation compounds, anastrozole, letrozole, and exemestane.
Exemestane liquid and, other forms of Exemestane, are available as the brand name Aromasin. Anyone purchasing Exemestane for research needs to understand that it is a steroidal aromatase inhibitor and its aim is to restrain the aromatase that exists in peripheral fat. In doing so, the aim is to restrict the levels of circulating estrogen that are present in test subjects, post menopause.
Exemestane has an androstenedione-like structure. This means that it is able to compete with androstenedione and testosterone. It proceeds to make covalent bonds with the substrate-binding part of the enzyme. This action leads to eventual irreversible aromatase inactivation.
Early in vitro studies recognized Exemestane to be a strong inhibitor. It has a stronger aromatase affinity in comparison with related compounds.
Following these early studies, work was carried out to study the antitumor effects of Exemestane. This involved the use of rats with induced mammary tumors. The results of these experiments showed that Exemestane has a high level of efficacy whether it is administered orally or subcutaneously.
Side effects of Exemestane
Anyone who is making use of Exemestane for research needs to have an in-depth understanding of Exemestane effects. There are several side effects that are associated with Exemestane. These side effects include:
- Alopecia which results in the loss of hair from parts of the body.
- Decrease in appetite.
- Arthralgia – pain in joints.
- Fracturing of bones.
- Change in bowel movements.
- Osteoporosis which results in lack of bone density.
- Hyperhidrosis – the excessive production of sweat.
- Peripheral oedema which causes swelling in tissues.
All of these side effects have been commonly observed. There are also more rare side effects which have been shown to exist, such as hepatic disorders.
Effectiveness of Exemestane needs to be taken into account, together with potential side effects, when making use of Exemestane for research purposes.
Exemestane can be purchased from Loti Labs, a leading online research supply company. Buying exemestane from loti labs ensures the integrity of your research due to their rigorous Quality control standards and third-party testing. When buying research liquids online it is important that you purchase them from a reputable online source that stands behind their products.