MOTS-c 10mg

Please Note: All products sold by Loti Labs are for research/laboratory use only. This description has been compiled from numerous sources and is not intended as advice of any kind nor does Loti Labs make any potential claims of the use of this product. Nothing in this description should be construed as advice or claims. Human use is strictly forbidden. 

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MOTS-c is a mitochondrial peptide that regulates metabolism and insulin sensitivity. It plays a key role in glucose and lipid metabolism, offering promise for treating obesity and type 2 diabetes. This article explores its functions, mechanisms, and potential applications.

Key Takeaways

• MOTS-c, a mitochondrial-encoded peptide, plays a significant role in metabolic regulation by influencing insulin sensitivity and glucose and lipid metabolism, showcasing potential for managing obesity and type 2 diabetes.
• The peptide enhances glucose metabolism and lipid utilization through the activation of the AMPK pathway, suggesting its critical involvement in maintaining energy homeostasis and preventing metabolic disorders.
• Ongoing research highlights MOTS-c’s therapeutic potential, encompassing improvements in metabolic health, cardiovascular function, and muscle preservation, with implications for treating age-related diseases.

Understanding MOTS-c

MOTS-c, a derived peptide mots c from the mitochondrial genome, consists of 16 amino acids crucial for metabolic regulation and cellular function. Encoded by a short open reading frame (sORF) in the mitochondrial 12S rRNA, MOTS-c is often termed a mitochondrial-encoded peptide, specifically mitochondrial encoded mots. Discovered through an in silico search, MOTS-c has shown potential in altering gene expression in response to metabolic cues, including those related to mitochondrial DNA.

MOTS-c primarily influences metabolic homeostasis and regulates insulin sensitivity. Research indicates that MOTS-c regulates glucose and lipid metabolism, playing a significant role in disease prevention. Functioning as a mitochondrial hormone, MOTS-c targets skeletal muscle, underscoring its importance in metabolic regulation.

The identification of MOTS-c marked a breakthrough in understanding the impact of mitochondrial peptides on cellular metabolism. By regulating metabolism and insulin sensitivity, MOTS-c shows potential for managing conditions such as obesity and type 2 diabetes. Ongoing research continues to highlight the significance of MOTS-c in metabolic health.

The Molecular Mechanisms of MOTS-c

Exploring the molecular mechanisms of MOTS-c reveals its influence on cellular metabolism. MOTS-c’s ability to translocate to the nucleus under metabolic stress suggests a direct role to regulate nuclear gene expression. This process involves regulating nuclear genes linked to glucose restriction and antioxidant responses, crucial for maintaining energy metabolism.

MOTS-c activates the AMP-activated protein kinase (AMPK) pathway, a key regulator of energy homeostasis. Through this pathway, MOTS-c enhances glucose metabolism and lipid utilization, highlighting its role in cellular metabolism. Activation of these pathways underscores MOTS-c’s potential in managing metabolic conditions.

The molecular signaling mechanisms of mitochondrial-encoded peptide MOTS-c are both complex and fascinating. As a mitochondrial hormone targeting specific metabolic pathways, MOTS-c exemplifies the intricate interplay between mitochondrial peptides and cellular function. This knowledge lays the groundwork for exploring MOTS-c’s therapeutic applications in more detail.

Research on MOTS-c and Glucose Metabolism

Research has highlighted MOTS-c’s significant impact on glucose metabolism, a crucial area for managing metabolic diseases. MOTS-c treatment has prevented age-related insulin resistance and obesity in mice, indicating its potential as a preventive strategy. Studies suggest lower plasma levels of MOTS-c may correlate with increased insulin resistance in both children and adults, further emphasizing its role in metabolic regulation.

A standout function of MOTS-c is its ability to enhance insulin sensitivity in skeletal muscle and improve glucose utilization. This is achieved by activating pathways that increase glucose transporter expression via AMPK activation, promoting glucose uptake independent of insulin. These mechanisms highlight the peptide’s potential in managing obesity and insulin resistance.

MOTS-c also influences overall metabolic homeostasis. By modulating cellular responses to metabolic stress, MOTS-c helps maintain a balanced metabolic state. Its ability to enhance glucose metabolism and regulate metabolic processes through retrograde signaling from mitochondria demonstrates its versatility.

These findings have profound implications. MOTS-c not only regulates glucose metabolism but also offers promising avenues for preventing and managing metabolic dysfunction. With ongoing research, the potential applications of MOTS-c in treating obesity, diabetes, and related conditions look increasingly promising.

MOTS-c and Lipid Metabolism

MOTS-c’s role in lipid metabolism is another area of significant interest. Research shows that MOTS-c administration in mice fed a high-fat diet reduced liver fat accumulation and improved glucose homeostasis. This suggests that MOTS-c may help mitigate the adverse effects of high-fat diets and promote metabolic health.

MOTS-c influences lipid metabolism by increasing energy expenditure, helping prevent weight gain in diet-induced obese models. Additionally, MOTS-c treatment has been associated with reduced fat accumulation in these models, highlighting its potential in managing obesity. MOTS-c enhances fatty acid metabolism by elevating the levels of carnitine shuttles, crucial for transporting fatty acids into mitochondria for oxidation.

MOTS-c further impacts lipid metabolism by boosting AMPK activity, a key regulator of lipid metabolism. The link between MOTS-c and AMPK underscores its role in enhancing lipid utilization and maintaining metabolic balance. These findings emphasize MOTS-c’s potential in addressing metabolic dysfunction and promoting overall health.

Impact of MOTS-c on Muscle Function

MOTS-c plays a pivotal role in muscle function, crucial for overall metabolic health. Studies indicate that MOTS-c lowers myostatin expression, a significant factor in muscle wasting and atrophy. This reduction in myostatin expression is facilitated by enhanced AKT phosphorylation, vital for inhibiting myostatin signaling in skeletal muscle.

The CK2-PTEN-mTORC2-AKT signaling pathway, influenced by MOTS-c, helps inhibit myostatin and muscle wasting. Research suggests MOTS-c may prevent muscle atrophy by affecting the transcription factor FOXO1, which regulates myostatin expression. These findings underline its potential in preserving muscle mass and function.

MOTS-c has been linked to enhanced muscle function and may improve recovery and performance, especially in age-related muscle decline. Its ability to support muscle homeostasis and prevent atrophy underscores its importance in metabolic health and physical performance.

Potential Therapeutic Applications of MOTS-c

MOTS-c’s potential therapeutic applications are vast and promising. Research suggests MOTS-c may enhance insulin-stimulated glucose uptake and reduce inflammation, indicating its potential for treating metabolic dysfunction. These properties make MOTS-c a compelling candidate for addressing conditions such as obesity and type 2 diabetes.

Beyond metabolic health, MOTS-c may improve cardiovascular disease health by positively impacting endothelial function and vascular tone. This effect on cardiovascular function underscores its broader therapeutic potential.

MOTS-c is also believed to play a role in healthy aging by improving mitochondrial function and potentially preventing age-related diseases. Overall, MOTS-c shows promise for treating metabolic dysfunction, cardiovascular diseases, and conditions related to aging. With ongoing research, the potential clinical applications of this peptide may expand, offering new avenues for treatment and prevention.

Storage and Handling of MOTS-c

Proper storage and handling of MOTS-c are essential for maintaining its integrity and effectiveness. Typically supplied in lyophilized form, MOTS-c peptides should be stored at -20 °C or colder for long-term storage. Maintaining peptide solutions at -80 °C can keep them viable for up to six months.

For short-term storage, keep peptide solutions at +4 °C. Avoid repeated freeze-thaw cycles to preserve peptide integrity. Excess moisture can reduce the long-term stability of lyophilized MOTS-c, so storing peptides in a dry environment is recommended.

Freezing aliquots of peptide solutions can prolong their storage life, ensuring researchers have access to stable and effective MOTS-c for their experiments. These guidelines help researchers maximize the utility and longevity of their MOTS-c samples.

Safety and Usage Guidelines

Safety and ethical considerations are paramount for working with MOTS-c. Qualified professionals should use MOTS-c solely for legitimate scientific research in appropriate laboratory settings. Sales of MOTS-c often include disclaimers stating it is for research purposes only, underscoring its lack of regulation.

It is crucial to emphasize that the product sold by Loti Labs is not for human use. This disclaimer ensures ethical and safe use of MOTS-c, adhering to all regulatory guidelines. Researchers must follow these guidelines to maintain the integrity and ethical standards of their work.

Following these safety and usage guidelines ensures responsible and effective studies on MOTS-c. These precautions are vital for advancing our understanding of this promising peptide while maintaining high standards of scientific research.

Summary

In summary, MOTS-c represents a groundbreaking discovery with the potential to revolutionize our understanding of metabolic health. From its molecular mechanisms and impact on glucose and lipid metabolism to its role in muscle function and therapeutic applications, MOTS-c offers a wealth of possibilities for future research.

As we continue to explore the potential of this mitochondrial-derived peptide, the promise of new treatments for metabolic dysfunction, cardiovascular diseases, and age-related conditions becomes increasingly tangible. The journey of MOTS-c research is just beginning, and its potential to transform the landscape of metabolic health is truly inspiring.

Frequently Asked Questions

What effect does MOTS-c have on lipid metabolism?

MOTS-c has a positive effect on lipid metabolism by reducing fat accumulation in diet-induced obese animal models. This suggests its potential for managing obesity-related metabolic disorders.

What cellular signaling pathway does MOTS-c activate?

MOTS-c activates the AMP-activated protein kinase (AMPK) pathway, essential for maintaining energy homeostasis. This activation plays a significant role in cellular energy regulation.

What potential role does MOTS-c have in muscle function?

MOTS-c may play a significant role in enhancing muscle function by reducing myostatin signaling, which is associated with muscle atrophy. This suggests its potential in promoting muscle growth and health.

In what area of research is MOTS-c showing promise?

MOTS-c shows promise particularly in the areas of aging, exercise performance, cardiovascular function, and inflammation. This multifaceted potential makes it a significant focus for ongoing research.

What should be noted about the use of MOTS-c?

MOTS-c is intended solely for legitimate scientific research by qualified professionals in appropriate laboratory environments. It is crucial to use this peptide responsibly and within the bounds of established scientific protocols.