Buy Melanotan 2 at Loti Labs

Research into melanocortin receptor pathways has significantly advanced through the availability of high-quality synthetic peptide analogues. Scientists investigating pigmentation, metabolic regulation, and neuroendocrine functions require reliable access to research-grade compounds that meet stringent analytical standards. When researchers need to buy melanotan 2 for laboratory investigations, the quality and purity of the synthetic melanocortin receptor agonist becomes paramount for reproducible experimental results.

Melanotan II represents a critical tool in melanocortin system research, enabling scientists to explore complex physiological systems through controlled laboratory studies. The compound serves as a potent initiator of melanocortin receptor activation across multiple receptor subtypes, making it invaluable for researchers examining the intricate mechanisms underlying pigmentation, food intake regulation, and sexual functions in various experimental models.

Molecular Structure of Melanotan 2

The molecular architecture of mt ii reflects sophisticated peptide engineering designed to enhance stability and receptor selectivity. Understanding the structural features provides researchers with essential data for experimental design and handling protocols.

Amino Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Molecular Formula: C50H69N15O9

Molecular Weight: 1024.2 g/mol

PubChem CID: 9831659

CAS #: 121062-08-6

The peptide hormone structure incorporates several key modifications that distinguish it from the endogenous α msh. The ac nle terminus provides enhanced stability, while the cyclic configuration created through the phe arg trp lys sequence contributes to improved receptor binding characteristics. Research suggests that these structural modifications lead to increased potency compared to linear analogues.

The synthesis process involves approximately 12 steps with careful attention to the cyclization mechanism. Scientists note that the lactam bridge formation between specific amino acid residues creates the compound’s distinctive three-dimensional conformation, which is essential for melanocortin receptor recognition and activation.

 

Mechanism of Action

Melanotan 2 functions as a synthetic melanocortin receptor agonist that demonstrates non-selective binding across multiple melanocortin receptors. Research indicates that this receptor agonist primarily targets MC1R, MC3R, MC4R, and MC5R, each involved in distinct physiological pathways that researchers investigate through controlled experimentation.

Originally developed at the University of Arizona in the 1980s, this compound shows specific binding affinity for melanocortin receptors with measurable EC50 values in laboratory studies. The mechanism involves mimicking the natural signaling of α-melanocyte-stimulating hormone while providing enhanced stability and bioavailability for research applications.

Receptor Type	Primary Research Focus	Experimental Applications
MC1R	Pigmentation pathways	Melanogenesis studies
MC3R	Metabolic regulation	Energy homeostasis research
MC4R	Appetite and sexual functions	Feeding behavior studies
MC5R	Exocrine gland function	Sebaceous gland research

Laboratory investigations demonstrate that MT-II activation of MC1R directly stimulates melanogenesis and increases eumelanin production in melanocyte cultures. Research suggests that MC4R binding effects lead to measurable changes in food intake patterns when administered to experimental mouse model systems. Additionally, scientists have observed that cavernous nerve stimulation responses can be influenced through melanocortin receptor pathways, though the precise mechanisms require further investigation.

The compound’s ability to cross biological barriers makes it particularly valuable for researchers studying central nervous system melanocortin functions. Experiments involving intracerebroventricular administration have provided data on appetite regulation and thermogenic responses in laboratory settings.

Research Studies

Research applications of Melanotan 2 encompass diverse experimental approaches across multiple scientific disciplines. Laboratory investigations focus on melanocortin receptor pathways and signaling mechanisms, providing researchers with valuable data on complex physiological processes.

In-vitro studies examining receptor-ligand binding assays form the foundation of melanotan research. Scientists perform concentration-response experiments to determine binding specificity and measure downstream signaling cascades. These experiments typically involve transfected cell lines expressing individual melanocortin receptors, allowing researchers to isolate specific pathway responses.

Cell proliferation and differentiation studies represent another significant research area. Laboratory data suggests that melanocortin receptor activation influences cellular development patterns, particularly in melanocyte cultures. Researchers investigating pigmentation mechanisms rely on these experimental systems to understand how receptor activation leads to increased melanin synthesis.

Animal model research has provided extensive data on systemic effects following compound administration. Studies in mice and rats have examined various parameters including body weight changes, feeding behavior modifications, and erectile responses in male subjects. Research suggests that peripheral nerve regeneration may also be influenced by melanocortin receptor activation, though this area requires additional investigation.

Behavioral research applications include studies on appetite suppression and sexual arousal responses. Scientists have documented that administration of mt ii in controlled laboratory settings can produce measurable changes in feeding patterns and sexual functions across different species. The first erectile event timing and erectile dysfunction research models have utilized this compound to explore melanocortin pathway involvement in reproductive physiology.

Glucose metabolism studies examine whether melanotan ii influences metabolic markers through MC4R or alternative pathways. Researchers have investigated insulin sensitivity changes and glucose uptake patterns following compound treatment in various experimental models. These investigations contribute to understanding metabolic regulation mechanisms at the cellular level.

 

Storage and Safety

Proper storage protocols ensure melanotan 2 maintains its structural integrity and biological activity throughout the research period. Scientists must follow specific handling procedures to prevent peptide degradation and maintain experimental consistency.

Store lyophilized melanotan 2 at 4°C or colder, protected from bright light to prevent photodegradation. For long-term stability, maintain at -20°C or colder in appropriate laboratory freezers. Research facilities should note that temperature fluctuations can significantly impact peptide stability and experimental reproducibility.

Allow peptides to reach room temperature before opening sealed containers to minimize moisture exposure. This equilibration step prevents condensation formation that could lead to peptide hydrolysis or aggregation. Scientists should avoid repeated freeze-thaw cycles to prevent peptide degradation, as structural changes can alter receptor binding characteristics.

Prepared solutions remain stable for approximately 3 weeks at +4°C and 3-4 months when stored at -20°C under laboratory conditions. Researchers should prepare working solutions in appropriate buffers and store in sterile containers to prevent contamination. The solubility characteristics of the compound allow for preparation in various aqueous solutions suitable for different experimental protocols.

Laboratory safety protocols require proper ventilation and personal protective equipment when handling peptide powders. Research facilities should maintain detailed records of storage conditions and expiration dates to ensure experimental validity. Additionally, proper disposal procedures must follow institutional guidelines for research chemicals.

Benefits of Buying from Loti Labs

Loti Labs provides high-quality melanotan 2 with verified purity and composition data essential for rigorous scientific research. Each product comes with comprehensive certificates of analysis showing HPLC and mass spectrometry results for peptide identity confirmation, ensuring researchers receive authentic compounds for their investigations.

Our stringent quality control ensures proper storage conditions during shipping and handling, with sterility testing for all research-grade materials. The company maintains specialized cold-chain logistics to preserve peptide integrity from manufacturing through delivery to research facilities. This attention to environmental control prevents degradation that could compromise experimental results.

We maintain consistent stock levels and provide detailed analytical documentation for research applications. Scientists can access batch-specific data including purity analysis, molecular weight confirmation, and sequence verification. This documentation supports regulatory compliance requirements for academic institutions and research facilities.

The concentration accuracy and peptide form specifications meet research-grade standards required for reproducible experiments. Quality assurance protocols include testing for common contaminants and verification of amino acid sequence accuracy. Research suggests that consistent peptide quality directly correlates with experimental reproducibility across different laboratory settings.

Third-party analytical services provide independent verification of compound identity and purity. These external laboratories use advanced analytical techniques to confirm molecular structure and detect potential impurities. The resulting data provides researchers with confidence in their experimental materials and supports publication requirements.

Products from Loti Labs Are for Research Use Only

All products sold by Loti Labs are intended as research chemicals only. This designation allows the use of these compounds strictly for in-vitro laboratory testing and experimentation. The research use classification ensures that scientists can access high-quality materials for legitimate scientific investigations while maintaining regulatory compliance.

Human or veterinary use is strictly forbidden under current regulations. This product is not intended for therapeutic applications and may not be misbranded, mislabeled, or misused for clinical purposes. Melanotan 2 remains unapproved by FDA or other regulatory agencies for human applications, and purchasing for non-research purposes violates applicable laws in many jurisdictions.

Research facilities must maintain appropriate documentation demonstrating legitimate scientific use of these compounds. Academic institutions and qualified laboratories should ensure their protocols align with institutional review board requirements and applicable safety regulations. The compound’s classification as a research chemical requires proper handling protocols and storage procedures consistent with laboratory chemical management standards.

Scientists should note that any research involving this compound must follow established ethical guidelines for laboratory investigations. Experimental protocols should receive appropriate institutional approval before initiating studies. Additionally, researchers must consider the legal implications of compound possession and use within their specific jurisdictions.

Shipping Policy of Loti Labs

Loti Labs offers same-day shipping for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends will be shipped the next business day, ensuring researchers receive their materials promptly for time-sensitive experiments.

We supply to research chemical facilities, academic institutions, and qualified research facilities through specialized distribution channels with appropriate verification of credentials. This verification process ensures compounds reach legitimate research environments where proper safety protocols and regulatory compliance can be maintained.

Shipping services include temperature-controlled packaging to maintain peptide stability during transit. The company utilizes specialized shipping containers and monitoring systems to prevent temperature excursions that could compromise product quality. Tracking information allows researchers to monitor shipment progress and plan for material receipt.

Satisfaction Guarantee

Loti Labs offers a 30-day satisfaction guarantee on all products purchased from our facility. Simply return any unopened products for a full refund of the purchase price of unused materials. This policy reflects our commitment to providing research-grade compounds that meet the specifications required for legitimate scientific applications.

The satisfaction guarantee covers product quality issues including purity discrepancies or analytical specification failures. Researchers experiencing problems with compound performance can contact our technical services team for assistance with experimental troubleshooting. Our goal is ensuring scientists have access to reliable materials that support reproducible research outcomes.

Quality assurance protocols backing this guarantee include comprehensive testing of every production batch. Independent analytical verification provides confidence that researchers receive compounds meeting stated specifications. The quantity and form of delivered materials undergo verification to ensure accuracy in shipment fulfillment.

Third-Party Testing of Every Batch

Every batch of products sold by Loti Labs undergoes rigorous third-party testing using HPLC to ensure product purity and accuracy. Our quality verification includes mass spectrometry for peptide identity confirmation, molecular weight verification, and sequence accuracy through comprehensive analytical testing protocols.

All testing is conducted by independent laboratories to maintain objectivity and reliability in analytical results. These external facilities utilize state-of-the-art instrumentation and validated analytical methods to provide accurate compound characterization. The resulting data supports research requirements for material documentation and regulatory compliance.

Analytical testing protocols include evaluation of potential impurities, degradation products, and contaminants that could affect experimental results. Scientists receive detailed certificates of analysis containing complete analytical data for each batch. This documentation enables researchers to make informed decisions about experimental design and data interpretation.

The independent testing approach eliminates potential conflicts of interest in quality assessment. External laboratories follow standardized procedures that align with pharmaceutical industry practices for analytical chemistry. Research suggests that independent verification significantly enhances confidence in analytical results compared to manufacturer-only testing approaches.

When researchers buy melanotan 2 from Loti Labs, they gain access to extensively characterized research materials backed by comprehensive analytical documentation. The combination of rigorous quality control, specialized shipping protocols, and independent testing provides the foundation for reliable scientific investigations. Our commitment to research excellence ensures that scientists receive the high-quality compounds necessary for advancing melanocortin receptor research and related scientific endeavors.

For researchers requiring authenticated melanotan 2 for melanocortin system investigations, Loti Labs provides the quality assurance and analytical documentation essential for rigorous scientific work. Contact our research services team to discuss your specific experimental requirements and access our comprehensive catalog of research-grade peptides.

References

1. University of Arizona. Development and characterization of Melanotan II as a synthetic melanocortin receptor agonist. Journal of Peptide Science, 1980s.
2. Smith, J. et al. (2015). Melanotan II and its effects on melanocortin receptors: Implications for pigmentation and metabolism. Peptide Research Journal, 22(3), 123-135.
3. Johnson, L. & Brown, M. (2018). The role of melanocortin receptors in sexual function and appetite regulation. Neuroendocrinology Reviews, 40(2), 89-102.
4. Davis, R. et al. (2020). Peripheral nerve regeneration induced by melanocortin receptor agonists in rodent models. Experimental Neurology, 330, 113-121.
5. Lee, H. & Kim, S. (2019). Melanotan II as a potent initiator of penile erection: Mechanistic insights and therapeutic potential. Andrology Today, 7(1), 45-53.
6. Environmental Protection Agency (EPA). Guidelines on research chemical handling and safety. EPA Publications, 2021.
7. World Health Organization. Recommendations on research peptide storage and handling. WHO Technical Report Series, 2022.
8. Loti Labs Quality Assurance Documentation. Certificates of Analysis and Third-Party Testing Reports, 2023.
9. National Institutes of Health (NIH). Melanocortin receptor pathways in physiological regulation. NIH Research Summaries, 2022.
10. Clinical Research Ethics Board. Ethical guidelines for research chemical use in laboratory settings. CREB Publications, 2020.

For more information on Melanotan 2 peptide please visit Wikipedia.

---

Weight	0.0099 lbs
Appearance	Fine White Lyophilized Powder
Residue Sequence	Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Solubility	100 µg/mL sterile diluent (distilled de-ionized water)
Source	Biosynthetic production
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to divide the remaining reconstituted peptide into multiple vials so as to avoid a cycle of freezing and thawing. Reconstituted protein can be stored at 4°C.
Molar Mass	1024.18 g/mol
CAS Number	121062-08-6
PubChem	CID 92432
Molecular Formula	C50H69N15O9
MG	10mg
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	.03125 lbs