Tamoxifen Citrate 20mg/ml (30ml)

Buy Tamoxifen Liquid at Loti Labs: Research-Grade SERM Formulations

Research scientists investigating selective estrogen receptor modulator mechanisms need access to precisely formulated compounds that meet laboratory standards. When labs buy tamoxifen liquid for experimental protocols the quality and documentation of the chemical formulation is key to getting reliable and reproducible results. Tamoxifen citrate is a benchmark SERM compound that has tissue specific effects that makes it invaluable for studies on estrogen receptor interactions across different biological systems.

The liquid form of tamoxifen gives researchers more flexibility in experimental design, allows for precise concentration adjustments and simplified administration protocols compared to solid forms. This is particularly useful in dose response studies where accuracy and reproducibility is crucial for scientific conclusions.

Molecular Structure of Tamoxifen

The foundation of tamoxifen research is understanding its molecular composition. Research grade tamoxifen has the following specifications:

Chemical Name: (Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine

Molecular Formula: C26H29NO·C6H8O7 (as citrate salt)

Molecular Weight: 563.6 g/mol

PubChem CID: 2733526

CAS Number: 54965-24-1

The triphenylethylene core is the critical component for tamoxifen’s SERM activity. The (Z)-isomer is important for antagonist activity at estrogen receptors, a detail that is important for laboratory researchers studying receptor binding. When scientists buy tamoxifen liquid from a reputable supplier they get formulations that maintain this isomeric form so results are consistent across all protocols.

The citrate salt formulation improves solubility and stability in aqueous solutions. This molecular arrangement allows the compound to stay dissolved in various solvents commonly used in laboratory settings including ethanol, methanol and water based solutions designed for specific experimental requirements.

Mechanism of Action

Tamoxifen is a selective estrogen receptor modulator that can act as both an antagonist and agonist depending on the tissue environment. In breast tissue it is an antagonist, competitively binding to estrogen receptors and preventing natural estrogen from triggering cellular responses. This tissue specific action makes tamoxifen very useful for researchers studying hormone dependent cellular mechanisms and breast cancer cell biology.

The liquid form gives researchers more precision in experimental dosing protocols. Unlike solid forms that may vary in dissolution rates, liquid tamoxifen gives consistent bioavailability in in vivo studies and uniform concentration in cell culture applications. Research has shown that this consistency is key to establishing dose response relationships in experimental settings.

Laboratory studies on the active metabolite formation of tamoxifen have used liquid forms to control pharmacokinetic variables. The compound is metabolized in the liver, where the liver converts tamoxifen into various metabolites that may have different receptor binding affinities. Researchers studying these metabolic pathways benefit from the precise dosing control of liquid forms.

Tamoxifen also has different effects across different tissues, it is a partial agonist in bone tissue and an antagonist in breast tissue. This tissue selectivity has led to extensive research on SERM mechanisms and has prompted studies on tamoxifen in bone density and endometrial tissue research.

Research Studies

Tamoxifen is one of the most studied SERM compounds in scientific literature, with research applications across multiple biological systems and experimental models. Laboratory have used tamoxifen in both in vitro cell culture studies and in vivo animal models to study estrogen receptor signaling pathways and cellular response mechanisms.

Research grade tamoxifen solutions are formulated in various solvents to optimize experimental conditions. Scientists studying breast cancer cells often use tamoxifen in DMSO or ethanol to achieve the desired working concentration in culture media. The liquid form allows for accurate serial dilutions and consistent experimental conditions across multiple research protocols.

Transgenic research has used tamoxifen extensively in Cre-Lox recombination systems where the compound is used to activate Cre recombinase activity in conditional knockout mouse models. These studies require precise timing and dosing, making liquid tamoxifen formulations very useful for reproducible results. The ability to administer exact concentrations ensures that gene activation occurs at specific time points, critical for developmental biology research.Cancer research has used tamoxifen to study apoptosis in hormone dependent tumor models. Studies on cellular response pathways have shown that tamoxifen treatment can affect cell cycle and programmed cell death in specific cancer cell lines. Research has shown that these effects may vary depending on the cellular environment and concurrent treatment conditions.

Prevention studies in high risk populations have provided valuable data on tamoxifen’s protective effects against breast cancer. Laboratory models of these protective mechanisms have used liquid tamoxifen to establish treatment protocols and dose response.

Storage and Safety

Proper storage protocols ensure tamoxifen liquid remains chemically stable and research grade throughout its shelf life. The recommended storage conditions are room temperature (20-25°C) in tightly sealed containers protected from direct light and moisture.

Temperature control is critical for tamoxifen’s molecular stability. Freezing can cause precipitation or crystallization that can alter the compound’s solubility, while excessive heat can promote degradation reactions that reduce the active compound concentration. Research facilities should have standard operating procedures for chemical storage that includes temperature monitoring and containment.

Light protection is another important storage consideration as tamoxifen is photosensitive and can degrade over time. Loti Labs packages tamoxifen liquid in light resistant containers to prevent photodegradation during storage and handling. Laboratories should continue this protection by storing opened containers in dark environments and minimizing light exposure during experimental procedures.

The FDA has issued important safety considerations for tamoxifen that research facilities should include in their safety protocols. These include awareness of uterine malignancies and thromboembolic events that have been associated with tamoxifen in clinical studies. While these apply primarily to therapeutic use, research facilities should have safety measures and documentation when handling tamoxifen compounds.

Laboratory personnel should follow established protocols for handling research chemicals, including personal protective equipment and storage procedures. Avoid skin and mucous membrane contact and direct any questions to qualified safety personnel.

Why Buy from Loti Labs

Loti Labs provides pharmaceutical grade tamoxifen citrate liquid that exceeds research grade standards. Our tamoxifen formulations are HPLC verified to 99% purity or better to ensure researchers receive compounds suitable for the most demanding protocols. This level of purity is critical when even small impurities can affect experimental outcomes or compromise data.The standard concentration of 20 mg/ml provides researchers with a convenient working strength that can be easily diluted to achieve desired experimental concentrations. For labs that require different concentrations, Loti Labs offers custom formulation services to produce tamoxifen liquid at specific concentrations to meet individual research needs. This flexibility allows research teams to optimize their protocols without being limited by standard formulation.

Each batch of tamoxifen liquid includes comprehensive certificates of analysis that document purity profiles, concentration verification and stability parameters. These certificates provide researchers with the documentation required for regulatory compliance and experimental validation. The detailed analytical data supports research integrity and confidence in experimental results.

Quality control extends beyond initial formulation to packaging considerations to preserve product integrity. Tamoxifen formulations are packaged in light resistant containers to prevent degradation during storage and shipping. This attention to packaging details ensures researchers receive products that meet specifications from production to use.

The company’s focus on research grade quality distinguishes its products from those intended for other applications. This specialization ensures researchers receive compounds optimized for lab use, with purity and documentation for scientific research requirements.

Products from Loti Labs are for Research Use Only

All tamoxifen liquid products sold by Loti Labs are for research use only and not for human or veterinary therapeutic use. This designation aligns with regulatory frameworks for laboratory chemicals and ensures products are properly classified for use in research settings.

The research use only status provides labs with access to high quality chemical formulations while keeping clear boundaries on use. This classification allows researchers to use tamoxifen in controlled experimental environments without the regulatory constraints of pharmaceutical products for therapeutic use.

Research institutions must ensure tamoxifen compounds are used only for lab use and not confused with pharmaceutical grade products for clinical use. Proper labeling and storage protocols will maintain this distinction and prevent any confusion on the product’s use.

The product catalog includes detailed specs and handling information to support use in research environments. Scientists need assistance with product selection or application questions should contact Loti Labs’ technical support for guidance on use protocols.

Shipping Policy of Loti Labs

Loti Labs has efficient shipping protocols to ensure product integrity during transit and meet the time sensitive needs of research institutions. Orders placed before 1 PM EST Monday through Friday will be processed and shipped the same day to minimize project delays.Orders received after the daily cutoff time or on weekends will be processed and shipped the next business day to maintain consistent handling protocols regardless of order timing. This will allow research institutions to plan their procurement schedules and anticipate delivery timeframes for ongoing projects.

All tamoxifen liquid formulations are carefully packaged to maintain chemical stability during shipping. The packaging protocols consider temperature control, light protection and physical protection to ensure products arrive in optimal condition for immediate use in research applications.

Research institutions can submit purchase orders through established procurement channels with proper documentation and credentials verified through secure ordering systems. This will accommodate institutional purchasing requirements while maintaining security and compliance standards.

Custom formulations requiring special testing protocols typically take 7-14 days for production and quality verification. This allows for complete analytical testing and documentation preparation to ensure custom products meet the same quality standards as standard formulations.

Satisfaction Guarantee

Loti Labs offers a 30 day satisfaction guarantee on all products. Researchers can return unopened products for a full refund if the formulation does not meet their experimental requirements. This guarantee gives research institutions confidence in their procurement decisions and reduces the risk of trying new suppliers or formulations.

The guarantee is especially valuable for research institutions ordering bulk quantities or establishing long term supply relationships. Institutions can evaluate product quality and suitability for their specific research applications while having the option to return products that do not meet their expectations.

All products are tested rigorously before shipping including analytical verification and stability testing. This comprehensive testing protocol ensures researchers receive products that meet or exceed specified quality parameters and reduces the chance of product related experimental issues.

Research institutions requiring special guarantee terms for bulk purchases or extended studies can contact customer service for custom arrangements. The company is flexible in addressing unique institutional needs to support diverse research requirements.

The guarantee only applies to unopened products, emphasizing the importance of initial product evaluation before use in experimental protocols. This protects both the researcher and the supplier while ensuring returned products remain in their original condition for potential resale.

Third Party Testing of Every Batch

Every batch of tamoxifen liquid is tested by third party HPLC to verify purity and concentration. This independent testing protocol ensures products meet specifications and gives researchers confidence in the analytical data supporting their research.

Third party testing eliminates potential conflict of interest in quality assessment and provides additional validation of product specifications. Independent labs use calibrated instruments and validated methods to ensure results meet industry standards for analytical accuracy.Each batch comes with a certificate of analysis that documents purity, concentration and absence of significant impurities. This is important for researchers working under Good Laboratory Practice (GLP) or other regulatory frameworks that require detailed analytical data.

Batch to batch consistency is a critical factor in maintaining experimental reproducibility across long term research projects. The consistent testing protocols and quality standards ensure researchers can rely on uniform product characteristics regardless of when they purchase or which batch they receive.

Research institutions can request specific testing parameters for custom formulations to have tailored analytical protocols for their unique experimental requirements. This flexibility ensures specialized research applications get the right analytical support while maintaining the company’s standard quality control protocols.

References and Citations

The extensive literature on tamoxifen as a selective estrogen receptor modulator provides researchers with a wealth of information for experimental design and interpretation. Scientific publications have described tamoxifen’s mechanism of action in various tissue types and experimental models, which is useful for new research applications.

Clinical studies on tamoxifen in breast cancer treatment and prevention have generated a lot of data on the compound’s pharmacology and tissue specific activities. While these studies are focused on therapeutic applications, they provide important mechanistic insights for basic research applications and experimental protocol development.

Lab studies on tamoxifen’s role in estrogen receptor signaling pathways have used various experimental models to characterize the compound’s molecular mechanisms. These studies have contributed to understanding SERM selectivity and identified key factors that influence tissue specific responses to tamoxifen treatment.

Research on tamoxifen’s metabolic pathways and the activity of its active metabolite has provided insights into factors that may impact experimental outcomes. Understanding these metabolic considerations helps researchers design appropriate experimental controls and interpret results in the context of compound pharmacokinetics.

Studies using tamoxifen in transgenic mouse models have established protocols for conditional gene expression systems that rely on tamoxifen-inducible Cre recombinase activity. These applications have expanded tamoxifen’s use in developmental biology and genetics research, demonstrating the compound’s versatility across different research disciplines.

When researchers buy tamoxifen liquid from Loti Labs, they get not only high quality research compounds but also technical support and documentation to ensure experimental success. The combination of product quality, analytical data and customer support is a complete resource for scientists studying SERM mechanisms and related research questions. For more information or assistance with product selection, research institutions can contact Loti Labs directly to discuss their specific experimental requirements and get the right product for their research applications.##

References

1. Jordan VC. Tamoxifen: a pioneering medicine in breast cancer treatment and prevention. Nat Rev Drug Discov. 2003;2(3):205-213. doi:10.1038/nrd1035
2. Howell A, Osborne CK, Morris C, Wakeling AE. ICI 182,780 (Faslodex): development of a novel antiestrogen. Cancer. 2000;89(4):817-825. doi:10.1002/(SICI)1097-0142(20000815)89:4<817::AID-CNCR21>3.0.CO;2-8
3. McDonnell DP, Wardell SE. The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug development in breast cancer. Curr Opin Pharmacol. 2010;10(6):620-628. doi:10.1016/j.coph.2010.08.004
4. Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998;90(18):1371-1388. doi:10.1093/jnci/90.18.1371
5. Loti Labs. Tamoxifen Liquid Product Information and Safety Data. 2024.
6. U.S. Food and Drug Administration. Tamoxifen (Nolvadex) Drug Safety Information. 2024.
7. Yildiz A, Guleryuz S, Ankerst DP, et al. Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen. Arch Gen Psychiatry. 2008;65(3):255-263. doi:10.1001/archgenpsychiatry.2007.29
8. Jordan VC. Selective estrogen receptor modulation: concept and consequences in cancer. Cancer Cell. 2004;5(3):207-213. doi:10.1016/S1535-6108(04)00049-8
9. Bayview Pharmacy. Tamoxifen Citrate 6 mg/ml Oral Liquid – Compounded Solution. 2024.10. Bayview Pharmacy. Tamoxifen Citrate 6 mg/ml Oral Liquid – Compounded Solution. 2024.

For more information on Tamoxifen Citrate visit Wikipedia.

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Weight	0.1875 lbs
Appearance	Viscous cloudy liquid
Stability	Room Temperature out of direct sunlight
Molar Mass	563.7
CAS Number	54965-24-1
Container	30ml Bottle
Molecular Formula	C32H37NO8
Concentration	20mg per ML
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.156 lbs