Survodutide 10mg

Buy Survodutide at Loti Labs

Research into metabolic disorders has revealed promising compounds that target multiple pathways simultaneously. Survodutide represents a significant discovery in this field as a dual receptor agonist with robust anti obesity efficacy demonstrated in preclinical studies. This synthetic peptide has garnered attention from researchers studying obesity and metabolic health due to its unique mechanism of action and enhanced stability profile.

When researchers seek to buy survodutide for their laboratory investigations, understanding its molecular characteristics and research applications becomes essential. The compound’s design addresses limitations found in naturally occurring peptides while offering extended pharmacokinetics suitable for research protocols. Our website provides comprehensive information about this research compound to support scientific discovery and experimental work.

Molecular Structure of Survodutide

The molecular architecture of survodutide reflects sophisticated peptide engineering designed to overcome stability challenges common in metabolic research compounds. This 29-amino-acid acylated peptide incorporates a C18 fatty acid chain that confers remarkable proteolytic resistance and extended residence time in research models.

Key Molecular Specifications:

Property	Value
Amino Sequence	29-amino-acid acylated peptide
Fatty Acid Chain	C18 with enhanced proteolytic stability
Molecular Formula	C192H289N47O61
Molecular Weight	4,231.62 g/mol
CAS Number	2805997-46-8
PubChem CID	N/A
The structural modifications include C-terminal amidation and Ac4c (amino cyclobutyric acid) substitution at position 2, which research suggests significantly enhances resistance to enzymatic degradation. This careful molecular design allows the compound to maintain integrity in research environments where other peptides might degrade rapidly.

The C18 fatty acid chain enables reversible albumin binding, a feature that research indicates extends the compound’s half-life to approximately 109-115 hours in preclinical models. This extended stability makes survodutide particularly valuable for researchers conducting longer-term studies on metabolic pathways.

Mechanism of Action

Survodutide (BI 456906) functions as a potent dual agonist targeting both the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R). Research demonstrates this compound exhibits EC50 values of 0.52 nM for GCGR and 0.33 nM for GLP-1R, indicating high binding affinity for both receptor types.

The dual receptor activation produces distinct physiological responses that researchers have documented in laboratory studies. GLP-1 receptor activation primarily influences satiety pathways and food intake regulation through central nervous system mechanisms. Meanwhile, glucagon receptor engagement promotes increasing energy expenditure through hepatic glucose production and thermogenic processes.

Research suggests that this dual mechanism provides advantages over single-receptor agonists in laboratory models. Studies comparing survodutide to semaglutide (a selective GLP-1 agonist) in diet induced obese mice revealed superior weight reduction at maximally effective concentrations. The enhanced efficacy appears to result from the additional energy expenditure component provided by glucagon receptor activation.

Importantly, research indicates that glucagon receptor activation by survodutide does not produce significant hyperglycemia in experimental models, likely due to the balancing effects of simultaneous GLP-1 receptor engagement. This balanced pharmacological profile represents a carefully engineered approach to metabolic pathway modulation.

The compound’s mechanism involves multiple metabolic processes:

• Appetite regulation: Through central GLP-1 pathways affecting food intake
• Energy metabolism: Via glucagon-mediated increases in energy expenditure
• Glucose homeostasis: Through balanced receptor activation
• Fat oxidation: Enhanced metabolic efficiency in research models

Research Studies

Preclinical investigations have provided extensive data on survodutide’s pharmacological properties and biological activity. Research demonstrates that this compound reduces body weight and plasma glucagon levels in a dose-dependent manner across multiple animal models.

Pharmacokinetic studies reveal impressive residence times that support the compound’s research utility. In laboratory mice, survodutide exhibits a 44-hour residence time, while canine models show extended activity lasting 140 hours. These findings reflect the compound’s albumin-binding properties and enhanced metabolic stability.

Research suggests that survodutide’s weight management effects result from both decreasing food intake and increasing energy expenditure, mirroring the dual activities of its receptor targets. Studies have documented enhanced fat oxidation and improved satiety responses in experimental models, providing researchers with multiple metabolic endpoints to evaluate.

Key Research Findings:

• Dose-dependent body weight reduction in laboratory models
• Enhanced satiety responses through central nervous system pathways
• Increased fat oxidation contributing to energy balance
• Sustained pharmacological activity over extended time periods
• Superior efficacy compared to single-receptor agonists in comparable studies

Cardiovascular monitoring in research models has shown modest heart rate increases (2.3-7.3 bpm mean increase) without associated arrhythmias or adverse cardiovascular events in the study populations. This safety profile supports continued research applications and experimental protocols.

Current Phase 3 clinical trials continue to investigate the compound’s properties, with ongoing studies examining cardiovascular outcomes and long-term effects in human subjects. These investigations will provide additional data to support research applications and scientific understanding.

Storage and Safety

Proper storage and handling protocols are essential for maintaining survodutide’s integrity and research quality. Loti Labs supplies this compound as a freeze-dried, lyophilized powder under vacuum seal to protect against degradation and ensure optimal stability for laboratory use.

Storage Requirements:

• Format: Freeze-dried lyophilized powder
• Environment: Vacuum-sealed containers for stability
• Temperature: Cold chain storage recommended
• Handling: Follow supplier specifications for reconstitution

Solubility characteristics make survodutide versatile for various research applications. The compound demonstrates high solubility in DMSO at concentrations up to 100 mg/ml, making it suitable for stock solution preparation. In phosphate-buffered saline (PBS) at pH 7.2, survodutide maintains solubility at concentrations up to 10 mg/ml.

Reconstitution procedures should follow specific supplier recommendations to ensure compound integrity. Researchers should use appropriate solvents and maintain cold chain storage conditions throughout the preparation and storage process. Proper handling prevents degradation that could compromise experimental results and research quality.

Important Safety Considerations:

• Research Use Only: This compound is intended strictly for laboratory research
• Not for Human Use: Cannot be used for diagnostic or therapeutic purposes
• Laboratory Protocols: Follow institutional safety guidelines for peptide handling
• Quality Control: Verify purity and identity before use in experiments

The compound’s stability profile supports extended research projects when stored appropriately. However, researchers should verify the integrity of each batch through appropriate analytical methods before beginning experimental work.

Benefits of Buying from Loti Labs

Loti Labs provides survodutide in high-purity freeze-dried format with verified potency and comprehensive documentation. Our product quality standards ensure researchers receive compounds suitable for rigorous scientific investigation into obesity and metabolic disorders.

Quality Assurance Features:

• High Purity: Verified through third-party testing protocols
• Detailed Documentation: Complete molecular and handling information
• Competitive Pricing: Cost-effective compared to other suppliers
• Research Focus: Specifically intended for laboratory applications

Our stock maintains consistent quality through rigorous batch testing and proper storage conditions. Each product undergoes comprehensive analysis to verify identity, purity, and potency before shipment. This quality control process ensures researchers receive compounds that meet their experimental requirements.

The freeze-dried format provides stability advantages for research applications. This preparation method preserves the compound’s integrity during storage and shipment while maintaining reconstitution properties suitable for various experimental protocols. Researchers can add the compound to their cart with confidence in product quality and consistency.

Research Applications:

• Metabolic pathway studies
• Obesity mechanism research
• Dual receptor agonist investigations
• Pharmacokinetic studies
• Comparative efficacy research

Our team understands the importance of reliable research compounds for scientific discovery. We maintain detailed product information and provide technical support to ensure researchers can effectively incorporate survodutide into their experimental protocols.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are intended as research chemicals only. This designation allows the use of these compounds strictly for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly forbidden. These products are not substances intended for food or cosmetic use and may not be misbranded, mislabeled, or misused as such.

The research use only classification ensures compliance with regulatory requirements while supporting legitimate scientific investigation. Researchers must understand that these compounds are not approved for any therapeutic applications and should only be used in controlled laboratory environments by qualified personnel.

Our commitment to research compliance protects both our customers and the scientific community. We provide detailed labeling and documentation to ensure proper use and handling of all research compounds. This approach supports the integrity of scientific research while maintaining adherence to applicable regulations.

Shipping Policy of Loti Labs

Loti Labs offers same day shipping for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends will be shipped the next business day. Our efficient shipping process ensures researchers receive their compounds promptly to support their experimental timelines.

Our packaging methods protect compound integrity during transit. We use appropriate shipping containers and temperature control measures to maintain product quality from our facility to your laboratory. This attention to shipping details ensures that researchers receive compounds in optimal condition for their research applications.

Tracking information is provided for all shipments, allowing researchers to monitor their orders and plan their experimental schedules accordingly. Our shipping partners are selected based on their reliability and ability to maintain proper handling conditions throughout the delivery process.

Satisfaction Guarantee

Loti Labs offers a 30 day satisfaction guarantee on all products purchased from us. Simply return any unopened products to us for a full refund of the purchase price of the unused products. This guarantee reflects our confidence in product quality and our commitment to researcher satisfaction.

Our return policy recognizes that research requirements can change and that product quality is essential for successful experimentation. We make the return process straightforward to minimize disruption to research activities while ensuring customer satisfaction.

To initiate a return, researchers can contact our customer service team via email or through our website. We provide clear instructions and support throughout the return process, making it easy for customers to resolve any product concerns.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs undergoes rigorous third party testing using HPLC to ensure product purity and accuracy. We provide certificates of analysis verifying the identity, purity, and potency of our survodutide and all other research compounds.

This comprehensive testing approach ensures that researchers receive products that meet their experimental requirements. Our testing protocols examine multiple quality parameters, including molecular identity, purity levels, and stability characteristics. These analyses support reproducible research results and scientific confidence.

Certificates of analysis are available for review before purchase, allowing researchers to verify that our products meet their specific requirements. This transparency supports informed purchasing decisions and helps researchers select appropriate compounds for their studies.

Testing Parameters:

• Identity Verification: Molecular structure confirmation
• Purity Analysis: Quantitative purity assessment
• Potency Testing: Activity level verification
• Stability Assessment: Storage condition validation
• Contaminant Screening: Detection of impurities

Our testing partnership with accredited laboratories ensures that all analyses meet industry standards for research compounds. This rigorous approach to quality control sets our products apart and supports the kind of reliable research that advances scientific understanding.

Conclusion

Survodutide represents a promising advancement in metabolic research compounds, offering researchers a sophisticated tool for investigating dual receptor pathways and obesity mechanisms. Its unique molecular design, combining enhanced stability with potent dual agonist activity, makes it particularly valuable for studies examining the intersection of appetite regulation and energy expenditure.

When researchers choose to buy survodutide from Loti Labs, they gain access to high-quality compounds backed by comprehensive testing and documentation. Our commitment to research compliance, quality assurance, and customer satisfaction ensures that scientists receive the reliable materials necessary for advancing their experimental work.

The compound’s demonstrated efficacy in preclinical models, combined with its favorable pharmacokinetic profile, positions survodutide as an important research tool for metabolic studies. As phase 3 clinical trials continue to provide additional data, researchers can use this compound to explore fundamental questions about metabolic regulation and therapeutic target validation.

For researchers ready to incorporate survodutide into their experimental protocols, our website provides easy ordering through our secure cart system. Simply click to add this compound to your research inventory and begin exploring its potential in your laboratory investigations. Our team stands ready to support your research goals with quality compounds and reliable service.

The future of metabolic research depends on access to sophisticated compounds like survodutide that can reveal new insights into complex biological pathways. By choosing Loti Labs as your supplier, you join a community of researchers committed to advancing scientific discovery through rigorous experimentation and high-quality research materials.

References

1. Zimmermann, T., et al. “BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy.” Molecular Metabolism, vol. 66, Dec. 2022, 101633.
2. MedChemExpress. “Survodutide (BI 456906) | GCGR/GLP-1R Agonist.” https://www.medchemexpress.com/survodutide.html
3. Modern Peptides. “Survodutide.” https://modernpeptides.com/product/survodutide/
4. BioSynth. “Survodutide acetate | 2805997-46-8.” https://www.biosynth.com/p/PS00010/2805997-46-8-survodutide
5. Cayman Chemical. “Survodutide (CAS 2805997-46-8).” https://www.caymanchem.com/product/40972/survodutide

Weight	.03125 lbs