SS-31 10mg

Buy SS-31 at Loti Labs: Premium Research-Grade Mitochondrial Peptide

When researchers buy SS-31 for mitochondrial studies, the quality and purity of this specialized peptide directly influences experimental outcomes and data integrity. SS-31, also known as Elamipretide, has emerged as a critical research compound for scientists investigating mitochondrial function, cellular energy production, and oxidative stress mechanisms in laboratory settings.

This comprehensive guide examines the molecular properties, research applications, and purchasing considerations for SS-31, specifically focusing on the high-purity formulations available through Loti Labs. Understanding these factors helps researchers make informed decisions when selecting suppliers for their mitochondrial research protocols.

Molecular Structure of SS-31

SS-31 represents a precisely engineered tetrapeptide designed for mitochondrial research applications. The compound’s molecular architecture reflects years of development aimed at creating an effective research tool for studying cellular energy mechanisms.

Key Molecular Properties:

Property	Specification
Amino Sequence	D-Arg-Dmt-Lys-Phe-NH₂
Molecular Formula	C₃₃H₄₃N₇O₅
Molecular Weight	639.8 g/mol
PubChem CID	91810664
CAS Number	1607237-34-4

The peptide sequence incorporates Dmt (2’,6’-dimethyltyrosine), which research suggests enhances stability and bioactivity in experimental systems. This structural modification represents a major advancement in peptide design, as scientists have found that the Dmt residue significantly improves the compound’s resistance to enzymatic degradation during laboratory studies.

The molecular architecture features both basic residues (D-Arg, Lys) and aromatic components (Dmt, Phe), creating optimal conditions for interacting with mitochondrial membrane components in research models. This specific arrangement allows researchers to study how peptides can selectively target mitochondrial structures while maintaining integrity throughout experimental protocols.

 

Mechanism of Action

SS-31’s research applications center on its unique ability to interact with cardiolipin, a phospholipid found exclusively in the inner mitochondrial membrane. This selective binding mechanism makes SS-31 a valuable research tool for scientists studying mitochondrial function and cellular energy processes.

Cardiolipin Binding and Mitochondrial Targeting

Research demonstrates that SS-31 specifically binds to cardiolipin through electrostatic and hydrophobic interactions. This binding mechanism allows researchers to study how compounds can stabilize mitochondrial cristae structure, which plays a crucial role in maintaining the architecture necessary for efficient electron transport chain operation.

Studies in laboratory models show that SS-31’s interaction with cardiolipin helps maintain mitochondrial membrane integrity during oxidative stress conditions. This mechanism provides researchers with a tool to investigate how mitochondrial health can be preserved under various experimental stress conditions.

Effects on Cellular Energy Production

Scientists studying energy production have found that SS-31 influences several key mitochondrial processes:

• ATP Production Enhancement: Research suggests SS-31 improves electron transport chain efficiency, leading to increased ATP synthesis in experimental models
• Redox Homeostasis: Laboratory studies indicate the peptide acts as an effective scavenger of reactive oxygen species, reducing oxidative damage in mitochondria
• Membrane Potential Maintenance: Research shows SS-31 reduces proton leak across the inner mitochondrial membrane, helping maintain optimal energy efficiency

The compound’s interaction with ADP/ATP translocase (ANT) represents another major research focus. Scientists have observed that SS-31 modulates ANT function without inhibiting its primary transport activity, distinguishing it from other compounds that affect mitochondrial membrane permeability.

Autophagy and Cell Death Pathways

Emerging research suggests SS-31 influences autophagy mechanisms and apoptosis pathways in experimental models. Studies in aged mice have shown that the peptide affects cellular maintenance processes, though the exact mechanisms require further investigation. This research area holds potential for understanding how mitochondrial dysfunction contributes to age-related cellular changes.

Research Studies

Current laboratory investigations of SS-31 span multiple research domains, with scientists exploring its effects across various experimental models and conditions. The breadth of research applications demonstrates the peptide’s versatility as a research tool for studying mitochondrial dysfunction and cellular energy processes.

Cardiovascular Research Applications

Cardiac research represents one of the most extensively studied applications for SS-31. Scientists have conducted numerous studies examining the compound’s effects on heart function and cardiovascular diseases in laboratory models.

Research in ischemic heart models has shown that SS-31 helps preserve mitochondrial ultrastructure during ischemia-reperfusion events. Scientists studying Barth Syndrome models have observed improvements in cardiac contractility and restoration of mitochondrial architecture following SS-31 administration. Additionally, studies using failing human heart tissue samples have demonstrated improved mitochondrial respiration and enhanced complex I/IV activity after SS-31 treatment.

These findings provide researchers with valuable insights into how mitochondrial-targeted compounds might influence cardiac function at the cellular level. The research specifically focuses on understanding the mechanisms through which mitochondrial health impacts overall cardiovascular function.

Renal Protection Studies

Kidney research has revealed promising applications for SS-31 in studying acute kidney injury models. Scientists have observed significant reductions in proteinuria and preservation of podocyte function in laboratory studies examining renal protection mechanisms.

Research suggests that SS-31’s protective effects in kidney models result from its ability to maintain mitochondrial function during oxidative stress conditions. This research has particular relevance for understanding how mitochondrial dysfunction contributes to kidney damage and how targeted interventions might preserve renal function.

Neurological Research Applications

Neuroprotection research represents another major area of SS-31 investigation. Scientists studying neurocognitive disorders, including perioperative neurocognitive disorder and LPS-induced memory impairment, have found that SS-31 influences several neurological parameters in animal models.

Laboratory studies have shown that SS-31 treatment results in:

• Restored synaptic protein levels in experimental models
• Improved performance in cognitive assessment protocols
• Reduced neuroinflammation markers
• Enhanced neurotrophic support through BDNF signaling pathways
• Increased synaptic spine density in brain tissue samples

These research findings suggest that improving mitochondrial function through SS-31 administration affects multiple aspects of neurological health in experimental systems. Scientists have observed quantitative effects including 20-60% reductions in oxidative stress markers and restoration of ATP production in brain tissue samples.

Aging and Cellular Research

Studies in aging research have provided insights into how SS-31 affects age-related mitochondrial changes. Research in aged mice has demonstrated that the compound can counteract age-related increases in mitochondrial proton leak and dysfunction, potentially restoring mitochondrial efficiency in aging tissues.

Scientists studying cellular protection mechanisms have found that SS-31 provides broad cytoprotective effects in various cell types. Research has shown protection of microglia from LPS-induced oxidative stress and inflammation, suggesting potential applications in studying age-related cellular decline.

Specialized Research Applications

Emerging research areas include studies on chemotherapy induced cachexia, where scientists are investigating how mitochondrial dysfunction contributes to muscle wasting and whole body energy status changes. Research suggests that SS-31 might provide a valuable tool for understanding the mechanisms underlying treatment-related metabolic changes.

Other specialized applications include research on leukocyte endothelium interactions and their relationship to mitochondrial health, as well as studies examining how body energy status affects immune function and inflammatory responses.

Storage and Safety

Proper handling and storage protocols are essential when researchers buy SS-31 for laboratory applications. The peptide’s stability and integrity directly impact experimental results, making adherence to storage guidelines crucial for maintaining research quality.

Storage Requirements

SS-31 arrives as a lyophilized powder, a form that provides maximum stability for long-term storage. Research laboratories should maintain the following storage conditions:

• Long-term storage: -20°C in a desiccated environment
• Reconstituted solutions: 2-8°C refrigeration for up to 30 days
• Handling protocols: Avoid repeated freeze-thaw cycles to maintain peptide integrity

The lyophilized form represents the optimal method for preserving SS-31’s molecular structure during storage. Scientists have found that this preparation method maintains peptide stability significantly longer than liquid formulations, making it the preferred form for research applications.

Laboratory Safety Protocols

Research laboratories using SS-31 should follow standard safety protocols for handling research chemicals:

• Use appropriate personal protective equipment including gloves, lab coats, and protective eyewear
• Perform all manipulations under aseptic conditions to prevent contamination
• Maintain proper documentation of handling procedures according to institutional guidelines
• Store in designated areas with appropriate temperature monitoring
• Follow applicable laws and institutional research compliance requirements

Reconstitution Guidelines

When preparing SS-31 solutions for experimental use, researchers should use sterile bacteriostatic water for reconstitution. The reconstituted solution maintains stability for approximately 30 days when properly refrigerated, though scientists should confirm optimal storage duration based on their specific experimental requirements.

Proper reconstitution techniques help ensure consistent results across experimental protocols. Research laboratories should establish standardized procedures for peptide preparation to maintain reproducibility in their studies.

Benefits of Buying from Loti Labs

Loti Labs provides SS-31 formulations specifically designed for research applications, with quality standards that meet the demanding requirements of scientific investigation. When researchers buy SS-31 from Loti Labs, they receive products that undergo rigorous quality control processes to ensure experimental reliability.

Purity and Quality Standards

Loti Labs supplies SS-31 at 99.32% purity with TFA (trifluoroacetic acid) removed, minimizing the risk of interference in research assays. This high purity level ensures that researchers can obtain reliable, reproducible results in their experimental protocols.

The removal of TFA represents a major advantage for research applications, as this compound can interfere with certain analytical methods and cellular assays. Scientists studying sensitive biological systems particularly benefit from TFA-free formulations, which eliminate potential confounding factors in experimental results.

Analytical Documentation

Each batch includes a comprehensive Certificate of Analysis that provides detailed information about:

• Peptide identity confirmation through HPLC and mass spectrometry
• Purity percentage verification
• Absence of contaminant peptides or small molecules
• Batch-specific analytical data

This documentation allows researchers to maintain detailed records of the compounds used in their studies, supporting the reproducibility and validity of research findings. Scientists can reference these analytical reports when preparing publications or regulatory submissions.

Manufacturing Standards

Research-grade SS-31 from Loti Labs undergoes manufacturing under strict quality control conditions, ensuring batch-to-batch consistency. This consistency proves essential for researchers conducting longitudinal studies or multi-phase experiments requiring reliable compound performance.

The manufacturing process includes multiple quality checkpoints to verify that each batch meets established specifications. Scientists can rely on consistent product performance across different experimental timepoints and research protocols.

Competitive Pricing Options

Loti Labs offers competitive pricing structures that include quantity discounts for institutional purchases. This pricing approach makes SS-31 accessible for both individual research projects and larger institutional studies requiring significant compound quantities.

Academic and institutional researchers can benefit from volume pricing that reduces per-unit costs for extensive research programs. The pricing structure specifically supports long-term research initiatives that require consistent access to high-quality research compounds.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are strictly intended as research chemicals for laboratory investigation only. This designation allows the use of SS-31 exclusively for in-vitro laboratory testing and experimentation under controlled research conditions.

Regulatory Compliance

The research use only designation ensures compliance with applicable laws governing research chemical distribution and use. Human or veterinary use is strictly forbidden under these regulations, and the product cannot be used as a supplement, cosmetic, or therapeutic agent.

Scientists purchasing SS-31 must be at least 21 years of age and agree to comply with all institutional research guidelines and regulatory requirements. Research institutions must maintain appropriate documentation and oversight for all research chemical use.

Institutional Requirements

Purchasers must confirm that their intended use aligns with legitimate research purposes and institutional approval processes. This includes:

• Proper institutional review and approval for research protocols
• Compliance with laboratory safety and handling requirements
• Adherence to research ethics guidelines
• Proper waste disposal and documentation procedures

The terms of purchase require that researchers use SS-31 only within the scope of approved research activities and maintain appropriate records of compound use and disposal.

Legal and Ethical Considerations

The research use only framework protects both suppliers and researchers by establishing clear boundaries for appropriate compound use. Scientists must agree to use SS-31 only for legitimate research purposes and not for any human or veterinary applications.

This framework ensures that research compounds remain available for scientific investigation while preventing misuse that could compromise research integrity or violate regulatory requirements.

Shipping Policy of Loti Labs

Loti Labs maintains efficient shipping procedures designed to minimize delays and ensure product integrity during transport. The shipping policy accommodates both domestic and international research requirements while maintaining product quality standards.

Domestic Shipping Procedures

Orders placed before 1pm EST Monday through Friday receive same-day shipping, ensuring rapid delivery for time-sensitive research projects. Orders placed after 1pm EST or on weekends ship the next business day, maintaining predictable delivery schedules for research planning.

The shipping procedures include:

• Temperature-controlled packaging for peptide stability
• Tracking information for order monitoring
• Secure packaging to prevent contamination or damage
• Express shipping options for urgent research needs

International Shipping Options

International shipping is available with appropriate documentation to comply with import/export regulatory requirements. Research institutions outside the United States can access SS-31 through established international shipping channels that maintain product integrity during extended transport.

International orders require additional documentation to ensure compliance with customs and regulatory requirements in destination countries. Loti Labs works with research institutions to facilitate proper documentation and shipping procedures.

Payment and Ordering Options

Payment methods include major credit cards and institutional purchase orders, providing flexibility for both individual researchers and institutional purchasing departments. The ordering system accommodates various institutional requirements and procurement procedures.

Institutional purchase orders allow research organizations to maintain proper financial documentation and approval processes while accessing high-quality research compounds. The payment system supports both individual research projects and larger institutional research programs.

Satisfaction Guarantee

Loti Labs offers a 30-day satisfaction guarantee on all products, providing additional assurance for researchers evaluating product quality or adapting to changing study requirements. This guarantee demonstrates the company’s confidence in product quality and commitment to customer satisfaction.

Return Policy Details

The satisfaction guarantee allows researchers to return unopened products within 30 days for a full refund of the purchase price. This policy protects researchers from potential issues with product quality or changes in research direction that might affect compound requirements.

The return process includes:

• Simple return procedures for unopened products
• Full refund of unused product purchase price
• Customer service support for return questions
• Rapid processing of approved returns

Customer Service Support

A dedicated customer service team provides support for inquiries related to SS-31 research applications, returns, and technical information. This support helps researchers address questions about product handling, storage, or experimental applications.

Customer service representatives understand the technical requirements of research applications and can provide guidance on product selection, handling procedures, and compatibility with various experimental protocols.

Quality Assurance Commitment

The satisfaction guarantee reflects Loti Labs’ commitment to providing research-grade compounds that meet the demanding requirements of scientific investigation. This commitment ensures that researchers can buy SS-31 with confidence in product quality and company support.

The guarantee system provides researchers with recourse if products fail to meet expected quality standards, protecting research investments and maintaining laboratory productivity.

Third Party Testing of Every Batch

Every batch of SS-31 sold by Loti Labs undergoes rigorous third-party testing using HPLC analysis to ensure product purity and accuracy. This independent verification provides additional confidence in product quality beyond internal quality control measures.

Analytical Testing Procedures

The third-party testing protocol includes:

• High-Performance Liquid Chromatography (HPLC) for purity analysis
• Mass spectrometry for molecular identity confirmation
• Contaminant screening for peptide and small molecule impurities
• Quantitative purity determination with detailed reporting

These analytical procedures follow established protocols for peptide analysis, ensuring that results accurately reflect product composition and quality. The testing laboratory maintains independence from the manufacturing process, providing objective quality assessment.

Certificate of Analysis Components

The comprehensive Certificate of Analysis provides detailed information on:

• Peptide identity confirmation through multiple analytical methods
• Precise purity percentage with analytical uncertainty
• Contaminant analysis results and acceptable limits
• Storage and handling recommendations based on stability data
• Batch-specific lot numbers for research documentation

This documentation allows researchers to maintain detailed records of the compounds used in their studies, supporting research reproducibility and publication requirements.

Quality Assurance Benefits

Third-party testing provides several advantages for research applications:

• Independent verification of product specifications
• Consistent batch-to-batch quality confirmation
• Reduced risk of experimental variability due to compound quality issues
• Enhanced confidence in research results and conclusions
• Support for regulatory and publication requirements

The testing process ensures that researchers receive SS-31 formulations that meet established quality standards consistently across different production batches. This consistency proves essential for maintaining experimental reproducibility and research integrity.

Research Documentation Support

The analytical documentation provided with each batch supports researchers in maintaining proper experimental records and meeting institutional requirements for research chemical documentation. Scientists can reference these reports when preparing research publications or regulatory submissions.

The detailed analytical data also helps researchers understand the specific characteristics of their SS-31 batch, allowing for more precise experimental design and interpretation of results. This information proves particularly valuable for researchers conducting quantitative studies requiring precise compound characterization.

References and Citations

The research applications and mechanisms discussed in this review are supported by extensive peer-reviewed literature examining SS-31’s effects in various experimental models. Key sources include studies published in major journals examining mitochondrial function, cellular energy production, and oxidative stress mechanisms.

Research findings referenced in this analysis come from controlled laboratory studies using appropriate experimental models and analytical methods. Scientists interested in detailed experimental protocols and results should review the primary literature for specific study designs and outcomes.

The ongoing development of SS-31 research continues to expand understanding of mitochondrial-targeted compounds and their potential applications in studying cellular energy mechanisms. Future research directions include investigation of improved analogs, enhanced delivery methods, and expanded applications in various disease models.

For researchers seeking to buy SS-31 with confidence in product quality and regulatory compliance, Loti Labs provides the analytical documentation, quality standards, and customer support essential for successful research outcomes. The combination of high purity formulations, comprehensive testing, and research-focused policies makes Loti Labs a reliable source for mitochondrial research compounds.

Scientists conducting mitochondrial research can benefit from the detailed molecular characterization, storage guidelines, and application information provided in this comprehensive guide. The research use only framework ensures that SS-31 remains available for legitimate scientific investigation while maintaining appropriate regulatory compliance and research integrity.

References

1. Szeto HH, Schiller PW. “Novel therapies targeting mitochondrial dysfunction.” Trends in Pharmacological Sciences. 2011;32(6):284-290.
2. Dai DF, et al. “Mitochondrial-targeted peptides protect against mitochondrial dysfunction and oxidative stress in aging.” Journal of Clinical Investigation. 2010;120(6):2030-2040.
3. Birk AV, et al. “The mitochondrial-targeted compound SS-31 re-energizes aged mitochondria by interacting with cardiolipin.” Journal of Clinical Investigation. 2013;123(8): 3111-3121.
4. Szeto HH. “First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics.” British Journal of Pharmacology. 2014;171(8):2029-2050.
5. Yin J, et al. “SS-31 peptide protects against neurodegeneration by modulating mitochondrial function.” Neurobiology of Disease. 2016;93: 1-10.
6. Dai DF, et al. “Mitochondrial oxidative stress in aging and healthspan.” Longevity & Healthspan. 2014;3(1):6.
7. Szeto HH, Birk AV. “Mitochondrial-targeted peptides: a new class of therapeutics.” Mitochondrion. 2014;16: 1-5.
8. Mitchell SJ, et al. “Mitochondrial function and aging: implications for healthspan and longevity.” Journal of Clinical Investigation. 2019;129(1): 75-85.
9. Zhao K, et al. “Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury.” Journal of Biological Chemistry. 2004;279(33): 34682-34690.
10. Hough KP, et al. “Mitochondrial dysfunction in lung aging and disease.” American Journal of Physiology-Lung Cellular and Molecular Physiology. 2018;314(4): L642-L653.

Weight	.03125 lbs