Sildenafil 50mg/ml (30ml)

Buy Liquid Sildenafil at Loti Labs

Researchers studying phosphodiesterase mechanisms and vascular biology need high-purity compounds that deliver consistent results across protocols. When you buy liquid sildenafil from trusted suppliers, you get a research chemical that has been studied for smooth muscle relaxation and blood flow modulation. The liquid form has advantages over solid forms, better bioavailability and precise dosing for rigorous lab work.

Sildenafil citrate, the active ingredient developed by Pfizer under the brand name Viagra, has gone far beyond its original clinical use. Research shows this phosphodiesterase type 5 inhibitor plays multiple roles in physiological pathways, making it a must have for scientists studying vascular function, pulmonary hypertension mechanisms and erectile function at the cellular level. The well characterized chemical structure and predictable pharmacology has made it a cornerstone of cardiovascular and sexual health research worldwide.

For lab professionals seeking reliable access to research grade compounds, understanding the molecular characteristics, storage requirements and quality standards becomes crucial. This guide explains why liquid sildenafil is the best choice for research, highlighting the benefits of Loti Labs’ formulations while complying with research use only.

Molecular Structure of Liquid Sildenafil

The molecular structure of sildenafil shows the complex molecular architecture behind its biological activity. With the molecular formula C28H38N6O11S and molecular weight 666.70 g/mol, this compound has the arrangement necessary for selective enzyme inhibition. Researchers can reference this substance with Pubchem CID 5212 or CAS number 171599-83-0 when documenting protocols or literature reviews.

Property	Details
Molecular Formula	C28H38N6O11S
Molecular Weight	666.70 g/mol
PubChem CID	5212
CAS Number	171599-83-0
Core Structure	Pyrazolopyrimidinone
Functional Groups	Sulfonamide, Aromatic side groups
Key Features	Multiple nitrogen atoms and oxygen-containing functional groups for hydrogen bonding and receptor recognition
Selectivity	Specific binding to phosphodiesterase type 5 (PDE5) enzyme
Solubility Profile	Better in liquid form than solid forms
Stability	Maintains molecular integrity in liquid preparations

Maintains molecular integrity in liquid preparationsThe pyrazolopyrimidinone core, sulfonamide and aromatic side groups create the 3D configuration for specific binding to target enzymes. Research shows these structural features contribute directly to the compound’s selectivity for phosphodiesterase type 5 over other related enzymes, explaining its targeted effects in models. The multiple nitrogen atoms and oxygen containing functional groups provide hydrogen bonding opportunities and electronic properties for receptor recognition.

Lab studies show the liquid form maintains these critical structural features while having better solubility profiles than solid forms. This improved dissolution is particularly useful when researchers need rapid compound distribution in cell culture media or precise concentration gradients in dose-response experiments. The molecular stability in liquid preparations allows for consistent experimental conditions across multiple research sessions, supporting reproducible results in published research.

The pyrazolopyrimidinone core, sulfonamide and aromatic side groups create the 3D configuration for specific binding to target enzymes. Research shows these structural features contribute directly to the compound’s selectivity for phosphodiesterase type 5 over other related enzymes, explaining its targeted effects in models. The multiple nitrogen atoms and oxygen containing functional groups provide hydrogen bonding opportunities and electronic properties for receptor recognition.

Lab studies show the liquid form maintains these critical structural features while having better solubility profiles than solid forms. This improved dissolution is particularly useful when researchers need rapid compound distribution in cell culture media or precise concentration gradients in dose-response experiments. The molecular stability in liquid preparations allows for consistent experimental conditions across multiple research sessions, supporting reproducible results in published research.

Mechanism of Action

Liquid sildenafil is a selective phosphodiesterase type 5 inhibitor, preventing the breakdown of cyclic guanosine monophosphate (cGMP) in smooth muscle cells. This is a key pathway in vascular biology where nitric oxide stimulation leads to guanylate cyclase activation and subsequent cGMP production. By inhibiting PDE5 enzyme activity, sildenafil prolongs the cellular signaling cascade that causes smooth muscle relaxation and increased blood flow to target tissues.Research shows this inhibition occurs through competitive binding at the enzyme’s active site where sildenafil’s molecular structure mimics natural substrate recognition patterns. The compound’s selectivity for PDE5 over other phosphodiesterase enzymes explains its effects in experimental models of erectile dysfunction, pulmonary arterial hypertension and related vascular conditions. Lab studies have shown this selectivity allows researchers to isolate PDE5 mediated effects without significant interference from other enzymatic pathways.

The liquid form enhances the compound’s research utility by providing better bioavailability and faster onset of action than tablet forms. Studies show liquid preparations have more predictable pharmacokinetic profiles in animal models, making them particularly useful for experiments where timing of compound exposure is critical. This is essential when researchers are investigating dose response or need to maintain specific plasma concentrations during the experiment.

In preclinical studies, sildenafil’s vasodilatory effects have been seen in multiple tissue types including penile corpus cavernosum and pulmonary vasculature. Research shows the compound increases blood flow by direct action on vascular smooth muscles leading to arterial dilation and reduced vascular resistance. These findings have established sildenafil as a research tool for cardiovascular function and therapeutic targets for heart problems and circulatory disorders.

Research Studies and Applications

Extensive lab studies have established sildenafil’s utility across multiple research areas with a focus on vascular health and pulmonary function studies. Clinical research has shown the compound’s efficacy in treating pulmonary arterial hypertension, specifically Group 1 PAH, in both adult and pediatric populations as young as one year old. These studies have given researchers valuable insights into the pathophysiology of pulmonary vascular resistance and the therapeutic potential of PDE5 inhibition in different patient populations.

Research suggests sildenafil shows promising results when combined with milrinone in neonatal models of persistent pulmonary hypertension. Lab studies of this combination have shown improved hemodynamic parameters and survival rates, offering researchers new avenues for understanding complex cardiovascular interactions in early development. The synergistic effects seen in these studies highlight the compound’s potential as a research tool for multi-target therapeutic approaches.

Studies on antidepressant induced sexual dysfunction have shown sildenafil’s ability to counteract the effects of selective serotonin reuptake inhibitors on sexual function in men and women. Research data from these studies provide valuable information on the intersection of neurotransmitter systems and vascular function, particularly on sexual stimulation pathways and erectile function mechanisms. These findings have opened up new research directions for understanding the complex relationship between psychological and physiological factors in sexual health.Beyond cardiovascular applications, researchers have looked into sildenafil’s use in conditions with vascular dysfunction such as alopecia and Raynaud’s phenomenon. Lab studies on these applications focus on the compound’s ability to improve microcirculation and blood flow in peripheral tissues. Research suggests the vasodilatory effects may extend to small vessel networks, making sildenafil a useful tool for studying circulation disorders and potential therapeutic interventions.

Exercise capacity studies have used sildenafil to investigate the relationship between vascular function and physical performance. Research in this area looks at how improved blood flow and reduced pulmonary vascular resistance affects exercise tolerance and cardiovascular adaptation. These studies provide researchers with insights into the physiological mechanisms of exercise limitation and the potential for pharmacological enhancement of physical performance in different populations.

Storage and Safety

Proper storage protocols are crucial for maintaining the chemical integrity and research efficacy of liquid sildenafil formulations. Lab studies have shown that optimal storage conditions are between 30°C and 40°C and away from direct sunlight. Research suggests these storage conditions preserve chemical stability and compound efficacy for up to 90 days, giving researchers a reliable shelf life for experimental planning.

The liquid form requires mixing before each use to ensure uniform distribution of the active ingredient throughout the solution. Lab protocols should include mixing procedures that guarantee homogeneous concentration across all parts of the sample. Research shows proper mixing prevents concentration variations that can compromise experimental reproducibility and data quality in dose response studies.

Safety protocols for handling research grade sildenafil must address the compound’s potential for drug interactions and physiological effects. Lab personnel should be aware that sildenafil is contraindicated with nitrates and other PDE5 inhibitors due to the risk of hypotension. Research facilities must have appropriate safety measures in place, including proper ventilation, personal protective equipment and emergency response procedures for accidental exposure.

Storage containers play a big role in maintaining compound stability and preventing degradation. Research shows cobalt blue glass bottles provide optimal protection against light induced chemical changes while allowing for precise dispensing in lab applications. The use of right packaging materials ensures researchers receive compounds with consistent potency and purity throughout the storage period, supporting reliable experimental results.

Lab protocols should include regular monitoring of storage conditions and compound appearance to detect any signs of degradation or contamination. Research guidelines recommend keeping records of storage temperatures, handling procedures and visual inspections to ensure compliance with quality standards. These documentation practices support research integrity and provide traceable records for regulatory compliance and peer review.Loti Labs offers research grade liquid sildenafil in 50mg/mL concentration for laboratory use. This concentration allows for precise dosing across a wide range of experimental protocols. Perfect for cell culture, animal studies or in vitro assays where specific compound concentrations are required.

The cobalt blue glass dropper bottles used by Loti Labs provide better protection against light induced degradation and allows for precise liquid dispensing for laboratory use. Research shows that this packaging approach maintains compound stability better than clear glass or plastic containers, so you receive products with consistent potency throughout the intended use period. The dropper design allows for accurate volume measurement and reduces waste during experimental procedures.

Quality is at the heart of Loti Labs’ research chemical supply. Each batch comes with comprehensive certificate of analysis documentation that verifies identity, purity and concentration through HPLC testing. This third party validation provides you with the analytical data required for regulatory compliance and scientific publication, supports research integrity and experimental reproducibility.

Same day shipping for orders placed before 1pm EST reflects our understanding of the time sensitive nature of research projects and laboratory workflows. This shipping policy allows you to maintain your experimental schedule and avoid delays that might compromise your ongoing studies. The reliable shipping timeline helps you plan your project and keep your research moving.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are for research use only, meaning they are intended for in vitro laboratory testing and experimentation only. This designation ensures compliance with regulations and provides you with high quality compounds for legitimate scientific research. The research chemical designation prohibits human or veterinary administration, keeping clear boundaries between research and clinical use.

The research use only status means these products cannot be misbranded, mislabeled or repurposed as pharmaceuticals, food products or cosmetic ingredients. This regulatory framework protects both suppliers and researchers by setting clear guidelines for use and preventing unauthorized use that could trigger enforcement actions. Research facilities must maintain records of compliance with these usage restrictions as part of their laboratory protocols.Researchers using these compounds must understand the legal and ethical boundaries of research chemicals. The designation is specific to controlled laboratory environments where trained personnel can handle and dispose of the compounds properly. Research institutions require additional oversight and documentation when working with compounds that have known pharmacological activity even in research only context.

The research use only framework allows for legitimate scientific research while preventing unauthorized clinical use. This system enables researchers to access valuable compounds for mechanistic studies, drug development research and basic science research without compromising regulatory compliance. The clear distinction between research and clinical use protects both scientific research and public health regulatory systems.

Educational institutions and commercial research facilities must have protocols in place to comply with research use only designation. These protocols typically include training for laboratory personnel, documentation for compound procurement and use and waste disposal procedures to prevent environmental contamination. The comprehensive approach to compliance supports research productivity and regulatory adherence.

Loti Labs Shipping Policy

Loti Labs has a fast and efficient shipping system to meet the demanding timelines of active research projects. Orders placed before 1pm EST on business days Monday to Friday are processed and shipped same day, so you receive your compounds as soon as possible. This rapid turnaround time is especially important for researchers working on time critical experiments or projects with tight deadlines.

Weekend and late weekday orders are processed the next business day to maintain consistent service level. The predictable shipping time allows research teams to plan their experimental protocols with confidence knowing that the compounds will arrive on time for their laboratory work. This helps with project management and prevents costly delays in research progress.

The shipping protocol includes appropriate packaging to maintain compound integrity during transport. Research shows that proper packaging prevents temperature fluctuations and physical damage that could compromise compound quality or safety during delivery. Our shipping procedure ensures you receive products in optimal condition ready to use in the laboratory without additional preparation or quality verification steps.

Tracking information provides researchers with real time updates on shipment status so you can coordinate with your experimental schedule. This transparency helps with laboratory planning and allows research teams to prepare for compound arrival so all necessary equipment and protocols are ready to go. The tracking also provides documentation for institutional procurement records and budget management.

Guarantee

Loti Labs offers a 30 day satisfaction guarantee so you can order with confidence. This policy allows you to return unopened products within the specified time frame for a full refund of the purchase price, reducing the financial risk for research institutions evaluating new suppliers or testing different compound formulations. The guarantee shows we stand behind our products and customer satisfaction.

The guarantee is especially useful for research institutions that need to evaluate multiple suppliers before establishing long term procurement relationships. This policy allows laboratories to test product quality, packaging, documentation and service level without significant financial commitment. The risk reduction helps with informed decision making and allows research institutions to identify suppliers that meet their specific requirements and standards.

The return process is designed to be easy and researcher friendly, minimizing administrative burden while ensuring proper handling of returned products. The policy requires returned items to be unopened and in original packaging, maintaining product integrity and safety standards. This protects both the supplier and subsequent customers while providing reasonable accommodation for legitimate return requests.

The guarantee period gives researchers time to evaluate product suitability for their specific applications and experimental requirements. Research shows that 30 days is enough time to initial quality assessment, compatibility testing with existing protocols and evaluation of documentation completeness without rushing critical procurement decisions. This timeframe allows for thorough evaluation while being reasonable business practice.

Third Party Testing of Every Batch

Every batch of liquid sildenafil from Loti Labs is tested by a third party using high performance liquid chromatography to ensure product purity and concentration accuracy. This independent validation provides researchers with objective analytical data to support experimental reproducibility and regulatory compliance requirements. HPLC is the gold standard for pharmaceutical analysis, providing precise quantification of active ingredients and identification of potential contaminants.

Third party testing eliminates potential conflict of interest that may arise from internal quality control procedures, providing researchers with unbiased analytical results. This independent verification supports the integrity of research findings by ensuring compound quality meets specified standards before laboratory use. The testing protocol follows established pharmaceutical analysis procedure, providing data that meets publication requirements and regulatory standards.

Certificate of analysis is included with every shipment, providing researchers with detailed information about batch specific quality parameters. These certificates include identity confirmation, purity analysis, concentration verification and testing methodology details to support experimental documentation and regulatory compliance. The comprehensive analytical data allows researchers to make informed decision about compound suitability for specific applications.Batch specific testing ensures quality standards are consistent across different production runs and shipping periods. Research shows this level of quality control is better than periodic sampling, so you can have confidence in compound quality regardless of when you order. The consistent testing supports experimental reproducibility and reduces variability that could impact research results.

Quality control includes stability testing that verifies compound integrity under different storage conditions and timeframes. This testing provides researchers with shelf life information and storage guidance to support proper laboratory practices. The stability data helps research institutions optimize storage protocols and minimize waste due to compound degradation or uncertainty about product viability.

Conclusion

When you need to buy liquid sildenafil for legitimate laboratory research, choosing a supplier that prioritizes quality, compliance and scientific support is key. Loti Labs meets these requirements with quality control, research use only compliance and customer service policies designed for the research community. The combination of pharmaceutical grade formulations, third party testing and reliable shipping is the optimal procurement solution for scientists studying vascular biology, erectile dysfunction mechanisms and related research areas.

The liquid formulation has advantages over solid forms, providing better bioavailability, precise dosing and more experimental flexibility. Research shows these features make liquid sildenafil ideal for dose response studies, pharmacokinetic studies and experiments that require rapid compound administration. The 50mg/mL concentration and available bottle sizes accommodate different experimental requirements while keeping costs low for high quality research materials.

For research institutions that need reliable access to sildenafil citrate for legitimate scientific purposes, Loti Labs provides the quality assurance, regulatory compliance and technical support for research success. Our research use only applications, combined with comprehensive analytical documentation and satisfaction guarantee, is the procurement framework that supports research productivity and regulatory compliance in today’s scientific environment.

References

1. Burnett AL, Nehra A, Breau RH, et al. Erectile Dysfunction: AUA Guideline. J Urol. 2018;200(3):633-641. doi:10.1016/j.juro.2018.05.017
2. Galiè N, Humbert M, Vachiery JL, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2016;37(1):67-119. doi:10.1093/eurheartj/ehv3173. Shamloul R, Ghanem H. Erectile dysfunction. Lancet. 2013;381(9861):153-165. doi:10.1016/S0140-6736(12)60520-0
3. Jackson G, Benjamin N, Jackson N, Allen MJ. Erectile dysfunction and coronary artery disease: recommendations for clinical management. Int J Clin Pract. 2000;54(7):377-381.
4. McMahon CG. Sildenafil for treatment of erectile dysfunction in men with spinal cord injury. J Spinal Cord Med. 2000;23(4):195-200.
5. Pulido T, Adzerikho I, Channick RN, et al. Safety and efficacy of oral sildenafil citrate in the treatment of pulmonary arterial hypertension: a randomized controlled trial. Circulation. 2008;117(3):301-309. doi:10.1161/CIRCULATIONAHA.107.728235
6. Galie N, Olschewski H, Oudiz RJ, et al. Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ARIES study. Circulation. 2008;117(23):3010-3019. doi:10.1161/CIRCULATIONAHA.107.742510
7. Klinger JR, Abman SH. Sildenafil for pulmonary hypertension: is it time for universal approval? Am J Respir Crit Care Med. 2007;175(11):1081-1083. doi:10.1164/rccm.200703-443ED
8. Nagiub M, Abdelrahman H, Abdelrazik M, et al. Combination therapy with sildenafil and milrinone for persistent pulmonary hypertension of the newborn: a randomized controlled trial. Pediatr Crit Care Med. 2015;16(9):e302-e308. doi:10.1097/PCC.0000000000000475
9. Galiè N, Brundage BH, Ghofrani HA, et al. Tadalafil therapy for pulmonary arterial hypertension. Circulation. 2009;119(22):2894-2903. doi:10.1161/CIRCULATIONAHA.108.81357011. Faghihi G, Sadeghian MH, Zare S, et al. Topical sildenafil citrate versus minoxidil in the treatment of female pattern hair loss: a randomized controlled trial. Int J Trichology. 2017;9(4):164-169. doi:10.4103/ijt.ijt_66_17
10. Gupta AK, Talukder M, Shear NH. Sildenafil in male pattern hair loss: a pilot study. J Am Acad Dermatol. 2019;80(3):AB100.
11. Wigley FM. Clinical practice. Raynaud’s Phenomenon. N Engl J Med. 2002;347(13):1001-1008. doi:10.1056/NEJMcp011829
12. Herrick AL, Matucci-Cerinic M. New and future treatments for Raynaud’s phenomenon and digital ulcers in systemic sclerosis. Rheumatology (Oxford). 2011;50(1):6-15. doi:10.1093/rheumatology/keq324

For more information on Sildenafil visit Wikipedia.

---

Weight	0.1875 lbs
Appearance	Viscous cloudy liquid
Stability	Room Temperature out of direct sunlight
Molar Mass	666.7 g/mol
CAS Number	171599-83-0
Container	30ml Bottle
Molecular Formula	C28H38N6O11S
Concentration	50mg per ML
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.156 lbs