Mazdutide 10mg

Buy Mazdutide: Premium Research-Grade Peptide for Metabolic Studies

Research into metabolic disorders has advanced significantly with the development of sophisticated peptide compounds that offer valuable insights into glucose metabolism and energy regulation. Scientists seeking to buy mazdutide for laboratory research can now access this innovative dual agonist through specialized suppliers like Loti Labs, where rigorous quality standards ensure consistent experimental results.

Mazdutide represents a breakthrough in peptide research, functioning as a synthetic peptide analog of the gut peptide hormone oxyntomodulin. This compound has garnered attention in laboratory research due to its unique dual receptor targeting mechanism, making it an essential tool for researchers investigating metabolic disorders and glucose dependent insulin secretion pathways.

Molecular Structure of Mazdutide

Mazdutide is a synthetic 33-amino acid peptide engineered with specific modifications to enhance its research applications. The molecular formula C225H348N48O68 corresponds to a molecular weight of approximately 4813 g/mol, though these values may vary slightly depending on the specific salt form and peptide configuration used in manufacturing.

A critical structural feature distinguishing this compound is the C20 fatty diacid moiety attached at the lysine residue at position 20. This modification serves as a hydrophilic linker that facilitates strong albumin binding in plasma, significantly extending the half life of the compound in experimental systems. Research indicates that mazdutide is highly bound to albumin, which prolongs its activity and enables sustained experimental protocols.

The compound typically appears as a solid white to off-white lyophilized powder, optimized for stability during shipping and long-term storage. Loti Labs maintains strict purity standards, with current stock achieving 99.74% purity as verified through comprehensive analytical testing.

Key Specifications:

• Amino Acid Sequence: His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2

• Purity: 99%+
• Alternative Names: IBI-362, LY3305677
• Physical Form: Lyophilized powder
• CAS number: 2259884-03-0

Mechanism of Action in Research Applications

Mazdutide functions as a dual agonist, simultaneously targeting both the glucagon receptor (GCGR) and GLP-1 receptor (GLP-1R). Research demonstrates that mazdutide binds human GCGR with a Ki value of 17.7 nM and human GLP-1R with Ki values of 28.6 nM, indicating potent receptor affinity for both targets.

In laboratory studies using mouse islets, the compound stimulates insulin secretion with an EC50 of 5.2 nM, providing researchers with a powerful tool for investigating glucose metabolism pathways. The dual agonist activity allows scientists to study the complex interplay between glucagon like peptide signaling and glucagon receptor activation in controlled experimental conditions.

Research suggests that this dual targeting approach offers multiple variants for studying energy expenditure and fat metabolism. The compound’s action on both human and mouse GCGR makes it valuable for comparative studies across species, while its GLP-1R activity enables investigation of glucose dependent insulin secretion mechanisms.

Studies indicate that mazdutide potently activates both receptor pathways, designed enhancing energy expenditure research in animal models. This dual functionality provides researchers with valuable insights into how these signaling pathways interact to influence body weight regulation and metabolic homeostasis.

Research Studies and Laboratory Applications

Laboratory research use of this compound spans multiple areas of metabolic investigation. Primary research applications include:

Metabolic Disorder Studies:

• Glucose metabolism pathway research
• Energy expenditure investigations in animal models
• Fat metabolism studies in diabetic mice
• Body weight regulation research

Experimental Protocols: Research teams have utilized this compound in studies examining metabolic responses in both cell culture and animal models. The long acting nature of the compound makes it particularly suitable for extended experimental protocols where sustained receptor activation is required.

Studies involving chinese adults and various animal models have provided researchers with data on how dual agonist compounds interact with metabolic pathways. The compound’s ability to reduce body weight in experimental settings has made it valuable for obesity research, while its effects on glucose metabolism support diabetes-related investigations.

Laboratory Preparation: When conducting research, scientists typically prepare stock solutions using sterile technique. The compound should be dissolved, filtered through a 0.22 μm filter, and sterilized before use. Researchers can use the standard dilution formula C1V1 = C2V2 for accurate preparation in animal studies and other experimental applications.

Storage and Safety Protocols

Proper storage is essential for maintaining peptide integrity and ensuring reproducible research results. Mazdutide should be stored under the following conditions:

Storage Requirements:

• Long-term: -80°C for up to 6 months
• Short-term: -20°C for maximum 1 month
• Protect from moisture and light at all times
• Store in sealed, light-protective vials

Preparation Guidelines: Stock solutions must be prepared using aseptic technique. The peptide should be aliquoted after initial dissolution to avoid repeated freeze-thaw cycles, which can compromise compound stability. When prepared correctly, researchers can maintain consistent experimental conditions across multiple studies.

Safety protocols require following institutional guidelines for handling research chemicals. All personnel should review the safety data sheet (SDS) and certificate of analysis (COA) provided with each batch to ensure proper handling procedures are followed.

Benefits of Purchasing from Loti Labs

Researchers who buy mazdutide from Loti Labs receive comprehensive documentation supporting their laboratory research. Each order includes:

Quality Assurance:

• Third-party HPLC testing confirming 99%+ purity
• Receptor binding affinity testing verifying dual GLP-1R/GCGR functionality
• Complete certificate of analysis (COA) for each batch
• Safety data sheet (SDS) for proper handling

Documentation Package: Every purchase includes detailed data sheets, handling instructions, and analytical results. This comprehensive documentation supports laboratory compliance requirements and enables researchers to maintain detailed experimental records.

Specialized Packaging: Products are packaged using specialized methods designed to preserve peptide integrity during shipping and storage. This attention to packaging details helps maximize shelf life and ensures researchers receive compounds in optimal condition.

Current Price and Ordering: Researchers can review current price information and product availability through the online catalog. Multiple variants may be available depending on research requirements, and bulk pricing options support larger research projects.

Research Use Only Compliance

All products sold by Loti Labs are designated strictly for laboratory research use. This designation allows the use of this compound exclusively for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly forbidden under these guidelines.

Mazdutide is not classified as a substance for human consumption and may not be misbranded, mislabeled, or misused outside of research applications. Researchers must follow institutional protocols for research chemical procurement and use, ensuring compliance with all applicable regulations.

Laboratory personnel should maintain proper documentation regarding compound procurement, storage, and use to support institutional compliance requirements. Any research involving this compound should be conducted under appropriate institutional oversight and approval.

Ordering Information and Policies

Shipping Policy: Loti Labs offers same-day shipping for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends ship the next business day. Researchers can add items to their cart and proceed to checkout select options for their specific requirements.

Satisfaction Guarantee: A 30-day satisfaction guarantee covers all products. Researchers may return any unopened products for a full refund of the purchase price, supporting laboratory budget management and reducing procurement risk.

Third-Party Testing: Every batch undergoes rigorous third-party testing using HPLC to ensure product purity and accuracy. Additional receptor binding studies confirm the dual GLP-1R/GCGR targeting functionality, providing researchers with confidence in their experimental results.

Advancing Metabolic Research

The availability of high-quality research compounds like mazdutide enables scientists to investigate complex metabolic pathways and develop new understanding of glucose metabolism, energy expenditure, and related physiological processes. As researchers continue to explore the potential benefits of dual agonist approaches in laboratory settings, compounds with verified purity and proper documentation become increasingly valuable for advancing scientific knowledge.

Research suggests that continued investigation of these mechanisms may yield valuable insights into metabolic regulation, supporting the broader scientific community’s efforts to understand complex physiological systems. For qualified researchers seeking to buy mazdutide for legitimate laboratory applications, Loti Labs provides the quality standards and documentation necessary for rigorous scientific investigation.

Scientists interested in incorporating this compound into their research protocols can review product specifications, request additional technical information, and place orders through established procurement channels. All research should be conducted following institutional guidelines and with appropriate scientific oversight to ensure both safety and scientific validity.

References

1. Chen T, et al. The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases. J Med Chem. 2022 Mar 10;65(5):3685-3705.
2. Jiang H, et al. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes. Nat Commun. 2022 Jun 24;13(1):3613.
3. Chen Y, Mezo A, Coskun T, et al. Novel dual glucagon and glucagon-like peptide-1 receptor agonist LY3305677 improves glucose control, reduces body weight, and increases energy expenditure in mice. Diabetes. 2021;70(Supplement_1).
4. Innovent Biologics. Efficacy and safety of Mazdutide on weight loss among diabetic and overweight adults. PubMed Central. 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911117/
5. Innovent Biologics. Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) in Chinese adults with overweight or obesity. PubMed Central. 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561728/
6. Ji, L., Gao, L., et al. Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) in Chinese adults with overweight or obesity. EClinicalMedicine, 54, 101691. https://doi.org/10.1016/j.eclinm.2022.101691
7. Innovent Biologics. Innovent announces Phase 2 clinical study of higher dose 9 mg Mazdutide (IBI362) in Chinese adults with obesity achieved the 24-week primary endpoint. PR Newswire. 2023. https://www.prnewswire.com/news-releases/innovent-announces-phase-2-clinical-study-of-higher-dose-9-mg-mazdutide-ibi362-in-chinese-adults-with-obesity-achieved-the-24-week-primary-endpoint-301821038.html
8. Innovent Biologics. Innovent’s first new drug application of Mazdutide for chronic weight management has been accepted by the NMPA of China. BioSpace. 2023. https://www.biospace.com/innovent-s-first-new-drug-application-of-mazdutide-for-chronic-weight-management-has-been-accepted-by-the-nmpa-of-china