Letrozole 2.5mg/ml (30ml)

ABOUT LETROZOLE: Liquid letrozole is a nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. It is a third-generation aromatase inhibitor, which selectively and reversibly inhibits aromatase. This may result in reduced growth of estrogen-dependent breast cancer cells in animal test subjects.

Liquid letrozole blocks the conversion of androgens to estrogens in selective tissues. Its effects on the ovaries and the breasts include:

1. A fall in local estrogen levels that may be effective in managing estrogen receptor-positive breast cancer.
2. A rise in ovarian androgens. This likely increases the follicular sensitivity to FSH, thereby facilitating ovulation.

Absorption of letrozole happens in the gastrointestinal tract of animal test subjects. Its excretion is through the kidneys in the form of a glucuronide conjugate.

The half-life of letrozole is 3-4 days. It is 2-5 times more potent than anastrozole and exemestane in its inhibition of aromatase.

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