GW0742 Capsules (10mg/capsule, 30 capsules)

Buy GW0742 Capsules: Premium Research Chemical for PPARδ Studies

Research into selective peroxisome proliferator-activated receptor delta (PPARδ) agonists has expanded significantly in recent years, with laboratories worldwide investigating metabolic pathways and energy homeostasis mechanisms. Among the most potent research chemicals in this category, GW0742 stands out as a highly selective compound that researchers utilize to investigate cellular metabolism, fatty acid oxidation, and inflammation pathways in controlled laboratory settings.

When laboratories seek to buy GW0742 capsules for their ongoing research, understanding the compound’s molecular properties, research applications, and supplier qualifications becomes essential for maintaining experimental integrity and regulatory compliance.

Molecular Structure of GW0742

GW0742 represents a sophisticated research chemical originally developed for investigating PPARδ receptor mechanisms. The compound’s complete chemical designation is 4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-acetic acid, reflecting its complex fluorinated structure that contributes to its enhanced biological activity compared to traditional anabolic steroids and other compounds.

Chemical Name: 4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-acetic acid

Molecular Formula: C21H17F4NO3S2

Molecular Weight: 471.49 g/mol

PubChem CID: 9893754

CAS #: 317318-84-6

The fluorinated structure distinguishes GW0742 from related compounds like Cardarine (GW501516), providing researchers with enhanced selectivity when investigating multiple nuclear receptors. Laboratory analysis demonstrates that this structural modification contributes to the compound’s ability to interact specifically with PPARδ receptors while showing weak activity toward other receptor systems including androgen receptors, thyroid hormone receptors, and vitamin D receptors.

Mechanism of Action

GW0742 functions as a selective PPARδ agonist with an impressive EC50 value of approximately 1 nanomolar, demonstrating remarkable potency in research settings. When researchers investigate this ppar agonist in laboratory conditions, the compound activates transcription of downstream genes involved in lipid metabolism and energy homeostasis by binding to PPARδ nuclear receptors.

Research suggests that GW0742’s primary mechanism involves enhancing fatty acid oxidation within muscle tissues while promoting expression of enzymes responsible for lipid breakdown. Laboratory investigations have demonstrated the compound’s potential ability to stimulate AMPK activity, effectively shifting cellular preference toward fat as an energy substrate rather than glucose. This metabolic shift supports glucose homeostasis while improving overall cellular energy utilization in experimental models.

The compound’s activation of PPARδ receptors influences multiple metabolic pathways, with researchers noting its effects on boosting metabolism through enhanced oxidative capacity in various tissues. Clinical research utilizing spontaneously hypertensive rats has shown that GW0742 modulates gene expression patterns related to inflammation and cardiovascular function, though further investigation remains necessary to fully understand these mechanisms.

Research Studies

Laboratory investigations consistently demonstrate GW0742’s significant influence on metabolic markers across various experimental models. In studies involving diet-induced obese mice, researchers observed increased fat oxidation and improved cellular energy metabolism following compound administration. The research data indicates enhanced glucose homeostasis and insulin sensitivity in diabetic animal models, supporting ongoing research into metabolic disorders.

As a fluorinated analog of Cardarine, GW0742 exhibits enhanced biological activity with structural differences that researchers have demonstrated affect its selectivity and potency in experimental settings. Some laboratory reports suggest the compound may be 150-200 times more effective than GW501516 in promoting fat loss and increasing fat loss mechanisms, though these findings require further investigation to verify their reproducibility across different research protocols.

Research suggests that GW0742 also exhibits anti-inflammatory properties, making it valuable for investigating chronic inflammatory disease models. Laboratories have utilized the compound to study cytokine production and oxidative stress in models of atherosclerosis, lung injury, kidney inflammation, and ocular diseases. However, researchers must carefully consider the context-dependent outcomes of PPARδ activation, as some studies have shown the compound’s potential ability to increase angiogenic markers in retinal models.

The compound’s effects on body fat reduction and muscle preservation have made it a subject of investigation in body composition studies, though researchers emphasize that all applications remain strictly within laboratory settings for research purposes only.

Storage and Safety

Proper storage protocols are essential when laboratories purchase GW0742 capsules to maintain compound integrity and experimental reproducibility. The research chemical requires cold chain storage at temperatures between -20°C and 2-8°C for optimal stability. Researchers should verify that their storage facilities can maintain these conditions consistently to prevent compound degradation.

GW0742 demonstrates limited solubility in water but readily dissolves in organic solvents such as DMSO, where it can achieve concentrations exceeding 5 mg/mL for experimental use. Laboratory protocols typically employ nanomolar to low micromolar concentrations (1-100 nM) to ensure selective PPARδ activation while maintaining experimental controls.

Research data indicates that cell viability remains above 90% at concentrations below approximately 12.1 μM, providing researchers with clear guidelines for concentration limits in cellular studies. This safety margin allows investigators to explore the compound’s effects on metabolism without significant cell death, supporting reliable experimental outcomes.

When handling GW0742 capsules, laboratory personnel should follow standard research chemical safety protocols, including proper ventilation, protective equipment, and documentation procedures. The compound’s stability profile requires careful attention to temperature control during transport and storage to maintain experimental consistency.

Benefits of Buying from Loti Labs

Loti Labs offers GW0742 capsules in convenient formulations designed specifically for research applications. The company provides multiple concentration options including 10mg, 20mg, 25mg, and 50mg capsules, allowing researchers to select appropriate amounts for their specific experimental protocols without waste or excess.

The company maintains strict purity standards, with products achieving 98-99.99% purity levels verified through comprehensive third-party testing. This high purity ensures that researchers can rely on consistent results across experiments while minimizing variables introduced by impurities or contaminants. Each batch undergoes rigorous analysis to verify compound identity, concentration, and stability.

Loti Labs provides complete documentation supporting research reproducibility and regulatory compliance. Researchers receive certificates of analysis, batch tracking information, and comprehensive testing data that supports their experimental validation requirements. This documentation proves essential for laboratories maintaining quality assurance protocols and regulatory guidelines.

The company’s commitment to great customer service extends beyond product quality to include responsive technical support and consultation services. Researchers can access guidance on storage protocols, concentration preparation, and experimental design considerations, supporting successful research outcomes.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs, including GW0742 capsules, are designated strictly as research chemicals for laboratory use only. This designation allows the use of these compounds exclusively for in-vitro laboratory testing and experimentation under controlled conditions. Human or veterinary use is strictly forbidden under all circumstances.

These products are not intended as substances for human consumption, and they may not be misbranded, mislabeled, or misused outside their designated research applications. Laboratories must maintain proper documentation and protocols ensuring compliance with research-only guidelines when purchasing and utilizing these compounds.

Researchers and institutions must verify their qualifications and intended use before completing any purchase. The absence of regulatory approval for human therapeutic applications means that all investigations must remain within approved research frameworks, with proper oversight and documentation maintained throughout the research cycle.

Shipping Policy of Loti Labs

Loti Labs offers same-day shipping for orders placed before 1pm EST Monday through Friday, ensuring researchers can maintain their experimental timelines without delays. Orders placed after 1pm EST or on weekends will be shipped the next business day, providing predictable delivery schedules for laboratory planning.

The company provides free international shipping options for qualifying orders, expanding access to high-quality research chemicals for laboratories worldwide. This global reach supports collaborative research efforts while maintaining the same quality standards and documentation requirements regardless of location.

Proper packaging protocols ensure compound integrity during transport, with temperature-controlled shipping available for compounds requiring specific storage conditions. Researchers can track their orders and receive confirmation when shipments are completed, supporting inventory management and experimental scheduling.

Satisfaction Guarantee

Loti Labs stands behind their product quality with a comprehensive 30-day satisfaction guarantee on all research chemicals. Researchers can return any unopened products within this timeframe for a full refund of the purchase price, demonstrating the company’s confidence in their quality control processes.

This guarantee provides laboratories with confidence when selecting new compounds for investigation, knowing that unsatisfactory products can be returned without financial loss. The policy supports research institutions in exploring new experimental directions while minimizing financial risk.

The guarantee applies specifically to unopened products in their original packaging, ensuring that returned items maintain their integrity for potential redistribution. Researchers should contact customer service to initiate returns and receive proper authorization before shipping products back to the company.

Third Party Testing of Every Batch

Every batch of GW0742 capsules undergoes rigorous third-party testing using high-performance liquid chromatography (HPLC) to ensure product purity and accuracy. This independent verification process confirms compound identity, concentration, and stability, supporting reproducible research outcomes across different laboratories and experimental conditions.

The testing protocols examine multiple parameters including chemical composition, impurity levels, and concentration accuracy. Results are documented in comprehensive certificates of analysis that researchers receive with their orders, providing essential data for experimental validation and regulatory compliance.

Quality control processes extend beyond basic purity testing to include stability analysis and contamination screening. This comprehensive approach ensures that researchers receive compounds suitable for sensitive experimental applications, whether investigating cellular metabolism, receptor binding, or other research applications.

The third-party verification process supports scientific integrity by providing independent confirmation of product specifications. Researchers can cite these testing results in their publications and grant applications, supporting the credibility of their experimental data and conclusions.

Conclusion

When laboratories seek to buy GW0742 capsules for their research into PPARδ mechanisms and metabolic pathways, selecting a reputable supplier with proven quality standards becomes essential. The compound’s potent biological activity and complex molecular structure require careful handling and storage protocols that only experienced research chemical suppliers can provide.

GW0742’s unique properties as a selective PPARδ agonist make it an invaluable tool for investigating fatty acid oxidation, glucose homeostasis, and inflammation pathways in controlled laboratory settings. Its enhanced potency compared to related compounds provides researchers with opportunities to investigate metabolic mechanisms with greater precision and reproducibility.

For researchers ready to expand their investigation into PPARδ agonists and metabolic research, Loti Labs provides the best place to purchase high-quality GW0742 capsules with comprehensive documentation and support. Their commitment to purity, testing, and compliance ensures that researchers can focus on their scientific objectives while maintaining the highest standards of experimental integrity.

References

1. Wang, Y.X. (2010). PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Research, 20(2), 124-137. https://doi.org/10.1038/cr.2010.13
2. Oliver, W.R. Jr., et al. (2001). A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proceedings of the National Academy of Sciences, 98(9), 5306-5311. https://doi.org/10.1073/pnas.091127198
3. Narkar, V.A., et al. (2008). AMPK and PPARδ agonists are exercise mimetics. Cell, 134(3), 405-415. https://doi.org/10.1016/j.cell.2008.06.051
4. Lee, C.H., et al. (2006). PPARδ regulates glucose metabolism and insulin sensitivity. Proceedings of the National Academy of Sciences, 103(9), 3444-3449. https://doi.org/10.1073/pnas.0511079103
5. Barish, G.D., et al. (2006). PPARδ regulates multiple proinflammatory pathways to suppress atherosclerosis. Proceedings of the National Academy of Sciences, 103(38), 14904-14909. https://doi.org/10.1073/pnas.0604259103
6. Wang, Y., et al. (2011). GW0742, a PPARδ agonist, improves insulin sensitivity and reduces inflammation in obese mice. Journal of Pharmacology and Experimental Therapeutics, 337(2), 543-551. https://doi.org/10.1124/jpet.110.176273
7. Lee, C.H., et al. (2008). PPARδ activation ameliorates hypertension and endothelial dysfunction in spontaneously hypertensive rats. Hypertension, 51(6), 1532-1538. https://doi.org/10.1161/HYPERTENSIONAHA.107.104581
8. Loti Labs. (2024). Product information and quality assurance for GW0742 capsules. Retrieved from https://lotilabs.com

Weight	.0625 lbs