GnRH (Triptorelin) 100mcg

Buy Triptorelin at Loti Labs: Premium GnRH Agonist for Research Applications

Researchers investigating gonadotropin releasing hormone pathways require access to high-purity synthetic analogues for reproducible experimental outcomes. Triptorelin, a potent gnrh agonist, represents a significant advancement in hormone research capabilities due to its enhanced stability and prolonged biological activity compared to the native molecule. When you buy gnrh triptorelin from Loti Labs, you receive a research-grade compound that meets the stringent purity standards essential for reliable scientific investigation.

This synthetic analogue of gonadotropin releasing hormone gnrh has become an indispensable tool in endocrinology research, offering researchers the ability to study hormone-dependent mechanisms with unprecedented precision. The compound’s unique molecular modifications provide extended plasma half life prolonged beyond that of naturally occurring gonadotropin releasing hormone, making it particularly valuable for studies requiring sustained hormonal modulation.

Molecular Structure of Triptorelin

Triptorelin exhibits a precisely engineered peptide sequence: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2. This sequence represents a strategic modification of the natural gonadotropin releasing hormone agonist structure, where the substitution of D-Tryptophan at position 6 significantly enhances both potency and stability.

The chemical formula C64H82N18O13 corresponds to a molecular weight of 1311.5 g/mol, with the compound catalogued under PubChem CID 638821 and CAS number 57773-63-4. The only change from the native gonadotropin sequence involves the incorporation of the D-isomer of tryptophan, which confers resistance to enzymatic degradation and extends the compound’s half-life in biological systems.

Property	Specification
Peptide Sequence	Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Molecular Formula	C64H82N18O13
Molecular Weight	1311.5 g/mol
PubChem CID	638821
CAS Number	57773-63-4

The sequence breakdown reveals the strategic positioning: trp ser tyr d trp forms the core modification region, while tyr d trp leu and trp leu arg pro maintain the essential binding characteristics. The terminal arg pro gly nh2 segment preserves the critical receptor interaction domain that enables the compound’s agonistic effect.

Mechanism of Action

Triptorelin functions as a hormone releasing hormone agonist through high-affinity binding to gonadotropin releasing hormone receptors in the anterior pituitary. Upon initial administration, the compound stimulates a surge in both luteinizing hormone lh and follicle stimulating hormone fsh release, demonstrating its potent agonistic properties.

Research indicates that triptorelin controls release of gonadotropins luteinizing hormone and follicle stimulating hormone fsh with remarkable efficiency. Studies have documented approximately 13-fold increased luteinizing hormone releasing activity and 21-fold enhanced follicle stimulating hormone release compared to the endogenous hormone. This enhanced potency results from the compound’s resistance to peptidase degradation and improved receptor binding characteristics.

The mechanism involves a biphasic response pattern. Initially, causing constant stimulation of pituitary receptors leads to increased hormone lh and follicle stimulating hormone secretion. However, continuous exposure results in receptor desensitization and downregulation, ultimately leading to decreased pituitary secretion of both luteinizing hormone and follicle stimulating hormone after approximately 3-4 weeks.

This dual-phase action makes the gnrh agonist triptorelin particularly valuable for research applications requiring either acute hormonal stimulation or chronic suppression protocols. The compound’s pharmacokinetics demonstrate complete absorption following administration, with a volume of distribution of approximately 30-33L in experimental models.

Research Studies

Oncological Research Applications

Triptorelin has demonstrated significant utility in advanced prostate cancer research models through androgen deprivation mechanisms. Research suggests that the compound’s ability to reduce testosterone levels to castrate ranges makes it comparable to surgical castration in experimental protocols. Studies investigating metastatic prostate cancer have shown that triptorelin therapy produces oncological outcomes similar to other gnrh agonists such as leuprolide acetate.

The compound’s efficacy in prostate cancer research stems from its capacity to halt hormone-dependent tumor progression by creating a hypogonadal state. Comparative studies between triptorelin and surgical castration demonstrate equivalent effectiveness in experimental models, though the time to achieve castrate testosterone levels may vary slightly from other hormone releasing hormone agonist compounds.

Pediatric Endocrinology Research

Research in central precocious puberty models has revealed triptorelin’s effectiveness in halting premature hormonal activation. Studies suggest that the compound successfully prevents premature epiphyseal closure and controls inappropriate sexual maturation in experimental settings. The gnrh agonist’s ability to suppress gonadotropin release makes it valuable for investigating developmental endocrinology.

Reproductive Biology Research

In assisted reproduction research, triptorelin serves as a critical tool for controlling endogenous gonadotropin release during experimental protocols. Research suggests that the compound improves cycle control and optimizes experimental conditions for oocyte studies. The substance’s application extends to research investigating hormone responsive cancers, particularly breast cancer models where estrogen dependent conditions require precise hormonal control.

Studies have also explored triptorelin’s effects in uterine fibroids research, where the compound’s ability to create a hypoestrogenic state provides valuable experimental conditions for investigating estrogen-dependent tissue growth mechanisms.

Storage and Safety Considerations

Triptorelin arrives as a sterile-filtered, freeze dried white powder optimized for research applications. The lyophilized formulation ensures stability during ambient temperature shipping while maintaining compound integrity for laboratory use.

Storage Requirements

Long-term storage requires desiccated conditions below -18°C to prevent hydrolysis and maintain peptide stability. The lyophilized form demonstrates remarkable stability at room temperature for up to three weeks, providing flexibility for laboratory handling procedures.

Upon reconstitution in sterile 18MΩ-cm H2O to achieve a minimum concentration of 100 µg/ml, prepare a stock solution suitable for experimental dilution required protocols. Reconstituted solutions maintain stability at 4°C for 2-7 days, though freeze storage extends usability for longer experimental timelines. Avoid repeated freeze-thaw cycles to preserve peptide integrity and ensure consistent experimental results.

Safety Protocols

Research indicates that triptorelin exhibits non-mutagenic, non-clastogenic, and non-teratogenic properties in standard laboratory assessments. However, the compound’s anti-gonadal effects necessitate appropriate handling protocols in research environments. Some studies have noted transient serum enzyme elevations, though these observations remain within acceptable parameters for research applications.

The compound demonstrates negligible protein binding at experimental concentrations, and metabolism does not appear to involve hepatic cytochrome P450 enzyme systems. These characteristics contribute to predictable pharmacokinetic behavior in research models.

Benefits of Purchasing from Loti Labs

When researchers buy gnrh triptorelin from Loti Labs, they receive a compound meeting rigorous quality standards essential for reproducible scientific investigation. Our triptorelin maintains guaranteed minimum purity of >98.0% as verified through comprehensive third-party HPLC analysis.

Quality Assurance Standards

Every batch undergoes rigorous validation by independent laboratories, ensuring consistent product identity and potency across research applications. The sterile-filtered and lyophilized preparation contains no additives, providing maximum flexibility for experimental design and custom reconstitution protocols.

Research Advantages

• High Purity: >98.0% purity verified by HPLC testing
• Consistent Potency: Batch-tested for reliable experimental outcomes
• Flexible Formulation: Additive-free preparation for custom protocols
• Bulk Options: Cost-effective purchasing for large-scale research programs
• Documentation: Complete batch records for regulatory compliance

The compound’s formulation as acetate or pamoate salts provides researchers with options suited to specific experimental requirements. Whether investigating diagnostic or therapeutic procedures in laboratory models or conducting fundamental hormone research, our triptorelin meets the exacting standards required for scientific advancement.

Research Use Only Designation

All products from Loti Labs are designated strictly for research applications and in-vitro laboratory testing. This designation ensures compliance with regulatory frameworks while providing researchers access to high-quality compounds for scientific investigation. The triptorelin compound is not intended for human or veterinary use and may not be utilized outside controlled laboratory environments.

Compliance Requirements

Researchers must ensure all handling procedures comply with institutional safety protocols and relevant regulatory guidelines. The substance cannot be used as food, cosmetic, or for any application beyond laboratory research. This research use designation protects both investigators and institutions while facilitating legitimate scientific inquiry.

Legal Considerations

The compound’s classification requires proper documentation and handling procedures consistent with research chemical protocols. Investigators should maintain appropriate records and ensure all experimental procedures align with institutional oversight requirements.

Shipping and Customer Service Policies

Expedited Shipping

Loti Labs provides same-day shipping for orders placed before 1pm EST Monday through Friday. Orders submitted after this time or during weekends ship the following business day, ensuring minimal delays in research timelines.

Satisfaction Guarantee

Our 30-day satisfaction guarantee permits returns of unopened products for full refund, reducing procurement risks for research institutions. This policy demonstrates our confidence in product quality while providing researchers with purchase security.

Customer Support

Our technical support team assists researchers with product specifications, storage recommendations, and experimental considerations. This support ensures optimal utilization of research materials and addresses any questions regarding product handling or applications.

Third-Party Testing and Quality Verification

Every batch of triptorelin undergoes comprehensive HPLC analysis by independent laboratories to confirm identity and verify purity exceeding 98.0%. This analytical approach ensures the main peptide peak remains free from significant contaminants that could compromise experimental validity.

Analytical Documentation

Complete batch documentation accompanies each product shipment, providing researchers with detailed analytical data necessary for regulatory compliance and experimental validation. These records include chromatographic data, purity specifications, and storage recommendations.

Quality Standards

Our purity benchmarks align with stringent requirements for research chemicals, recognizing that even minor variations in peptide composition can significantly impact experimental reproducibility and result interpretation. The >98.0% purity specification ensures researchers receive a compound suitable for the most demanding scientific applications.

Understanding GnRH Agonist Research

The field of gonadotropin releasing hormone research continues expanding as investigators explore the compound’s applications across multiple research domains. From fundamental endocrinology studies to complex oncological research, triptorelin provides researchers with a reliable tool for investigating hormone-dependent mechanisms.

Research suggests that understanding the first few weeks of triptorelin exposure remains critical for experimental design, as the compound’s biphasic response pattern influences experimental outcomes. The initial stimulatory phase followed by suppression creates opportunities for diverse research applications, from acute hormone studies to chronic suppression protocols.

Studies comparing triptorelin with other gnrh agonists reveal subtle differences in onset timing and potency that may influence experimental design choices. While most common side effects in research models relate to expected hormonal changes, investigators should consider these factors when designing experimental protocols.

The compound’s applications extend beyond traditional endocrinology research, with emerging studies investigating its role in metabolic changes, behavioral research including gender identity disorder models, and even potential interactions with selective serotonin reuptake inhibitors in complex experimental paradigms.

For researchers requiring locally advanced expertise in hormone research, triptorelin represents a cornerstone compound enabling investigation of fundamental biological processes. Whether studying the basic mechanisms of lh rh action or exploring complex hormone-dependent pathways, this gnrh agonist provides the reliability and potency necessary for advancing scientific understanding.

The continuing evolution of gonadotropin releasing hormone research demands access to high-quality research compounds that meet the exacting standards of modern scientific investigation. When researchers choose to buy gnrh triptorelin from Loti Labs, they gain access to a compound that supports the rigorous requirements of contemporary hormone research while maintaining the compliance standards essential for legitimate scientific inquiry.

References

1. Abbara A, Phylactou M, Eng PC, et al. Endocrine responses to triptorelin in healthy women, women with Polycystic Ovary Syndrome and Hypothalamic Amenorrhea. J Clin Endocrinol Metab. 2023;dgad026. doi:10.1210/clinem/dgad026
2. Zhou Y, Jia R, Kong FS, et al. A single blood sample for stimulated LH assayed by ICMA is useful for monitoring the treatment efficacy of triptorelin depot in girls. Scand J Clin Lab Invest. 2022;82(7-8):588-594. doi:10.1080/00365513.2022.2148120
3. García García E, Álvarez Del Vayo C, Castaño L. Familial male-limited precocious puberty (testotoxicosis): Usefulness of treatment with ketoconazole and triptorelin. Med Clin (Barc). 2022;159(11):e79-e80. doi:10.1016/j.medcli.2022.08.007
4. Li X, Li H, Shi H, et al. Assessment of Two Formulations of Triptorelin in Chinese Patients with Endometriosis: A Phase 3, Randomized Controlled Trial. Adv Ther. 2022;39(10):4663-4677. doi:10.1007/s12325-022-02264-5
5. Uzonwanne VO, Navabi A, Obayemi JD, et al. Triptorelin-functionalized PEG-coated biosynthesized gold nanoparticles: Effects of receptor-ligand interactions on adhesion to triple negative breast cancer cells. Biomater Adv. 2022;136:212801. doi:10.1016/j.bioadv.2022.212801
6. Metbulut AP, Adıgüzel KT, İslamoğlu C, et al. Evaluation of Hypersensitivity Reactions with Leuprolide Acetate and Triptorelin Acetate in Children. Indian J Endocrinol Metab. 2021;25(6):527-531. doi:10.4103/ijem.ijem_333_21
7. Zhu L, Guan Z, Huang Y, et al. The efficacy and safety of triptorelin-therapy following conservative surgery for deep infiltrating endometriosis: A multicenter, prospective, non-interventional study in China. Medicine (Baltimore). 2022;101(5):e28766. doi:10.1097/MD.0000000000028766
8. Nikzad F, Sadjadi SA, Mohammadpour AH, et al. Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs). Iran J Psychiatry. 2021;16(4):444-450. doi:10.18502/ijps.v16i4.7232
9. Lu X, Sun Y, Han M, et al. Silk fibroin double-layer microneedles for the encapsulation and controlled release of triptorelin. Int J Pharm. 2022;613:121433. doi:10.1016/j.ijpharm.2021.121433
10. Vukovic R, Milenkovic T, Soldatovic I, et al. Triptorelin stimulated luteinizing hormone concentrations for diagnosing central precocious puberty: study of diagnostic accuracy. Endocrine. 2022;75(3):934-941. doi:10.1007/s12020-021-02947-z

For more information on GnRH Triptorelin please visit Wikipedia.

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Weight	0.0099 lbs
Appearance	Fine White Lyophilized Powder
Residue Sequence	pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Solubility	100 µg/mL sterile diluent (distilled de-ionized water)
Source	Biosynthetic production
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to divide the remaining reconstituted peptide into multiple vials so as to avoid a cycle of freezing and thawing. Reconstituted protein can be stored at 4°C.
Molar Mass	1311.45 g/mol
CAS Number	57773-63-4
PubChem	CID 25077179
Molecular Formula	C64H82N18O13
MG	5mg
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	.03125 lbs