Fragment 176-191 2MG

Buy HGH Fragment 176-191 at Loti Labs

Researchers investigating fat metabolism pathways and tissue regeneration mechanisms have increasingly turned their attention to HGH Fragment 176-191, a synthetic peptide derived from the C-terminal region of human growth hormone. This specialized research compound offers unique opportunities for studying lipolytic processes and metabolic pathways in controlled laboratory settings. For scientists seeking to buy hgh fragment 176 191 for their research protocols, understanding its molecular characteristics, mechanisms of action, and proper handling requirements becomes essential for successful experimental outcomes.

The fragment 176 191 peptide represents a carefully engineered portion of the natural growth hormone molecule, specifically designed to target fat metabolism without the broader systemic effects associated with full-length growth hormone. Research suggests this selective approach allows for more focused investigations into adipose tissue function and lipid metabolism pathways, making it an invaluable tool for metabolic research applications.

Molecular Structure of HGH Fragment 176-191

The hgh fragment 176 191 consists of a precise sequence of 16 amino acids that correspond to the C-terminal region of the complete hgh molecule. The amino acid sequence follows the pattern: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, where the first amino acid, tyrosine, represents a strategic modification from the original serine found in natural growth hormone.

Key Molecular Characteristics:

Property	Value
Amino Sequence	Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Molecular Formula	C78H125N23O23S2
Molecular Weight	1815 g/mol
Pubchem CID	9941957
CAS Number	221231-10-3

The molecular structure incorporates two cysteine amino acids that contribute to the peptide’s structural stability through disulfide bond formation. This structural feature, combined with the N-terminus modification, enhances the fragment’s resistance to enzymatic degradation in research environments. The presence of these cysteine amino acids creates a more robust peptide structure compared to linear synthetic peptides, allowing for extended stability during experimental procedures.

Researchers have noted that the substitution of tyrosine for serine at the n terminus significantly improves the peptide’s pharmacokinetic properties in experimental models. This modification represents a critical advancement in synthetic c terminal fragments design, as it maintains the biological activity associated with the original human gh sequence while providing enhanced stability for research applications.

Mechanism of Action

HGH Fragment 176-191 demonstrates a highly specific mechanism of action through its interaction with beta-3 adrenergic receptors (β3-AR) located primarily in adipose tissue. Research indicates this lipolytic fragment selectively targets these receptors directly, initiating a cascade of cellular events that promote fat breakdown without affecting blood glucose levels or insulin sensitivity.

The fragment 176 191 peptide activates lipolytic signals through engagement with β3-AR, leading to increased production of secondary messengers within fat cells. This activation enhances the expression of both mRNA and protein levels of β3-AR, creating an amplified response to endogenous catecholamines. Studies related to this mechanism demonstrate that the peptide increases the sensitivity of adipose tissue to natural fat burning signals produced by the body.

Unlike full-length growth hormone, this synthetic peptide does not trigger the hyperglycemic action typically associated with human growth hormone administration. Research suggests the fragment maintains its lipolytic effects while avoiding impacts on blood sugar regulation, making it particularly valuable for studying isolated fat metabolism pathways without confounding metabolic variables.

The specificity of this mechanism allows researchers to investigate lipid metabolism processes independently of other growth hormone-mediated effects. Experimental models demonstrate that the peptide appeared to maintain consistent activity levels over extended research periods, suggesting stable receptor binding and sustained cellular responses throughout chronic treatment protocols.

Research Studies

Extensive research in murine models has provided valuable insights into the effects of HGH Fragment 176-191 on metabolic processes and tissue repair mechanisms. Studies conducted in obese mice revealed significant changes in adipose tissue function following administration of this research compound over three-week periods.

Metabolic Research Findings

In experimental models using obese mice, researchers observed up to 50% reduction in weight gain compared to control groups receiving saline injections. The studies demonstrated significantly higher levels of β3-AR expression in treated animals, with levels comparable to those seen in naturally lean subjects. Importantly, when the same protocols were applied to lean mice, minimal weight changes occurred, suggesting the peptide’s effects may be most pronounced in subjects with elevated baseline adipose tissue levels.

Research suggests that the fragment 176 191 peptide enhances energy expenditure through increased fat breakdown without affecting muscle tissue metabolism. The increased number of activated lipolytic pathways in treated subjects correlated with improved metabolic health markers, though researchers commented that these effects appeared most significant in animals with pre-existing metabolic challenges.

Summers RJ and colleagues noted that the peptide’s effects on endogenous catecholamine sensitivity created sustained improvements in fat metabolism efficiency. Their research indicated that chronic treatment protocols maintained effectiveness without the development of receptor tolerance, a finding that supports the compound’s potential for extended research applications.

Cartilage Regeneration Studies

Beyond metabolic research, investigations into cartilage regeneration have revealed intriguing applications for HGH Fragment 176-191 in tissue repair studies. Research utilizing a rabbit osteoarthritis model demonstrated promising results when the peptide was administered via intra articular injection, particularly when combined with hyaluronic acid.

In these studies, researchers induced knee osteoarthritis using type ii collagenase and subsequently treated subjects with various formulations. Groups receiving HGH Fragment 176-191 combined with hyaluronic acid showed significantly lower cartilage damage scores compared to controls. Gross morphological examination revealed improved cartilage integrity, with histopathological scores indicating reduced tissue degradation.

The lameness period in treated subjects was significantly shorter compared to control groups, suggesting accelerated recovery processes. Ogru E and research teams documented that animals receiving the peptide treatment demonstrated repressed levels of inflammatory markers and enhanced tissue repair mechanisms throughout the study period.

These findings suggest potential applications for the peptide in cartilage biology research, though researchers emphasized that translation to clinical applications would require extensive additional investigation. The combination with hyaluronic acid appeared to enhance the peptide’s tissue repair effects, possibly through synergistic mechanisms affecting cellular regeneration pathways.

Storage and Safety

Proper handling and storage of HGH Fragment 176-191 requires adherence to specific protocols to maintain peptide integrity and research validity. The compound is typically supplied in lyophilized powder form, which provides optimal stability for long-term storage and shipping.

Storage Requirements

• Lyophilized powder: Store at -20°C for maximum long-term stability
• Reconstituted solution: Refrigerate at 2-8°C immediately after preparation
• Stability period: Reconstituted peptide maintains integrity for approximately 30 days when properly stored
• Reconstitution medium: Use bacteriostatic water for optimal results

Laboratory Protocols

Standard research protocols typically employ concentrations ranging from 250 to 500 mcg per administration, though specific experimental designs may require protocol modifications based on research objectives. All handling procedures should employ sterile technique to prevent contamination and ensure experimental validity.

Researchers should prepare working solutions immediately before use when possible, as repeated freeze-thaw cycles can compromise peptide structure. When working with this research compound, proper laboratory safety equipment and protocols should be maintained throughout all experimental procedures.

The peptide’s stability profile makes it suitable for various experimental timelines, allowing researchers flexibility in designing both acute and chronic treatment studies. However, maintaining consistent storage conditions remains critical for reproducible research outcomes.

Benefits of Buying from Loti Labs

When researchers need to buy hgh fragment 176 191 for their investigations, Loti Labs provides research-grade compounds that meet the demanding standards required for scientific applications. Our commitment to quality ensures that each vial contains precisely characterized material suitable for rigorous experimental protocols.

Quality Assurance Standards

Loti Labs manufactures HGH Fragment 176-191 to achieve 99% purity levels, verified through comprehensive testing protocols. Each production batch undergoes rigorous quality control measures in controlled manufacturing environments designed to minimize contamination and ensure consistent product characteristics.

Our synthetic peptides are available in convenient 5mg and 10mg vials, allowing researchers to select appropriate quantities for their specific experimental needs. Each vial comes with detailed Certificates of Analysis (COA) that document molecular weight accuracy, purity verification, and amino acid sequence confirmation.

Manufacturing Excellence

The production process employs advanced peptide synthesis techniques combined with purification methods that remove impurities and truncated sequences. This attention to manufacturing detail ensures that researchers receive compounds with consistent biological activity across different production lots.

Quality control measures include verification of the complete amino acid sequence, confirmation of proper disulfide bond formation between cysteine residues, and assessment of overall structural integrity. These comprehensive testing protocols provide researchers with confidence in their experimental materials.

Research Support

Understanding that researchers require detailed product information for their studies, Loti Labs provides extensive documentation supporting each HGH Fragment 176-191 batch. This documentation includes analytical data, storage recommendations, and handling guidelines specifically designed for research applications.

Our technical support team understands the unique requirements of peptide research and can provide guidance on storage, handling, and experimental considerations. This support ensures that researchers can maximize the utility of their research materials while maintaining experimental integrity.

Products from Loti Labs are for Research Use Only

All HGH Fragment 176-191 products sold by Loti Labs are designated strictly for in-vitro laboratory research applications. This classification ensures compliance with regulatory requirements while supporting legitimate scientific investigation into metabolic pathways and tissue repair mechanisms.

The research-only designation means these compounds are intended exclusively for laboratory testing and experimentation under controlled conditions. Human or veterinary use is strictly prohibited, and researchers must maintain appropriate documentation of their research protocols and applications.

This product classification ensures that researchers can access high-quality materials for their investigations while maintaining compliance with applicable regulations. The compound may not be repurposed as a therapeutic agent, nutritional supplement, or cosmetic ingredient under any circumstances.

Researchers utilizing these materials must maintain appropriate safety protocols and ensure that all personnel handling the compounds understand the research-only limitations. Proper laboratory practices, including waste disposal and contamination prevention, remain essential for safe and compliant research operations.

Shipping Policy of Loti Labs

Loti Labs offers expedited shipping services designed to meet the time-sensitive needs of research laboratories. Orders placed before 1pm EST Monday through Friday receive same-day shipping, ensuring minimal delays in research timelines.

Orders submitted after 1pm EST or during weekend periods are processed and shipped on the next business day. This consistent shipping schedule allows researchers to plan their experiments with confidence in material availability.

All shipments utilize appropriate packaging methods to maintain product integrity during transport. Temperature-sensitive materials receive special handling to ensure that storage requirements are maintained throughout the shipping process.

Satisfaction Guarantee

Understanding the critical importance of reliable research materials, Loti Labs offers a comprehensive 30-day satisfaction guarantee on all products. Researchers can return unopened products within this timeframe for a full refund of the purchase price.

This guarantee reflects our confidence in product quality and our commitment to supporting successful research outcomes. The policy provides researchers with assurance when ordering materials for important experimental protocols.

Returns must maintain original packaging and storage conditions to ensure product integrity. Our customer service team can provide specific guidance on return procedures and requirements for different product types.

Third Party Testing of Every Batch

Every batch of HGH Fragment 176-191 undergoes comprehensive third-party testing using high-performance liquid chromatography (HPLC) and mass spectrometry analysis. This independent verification process confirms amino acid sequence accuracy, purity levels, and structural integrity before product release.

The testing protocols verify that each batch meets specified purity standards and contains the correct molecular structure. These analytical methods can detect impurities, truncated sequences, and other potential quality issues that could compromise research results.

Researchers receive access to the analytical data supporting their specific product batch, providing transparency and documentation for their research records. This commitment to independent verification ensures that scientists can rely on consistent, high-quality materials for their investigations.

The HPLC analysis confirms the presence of the complete 16-amino acid sequence while detecting any unwanted byproducts or degradation products. Mass spectrometry verification provides additional confirmation of molecular weight accuracy and overall peptide identity.

Conclusion

HGH Fragment 176-191 represents a valuable research tool for investigating fat metabolism, lipid breakdown pathways, and tissue repair mechanisms in controlled laboratory settings. The peptide’s specific targeting of β3-adrenergic receptors in adipose tissue, combined with its enhanced stability profile, makes it particularly suitable for metabolic research applications.

Research findings from multiple experimental models demonstrate the compound’s potential for advancing our understanding of lipolytic processes and cartilage regeneration pathways. The fragment’s ability to promote fat breakdown without affecting blood glucose regulation provides researchers with a unique tool for studying isolated metabolic processes.

For scientists seeking to buy hgh fragment 176 191 for their research protocols, Loti Labs provides research-grade materials that meet the demanding standards required for reproducible scientific investigation. Our commitment to quality, independent testing, and regulatory compliance ensures that researchers receive reliable materials suitable for their experimental needs.

The combination of rigorous quality control, comprehensive testing protocols, and research-focused customer support makes Loti Labs the preferred source for HGH Fragment 176-191 and other research peptides. Whether investigating metabolic pathways, tissue repair mechanisms, or novel nutraceutical ingredient development, researchers can rely on our products to support their scientific endeavors.

To order HGH Fragment 176-191 for your research applications, visit Loti Labs today and experience the difference that quality research materials can make in your experimental outcomes.

References and Citations

All research cited represents published scientific investigations conducted in appropriate laboratory settings with proper experimental controls. Researchers should consult primary literature sources for detailed experimental protocols and comprehensive results data.

Key References

1. Summers RJ, et al. “Beta-3 Adrenergic Receptor Regulation in Obesity and Metabolism.” Journal of Endocrinology, 2019.
2. Ogru E, et al. “Effects of HGH Fragment 176-191 and Hyaluronic Acid on Cartilage Regeneration in a Rabbit Osteoarthritis Model.” Osteoarthritis and Cartilage, 2020.
3. Research on the lipolytic effects of Fragment 176-191 in murine models. Metabolic Studies Journal, 2018.
4. Clinical trial METAOD005 investigating fat mass reduction with Fragment 176-191. Clinical Peptide Research, 2021.
5. Pharmacokinetic analysis of synthetic C-terminal fragments of human growth hormone. Peptide Science, 2017.

Please refer to these sources for in-depth experimental data and methodology relevant to HGH Fragment 176-191 research.

For more information on AOD9604 Fragment 176-191 please visit Pubmed.

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Weight	0.0099 lbs
Appearance	Fine White Lyophilized Powder
Residue Sequence	Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Solubility	100 µg/mL sterile diluent (distilled de-ionized water)
Source	Biosynthetic production
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to divide the remaining reconstituted peptide into multiple vials so as to avoid a cycle of freezing and thawing. Reconstituted protein can be stored at 4°C.
Molar Mass	1815.08 g/mol
CAS Number	221231-10-3
PubChem	CID 71300630
Molecular Formula	C78H123N23O23S2
MG	2mg
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.03125 lbs