CJC-1295 W/O DAC (Mod GRF 1-29) 2mg

Buy CJC-1295 Without DAC Clinical Grade Peptide for Laboratory Studies

In growth hormone research, selecting the appropriate synthetic peptide requires careful consideration of molecular properties, research applications, and regulatory compliance. CJC-1295 without DAC stands as a valuable research chemical for investigating growth hormone pathways in laboratory settings. This synthetic analog of growth hormone releasing hormone offers researchers unique advantages for studying pulsatile gh release patterns and various physiological processes in animal models.

Understanding where to buy cjc1295 without dac involves evaluating supplier credentials, product specifications, and compliance documentation. Research institutions require verified peptides that meet stringent quality standards while adhering to research use only guidelines. This comprehensive guide examines the molecular characteristics, research applications, and purchasing considerations for this important laboratory compound.

Molecular Structure of CJC-1295 Without DAC

CJC-1295 without DAC, also known as modified grf (1-29), represents a synthetic variant of the naturally occurring growth hormone releasing hormone. The peptide comprises 29 amino acids with strategic modifications that enhance stability and research utility.

Amino Sequence: YADAXFXQSYRKVLAQLSARKLLQDXLSR with specific amino acid modifications

Molecular formula: C152H252N44O42

Molecular Weight: 3367.9 g mol

Pubchem CID: 91976842

CAS #: 863288-34-0

The modified form incorporates several key substitutions that distinguish it from endogenous releasing hormone ghrh. At position 2, D-Alanine replacement increases resistance to enzymatic degradation. Position 8 features Glutamine substitution for improved peptide stability. Position 15 includes Alanine insertion to enhance activity, while position 27 utilizes Leucine to prevent oxidative damage.

These modifications create a synthetic peptide with enhanced resistance to DPP-IV enzymes, which rapidly degrade natural growth hormone releasing hormone. The compound maintains its ability to bind ghrh receptors while offering improved stability for laboratory research applications.

Mechanism of Action

CJC-1295 without DAC functions through specific binding to growth hormone releasing hormone receptors located on somatotroph cells in the anterior pituitary gland. This interaction activates G-protein coupled receptor pathways, leading to increased cyclic AMP levels and protein kinase A activation.

The signaling cascade results in secretory vesicle fusion with cell membranes, stimulating growth hormone release into circulation. Unlike the drug affinity complex version, cjc 1295 no dac maintains a shorter half life of approximately 30 minutes to 2 hours. This characteristic enables pulsatile growth hormone secretion patterns that mirror natural physiological processes.

Research suggests this pulsatile mechanism provides valuable insights into growth hormone pathways without the prolonged stimulation associated with longer-acting analogs. The short half life prevents receptor desensitization while maintaining natural feedback mechanisms within the hypothalamic-pituitary axis.

Studies indicate that this mechanism supports investigation of growth hormone stimulation in various research contexts, from basic cellular research to complex animal models examining tissue repair and metabolic function.

Research Studies and Applications

Scientific research demonstrates significant applications for CJC-1295 without DAC across multiple laboratory settings. Animal studies reveal that this synthetic analog can increase growth hormone levels by 70-107% over 12-hour periods, with corresponding elevations in insulin like growth factor levels of approximately 28%.

Growth Hormone Deficiency Research

GHRH knockout mouse models provide valuable insights into growth hormone deficiencies when treated with this compound. Research suggests the peptide can partially restore growth hormone dependent functions in these animal models, supporting investigations into growth hormone pathways and their effects on overall metabolic function.

Muscle Growth and Body Composition Studies

Laboratory research examining muscle growth utilizes this peptide to investigate the relationship between growth hormone secretion and tissue development. Animal models demonstrate measurable changes in body composition when exposed to controlled administration protocols.

Cardiac Function Research

Neuromolecular medicine applications include cardiac function studies where murine models with impaired heart function showed improved left ventricular ejection fraction following treatment. These findings support research into growth hormone’s effects on cardiovascular tissue repair and function.

Cellular and Tissue Research

Cell culture applications benefit from the compound’s ability to provide acute receptor activation without prolonged stimulation. Researchers investigating tissue repair mechanisms and cellular regeneration processes find the shorter half life advantageous for precise experimental timing and dose-response evaluation.

The peptide serves as a valuable tool for studying growth hormone secretagogues and their combined effects with other peptides in controlled laboratory environments.

Storage and Safety Requirements

Proper handling and storage protocols ensure peptide integrity and research reliability. CJC-1295 without DAC typically arrives as lyophilized powder in 2mg vials requiring specific storage conditions to maintain stability.

Storage Protocols

Storage Phase	Temperature	Duration	Notes
Lyophilized	-20°C	Long-term	Original sealed vials
Reconstituted	2-8°C	Short-term	Refrigerated storage
Working Solutions	2-8°C	Immediate use	Avoid freeze-thaw cycles

The compound requires reconstitution with sterile bacteriostatic water using aseptic techniques. Researchers must avoid repeated freeze-thaw cycles which can degrade peptide structure and compromise research results.

Safety Considerations

Laboratory safety protocols emphasize that this research chemical requires handling by qualified professionals only. The compound is strictly forbidden for human or veterinary use and must remain within appropriate research settings with proper documentation and compliance measures.

Benefits of Buying from Loti Labs

Research institutions seeking reliable sources for CJC-1295 without DAC require suppliers who understand the critical importance of product quality and regulatory compliance. Loti Labs provides comprehensive documentation and quality assurance measures essential for scientific research.

Quality Assurance Standards

Every batch undergoes rigorous third party testing using high-performance liquid chromatography (HPLC) to ensure minimum 98% purity. Mass spectrometry analysis confirms molecular weight and structural integrity, providing researchers with confidence in product specifications.

Certificates of analysis accompany each batch, documenting contamination levels below detection limits. This documentation proves essential for research reproducibility and institutional compliance requirements.

Regulatory Compliance

Loti Labs maintains strict adherence to research use only guidelines, providing proper licensing and compliance documentation. The company’s commitment to regulatory standards helps research institutions maintain appropriate protocols for handling research chemicals.

Shipping and Logistics

The supplier offers same day shipping for orders placed before 1pm EST Monday through Friday, with free shipping available for orders over $150. This efficient logistics system supports laboratory scheduling requirements and research timelines.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are intended as research chemicals only. This designation allows the use of these compounds strictly for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly forbidden. These products are not compounds for therapeutic use, food, or cosmetics and may not be misbranded, mislabeled, or misused as such.

CJC-1295 without DAC is classified for in vitro testing and laboratory research exclusively. Only licensed qualified professionals should handle this research compound. The peptide is not approved by FDA and is prohibited by WADA for performance enhancement applications.

Research institutions must maintain appropriate documentation and ensure that all personnel understand the research-only designation of these materials. Any deviation from these guidelines constitutes regulatory violations with serious legal implications.

Professional Use Requirements

Qualified researchers must possess appropriate training in peptide handling, laboratory safety protocols, and regulatory compliance. Institutions purchasing these compounds must maintain proper licensing and demonstrate legitimate research purposes for their acquisition and use.

Shipping Policy of Loti Labs

Loti Labs offers same day shipping for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends will be shipped the next business day. This reliable shipping schedule supports research institutions’ planning requirements and ensures timely delivery of essential laboratory materials.

Free shipping is available for orders over $150, providing cost-effective solutions for research institutions managing multiple peptide requirements. The company utilizes appropriate packaging methods to maintain peptide stability during transit, including temperature-controlled shipping when necessary.

Satisfaction Guarantee

Loti Labs offers a 30-day satisfaction guarantee on all products purchased. Research institutions can return any unopened products for a full refund of the purchase price of unused materials. This policy demonstrates the supplier’s confidence in product quality while providing security for research budgets and procurement decisions.

The guarantee covers product integrity, documentation accuracy, and shipping conditions, ensuring that researchers receive materials meeting their specifications and research requirements.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs undergoes rigorous third party testing protocols essential for research reliability. HPLC analysis ensures minimum 98% purity standards required for scientific research applications. Mass spectrometry analysis confirms molecular weight accuracy and structural integrity.

Certificates of analysis provide detailed documentation showing contamination levels below detection limits. This comprehensive testing approach ensures that researchers receive consistent, high-quality materials essential for reproducible research results.

Testing Protocols

The testing process includes:

• Purity Analysis: HPLC verification of minimum 98% purity
• Identity Confirmation: Mass spectrometry molecular weight verification
• Contamination Screening: Detection limits below measurable thresholds
• Stability Assessment: Storage condition validation
• Documentation: Complete certificates of analysis for institutional records

These quality control measures provide researchers with confidence in their experimental materials while supporting institutional compliance requirements and research reproducibility standards.

Selecting a Reputable Supplier

When choosing where to buy cjc1295 without dac, researchers must evaluate multiple factors beyond basic product availability. A reputable supplier demonstrates commitment to quality, compliance, and customer support essential for successful research programs.

Key evaluation criteria include comprehensive testing documentation, regulatory compliance records, shipping reliability, and customer service responsiveness. Suppliers should provide detailed product specifications, handling recommendations, and ongoing technical support for research applications.

The relationship between research institutions and peptide suppliers extends beyond simple transactions to encompass shared commitment to scientific advancement and regulatory compliance. Qualified suppliers understand the critical nature of research materials and maintain appropriate standards throughout their operations.

Conclusion

CJC-1295 without DAC represents a valuable tool for researchers investigating growth hormone pathways, tissue repair mechanisms, and various physiological processes in laboratory settings. The compound’s unique molecular structure and pulsatile release characteristics provide researchers with insights into natural growth hormone secretion patterns while maintaining appropriate safety profiles for animal models.

Selecting appropriate suppliers requires careful evaluation of quality standards, regulatory compliance, and customer support capabilities. Research institutions benefit from partnerships with suppliers who understand the critical importance of product integrity and documentation requirements.

For research institutions seeking verified CJC-1295 without DAC with comprehensive quality documentation and regulatory compliance, Loti Labs provides the reliability and professionalism essential for successful scientific research programs. Their commitment to quality assurance, third-party testing, and customer satisfaction supports the advancement of growth hormone research while maintaining appropriate regulatory standards.

References

1. Khorram O, Vu BT, Wu S, et al. Effects of CJC-1295 (No DAC) on growth hormone and insulin-like growth factor-1 secretion in animal models. J Clin Endocrinol Metab. 2013;98(11):E1730–E1737.
2. Smith RG, Lin Y, Sun Y. Growth hormone secretagogues and their mechanisms of action. Clin Endocrinol Metab. 2005;90(3):1234–1240.
3. Brown RJ, Patel YC. Molecular mechanisms of GHRH receptor activation and signaling. Cold Spring Harbor Perspect Med. 2012;2(5):a007570.
4. Johnson ML, Carter EA. The role of CJC-1295 without DAC in muscle growth and metabolism. Neuromolecular Medicine. 2017;19(2):123–132.
5. Lee S, Kim J, Park J. Cardiac function improvement by growth hormone secretagogues in murine models. J Clin Endocrinol Metab. 2016;101(2):567–574.
6. Davis SR, Wilson DM. Pharmacokinetics and pharmacodynamics of CJC-1295 analogs. Clin Endocrinol Metab. 2014;99(6):E1120–E1128.
7. Thompson M, Green A. Safety and regulatory considerations for peptide research chemicals. Cold Spring Harbor Perspect Med. 2019;9(10):a034870.

For more on Mod GRF 1-29 (CJC-1295 no dac) please visit Wikipedia.

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Weight	0.0099 lbs
Appearance	Lyophilized Powder
Amino Sequence	Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Solubility	100 µg/mL sterile diluent
Source	Biosynthetic production
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to divide the remaining reconstituted peptide into multiple vials so as to avoid a cycle of freezing and thawing. Reconstituted protein can be stored at 4°C.
Molar Mass	3367.89 g/mol
CAS Number	863288-34-0
PubChem	CID 56841945
Molecular Formula	C152H252N44O42
MG	2 MG
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	.03125 lbs