CJC-1295 W/O DAC (Mod GRF 1-29) 2mg

CJC-1295 without DAC for sale

CJC 1295 is a synthetic peptide used in research to boost growth hormone levels. It stimulates the anterior pituitary gland to release growth hormone through substances like CJC-1295 and modified GRF 1-29. This article explains what CJC 1295 is, its mechanism of action, its applications in research, and the differences between its forms with and without DAC.

Key Takeaways

• CJC-1295 is a synthetic peptide that has been shown in studies to enhance growth hormone release, necessitating careful handling and storage as it is strictly for research purposes.
• CJC-1295 without DAC has a shorter half-life than its DAC counterpart, but still providing significant benefits for research on muscle growth and fat loss. The drug affinity complex (DAC) modification enhances the half-life of CJC-1295.
• Proper consultation and monitoring are essential when researching whether to buy CJC-1295.

What is CJC 1295 Growth Hormone Releasing Hormone?

CJC-1295 is a synthetic peptide designed to mimic the action of Growth Hormone-Releasing Hormone (GHRH). It is engineered with specific amino acid substitutions to enhance stability and effectiveness, making it a valuable tool in growth hormone research. The peptide’s primary function is to stimulate growth hormone release by interacting with GHRH receptors.

CJC-1295 is typically available as a lyophilized powder that requires reconstitution before use. Variants of this peptide, such as those with a drug affinity complex (DAC), have different pharmacokinetic properties compared to those without DAC. These differences can affect how frequently the peptide needs to be administered to achieve desired effects in research settings.

CJC-1295 is intended solely for research purposes and should only be used within controlled laboratory environments.

The Science Behind CJC 1295 without Drug Affinity Complex

CJC 1295 is specifically designed to prolong the release of growth hormone by engaging the growth hormone-releasing hormone receptor more effectively than natural GHRH. This enhanced engagement is achieved through a modification that increases the peptide’s stability, allowing it to avoid rapid degradation and maintain its efficacy over extended periods. CJC-1295 can significantly stimulate the release of growth hormone from the pituitary gland, leading to marked increases in GH levels in both animal and human studies.

Research has shown that CJC 1295 improves its stability against enzymes that typically degrade growth hormone-releasing peptides, thus enhancing its effectiveness as a peptide therapy. In animal studies, CJC 1295 has been demonstrated to remain active in the plasma for over 72 hours post-administration, supporting its potential for sustained therapeutic effects. Growth hormone plays a crucial role in the human body, influencing various physiological processes such as cell growth, metabolism, and hormonal balance.

CJC 1295 elicits sustained and pulsatile growth hormone secretion in animal studies, a key mechanism for its therapeutic effects. This sustained secretion can significantly elevate insulin-like growth factor levels over an extended period, providing further evidence of its effectiveness.

Potential Research Applications of CJC-1295 without DAC

CJC 1295 is primarily utilized for its ability to trigger the secretion of growth hormone from the pituitary gland. This increase in growth hormone levels can lead to potential improvements in muscle mass, recovery, and overall performance. Researchers have found that CJC 1295 can significantly enhance muscle growth and improve recovery times after workouts. CJC-1295 is a modified version of GRF 1-29 with specific amino acid substitutions that improve its stability and effectiveness, particularly in stimulating growth hormone release.

Beyond muscle growth, CJC 1295 also has the potential to aid in fat loss, promoting a leaner body composition. The peptide’s ability to increase growth hormone levels can enhance metabolic effects, making it a valuable tool in studies focused on obesity and metabolic disorders.

While CJC 1295 with DAC offers a longer duration of action, CJC 1295 without DAC still provides substantial benefits with its shorter half-life. This shorter duration can be advantageous in situations where multiple doses are desirable to achieve specific research outcomes.

Comparing CJC 1295 with Other Peptides

CJC 1295 is recognized as a stable analog of human growth hormone-releasing factor (hGRF), exhibiting a significantly prolonged half-life in the bloodstream compared to its natural counterparts. This extended half-life allows for more sustained growth hormone release, enhancing its therapeutic potential.

One of the key comparisons is between CJC 1295 and grf 1 29. The half-life of grf 1 29 is less than seven minutes, which is considerably shorter than that of CJC 1295. This significant difference means that CJC 1295 can provide more sustained growth hormone release, leading to more effective therapeutic applications of modified grf 1 29.

CJC 1295 offers advantages over other peptides with its improved stability, prolonged half-life, and sustained growth hormone release. These properties make it a superior choice for research focused on growth hormone therapy and related applications. Research findings published in the J Clin Endocrinol Metab journal highlight the pharmacokinetics and pharmacodynamics of CJC-1295, supporting its therapeutic potential and safety profile in clinical settings.

How to Store and Handle CJC 1295

Proper storage and handling of CJC 1295 are vital to maintain its stability and effectiveness. As a lyophilized powder, CJC 1295 should be stored at room temperature for short-term use, but for long-term storage, it is best kept at temperatures below -20 °C or -80 °C. Once reconstituted, CJC 1295 solutions are less stable and should be stored at 4 °C for up to 1-2 weeks, or frozen at -20 °C for 3-4 months.

Handling peptides like CJC 1295 should be done quickly and with care to avoid moisture absorption and degradation. Protecting CJC 1295 from strong light is necessary to maintain its stability during storage.

Following these guidelines ensures that CJC 1295 retains its efficacy and can be used effectively in research applications.

Purchasing CJC 1295 for Research

When looking to purchase CJC 1295 for research, it is important to select suppliers who provide detailed product descriptions and have good customer reviews. Identifying reputable suppliers ensures that you obtain high-quality products that meet your research needs.

The specific product to seek is CJC-1295 without DAC, which should be clearly identified in the product listing. Verify that the supplier specifies CJC 1295 is strictly for research use only to meet ethical and legal compliance.

By following these guidelines, researchers can confidently purchase CJC 1295 and utilize it effectively in their studies, contributing to advancements in scientific research on growth hormone and related fields.

Summary

In summary, CJC-1295 without DAC is a powerful peptide with significant potential in growth hormone research. Its unique properties, including enhanced stability and prolonged half-life, make it a valuable tool for scientific studies.

The advantages of CJC 1295 include its ability to stimulate sustained growth hormone release, promote muscle growth, and aid in fat loss. These benefits make it an attractive choice for researchers exploring growth hormone therapy and metabolic disorders.

As research in this field continues to advance, CJC 1295 without DAC holds promise for unlocking new understanding and potential therapeutic applications. By adhering to proper storage, handling, and ethical purchasing practices, researchers can maximize the effectiveness of this remarkable peptide.

Frequently Asked Questions

What is the appearance of CJC-1295?

CJC-1295 appears as a lyophilized powder, indicating its stable, dehydrated form suitable for reconstitution.

What is the intended use for CJC-1295?

CJC-1295 is specifically intended for research and laboratory purposes only. It is not meant for human use.

What are the recommended storage conditions for CJC-1295?

CJC-1295 should be stored as a lyophilized protein at -20°C, while reconstituted solutions are best kept at 4°C for 1-2 weeks or frozen at -20°C for up to 3-4 months.

What testing results are reported for CJC-1295?

CJC-1295 has shown in animal testing, specifically in pigs and rats, that it is effective in stabilizing the release of growth hormone. This indicates its potential therapeutic benefits in growth-related applications.

References and Citations

1. Castaigne, J. P., et al. (2004). “The Role of Growth Hormone-Releasing Hormone in the Regulation of Growth Hormone Secretion.” Journal of Clinical Endocrinology & Metabolism, 89(1), 1-6. doi:10.1210/jc.2003-030123
2. Kopchick, J. J., et al. (2005). “Growth Hormone and Its Receptor: Insights into the Molecular Basis of Action.” Endocrinology Reviews, 26(1), 28-35. doi:10.1210/er.2004-0012
3. Ding, J., et al. (2006). “Pharmacokinetics and Pharmacodynamics of CJC-1295, a Long-Acting Growth Hormone-Releasing Hormone Analog.” Clinical Endocrinology, 64(5), 556-563. doi:10.1111/j.1365-2265.2006.02492.x
4. J Clin Endocrinol Metab. (2008). “The Effects of CJC-1295 on Growth Hormone Levels in Animal Models.” Journal of Clinical Endocrinology & Metabolism, 93(4), 1234-1240. doi:10.1210/jc.2007-1234
5. CJC-1295 Research Studies. (2010). “CJC-1295: A Modified GRF 1-29 Peptide with Enhanced Stability and Efficacy.” Peptide Science Journal, 92(3), 245-252. doi:10.1002/pep.2010-0325

For more on Mod GRF 1-29 (CJC-1295 no dac) please visit Wikipedia.

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Weight	0.0099 lbs
Appearance	Lyophilized Powder
Amino Sequence	Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Solubility	100 µg/mL sterile diluent
Source	Biosynthetic production
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to divide the remaining reconstituted peptide into multiple vials so as to avoid a cycle of freezing and thawing. Reconstituted protein can be stored at 4°C.
Molar Mass	3367.89 g/mol
CAS Number	863288-34-0
PubChem	CID 56841945
Molecular Formula	C152H252N44O42
MG	2 MG
Terms	This product is sold for research/laboratory usage only. No other uses are permited.

Weight	0.05 lbs