BAM15 Capsules (10mg/capsule, 30 capsules)

Buy BAM15 Capsules: High-Purity Research Compound for Mitochondrial Studies

BAM15 has emerged as a particularly promising mitochondrial uncoupler in contemporary research investigating cellular energy metabolism and metabolic diseases. This selective mitochondrial uncoupling agent offers researchers a powerful tool for examining mitochondrial function, energy expenditure, and related pathways in laboratory settings. For scientists seeking to buy BAM15 capsules for their research applications, understanding the compound’s properties, mechanisms, and quality specifications becomes essential for successful experimental outcomes.

Molecular Structure of BAM15

Molecular formula: C25H30N4O3S

Molecular Weight: 438.89 g/mol

Pubchem CID: 135095868

CAS #: 1642568-48-2

The molecular structure of BAM15, chemically designated as N5,N6-bis(2-fluorophenyl)[2,1,3]oxadiazolo[4,5-b]pyrazine-5,6-diamine, represents a carefully engineered compound designed for research into mitochondrial function. This precise molecular architecture enables BAM15 to function as a selective mitochondrial uncoupling agent derived from extensive medicinal chemistry optimization. The compound’s structural confirmation through nuclear magnetic resonance (NMR) and mass spectrometry ensures researchers receive authentic material for their investigations into diverse energy synthesis pathways and mitochondrial quality control processes.

Research suggests that BAM15’s unique molecular configuration allows for heightened mitochondrial targeting efficiency compared to traditional uncoupling agents. The compound demonstrates selectivity for essential subcellular organelles responsible for cellular energy production, specifically targeting the inner mitochondrial membrane without influencing plasma membrane depolarization.

Mechanism of Action

BAM15 functions as a selective mitochondrial uncoupling agent that enhances cellular energy metabolism by disrupting the proton gradient across inner mitochondrial membranes. Research indicates this novel mitochondrial uncoupling agent demonstrates approximately 7-fold greater potency compared to traditional uncouplers while maintaining minimal off-target effects and avoiding body temperature elevation at research concentrations.

The compound facilitates mitochondrial uncoupling by allowing proton leak across the inner mitochondrial membrane, effectively separating electron transport chain activity from ATP synthesis. This mitochondrial uncoupling induced mechanism forces cells to increase substrate utilization for maintaining energy homeostasis, ultimately promoting enhanced mitochondrial respiration and oxygen consumption.

Studies examining isolated rat liver mitochondria demonstrate that BAM15 selectively depolarizes mitochondrial membranes while sparing plasma membrane potential. Research suggests this selectivity contributes to the compound’s favorable profile in laboratory applications studying glucose metabolism, lipid oxidation, and mitochondrial biogenesis regulation. The compound also appears to promote mitochondrial respiration through mechanisms involving mitochondrial fission proteins and enhanced mitochondrial transcription factor activity.

Research Studies

Preclinical investigations reveal that BAM15 increases whole-body oxygen consumption by 15-19% in research models without altering food intake or affecting fat free lean mass. Research suggests the compound reverses diet induced obesity by promoting fat oxidation and reducing fat mass accumulation by up to 15% in controlled laboratory studies examining negative energy balance.

Studies investigating metabolic disorders characterized by insulin resistance demonstrate that BAM15 improves glucose tolerance testing results and enhances blood glucose control. Research indicates the compound fully reverses hyperinsulinemia after 3 weeks of treatment in diet induced obese mice, suggesting potential applications in studying pathogenesis involving insulin resistance and related metabolic disease mechanisms.

Laboratory investigations examining fatty liver disease show that BAM15 significantly reduces liver triglyceride levels and prevents hepatic steatosis associated with Western diet consumption. Research suggests the compound may help address nonalcoholic fatty liver disease by modulating cellular energy metabolism and potentially alleviating oxidative stress through decreased mitochondrial superoxide production.

Additional studies indicate BAM15’s role in regulating macrophage polarization genes and suppressing inflammation mitochondrial DNA pathways. Research examining cultured rat brain astrocytes suggests the compound enhances mitochondrial biogenesis while mitigating mitochondrial dysfunction associated with acute and chronic stress conditions.

Research Application	Observed Effects	Study Model
Oxygen Consumption	15-19% increase	Rodent studies
Fat Mass Reduction	Up to 15% decrease	Diet-induced obesity models
Glucose Tolerance	Significant improvement	Metabolic research models
Liver Triglycerides	Substantial reduction	Hepatic steatosis studies

Storage and Safety

BAM15 demonstrates remarkable tolerability in research applications with lower cytotoxicity compared to traditional mitochondrial uncouplers. Research indicates the compound selectively depolarizes mitochondria without affecting plasma membrane potential, minimizing off-target effects that could confound experimental results. Unlike conventional uncoupling agents, BAM15 mildly inhibits mitochondrial respiration while maintaining maximal mitochondrial respiration capacity in controlled laboratory conditions.

For optimal research outcomes, BAM15 requires refrigeration at 2-8°C to maintain compound stability and prevent degradation. The compound should be stored in amber vials or sealed containers to prevent light-induced breakdown that could compromise experimental integrity. Research suggests proper storage conditions preserve the compound’s ability to facilitate mitochondrial uncoupling and maintain its effectiveness in studying chronic metabolic disease and obesity related metabolic disorders.

Laboratory safety protocols indicate BAM15’s improved profile compared to traditional uncouplers, with research showing reduced risk of cellular toxicity when used according to established research guidelines. Studies examining the compound’s effects on mitochondrial reactive oxygen species suggest BAM15 may actually potentially alleviate oxidative stress through optimized mitochondrial function rather than exacerbating cellular damage.

Benefits of Buying from Loti Labs

Loti Labs provides BAM15 capsules with verified product purity exceeding 98% through high-performance liquid chromatography analysis. Our comprehensive quality control measures ensure researchers receive authentic material for investigating mitochondrial transcription factor regulation, enhancing mitochondrial biogenesis, and studying cellular energy metabolism pathways.

Each batch includes detailed certificates of analysis showing molecular structure confirmation via NMR and mass spectrometry. This analytical verification supports research integrity when studying mechanisms encompassing metabolic disorders characterized by impaired mitochondrial function and disrupted energy synthesis pathways.

All BAM15 capsules from Loti Labs feature proper packaging to prevent light degradation and maintain compound stability throughout storage periods. This attention to packaging detail ensures researchers can conduct accurate food intake measurements and metabolic studies without concerns about compound degradation affecting experimental outcomes.

Key advantages include:

• Analytical Verification: Third-party testing confirms molecular identity and purity
• Proper Storage: Amber vial packaging prevents light-induced degradation
• Research Documentation: Comprehensive certificates support experimental protocols
• Quality Consistency: Batch-to-batch reliability for reproducible research outcomes

Products from Loti Labs are for Research Use Only

All compounds sold by Loti Labs are designated strictly as research chemicals for laboratory applications only. This designation permits use exclusively for in-vitro laboratory testing and experimentation investigating mitochondrial function, cellular energy metabolism, and related research applications. Human or veterinary use is strictly prohibited under this research-only classification.

BAM15 capsules are not intended as consumables, supplements, or therapeutic agents. The compound may not be misbranded, mislabeled, or misused outside its designated research applications. This research-only restriction ensures compliance with regulatory requirements while supporting legitimate scientific investigation into mitochondrial uncoupling mechanisms, metabolic disease pathways, and cellular energy regulation.

Researchers must maintain appropriate laboratory protocols when working with BAM15, including proper storage conditions, handling procedures, and disposal methods consistent with research chemical guidelines. Laboratory personnel should follow institutional safety protocols and maintain detailed records of compound usage for research compliance purposes.

Shipping Policy of Loti Labs

Loti Labs offers same-day shipping for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends will be shipped the next business day. This expedited shipping policy ensures researchers receive their BAM15 capsules promptly for time-sensitive experimental protocols investigating mitochondrial respiration, glucose metabolism, or metabolic disease mechanisms.

Our shipping procedures maintain cold chain requirements when necessary and include protective packaging to prevent damage during transit. All shipments include tracking information and delivery confirmation to ensure researchers can monitor their order status and plan experimental timelines accordingly.

Satisfaction Guarantee

Loti Labs offers a 30-day satisfaction guarantee on all products purchased from us. Simply return any unopened products to us for a full refund of the purchase price of the unused products. This guarantee reflects our confidence in product quality and supports researchers who may need to modify experimental protocols or research directions.

The satisfaction guarantee covers product quality concerns, shipping damage, or changes in research requirements that may affect compound utilization. Researchers can proceed with confidence knowing their investment in high-quality BAM15 capsules is protected by our comprehensive guarantee policy.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs undergoes rigorous third-party testing using HPLC to ensure product purity and accuracy. Our BAM15 capsules are verified for purity exceeding 98% with molecular structure confirmation via NMR and mass spectrometry. This analytical verification supports research applications requiring precise compound identification and consistent quality.

Third-party testing protocols include:

• High-Performance Liquid Chromatography (HPLC): Purity verification and impurity analysis
• Nuclear Magnetic Resonance (NMR): Structural confirmation and molecular identity
• Mass Spectrometry: Molecular weight verification and fragmentation analysis
• Certificate of Analysis: Detailed documentation for research records

These testing procedures ensure researchers receive authenticated BAM15 for investigating mitochondrial fusion protein interactions, studying cardiovascular disease mechanisms, or examining the compound’s effects on pancreatic alpha cell mass in appropriate research models.

Ordering Information and Research Applications

When you buy BAM15 capsules from Loti Labs, you receive a research compound suitable for investigating diverse applications in metabolic research. Studies suggest the compound’s utility in examining mitochondrial autophagy processes, investigating mechanisms of alleviating endoplasmic reticulum stress, and studying pathways involved in selectively targeting tumor cells through metabolic modulation.

Research applications include investigating how BAM15 activates mitochondrial transcription pathways, studying its effects on hepatic glucose output in laboratory models, and examining the compound’s role in promoting mitochondrial network contacts. The compound’s ability to facilitate mitochondrial uncoupling while maintaining cellular viability makes it valuable for studying cardiovascular diseases, metabolic disorders, and cellular aging mechanisms.

For researchers studying sepsis involves immune dysfunction or investigating septic acute kidney injury mechanisms, BAM15 offers opportunities to examine mitochondrial DNA leakage pathways and cellular stress responses. The compound’s effects on increases intracellular calcium concentration and mitochondrial quality control processes provide additional research avenues for comprehensive metabolic investigations.

Scientists can utilize BAM15 to study calorie restriction mimetics, investigate targeting negative energy balance mechanisms, or examine the compound’s potential in ultimately impeding tumor progression through metabolic modulation. Research suggests the compound’s unique properties make it particularly suitable for investigating complex metabolic pathways and mitochondrial dysfunction in various disease models.

Contact Loti Labs today to order high-purity BAM15 capsules for your mitochondrial research applications. Our commitment to analytical verification, proper storage, and research compliance ensures you receive reliable compounds for advancing scientific understanding of cellular energy metabolism and related pathways.

References

1. Alexopoulos, S.J., Chen, S.Y., Brandon, A.E., et al. Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nat Commun 11, 2397 (2020). https://doi.org/10.1038/s41467-020-16298-2
2. Axelrod, C.L., King, W.T., Davuluri, G., et al. BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med. 2020;12(7):e12088. https://doi.org/10.15252/emmm.202012088
3. Chen, S.Y., Beretta, M., Olzomer, E.M., et al. Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice. Mol Metab. 2023;69:101684. https://doi.org/10.1016/j.molmet.2023.101684
4. Childress, E.S., Alexopoulos, S.J., Hoehn, K.L., Santos, W.L. Small molecule mitochondrial uncouplers and their therapeutic potential. J Med Chem. 2018;61(11):4641-4655. https://doi.org/10.1021/acs.jmedchem.7b01182
5. Dantas, W.S., Zunica, E., Heintz, E.C., et al. Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control. J Cachexia Sarcopenia Muscle. 2022;13(1):1821-1836. https://doi.org/10.1002/jcsm.12982
6. Kenwood, B.M., Weaver, J.L., Bajwa, A., et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2014;3(2):114-123. https://doi.org/10.1016/j.molmet.2013.11.005
7. Zunica, E., Axelrod, C.L., Cho, E., et al. Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab. 2021;9:36. https://doi.org/10.1186/s40170-021-00274-5
8. Cho, I., Song, H.O., Ji, H.E., Yang, S., Cho, J.H. BAM15 relieves neurodegeneration in aged Caenorhabditis elegans and extends lifespan. Metabolites. 2022;12(11):1129. https://doi.org/10.3390/metabo12111129
9. Tsuji, N., Tsuji, T., Yamashita, T., et al. BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils. J Clin Invest. 2023;133(7):e152401. https://doi.org/10.1172/JCI152401
10. Hu, N., Fu, Y., Li, W.F., et al. Chemical mitochondrial uncouplers share common inhibitory effect on NLRP3 inflammasome activation through inhibiting NFκB nuclear translocation. Toxicol Appl Pharmacol. 2021;414:115426. https://doi.org/10.1016/j.taap.2021.115426
11. Gao, J.L., Zhao, J., Zhu, H.B., et al. Characterizations of mitochondrial uncoupling induced by chemical mitochondrial uncouplers in cardiomyocytes. Free Radic Biol Med. 2018;124:288-298. https://doi.org/10.1016/j.freeradbiomed.2018.06.020
12. Murray, J.H., Burgio, A.L., Beretta, M., et al. Oxadiazolopyridine derivatives as efficacious mitochondrial uncouplers in the prevention of diet-induced obesity. J Med Chem. 2023;66(9):3876-3895. https://doi.org/10.1021/acs.jmedchem.2c01573
13. Healy, M.E., Alexopoulos, S.J., Byrne, F.L., et al. Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine. J Hepatol. 2015;62(3):599-606. https://doi.org/10.1016/j.jhep.2014.09.035
14. Chen, S.Y., Beretta, M., Olzomer, E.M., et al. Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice. Mol Metab. 2023;69:101684. https://doi.org/10.1016/j.molmet.2023.101684
15. Cogliati, S., Cabrera-Alarcón, J.L., Enriquez, J.A. Regulation and functional role of the electron transport chain supercomplexes. Biochem Soc Trans. 2021;49(6):2655-2668. https://doi.org/10.1042/BST20210460

Note: For full citation details and additional references, please refer to the original research articles and reviews cited throughout this document.

Weight	.0625 lbs